Article
Chemistry, Multidisciplinary
Ignacio Esteban-Gorgojo, Manuel Jorge Rial, Joaquin Sastre
Summary: This study analyzed the relationship between eosinophilia and asthma, finding that eosinophilia is associated with rhinitis, atopy, and decreased lung function, specifically in persistent asthma.
APPLIED SCIENCES-BASEL
(2022)
Article
Otorhinolaryngology
Ji-Hyeon Shin, Jeong-Bae Jeon, Min Chae Jeon, Sohee Park, Hyojung Kim
Summary: The expression of periostin in hypertrophic tonsils and adenoids was investigated in this study. The atopic group showed significantly higher levels of periostin mRNA expression and protein levels in both the tonsils and adenoids compared to the control group. The atopic group also had higher levels of TGF-β1 in the tonsils and adenoids. These findings suggest a potential association between periostin and atopic status in children.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2023)
Article
Health Care Sciences & Services
Clara Padro-Casas, Maria Basagana, Maria Luisa Rivera-Ortun, Ignasi Garcia-Olive, Carlos Pollan-Guisasola, Aina Teniente-Serra, Eva Martinez-Caceres, Jose-Tomas Navarro, Jorge Abad-Capa, Antoni Rosell, Albert Roger, Carlos Martinez-Rivera
Summary: This study examined a group of 98 adult patients with severe eosinophilic asthma and followed them for one year. The majority of patients were diagnosed with uncontrolled severe asthma at the initial visit, and a high percentage of patients were also found to have allergies. The study also found a significant correlation between sputum eosinophils and peripheral eosinophil count.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jakub Novosad, Irena Krcmova, Ondrej Soucek, Marcela Drahosova, Vratislav Sedlak, Martina Kulirova, Pavlina Kralickova
Summary: The existence of eosinophils was documented in the 19th century, and they have since been associated with asthma, allergies, and antihelminthic immunity. However, a fundamental reassessment of eosinophil population has shown that they are not homogeneous, but rather form subtypes with different characteristics. Improved understanding and characterization of pathogenic eosinophils may lead to better treatment outcomes in severe asthma patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Sanja Popovic-Grle, Anamarija Stajduhar, Marina Lampalo, Dina Rnjak
Summary: Asthma, the most common respiratory disease, has multiple phenotypes that can be differentiated by measuring specific biomarkers. Choosing suitable biomarkers to stratify patients remains a challenge, but the use of multiple biomarkers is superior for better disease evaluation.
Article
Allergy
Millie Nguyen Basu, Charlotte G. Mortz, Tina Kold Jensen, Torben Barington, Kate Lykke Lambertsen, Susanne Halken
Summary: The clinical and molecular characteristics of an AD+asthma phenotype were investigated and compared with AD, asthma, and control groups. The study found an increased number of IgE sensitizations and elevated levels of Pro-Th-2 cytokines in the AD+asthma group. NMF levels were decreased in AD. These findings suggest potential biomarkers and provide insights into the pathogenesis of AD+asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Krzysztof Gomulka, Maciej Tota, Kacper Brzdak
Summary: This study aimed to investigate the expression of CD11b activation marker on peripheral eosinophils in asthmatics with different degrees of airway narrowing. The results showed that CD11b was slightly presented on unstimulated eosinophils in asthmatics, and stimulation with VEGF enhanced their activity and induced CD11b expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Francesca Levi-Schaffer
Summary: The understanding of the pathologic mechanisms of asthma and atopic dermatitis has improved in recent years. However, the high heterogeneity of both diseases complicates diagnosis and treatment, with current strategies mainly focusing on symptom control rather than full healing. There is a need for more personalized approaches to improve diagnosis and treatment efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Allergy
Maura Kere, Susanna Klevebro, Natalia Hernandez-Pacheco, Maria Odling, Sandra Ekstrom, Ida Mogensen, Christer Janson, Lena Palmberg, Marianne van Hage, Antonios Georgelis, Anna Bergstrom, Inger Kull, Erik Melen, Sophia Bjorkander
