Review
Pharmacology & Pharmacy
Surojit Banerjee, Abhijit De
Summary: This article discusses the role of CETP inhibitors in reducing 'bad' cholesterol and preventing cardiovascular disease, including the current status of trials with different drugs, their adverse effects and limitations, as well as the pathophysiology of CETP.
DRUG DISCOVERY TODAY
(2021)
Article
Sport Sciences
Charles A. German, Jason Fanning, Matthew J. Singleton, Michael D. Shapiro, Peter H. Brubaker, Alain G. Bertoni, Joseph Yeboah
Summary: This study found that high levels of physical activity are negatively correlated with cardiovascular disease and all-cause mortality, indicating that high PA can reduce the risk of CVD and overall death. The research also suggests that even among individuals at high risk of CVD, high levels of PA do not pose additional risks.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Hematology
Antonella Tufano, Antonio Coppola, Maurizio Galderisi
Summary: Progress in cancer treatment has significantly improved patient survival, but cardiovascular complications may adversely affect prognosis. Cardiovascular oncology is an emerging field focusing on prevention, early detection, and management of cardiovascular disease in cancer patients.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Review
Cardiac & Cardiovascular Systems
Gurneet S. Sangha, Craig J. Goergen, Steven J. Prior, Sushant M. Ranadive, Alisa M. Clyne
Summary: Atherosclerosis is a dynamic process that begins with endothelial dysfunction and inflammation, leading to arterial plaques. Exercise can improve endothelial function by altering hemodynamics, but excessive exercise may also contribute to arterial plaques. Studying the mechanisms of atherosclerosis in sedentary versus exercise states may lead to novel ways to improve exercise compliance and physical activity.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Zahra Raisi-Estabragh, Luca Biasiolli, Jackie Cooper, Nay Aung, Kenneth Fung, Jose M. Paiva, Mihir M. Sanghvi, Ross J. Thomson, Elizabeth Curtis, Julien Paccou, Jennifer J. Rayner, Konrad Werys, Henrike Puchta, Katharine E. Thomas, Aaron M. Lee, Stefan K. Piechnik, Stefan Neubauer, Patricia B. Munroe, Cyrus Cooper, Steffen E. Petersen, Nicholas C. Harvey
Summary: The study found a positive association between bone health and vascular health with consistent patterns in men and women. Blood biomarkers played an important role in mediating the association, with different directions of effect, but did not fully explain the observed effects.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Bo Abrahamsen
Summary: This article summarizes the recent advances in the understanding of vertebral fractures, with a focus on endocrine diseases, prevention, and treatment. It highlights the increased risk of vertebral fractures in patients with endocrine diseases and the current focus on invasive treatments. It also mentions that licensed treatments are effective in reducing the occurrence of vertebral fractures in osteoporosis patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Hematology
Jonathan Golledge, Shivshankar Thanigaimani
Summary: Sclerostin plays a crucial role in controlling bone formation and is also expressed in cardiovascular tissues. Research has shown that Sclerostin can prevent abdominal aortic aneurysm and atherosclerosis formation. High serum Sclerostin levels are associated with arterial calcification, stiffness, and increased risk of cardiovascular events in humans.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Urology & Nephrology
Joshua D. Bundy, Mahboob Rahman, Kunihiro Matsushita, Byron C. Jaeger, Jordana B. Cohen, Jing Chen, Rajat Deo, Mirela A. Dobre, Harold I. Feldman, John Flack, Radhakrishna R. Kallem, James P. Lash, Stephen Seliger, Tariq Shafi, Shoshana J. Weiner, Myles Wolf, Wei Yang, Norrina B. Allen, Nisha Bansal, Jiang He, CRIC Study Investigators
