Article
Oncology
Nasrin S. Sani, Habib Onsori, Somayeh Akrami, Mohammad Rahmati
Summary: This study found that nano-capsulated hydroxytyrosol had better anti-proliferative and anti-tumor effects on colorectal cancer cells, and could significantly affect the expression of related genes.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Stephanie St-Jean, Ariane Cristina De Castro, Mia Lecours, Christine Jones, Nathalie Rivard, Francis Rodier, Nathalie Perreault, Francois Boudreau
Summary: NCOR1 is essential for colorectal cancer cell growth, and its depletion leads to cellular senescence. Transcriptomic signatures confirm this and predict a potential pro-invasive phenotype. It plays a novel role in preventing cancer-associated senescence and could be a target for controlling colon cancer progression.
Article
Food Science & Technology
Xi Chen, Jiamin Shen, Jingwen Xu, Thomas Herald, Dmitriy Smolensky, Ramasamy Perumal, Weiqun Wang
Summary: Phenolic compounds extracted from specialty sorghums were found to inhibit the proliferation of HepG2 and Caco-2 cancer cells through cytostatic and apoptotic mechanisms.
Article
Chemistry, Medicinal
Rui Wu, Jiajia Zhao, Panhong Wei, Minghai Tang, Ziyan Ma, Yunyan Zhao, Leilei Du, Li Wan
Summary: This study found that Piper nigrum extract (PNE) has an inhibitory effect on HT-29 cells, inhibiting cell proliferation and colony formation, inducing cell apoptosis, and inhibiting tumor growth in experimental animals. Furthermore, PNE can regulate p53 and its downstream proteins, activating the apoptosis pathway.
Article
Oncology
In-Hye Kim, Taekil Eom, Joon-Young Park, Hyung-Joo Kim, Taek-Jeong Nam
Summary: This study investigated the biological activity of Calystegia soldanella extracts in colorectal cancer cells. It was found that the DCM fraction of the extract can inhibit cell viability and induce apoptosis in HT-29 cells. These effects were associated with regulation of mitochondrial membrane potential and S-phase arrest. The results suggest that the DCM fraction has potential anticancer activity in colorectal cancer cells.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Cell Biology
Dasa Cizkova, Milan Cizek, Marcela Maloveska, Marta Kmetova, Vladimir Kmet, Dobroslava Bujnakova
Summary: The findings suggest that cell-free L. casei 21L10 supernatant may have potential in attenuating LPS-induced inflammation, inhibiting proliferation, and promoting apoptosis/necrosis. While this study provides insight into using L. casei exoproducts as anti-inflammatory or anti-proliferative agents for gut diseases, further data is required to confirm their efficacy.
Article
Oncology
Arghavan Kouroshnia, Sirous Zeinali, Shiva Irani, Akram Sadeghi
Summary: This study demonstrates the promising anti-cancer activity of Streptomyces sp. 801 on colorectal cancer cells in vitro by inducing apoptosis, cell cycle arrest, and inhibiting cell migration. Nine anti-cancer compounds were identified from the strain, suggesting its potential as a source of anticancer metabolites.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Jeremy N. Myers, Kelly L. Harris, Perumalla V. Rekhadevi, Siddharth Pratap, Aramandla Ramesh
Summary: The study demonstrated that exposure of colon cancer cells to benzo(a)pyrene resulted in dose-dependent decrease in cell growth, cytotoxicity, and modulation of the cell cycle, as well as elevated concentrations of BaP metabolites contributing to DNA damage and stable DNA adduct formation. Additionally, the expression of phase I biotransformation enzymes showed BaP concentration-dependent changes, while phase II enzymes remained relatively stable. This study highlights the role of BaP biotransformation in cytotoxicity, proliferation of tumor cells, and alteration of gene expression.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hsueh-Yun Lee, Di-Wei Tang, Chi-Yuan Liu, Er-Chieh Cho
Summary: This study focuses on the development of benzamide-based compounds as potential HDAC1/2 inhibitors for colorectal cancer treatment. Compound 9 is identified as a selective HDAC inhibitor with significant anticancer activity against colorectal cancer cells. The study also investigates the molecular regulatory mechanisms of compound 9, demonstrating its potential in apoptosis activation, cell cycle arrest induction, DNA damage facilitation, and cancer migration suppression in colorectal cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Sara Abreu, Nuno Vale, Olivia Salome G. P. Soares
Summary: Due to the increase in new types of cancer cells and resistance to drugs, nanotechnology is being applied to biomedical areas as an alternative cancer treatment to minimize side effects and drug resistance and improve treatment efficacy. This study focused on finding a promising cancer treatment for colorectal adenocarcinoma cells using carbon nanotubes (CNTs) combined with different drugs (5-fluorouracil (5-FU) and repurposing drugs tacrine (TAC) and ethionamide (ETA)). CNT samples with different functional groups and textural properties were prepared and characterized, and the results showed that CNTs doped with nitrogen and sulfur groups (CNT-BM-N and CNT-H2SO4-BM) improved the activity of 5-FU and TAC.
