Article
Biochemistry & Molecular Biology
Oliver Neuhaus, Wolfgang Koehler, Florian Then Bergh, Wolfgang Kristoferitsch, Juergen Faiss, Thorsten Rosenkranz, Dirk Reske, Robert Patejdl, Hans-Peter Hartung, Uwe K. Zettl
Summary: This study aimed to investigate the correlation between clinical, neuropsychological, and immunological parameters in RRMS patients with fatigue before and during treatment with GA. After 12 months of treatment, 13 patients showed improvement in all three fatigue assessment scales, while 5 patients deteriorated and 7 patients showed inconsistent effects. Fatigue and overall quality of life improved, but no clear correlation between clinical and molecular effects of GA was found in RRMS patients with fatigue.
Article
Multidisciplinary Sciences
Ioana S. Barac, Vitalie Vacaras, Mihaela Iancu, Dafin F. Muresanu, Lucia M. Procopciuc
Summary: This study aimed to test the association between interferon and long-chain synthesis gene polymorphisms with multiple sclerosis (MS) patients. The results showed a significant correlation between serum levels of IL-27 and IL-23 with gene polymorphisms in RRMS patients.
Article
Medicine, Research & Experimental
Paulina Maria Reyes-Mata, Argelia Esperanza Rojas-Mayorquin, Lucrecia Carrera-Quintanar, Celia Gonzalez-Castillo, Mario Alberto Mireles-Ramirez, Jose de Jesus Guerrero-Garcia, Daniel Ortuno-Sahagun
Summary: This study aimed to investigate the serum levels of Pleiotrophin (PTN) in patients with Multiple Sclerosis (MS). The results showed that PTN serum levels were significantly higher in RRMS patients compared to the healthy control group, and were associated with sex, body mass index (BMI), and IFN-beta treatment.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Dina Erzina, Alice Capecchi, Sacha Javor, Jean-Louis Reymond
Summary: Researchers synthesized a library of peptide dendrimers with an amino acid composition similar to GA, some of which were as active as GA. Detailed profiling showed that the best hit dendrimer can induce the differentiation of monocytes towards an M2 state with a distinct immune marker profile. This peptide dendrimer might serve as a starting point to develop a well-defined immunomodulatory analog of GA.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Clinical Neurology
Mahmoud A. AbdelRazek, Subhash Tummala, Fariha Khalid, Shahamat Tauhid, Youmna Jalkh, Samar Khalil, Shelley Hurwitz, Jonathan Zurawski, Rohit Bakshi
Summary: This study compared gray matter atrophy in patients with multiple sclerosis (MS) treated with glatiramer acetate (GA) and patients with clinically benign MS (BMS). The results showed that there was no significant change in gray matter and whole brain atrophy in the GA group over 2 years, similar to the BMS group.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ignacio Casanova, Maria I. Dominguez-Mozo, Laura De Torres, Yolanda Aladro-Benito, Angel Garcia-Martinez, Patricia Gomez, Sara Abellan, Esther De Antonio, Roberto Alvarez-Lafuente
Summary: This study investigates the association between a preselected list of miRNAs in the serum of relapsing-remitting multiple sclerosis (RRMS) patients with therapeutic response to Glatiramer Acetate (GA) and clinical evolution. The findings suggest that certain miRNAs may serve as potential biomarkers for disease progression and response to treatment in multiple sclerosis.