Summary: This study developed 10-year ASCVD risk prediction models in patients with CKD, including novel biomarkers, which performed better than models using only traditional risk factors developed for the general population.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Environmental Sciences
Adjani A. Peralta, Joel Schwartz, Diane R. Gold, Judith M. Vonk, Roel Vermeulen, Ulrike Gehring
Summary: This study found suggestive associations between early childhood exposure to ambient air pollution and the distribution of CIMT in adolescence. Specifically, exposure to PM2.5 absorbance was significantly associated with the 10th quantile of CIMT, while no significant associations were observed with other quantiles.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Taoreed Adegoke Azeez
Summary: Osteoporosis and cardiovascular disease share similar risk factors and mechanisms, suggesting a link between the two. Emerging evidence shows that individuals with osteoporosis are at an increased risk of coronary artery disease and stroke. This calls for a shift in the perspective of osteoporosis as a metabolic disease to a cardio-metabolic disorder.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Multidisciplinary Sciences
Xin-zheng Hou, En-qi Liu, Si-qi Liu, Hao Lv, Hua-feng Cui, Jing Han
Summary: This study aimed to assess the correlation between serum albumin levels and coronary heart disease (CHD) risk in adults aged over 45 years. Multiple logistic regression and smooth curve fitting analysis were performed using the non-institutionalized US population from NHANES 2011-2018. The results showed an inverse association between serum albumin levels and CHD risk, with lower levels of serum albumin associated with a higher risk of CHD. Subgroup analysis indicated that this correlation was statistically significant in female patients over 60 years with hypertension but without diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Aaron W. Aday, Meredith S. Duncan, Olga Patterson, Scott L. DuVall, Patrick R. Alba, Charles W. Alcorn, Hilary A. Tindle, Mark A. Creager, Marc P. Bonaca, Scott M. Damrauer, Quinn S. Wells, Adam Behroozian, Joshua A. Beckman, Matthew S. Freiberg
Summary: The risk of incident PAD varies by sex and race, with women having a lower risk compared to men and Black participants having a slightly higher risk compared to White participants, particularly for nontraumatic amputation. Diabetes and smoking are associated with incident PAD.
Review
Biochemistry & Molecular Biology
Maryam Mahjoubin-Tehran, Yong Teng, Amin Jalili, Seyed Hamid Aghaee-Bakhtiari, Alexander M. Markin, Amirhossein Sahebkar
Summary: Atherosclerosis, a common type of cardiovascular disease, is caused by inflammatory chronic lesions in the arterial wall and can lead to heart disease and stroke. Despite efforts to improve therapeutic approaches, challenges remain, necessitating the search for more effective treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Shibo Wei, Thanh T. Nguyen, Yan Zhang, Dongryeol Ryu, Karim Gariani
Summary: Sarcopenic obesity is the combination of muscle loss and obesity in the same individual, which is detrimental to health and associated with various diseases and increased mortality rates. The condition primarily affects older individuals and requires improvements in definition, prevalence identification, and therapeutic interventions for better prognosis. This review provides an overview of sarcopenic obesity and its associations with cardiovascular diseases and mortality.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Weronika Frak, Armanda Wojtasinska, Wiktoria Lisinska, Ewelina Mlynarska, Beata Franczyk, Jacek Rysz
Summary: Cardiovascular diseases (CVDs) are disorders associated with the heart and circulatory system, with atherosclerosis as its underlying cause. CVDs are the leading cause of morbidity and mortality globally, creating a significant public health concern. This review summarizes the pathophysiological implications of CVDs, focusing on coronary artery disease and atherosclerosis. Inflammatory factors and genetic risk factors have been identified in association with CVDs.