Summary: This study investigated the relationship between clinical characteristics, inflammation-related plasma proteins, and blood eosinophil and neutrophil concentrations in subjects with and without asthma. The findings suggest that eosinophilic asthma is associated with a distinct clinical phenotype, and MMP10 may serve as a potential plasma biomarker for eosinophilic asthma, while CCL4 is linked to neutrophilic asthma.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Allergy
Suleyman Tolga Yavuz, Soyhan Bagci, Ahmet Bolat, Onur Akin, Rainer Ganschow
Summary: The study found that children with asthma had significantly higher serum periostin levels than control subjects, and there was a positive correlation between serum periostin levels and asthma severity.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Adnan Custovic, Salman Siddiqui, Sejal Saglani
Summary: Among patients with asthma, there is a need for accurate biomarkers that can predict risk and treatment stratification. Most severe asthma patients have type-2 inflammation-mediated disease, and biomarkers such as airway/blood eosinophils and fractional exhaled nitric oxide can be potentially important for severe disease. Composite type-2 biomarkers of blood eosinophils and fractional exhaled nitric oxide can improve the prediction of severe attacks in both adults and children. Technological advances in diagnostics microarray technologies offer the possibility of using component-resolved diagnostics as biomarkers for asthma severity. Genetic factors and polygenic risk scores may also contribute to prediction algorithms. Asthma cannot be accurately defined in an individual patient by a discrete and static endotype, and new tools and approaches are needed for therapy stratification.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Akira Yamasaki, Ryota Okazaki, Tomoya Harada
Summary: Eosinophilic inflammation is a characteristic of asthma, but neutrophilic inflammation can also occur. Asthma can be classified into eosinophilic asthma, neutrophilic asthma, and mixed subtypes. Neutrophilic asthma is associated with certain biomarkers and physiological pathways, as well as factors such as obesity, gastroesophageal reflux disease, and smoking. Targeting neutrophilic asthma is important, and various treatments have been tested, but more research is needed to determine the optimal treatment.
Article
Allergy
Rikke Bjersand Sunde, Jonathan Thorsen, Frederikke Skov, Laura Hesselberg, Julie Kyvsgaard, Nilofar V. Folsgaard, Ann-Marie Malby Schoos, Jakob Stokholm, Klaus Bonnelykke, Bo Chawes
Summary: Fraction of exhaled nitric oxide is elevated in children with asthma and is correlated with asthma-associated traits depending on the presence of aeroallergen sensitization.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Pediatrics
Ketan Kumar, Meenu Singh, Joseph L. Mathew, Pankaj C. Vaidya, Savita Verma Attri
Summary: The average serum periostin level in children with asthma between 6 and 16 years old was determined in this study, aiming to investigate its correlation with markers of eosinophilic inflammation, asthma control, and severity. The results showed that there was no significant correlation between serum periostin levels and these factors. This suggests that serum periostin may not be an ideal marker for assessing inflammatory status in children with asthma.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Medicine, General & Internal
Adil Adatia, Harissios Vliagoftis
Summary: Severe asthma is a complex airway condition, and monoclonal antibody therapies targeting inflammation have made significant progress in its management. However, some patients still cannot achieve optimal control, prompting the search for new biomarkers to guide treatment.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
David F. Choy, Joseph R. Arron
EXPERT OPINION ON THERAPEUTIC TARGETS
(2020)
Article
Allergy
Cheryl A. Steiman, Michael D. Evans, Kristine E. Lee, Michael R. Lasarev, Ronald E. Gangnon, Brent F. Olson, Kathrine L. Barnes, Casper G. Bendixsen, Christine M. Seroogy, James E. Gern
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Allergy