Review
Clinical Neurology
Massimiliano Mirabella, Pietro Annovazzi, Wallace Brownlee, Jeffrey A. Cohen, Christoph Kleinschnitz, Christian Wolf
Summary: Earlier diagnosis, access to disease-modifying therapies, and improved supportive care have positively influenced the disease course of multiple sclerosis, leading to improved long-term outcomes for patients. However, the complexity of treatment selection has increased due to the presence of comorbidities, immune senescence, and the growing number of approved therapies.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Candace Marsters, Nabeela Nathoo, Lindsay Amatto, Russell Wong, Muhammad N. Mahmood, Jennifer A. McCombe
Summary: Glatiramer acetate, an old and safe therapy for relapsing-remitting multiple sclerosis, can rarely cause urticarial vasculitis. We present a case of normocomplementemic urticarial vasculitis diagnosed by skin punch biopsy in a patient treated with glatiramer acetate for five years. The urticaria resolved after treatment with steroids and an antihistamine, as well as discontinuing glatiramer acetate.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Niloufar Rahiman, Parvin Zamani, Leila Arabi, Seyedeh Hoda Alavizadeh, Aminreza Nikpoor, Mohammad Mashreghi, Ali Badiee, Mahmoud Reza Jaafari
Summary: The study explores the use of liposomal formulations of Glatiramer acetate (GA) to overcome the frequent administration rate required for MS therapy. The results show that liposomal GA has higher efficacy in a murine model of MS, suggesting its potential as a reliable nanomedicine-based platform for MS treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Immunology
Rongzeng Liu, Shushu Du, Lili Zhao, Sahil Jain, Kritika Sahay, Albert Rizvanov, Vera Lezhnyova, Timur Khaibullin, Ekaterina Martynova, Svetlana Khaiboullina, Manoj Baranwal
Summary: Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by destruction of the myelin sheath. Immune mechanisms, particularly abnormal lymphocyte activity, play a key role in the pathogenesis of multiple sclerosis. This review summarizes the abnormal function and count of lymphocytes and their contributions to the mechanisms of multiple sclerosis. Additionally, novel therapies aimed at correcting the aberrant function or count of these lymphocytes are discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Health Care Sciences & Services
Maria Jose Zarzuelo-Romero, Cristina Perez-Ramirez, Yasmin Cura, Maria Isabel Carrasco-Campos, Luciana Maria Marangoni-Iglecias, Maria Carmen Ramirez-Tortosa, Alberto Jimenez-Morales
Summary: The response to glatiramer acetate (GA) therapy in MS patients may be influenced by genetic polymorphisms in genes such as CD86, CTSS, and FAS. Identifying these polymorphisms could serve as a predictive marker for the response to GA treatment in the future, but further validation studies are needed.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Masoumeh Cheshmavar, Omid Mirmosayyeb, Negin Badihian, Shervin Badihian, Vahid Shaygannejad
Summary: The study found that both rituximab (RTX) and glatiramer acetate (GA) did not significantly affect the Expanded Disability Status Scale (EDSS) in secondary progressive multiple sclerosis (SPMS) patients, but were equally effective in reducing relapses.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Pharmacology & Pharmacy
Peter Lipsky, Patrick T. Vallano, Jeffrey Smith, Walter Owens, Daniel Snider, Viswanath Bandaru, Yunfu Sun, Ross Wallingford, Joseph Duncan, Joshua Lewis, Jason Southall, Azeem Ansari, Hong Li