Letter
Allergy
Eline A. Casassa, Claire Mailhol, Emilie Tournier, Camille Laurent, Yannick Degboe, Marine Eischen, Natalia Kirsten, Jacques Moreau, Solene M. Evrard, Veronique Mansat-De Mas, Laurence Lamant, Patrice Dubreuil, Pol Andre Apoil, Olivier Hermine, Carle Paul, Cristinai Bulai Livideanu
ALLERGOLOGY INTERNATIONAL
(2019)
Article
Genetics & Heredity
Cecile Luxembourger, Adeline Ruyssen-Witrand, Chayma Ladhari, Cecile Rittore, Yannick Degboe, Jean-Francis Maillefert, Philippe Gaudin, Hubert Marotte, Daniel Wendling, Christian Jorgensen, Alain Cantagrel, Arnaud Constantin, Delphine Nigon, Isabelle Touitou, Jacques-Eric Gottenberg, Yves-Marie Pers
PHARMACOGENOMICS JOURNAL
(2019)
Article
Immunology
Yannick Degboe, Benjamin Rauwel, Michel Baron, Jean-Frederic Boyer, Adeline Ruyssen-Witrand, Arnaud Constantin, Jean-Luc Davignon
FRONTIERS IN IMMUNOLOGY
(2019)
Letter
Rheumatology
Marion Magnol, Yannick Degboe, Guillaume Couture, Arnaud Constantin, Michel Laroche
Article
Endocrinology & Metabolism
Y. Degboe, M. Eischen, P. A. Apoil, C. Mailhol, P. Dubreuil, O. Hermine, C. Paul, C. Bulai Livideanu, M. Laroche
OSTEOPOROSIS INTERNATIONAL
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Helene Braun, Clement Geniez, Yannick Degboe, Arnaud Constantin, Alain Cantagrel, Delphine Nigon, Nicolas Sans, Marie Faruch-Bilfeld, Adeline Ruyssen-Witrand
EUROPEAN RADIOLOGY
(2019)
Article
Dermatology
M. Fradet, M. Negretto, E. Tournier, C. Laurent, P. A. Apoil, S. Evrard, Y. Degboe, V. Del Mas, L. Lamant, P. Dubreuil, M. Laroche, C. Mailhol, O. Hermine, C. Paul, C. Bulai Livideanu
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2019)
Article
Immunology
Souraya Sayegh, Oula El Atat, Katy Diallo, Benjamin Rauwel, Yannick Degboe, Etienne Cavaignac, Arnaud Constantin, Alain Cantagrel, Viviane Trak-Smayra, Nada Alaaeddine, Jean-Luc Davignon
FRONTIERS IN IMMUNOLOGY
(2019)
Letter
Rheumatology
Guillaume Couture, Yannick Degboe, Clement Geniez, Ivan Tack, Marion Vallet, Michel Laroche
Article
Medicine, General & Internal
Yannick Degboe, Michael Schiff, Michael Weinblatt, Roy Fleischmann, Harris A. Ahmad, Arnaud Constantin
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Yannick Degboe, Remy Poupot, Mary Poupot
Summary: Monocytes and macrophages play a crucial role in the immune system, detecting and eradicating danger signals while maintaining tissue homeostasis. Imbalance in their response can lead to pathological disorders, and repolarization of these unbalanced macrophages shows promise as a therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Michel Laroche, Yannick Degboe, Arnaud Constantin
Summary: 10% of rheumatoid arthritis cases are associated with secondary Sjogren's syndrome, which may result in poorer treatment response and long-term prognosis. Secondary Sjogren's syndrome exacerbates the clinical course of rheumatoid arthritis and affects the efficacy of DMARDs and biologic therapies.
RHEUMATOLOGY INTERNATIONAL
(2023)
Review
Rheumatology
Yannick Degboe, Sebastiaan J. Vastert, Berent J. Prakken, Iain B. McInnes
Summary: Age plays a significant role in the development of immune-mediated arthritis. While children usually do not develop this inflammation during their first year, juvenile idiopathic arthritis patients experience a loss of immune privilege, leading to chronic inflammation and autoantibody signatures similar to adult arthritis. Factors such as genetic and epigenetic predisposition, immune system maturation, microbial dysbiosis, and environmental exposures contribute to this shift.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Rheumatology
Benedicte Champs, Yannick Degboe, Thomas Barnetche, Alain Cantagrel, Adeline Ruyssen-Witrand, Arnaud Constantin
Article
Rheumatology
Adeline Ruyssen-Witrand, Cecile Luxembourger, Alain Cantagrel, Delphine Nigon, Pascal Claudepierre, Yannick Degboe, Arnaud Constantin
ARTHRITIS RESEARCH & THERAPY
(2019)
Review
Rheumatology
Maria Chiara Maccarone, Daniele Coraci, Gianluca Regazzo, Nicola Sarandria, Anna Scanu, Stefano Masiero
Summary: Long COVID syndrome refers to the new, returning, or persistent symptoms after the initial SARS-CoV-2 infection. Musculoskeletal symptoms have a significant impact on the quality of life in many patients. A literature review was conducted to explore the evolution of musculoskeletal symptoms in Long COVID syndrome. The findings highlight the need for interdisciplinary management and timely rehabilitative interventions.