Article
Pharmacology & Pharmacy
Fengfeng Qu, Zeyi Ai, Shuyuan Liu, Haojie Zhang, Yuqiong Chen, Yaomin Wang, Dejiang Ni
Summary: This study revealed that the low bioavailability of theaflavins in Caco-2 monolayers is attributed to their structural instability, efflux transporters, and cell metabolism.
Article
Oncology
Sicheng Guo, Hanyu Yan, Liqin Wang, Yue Liu, Bo Yu
Summary: The study aimed to investigate the effect of GlyH-101 and CaCCinh-A01 on HT-29 cell activity and suggest possible molecular mechanisms. The results showed that GlyH-101 and CaCCinh-A01 inhibited HT-29 cell proliferation through cell cycle arrest and mitochondrial-related pathways, and the combination of these inhibitors further enhanced their anti-proliferative effects.
ANTICANCER RESEARCH
(2023)
Article
Microbiology
Ramin Hosseinzadeh, Ali Bahadori, Mahdi Ghorbani, Mojgan Mohammadimehr
Summary: This study investigated the effect of Lactobacillus casei condition medium on miR-21 expression in colorectal cancer cells. The results showed that L. casei condition medium induced apoptosis in HT-29 cells and significantly downregulated miR-21 expression after treatment with high doses of the medium.
FEMS MICROBIOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Andrea del Saz-Lara, Hatim Boughanem, Maria-Carmen Lopez de las Hazas, Carmen Crespo, Alicia Saz-Lara, Francesco Visioli, Manuel Macias-Gonzalez, Alberto Davalos
Summary: The Mediterranean diet is associated with lower incidence of cardio-vascular and cerebrovascular diseases as well as cancer. Extra virgin olive oil, with its phenolic components such as hydroxytyrosol, has been attributed with many healthful effects. Recent studies show that extra virgin olive oil and hydroxytyrosol modulate epigenetic mechanisms, specifically DNA methylation, in human tissues. In this study, colorectal cancer cells treated with hydroxytyrosol demonstrated an increase in global DNA methylation, suggesting a potential gene target for this compound.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Mengying Sun, Wenwen Liu, Yinglong Song, Yanfeng Tuo, Guangqing Mu, Fenglian Ma
Summary: The EPS produced by Lactobacillus plantarum-12 was found to significantly inhibit HT-29 cell proliferation and induce apoptosis through the mitochondrial pathway, by upregulating pro-apoptotic proteins and downregulating anti-apoptotic proteins.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Review
Oncology
David Bars-Cortina, Ali Sakhawat, Carme Pinol-Felis, Maria-Jose Motilva
Summary: This review summarizes the current state of diet anthocyanin research in breast cancer and colorectal cancer animal models as well as human studies. Animal studies suggest a chemoprevention effect of anthocyanin, but results from human studies are contradictory. Low doses of anthocyanins used in recent human studies call for more toxicological data to support relevant results.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Nutrition & Dietetics
Ursula Catalan, Anna Pedret, Silvia Yuste, Laura Rubio, Carme Pinol, Berner Andree Sandoval-Ramirez, Judit Companys, Elisabet Foguet, Pol Herrero, Nuria Canela, Maria-Jose Motilva, Rosa Sola
Summary: Proteomic analysis showed that both red-fleshed and white-fleshed apples exhibited anti-inflammatory effects, with red-fleshed apples also reducing the expression of the inflammatory protein CRP. Additionally, an extract from Aronia fruit was found to modulate proteins related to cellular signaling.