Howard H. F. Tang, Anna Lang, Shu Mei Teo, Louise M. Judd, Ronald Gangnon, Michael D. Evans, Kristine E. Lee, Rose Vrtis, Patrick G. Holt, Robert F. Lemanske, Daniel J. Jackson, Kathryn E. Holt, Michael Inouye, James E. Gern
Summary: The developmental trajectories of the nasopharyngeal microbiome in early life and the composition of the microbiome during illnesses are associated with the risk of childhood asthma. A Staphylococcus-dominant microbiome in early infancy is linked to an increased risk of recurrent wheezing and persistent asthma, while detection of rhinoviruses and predominance of Moraxella during wheezing illnesses are associated with asthma that persists throughout later childhood.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Dermatology
Yuan-Hsin Lo, Chi-Shan Li, Hung-Lin Chen, Cho-Ying Chiang, Chi-Chun Huang, Ting-Jui Tu, Tzu-Han Lo, David F. Choy, Joseph R. Arron, Huan-Yuan Chen, Fu-Tong Liu
Summary: The study demonstrates the upregulation of galectin-8 in psoriatic skin lesions and mouse models of psoriasis. Knocking out galectin-8 leads to reduced keratinocyte proliferation and delayed cell cycle progression. Galectin-8 interacts with alpha-tubulin to maintain centrosome integrity, facilitating keratinocyte hyperproliferation in psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Oncology
Somya Rastogi, Amye J. Tevaarwerk, Mary Sesto, Brittany Van Remortel, Preshita Date, Ronald Gangnon, Keith Thraen-Borowski, Lisa Cadmus-Bertram
Article
Mathematical & Computational Biology
Junho Lee, Maria E. Kamenetsky, Ronald E. Gangnon, Jun Zhu
Summary: This article proposes a varying coefficient regression method for spatio-temporal data, which can identify clusters of regression coefficients over space and time, extending from spatial-only data. The methodology is validated through a simulation study and applied to a cancer mortality dataset in the Southeast of the U.S.
STATISTICS IN MEDICINE
(2021)
Article
Critical Care Medicine
Timothy Choi, Mark Devries, Leonard B. Bacharier, William Busse, Carlos A. Camargo, Robyn Cohen, Gregory P. Demuri, Michael D. Evans, Anne M. Fitzpatrick, Peter J. Gergen, Kristine Grindle, Rebecca Gruchalla, Tina Hartert, Kohei Hasegawa, Gurjit K. Khurana Hershey, Patrick Holt, Kiara Homil, Tuomas Jartti, Meyer Kattan, Carolyn Kercsmar, Haejin Kim, Ingrid A. Laing, Petra LeBeau, Kristine E. Lee, Peter N. Le Souef, Andrew Liu, David T. Mauger, Carole Ober, Tressa Pappas, Shilpa J. Patel, Wanda Phipatanakul, Jacqueline Pongracic, Christine Seroogy, Peter D. Sly, Christopher Tisler, Ellen R. Wald, Robert Wood, Ronald Gangnon, Daniel J. Jackson, Robert F. Lemanske, James E. Gern, Yury A. Bochkov
Summary: This study analyzed longitudinal data to investigate the impact of age and other factors on susceptibility to RV-C infections. The results showed that while RV-A and RV-C infections were similar in infancy, RV-C detection decreased with age while neutralizing antibody prevalence increased. The ratio of RV-C to RV-A detection during illnesses was found to be related to age, genetics, and wheezing illnesses, indicating potential factors influencing susceptibility to RV-C.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Oncology
Jessica Gorzelitz, Erin Costanzo, Ronald Gangnon, Kelli Koltyn, Amy Trentham Dietz, Ryan J. Spencer, Joanne Rash, Lisa Cadmus-Bertram
Summary: The study aimed to determine the feasibility of home-based muscle strengthening activity for endometrial cancer survivors. The results showed that the home-based program was feasible, with high participant satisfaction.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Medicine, Research & Experimental
Daryle J. DePianto, Jason A. Vander Heiden, Katrina B. Morshead, Kai-Hui Sun, Zora Modrusan, Grace Teng, Paul J. Wolters, Joseph R. Arron
Summary: The compromised regenerative capacity of lung epithelial cells can lead to cellular senescence, which may contribute to fibrosis. Senescent cells with the marker p16 are predominantly located in bronchiolized epithelial structures in scarred regions of IPF and SSc-ILD lung tissue, overlapping with basal epithelial markers Keratin 5 and Keratin 17. These senescent basal epithelial cells in ILD show gene expression patterns similar to terminally differentiating cells in stratified epithelia, driven by p53 activation as part of the senescence program.