Summary: The study demonstrates the equivalence of Mylan's glatiramer acetate (MGA) to the reference product Copaxone(R) (COP) in terms of physicochemical properties, structural signatures, and biological activity. The findings provide compelling evidence that the FDA-approved generic MGA can be substituted for COP in the treatment of patients with relapsing-remitting multiple sclerosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Mathilde Lefort, Sandra Vukusic, Romain Casey, Gilles Edan, Emmanuelle Leray
Summary: Early treatment initiation has a significant impact on disability progression in patients with relapsing-remitting multiple sclerosis (RRMS), reducing the risk of disability development, particularly in older patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Ursula Munoz, Cristina Sebal, Esther Escudero, Elena Urcelay, Rafael Arroyo, Maria A. Garcia-Martinez, Francisco J. Quintana, Roberto Alvarez-Lafuente, Maria Cruz Sadaba
Summary: We developed an ELISA assay, which demonstrated the high prevalence of serum IgM-PC in the early stages of multiple sclerosis. The study found that serum IgM-PC could be a biomarker of response to natalizumab or interferon-beta treatment.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Jacqueline R. Rivas, Sara J. Ireland, Rati Chkheidze, William H. Rounds, Joseph Lim, Jordan Johnson, Denise M. O. Ramirez, Ann J. Ligocki, Ding Chen, Alyssa A. Guzman, Mark Woodhall, Patrick C. Wilson, Eric Meffre, Charles White, Benjamin M. Greenberg, Patrick Waters, Lindsay G. Cowell, Ann M. Stowe, Nancy L. Monson
ACTA NEUROPATHOLOGICA
(2017)
Article
Immunology
Ding Chen, Sara J. Ireland, Laurie S. Davis, Xiangmei Kong, Ann M. Stowe, Yue Wang, Wendy I. White, Ronald Herbst, Nancy L. Monson
JOURNAL OF IMMUNOLOGY
(2016)
Article
Immunology
Sara J. Ireland, Alyssa A. Guzman, Elliot M. Frohman, Nancy L. Monson
JOURNAL OF NEUROIMMUNOLOGY
(2016)
Article
Immunology
Sara J. Ireland, Monica Blazek, Christopher T. Harp, Benjamin Greenberg, Elliot M. Frohman, Laurie S. Davis, Nancy L. Monson
Article
Immunology
Christopher T. Harp, Sara Ireland, Laurie S. Davis, Gina Remington, Bonnie Cassidy, Petra D. Cravens, Olaf Stuve, Amy E. Lovett-Racke, Todd N. Eagar, Benjamin M. Greenberg, Michael K. Racke, Lindsay G. Cowell, Nitin J. Karandikar, Elliot M. Frohman, Nancy L. Monson
EUROPEAN JOURNAL OF IMMUNOLOGY
(2010)
Article
Endocrinology & Metabolism
Nancy L. Monson, Sara J. Ireland, Ann J. Ligocki, Ding Chen, William H. Rounds, Min Li, Ryan M. Huebinger, C. Munro Cullum, Benjamin M. Greenberg, Ann M. Stowe, Rong Zhang
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2014)
Article
Immunology
Ding Chen, Monica Blazek, Sara Ireland, Sterling Ortega, Xiangmei Kong, Anouk Meeuwissen, Ann Stowe, Laura Carter, Yue Wang, Ronald Herbst, Nancy L. Monson
JOURNAL OF IMMUNOLOGY
(2014)
Article
Immunology
Nancy L. Monson, Sterling B. Ortega, Sara J. Ireland, Anouk J. M. Meeuwissen, Ding Chen, Erik J. Plautz, Erin Shubel, Xiangmei Kong, Min K. Li, Laura H. Freriks, Ann M. Stowe
JOURNAL OF NEUROINFLAMMATION
(2014)
Article
Microbiology
Molly R. Perkins, Caroline Ryschkewitsch, Julia C. Liebner, Maria Chiara G. Monaco, Danielle Himelfarb, Sara Ireland, Annelys Roque, Heather L. Edward, Peter N. Jensen, Gina Remington, Thomas Abraham, Jaspreet Abraham, Benjamin Greenberg, Charles Kaufman, Chris LaGanke, Nancy L. Monson, Xiaoning Xu, Elliot Frohman, Eugene O. Major, Daniel C. Douek
Article
Clinical Neurology
Sara J. Ireland, Alyssa A. Guzman, Dina E. O'Brien, Samuel Hughes, Benjamin Greenberg, Angela Flores, Donna Graves, Gina Remington, Elliot M. Frohman, Laurie S. Davis, Nancy L. Monson
Article
Neurosciences
Carrie B. Wiese, Sara Ireland, Nicole L. Fleming, Jing Yu, M. Todd Valerius, Kylie Georgas, Han Sheng Chiu, Jane Brennan, Jane Armstrong, Melissa H. Little, Andrew P. McMahon, E. Michelle Southard-Smith
FRONTIERS IN NEUROSCIENCE
(2012)
Review
Clinical Neurology
Sara Ireland, Nancy Monson
MULTIPLE SCLEROSIS INTERNATIONAL
(2011)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.