Article
Food Science & Technology
Bianca Souza da Costa, German Soldevilla Muro, Marta Olivan Garcia, Maria-Jose Motilva
Summary: The by-products of winemaking can be used to produce high-value ingredients through dehydration processes. The skin is rich in anthocyanins, while the seeds are an important source of hydroxybenzoic acids, procyanidins, and lignans. Regardless of the dehydration method, the stems are a rich source of a wide range of phenolic compounds.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Nutrition & Dietetics
Andrea del Saz-Lara, Maria-Carmen Lopez de las Hazas, Francesco Visioli, Alberto Davalos
Summary: This article systematically reviews the effects of extra virgin olive oil (EVOO) and its phenolic compounds on the epigenetic landscape. The results show that EVOO and its phenolic compounds can induce epigenetic changes that regulate gene expression and molecular targets involved in various metabolic processes. Oleuropein and hydroxytyrosol, for example, have been shown to have epigenetic effects in cancer and other diseases. Understanding the epigenetic effects of EVOO and its phenolic compounds can contribute to the development of pharma-nutritional strategies.
ADVANCES IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Carlos Eduardo Iglesias-Aguirre, Maria Angeles Avila-Galvez, Maria-Carmen Lopez de las Hazas, Alberto Davalos, Juan Carlos Espin
Summary: This exploratory study provides the first evidence that resveratrol metabolites are transported by E-EVs, with a preference for glucuronide vs. sulfates, the gut microbial metabolites concentration and kinetic profiles are closely similar in E-EVs and plasma, and resveratrol intake elicits E-EVs secretion.
Article
Biochemistry & Molecular Biology
Marta Farras, Jonathan Richard Swann, Ian Rowland, Laura Rubio, Isaac Subirana, Ursula Catalan, Maria Jose Motilva, Rosa Sola, Maria Isabel Covas, Francisco Blanco-Vaca, Montserrat Fito, Jordi Mayneris-Perxachs
Summary: The consumption of phenol-rich oils, such as virgin olive oil, has been shown to have beneficial effects on cardiovascular health. This study aimed to explore the broader biochemical impact of phenol-enriched olive oils. The results showed that both interventions with phenol-enriched olive oils led to a favorable shift in the circulating metabolic phenotype, reducing metabolites associated with cardiometabolic diseases.
Article
Food Science & Technology
Bianca Souza da Costa, Marta Olivan Garcia, German Soldevilla Muro, Maria-Jose Motilva
Summary: This study focused on dehydrating industrial tomato pomace using innovative techniques (microwave and spiral flash dryer) and conventional techniques (freeze-drying and hot air-drying) to produce ingredients rich in bioactive compounds. The effect of different drying methods on the bioactive composition of the tomato by-products was analyzed. Microwave dehydration improved the retention of flavanone-like compounds and lycopene, while spiral flash drying resulted in higher concentrations of flavonols and phenolic acids. These findings suggest that drying processes using microwave and spiral flash could be promising for producing high added-value ingredients from tomato by-products.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alicia Moreno-Ortega, Gema Pereira-Caro, Iziar A. Ludwig, Maria-Jose Motilva, Jose Manuel Moreno-Rojas
Summary: By using UHPLC-HRMS, this study identified and quantified 33 OSCs excreted in urine 24 h after the consumption of 20 g of black garlic. The main OSCs were methiin, isoalliin, S-(2-carboxypropyl)-L-cysteine, and S-propyl-L-cysteine. Metabolites such as NASAC, NASACS, and NACPC derived from SAC, alliin, and S-(2-carboxypropyl)-L-cysteine were also detected. The total excretion of OSCs after the ingestion of black garlic was 64,312 +/- 26,584 nmol.