Article
Multidisciplinary Sciences
Seoyeon Lee, Mohammad Naimul Islam, Kaveh Boostanpour, Dvir Aran, Guangchun Jin, Stephanie Christenson, Michael A. Matthay, Walter L. Eckalbar, Daryle J. DePianto, Joseph R. Arron, Liam Magee, Sunita Bhattacharya, Rei Matsumoto, Masaru Kubota, Donna L. Farber, Jahar Bhattacharya, Paul J. Wolters, Mallar Bhattacharya
Summary: Analysis of lung samples from healthy human donors reveals an increase in cellular senescence and pro-fibrotic pathway activation with age. Telomere shortening, decreased lung epithelial cells, and increased fibroblasts are associated with aging. This study shows a profile of increased vulnerability to lung diseases with age, highlighting the importance of genomic analysis and live lung imaging in understanding the natural history of human lung aging.
NATURE COMMUNICATIONS
(2021)
Article
Critical Care Medicine
P. Jane McDowell, John Busby, Catherine E. Hanratty, Ratko Djukanovic, Ashley Woodcock, Samantha Walker, Timothy Colin Hardman, Joseph R. Arron, David F. Choy, Peter Bradding, Chris E. Brightling, Rekha Chaudhuri, Douglas Cowan, Adel H. Mansur, Stephen J. Fowler, Sarah E. Diver, Peter Howarth, James Lordan, Andrew Menzies-Gow, Timothy Harrison, Douglas S. Robinson, Cecile T. J. Holweg, John G. Matthews, Ian D. Pavord, Liam G. Heaney
Summary: This study examined the differences between T2-low and T2-high asthma during exacerbation and found that they are physiologically and symptomatically similar during exacerbation. It also discovered that the inflammatory phenotype of T2-low asthma may be dynamic between stable and exacerbation states. The findings emphasize the importance of understanding the mechanisms of non-T2 asthma.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Natalie Guerrero, Ronald Gangnon, Marah A. Curtis, Carmen R. Valdez, Deborah B. Ehrenthal, Elizabeth A. Jacobs
Summary: The study found that maternal depression at a child's age of two has a negative impact on the child's internalizing and externalizing behavior, especially at the age of nine. Race/ethnicity did not moderate this relationship.
MATERNAL AND CHILD HEALTH JOURNAL
(2021)
Article
Medicine, Research & Experimental
Jane E. Mahoney, Ron Gangnon, Lindy Clemson, LaVerne Jaros, Sandy Cech, Jill Renken
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2020)
Article
Critical Care Medicine
Carole Ober, Chris G. McKennan, Kevin M. Magnaye, Matthew C. Altman, Charles Washington, Catherine Stanhope, Katherine A. Naughton, Mario G. Rosasco, Leonard B. Bacharier, Dean Billheimer, Diane R. Gold, Lisa Gress, Tina Hartert, Suzanne Havstad, Gurjit K. Khurana Hershey, Brian Hallmark, D. Kyle Hogarth, Daniel J. Jackson, Christine C. Johnson, Meyer Kattan, Robert F. Lemanske, Susan Lynch, Eneida A. Mendonca, Rachel L. Miller, Edward T. Naureckas, George T. O'Connor, Christine M. Seroogy, Ganesa Wegienka, Steven R. White, Robert A. Wood, Anne L. Wright, Edward M. Zoratti, Fernando D. Martinez, Dennis Ownby, Dan L. Nicolae, Albert M. Levin, James E. Gern
LANCET RESPIRATORY MEDICINE
(2020)
Article
Gerontology
Betty Chewning, Kristine M. Hallisy, Jane E. Mahoney, Dale Wilson, Nisaratana Sangasubana, Ronald Gangnon