Review
Pharmacology & Pharmacy
Jitao Chen, Penghui Ye, Rifang Gu, Huan Zhu, Wenjie He, Xingrui Mu, Xingqian Wu, Huiwen Pang, Felicity Han, Xuqiang Nie
Summary: This paper reviews the regulatory characteristics of neuropeptide substance P (SP) in normal and diabetic wound healing. SP actively regulates wound healing-related cells, exhibiting strong inflammatory properties, promoting cell proliferation and migration, and restoring skin cell activity and paracrine ability under diabetic conditions. Additionally, SP not only regulates healing-related cells but also orchestrates the immune environment, presenting unique and promising application prospects in wound intervention, particularly for diabetic foot ulcers (DFU) treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yingzheng Zhao, Lantian Huang, Gaolong Lin, Mengqi Tong, Yilin Xie, Hanxiao Pan, Jianxun Shangguan, Qing Yao, Shihao Xu, Helin Xu
Summary: In this study, a three-layered skin-adaptive dressing was designed for the treatment of diabetic wounds. The dressing, made of different materials, showed flexibility and strong adhesive force. It could release anti-inflammatory and growth factors to promote wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Endocrinology & Metabolism
Ya Li, Jing Li, Can Zhao, Lingling Yang, Xia Qi, Xiaochuan Wang, Qingjun Zhou, Weiyun Shi
Summary: Hyperglycemia reduces NAD(+) biosynthesis in the cornea, leading to impaired epithelial wound healing in diabetic mice and patients. Replenishment of NAD(+) and its precursors can facilitate corneal wound healing and nerve regeneration in diabetic conditions, suggesting a novel therapeutic strategy for diabetic corneal complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Giuseppe Caruso, Basma G. Eid, Usama A. Fahmy, Osama A. A. Ahmed, Ashraf B. Abdel-Naim, Abdulmohsin J. Alamoudi, Shareefa A. Alghamdi, Hadeel Al Sadoun, Basmah M. Eldakhakhny, Filippo Caraci, Wesam H. Abdulaal
Summary: The study investigates the potential of a nanoconjugate of CTX and MEL loaded in hydroxypropyl methylcellulose gel to improve wound healing in diabetic rats. The results show that the nanocomplex enhances epithelium regeneration, reduces oxidative stress, decreases pro-inflammatory cytokines, and increases collagen expression, highlighting its promising application in wound healing research.
Article
Biochemistry & Molecular Biology
Mohammed Z. Z. Nasrullah
Summary: Caffeic acid phenethyl ester-loaded PEG-PLGA nanoparticles have potent healing effects in diabetic wounds by accelerating wound closure and exhibiting antioxidant, anti-inflammatory, pro-collagen, and angiogenic activities.
Article
Plant Sciences
Qin Pan-Yue, Xu Ya-Jing, Zuo Xiang-Duo, Duan Jun-Hua, Qiu Bin, Li Xue-Fang, Li Jing-Ping, Yu Jie
Summary: This study aims to investigate the effects of PK extract on skin wound healing in diabetic rats and explore the regulatory mechanism of PK on wound microenvironment pollution, antioxidative stress signaling pathway, and latent injury of wound skin tissue.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rong-Fu Chen, Keng-Fan Liu, Su-Shin Lee, Shu-Hung Huang, Yi-Chia Wu, Yun-Nan Lin, Chun-Ting Wang, Yur-Ren Kuo
Summary: The study revealed that FIR therapy could significantly accelerate diabetic wound healing, associated with suppressed inflammatory response, increased neovascularization, and tissue regeneration.
Article
Nanoscience & Nanotechnology
Min Tan, Jing Zeng, Fu-Zhong Zhang, Ye-Tao Zhang, Hongli Li, Shu-Ting Fan, Jia-Xin Wang, Minglong Yuan, Bang-Jing Li, Sheng Zhang
Summary: This study developed a new double-layer hydrogel for diabetic wound healing. The hydrogel demonstrated two-stage ROS regulation, antibacterial properties, and effective ROS clearance. This research provides a promising dressing option for treating diabetic wounds in the future.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Pharmacology & Pharmacy
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
Summary: Chronic wounds in poorly managed diabetics are difficult to heal due to long-term uncontrolled blood glucose levels. To prevent complications, special medical care is needed. Nanofibrous scaffolds are a promising treatment due to their flexibility, ability to load bioactive compounds, and biomimetic environment for cell proliferation.
Article
Biochemistry & Molecular Biology
Masoud Rezvanian, Shiow-Fern Ng, Taradokht Alavi, Waqas Ahmad
Summary: The study demonstrated that the novel hydrogel film wound dressing showed significant efficacy in accelerating diabetic wound healing, with pro-angiogenic effects, faster re-epithelialization, and increased collagen deposition.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Giuseppe Caruso, Anna Privitera, Osama A. A. Ahmed, Usama A. Fahmy, Shadab Md, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Basma G. Eid, Ashraf B. Abdel-Naim, Filippo Caraci
Summary: Impaired diabetic wound healing is a global concern for healthcare professionals. This study developed a fluoxetine ecofriendly nanoemulsion (FLX-EFNE) and demonstrated its significant efficacy in promoting wound healing in diabetic rats.