Review
Rheumatology
Alexis Mathian, Renaud Felten, Marta E. Alarcon-Riquelme, Antony Psarras, Philippe Mertz, Francois Chasset, Edward M. Vital, Laurent Arnaud
Summary: Improved understanding of the molecular basis of innate immunity has led to the recognition of type I interferons (IFNs) as key mediators in the development of immunemediated inflammatory diseases (IMIDs). Pharmacological targeting of IFNs and their downstream signaling pathways, such as JAK1 and Tyk2, holds promise for the treatment of IMIDs.
Review
Rheumatology
Marie Robert, Marc Scherlinger
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and organ injury, involving the active role of platelets in the pathogenesis and disease progression. Platelets in SLE patients show intrinsic differences and can perpetuate inflammation by interacting with immune cells, thereby participating in organ damage and heightened cardiovascular mortality.
Review
Rheumatology
Jean Sibilia, Fabrice Berna, Jean-Gerard Bloch, Marc Scherlinger
Summary: Mind-body practices, such as mindfulness meditation, yoga, and Tai Chi, show promise in improving patient-reported outcomes in chronic rheumatic diseases, but their impact on inflammation and structural progression remains unclear.
Review
Rheumatology
Anne Tournadre, Marine Beauger
Summary: Obesity alters the characteristics of adipose tissue, leading to chronic low-grade inflammation, increased risk of chronic inflammatory diseases, and impact on treatment efficacy. Dietary and weight adjustments have a positive effect on improving inflammatory rheumatic diseases.
Article
Rheumatology
Romain Fore, Eric Liozon, Stephanie Dumonteil, Thomas Sene, Emmanuel Heron, Valentin Lacombe, Mathilde Leclercq, Julie Magnant, Clement Beuvon, Alexis Regent, Donatienne de Mornac, Maxime Samson, Perrine Smets, Jean-Francois Alexandra, Brigitte Granel, Pierre-Yves Robert, Muhammad Faiz Curumthaullee, Simon Parreau, Sylvain Palat, Holy Bezanahary, Kim Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
Summary: This study aimed to evaluate whether the use of intravenous pulse of methylprednisolone reduces the risk of bilateral visual ischemia in patients with giant cell arteritis. The results showed no significant difference in the incidence of bilateral visual ischemia between the group receiving intravenous pulse of methylprednisolone and the group receiving direct prednisone.
Review
Rheumatology
Florent Eymard, Judith Aron-Wisnewsky
Summary: Obesity is a major modifiable risk factor for osteoarthritis (OA) and is associated with poorer outcomes in terms of pain, functional limitations, and response to treatments. Bariatric surgery (BS) can significantly reduce symptoms and improve function in patients with symptomatic knee OA, but its impact on long-term complications of arthroplasties appears to be disappointing. Overall, BS shows promise in reducing OA symptoms and potentially slowing disease progression.
Review
Rheumatology
Georges Marouna, Christina Fissouna, Marina Villaverde, Jean-Marc Brondelloa, Yves-Marie Pers
Summary: Recent discoveries have shown that the presence of senescent cells in osteoarticular tissues plays a crucial role in the development of osteoarthritis (OA). However, the senescence-regulatory factors associated with OA still need to be identified. Additionally, there is a lack of diagnostic and prognostic biomarkers currently used in clinics to evaluate OA patients. In the future, detecting senescence-regulatory biomarkers in patient fluids, along with imaging and clinical examination, could become a promising method for diagnosing, monitoring, assessing progression, and predicting prognosis in OA patients.
Article
Rheumatology
Patrick Yousif, Vicky Nahra, Muhammad A. Khan, Marina Magrey
Summary: Axial psoriatic arthritis (axPsA) has unique clinical and radiographic features compared to axial spondyloarthritis (axSpA). IL-23 inhibitors may be effective in treating axPsA, but further clinical trials are needed. Developing classification criteria and assessment tools for axPsA is also necessary.
Review
Rheumatology
Baptiste Gerard, Florian Bailly, Anne-Priscille Trouvin
Summary: This review aims to critically evaluate the effectiveness and safety of pharmacological treatments for chronic pain in rheumatic diseases, providing guidance for clinicians in selecting appropriate treatment options. The recommended pharmacological treatments vary depending on the specific rheumatic disease.