Article
Food Science & Technology
Loubna Abou el Qassim, Beatriz Martinez, Ana Rodriguez, Alberto Davalos, Maria-Carmen Lopez de las Hazas, Mario Menendez Miranda, Luis J. Royo
Summary: MicroRNAs (miRNAs) are potential biomarkers due to their ability to regulate gene expression and resist adverse conditions. Studies have investigated their potential as biomarkers for dairy production systems based on their levels in raw milk, but it is unclear if these levels remain consistent after technological or culinary treatments such as fermentation.
Review
Biochemistry & Molecular Biology
Victor Navalon-Monllor, Laura Soriano-Romani, Mariana Silva, Maria-Carmen Lopez de las Hazas, Natalia Hernando-Quintana, Teodoro Suarez Dieguez, Pere Morell Esteve, Juan Antonio Nieto
Summary: Microbiota dysbiosis and metabolic syndrome due to non-adequate diet lead to a feedback pathogenic state that contributes to the development of Alzheimer's disease. The dysbiosis status results in lower production of SCFAs, which disrupts lipid homeostasis and causes adipose tissue dysfunction. This leads to increased lipid storage, high cholesterol levels, and reduced satiety sensation and energy expenditure, resulting in weight gain and dyslipidemia. Additionally, dysbiosis and low SCFA generation lead to increased intestinal permeability, chronic inflammation, and insulin resistance, creating an environment conducive to the formation and progression of Alzheimer's disease through the impact on secretase enzymes and tau hyperphosphorylation.
Article
Biochemistry & Molecular Biology
Alicia Moreno-Ortega, Iziar A. Ludwig, Maria-Jose Motilva, Jose Manuel Moreno-Rojas, Gema Pereira-Caro
Summary: This study monitored the excretion of organosulfur compounds (OSCs) in urine after acute ingestion of black onion. A total of 31 OSCs were detected, with the main components being methiin, isoalliin, and deoxypropiin. N-acetylated metabolites of the major OSCs were also found in urine. This study provides the basis for further research on the metabolism of OSCs after black onion consumption.
Article
Agriculture, Multidisciplinary
Juana Mosele, Bianca Souza da Costa, Silvia Bobadilla, Maria-Jose Motilva
Summary: The phenolic composition of grape byproducts varies between red and white grape cultivars, as well as between different parts of the grape (skin, seed, and stem). Carbonic maceration has a negative impact on the phenolic content. The specific phenolic composition of these byproducts can be used for various applications.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Maria-Carmen Lopez de las Hazas, Andrea del Saz-Lara, Lidia Cedo, Maria Carmen Crespo, Joao Tome-Carneiro, Luis A. Chapado, Alba Macia, Francesco Visioli, Joan C. Escola-Gil, Alberto Davalos
Summary: HT supplementation in humanized mice resulted in systemic dyslipidemia, impaired glucose metabolism, increased body weight, and accumulation of triacylglycerols in different tissues. The expression of genes related to lipid metabolism, such as Pltp or Lpl, was also modulated by HT. Further studies are needed to fully understand the potential effects of HT consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Alba Macia, Maria-Paz Romero, Anna Pedret, Rosa Sola, Michael N. Clifford, Laura Rubio-Pique
Summary: This study aimed to assess the inter-individual variation in phloretin absorption and metabolism and to seek possible phloretin metabotypes following apple snack consumption. The results showed that there is extensive inter-individual variability in the excretion of phloretin phase-II conjugates, which could be related to factors such as oral microbiota activity and lactase non-persistence trait. The study also found inconsistent effects on post-prandial serum glucose concentrations, with a tendency for decreases to be associated with higher excretion of phloretin phase-II conjugates.
Review
Biochemistry & Molecular Biology
Silvia Yuste, Iziar A. Ludwig, Maria-Paz Romero, Maria-Jose Motilva, Laura Rubio
Summary: This paper provides a comprehensive overview of new hybrid red-fleshed apples, highlighting their (poly)phenolic composition, processing effects, (poly)phenolic bioavailability, and biological effects. Evidence from in vitro and in vivo studies supports their added beneficial effects on health outcomes, such as cancer, cardiovascular disease, inflammation, and immune function, which are mainly attributed to their specific (poly)phenol composition.