Article
Veterinary Sciences
Ahmed Hesham, Marwa Abass, Haanin Abdou, Reham Fahmy, Maha M. Rashad, Abdelnaser A. Abdallah, Wael Mossallem, Ibrahim F. Rehan, Asmaa Elnagar, Frantisek Zigo, Silvia Ondrasovicova, Ahmed F. Abouelnaga, Awad Rizk
Summary: This experiment aimed to investigate the effects of intradermal administration of ozonated water on acute skin wound healing in diabetic rats. The results showed that the ozonated water group had lower blood glucose levels, smaller wound size, and increased body weight. Additionally, there were significant improvements in epithelial vascularization, stromal edema, and TGF and VEGF gene expression in the ozonated water group.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Engineering, Biomedical
Jueying Chen, Jiahui He, Yutong Yang, Lipeng Qiao, Juan Hu, Jie Zhang, Baolin Guo
Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.
ACTA BIOMATERIALIA
(2022)
Review
Pharmacology & Pharmacy
Gaofeng Wang, Zhen Lin, Yue Li, Lu Chen, Sashank K. Reddy, Zhiqi Hu, Luis Garza
Summary: With the development of society and the improvement of life quality, over 500 million people are affected by diabetes. More than 10% of diabetes patients suffer from diabetic wounds, and 80% of these wounds reoccur, highlighting the importance of developing new diabetic wound treatments. Skin microbe research has shed light on the complex relationship between microbes and diabetic wounds. Understanding the skin microbe composition in diabetic wounds can provide valuable guidance for clinical treatment and even lead to potential therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Physical
Xiang Gao, Rui Huang, Yanpeng Jiao, Thomas Groth, Wufeng Yang, Chenlin Tu, Hailong Li, Fan Gong, Jiaqi Chu, Mingyan Zhao
Summary: In this study, bioactive coatings were developed using Michael addition reaction for sustained release of insulin on PLLA nanofibrous mats, showing superior wound healing effects in animal models.
APPLIED SURFACE SCIENCE
(2022)
Article
Materials Science, Ceramics
Mukesh Kumar, Anil Kumar Gupta, Dinesh Kumar
CERAMICS INTERNATIONAL
(2016)
Article
Immunology
Dinesh Kumar, Ashoo Grover, Vishwa Mohan Katoch
INDIAN JOURNAL OF MEDICAL RESEARCH
(2016)
Article
Nanoscience & Nanotechnology
Kavita, Dinesh Kumar, Karamjit Singh, Sunil Kumar, H. S. Bhatti
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
(2016)
Article
Surgery
Vinay Kant, Dinesh Kumar, Raju Prasad, Anu Gopal, Nitya N. Pathak, Pawan Kumar, Surender K. Tandan
JOURNAL OF SURGICAL RESEARCH
(2017)
Article
Pharmacology & Pharmacy
Dhirendra Kumar, Geeta Rani Jena, Mahendra Ram, Madhu Cholenahalli Lingaraju, Vishakha Singh, Raju Prasad, Sanjay Kumawat, Vinay Kant, Priyanka Gupta, Surendra Kumar Tandan, Dinesh Kumar
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2019)
Article
Chemistry, Physical
Dinesh Kumar, Prashant Uday Manohar
CHEMICAL PHYSICS LETTERS
(2019)
Article
Pharmacology & Pharmacy
Abhinav Choudhary, Vinay Kant, Babu Lal Jangir, V. G. Joshi
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Cell Biology
Vinay Kant, Babu Lal Jangir, Vinod Kumar, Ankit Nigam, Vikash Sharma
Article
Dermatology
Vinay Kant, Manish Kumar, Babu Lal Jangir, Vinod Kumar
Summary: This study explored the wound healing potential of 0.3% quercetin formulated in three different vehicles in rats. The results show that 0.3% quercetin mixed in ointment base produced the fastest and better wound healing, with increased blood vessel formation, collagen deposition, and regenerated epithelial layer. Quercetin treatment also improved antioxidant enzyme activity and reduced oxidative damage markers in the wound tissues.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Dermatology
Vinay Kant, Puspendra S. Mahapatra, Vijayta Gupta, Sadhan Bag, Anu Gopalakrishnan, Dhirendra Kumar, Dinesh Kumar
Summary: This study aimed to evaluate the in vitro wound healing effect of substance P (SP). The results showed that SP could promote proliferation and migration of fibroblast cells, and its actions were mainly mediated through the NK-1 receptor.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Article
Immunology
Vinay Kant, Babu Lal Jangir, Maneesh Sharma, Vinod Kumar, Vinay G. Joshi
Summary: The study showed that 0.3% quercetin ointment can accelerate wound closure and promote cell regeneration and repair in diabetic rats, while reducing inflammation response.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Vinay Kant, Maneesh Sharma, Babu Lal Jangir, Vinod Kumar
Summary: Increased oxidative stress in diabetic wound areas impairs wound healing. Quercetin, with its significant antioxidant properties, was found to improve antioxidant status in wounds of diabetic rats and stimulate the proliferation phase, thereby accelerating wound healing.
BIOTECHNIC & HISTOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Dhaval J. Kamothi, Vinay Kant, Babu L. Jangir, Vinay G. Joshi, Munish Ahuja, Vinod Kumar
Summary: This study demonstrated the effectiveness of encapsulated bilirubin nanoparticles in promoting wound healing, as compared to native bulk bilirubin. The nanoparticles, formed using Pluronic F-127, showed promising results in accelerating wound closure, reducing inflammation, and promoting tissue regeneration. These findings highlight the potential of encapsulated bilirubin nanoparticles as a novel biomaterial for wound healing in the future.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Agriculture, Multidisciplinary
O. P. Yadav, B. M. Prasanna, P. Yadava, S. L. Jat, D. Kumar, B. S. Dhillon, I. S. Solanki, J. S. Sandhu
INDIAN JOURNAL OF AGRICULTURAL SCIENCES
(2016)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.