Review
Biochemistry & Molecular Biology
Federica Li Pomi, Francesco Borgia, Paolo Custurone, Mario Vaccaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: HMGB1 plays a crucial role in the pathogenesis, prognosis, and therapeutic response of human melanoma. Its ability to promote cell migration directly contributes to tumor cell metastasis. Future perspectives include the development of new target therapy against HMGB1 to provide a new approach for the treatment of melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Antonino Palumbo, Fabiola Atzeni, Giuseppe Murdaca, Sebastiano Gangemi
Summary: Osteoarthritis (OA) is a prevalent and disabling joint disease influenced by various factors. Recent research has revealed the involvement of damage-associated molecular patterns (DAMPs), particularly alarmins like HMGB1, IL-33, and S100B, in promoting inflammation and degradation in OA chondrocytes. Identifying the molecular signaling of these molecules, their potential use as biomarkers for disease staging, and their suitability as therapeutic targets are important objectives. High levels of HMGB1, in particular, have been observed in OA cartilage, synovium, and synovial fluid, and are associated with disease severity. Strategies targeting HMGB1 have shown promising results in OA cells and animal models and could provide new treatment options for modifying disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Hiroshi Ueda
Summary: Nuclear protein prothymosin α (ProTα) is a member of DAMPs/alarmins, which prevents neuronal necrosis by causing a cell death mode switch. Its extracellular release is a Ca2+-dependent process involving the formation of a protein complex and subsequent release. This non-vesicular and non-classical release mediated by ANXA2 flop-out could play key roles in DAMPs/alarmins release.
Article
Cell Biology
Hayato Matsunaga, Sebok Kumar Halder, Hiroshi Ueda
Summary: The study revealed the release of ProT alpha and S100A13 under serum-free conditions via interactions with Syt-1 and ANXA2, as well as stress-induced responses due to membrane lipid asymmetry.
Article
Cell Biology
Hayato Matsunaga, Sebok Kumar Halder, Hiroshi Ueda
Summary: This study demonstrates the essential role of SNARE proteins in stress-induced non-classical release of ProT alpha and S100A13 proteins from C6 glioma cells.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Kaiqiao He, Wei Wu, Xinju Wang, Wei Dai, Sijia Wang, Chunying Li, Shuli Li
Summary: This study found that serum levels of S100B, S100A9, and HMGB1 may serve as biomarkers for diagnosing and assessing the activity/severity of non-segmental vitiligo (NSV). The combination of these markers can improve the accuracy of diagnosis and assessment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Jasleen Kaur, Harsimar Singh, Saba Naqvi
Summary: Neuroinflammation, triggered by cellular injury and the innate immune system, is a critical factor in neurodegenerative diseases. Damage-associated molecular patterns (DAMPs) are endogenous danger indicators released from different compartments of cells under pathological stimulation, and they play a significant role in the inflammatory cascade and cytokine release. This review focuses on DAMP molecules originating from intracellular compartments and their roles in neurodegenerative events, including downstream mediators and signaling pathways. Additionally, recent interventions involving DAMPs as clinical biomarkers for disease detection and targeting the innate immune activation response to reduce sterile neuroinflammation are discussed.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Yang Yu, Na Xu, Qi Cheng, Fei Deng, Meiqin Liu, Airu Zhu, Yuan-Qin Min, Dan Zhu, Wenbo Huang, Xu Feng, Xizhong Jing, Ying Chen, Daoyuan Yue, Yawei Fan, Chang Shu, Qing Guan, Zifeng Yang, Jincun Zhao, Wenjun Song, Deyin Guo, Huanliang Liu, Jindong Zhao, Ping Lan, Zhengli Shi, Yingfang Liu, Xiaoping Chen, Huanhuan Liang
Summary: Previous studies have shown that interferon-induced protein 35 (IFP35) plays a critical role in the cytokine storm induced by SARS-CoV-2 and influenza virus, with levels correlating with disease severity, and neutralizing antibodies against IFP35 significantly reducing lung injury and mortality in viral infection.
Review
Biochemistry & Molecular Biology
Sandra Santos-Sierra
Summary: Inflammatory arthritis is a group of diseases caused by dysregulated immune system activity, and various medications are used to control the excessive immune response. However, drug resistances, flare-reactions, and adverse effects to current therapies are common in affected patients.
Article
Gastroenterology & Hepatology
Carlijn E. Bruggeling, Maarten te Groen, Daniel R. Garza, Famke van Heeckeren Tot Overlaer, Joyce P. M. Krekels, Basma-Chick Sulaiman, Davy Karel, Athreyu Rulof, Anne R. Schaaphok, Daniel L. A. H. Hornikx, Iris D. Nagtegaal, Bas E. Dutilh, Frank Hoentjen, Annemarie Boleij
Summary: This prospective cohort study found that colonic bacterial biofilms are common in ulcerative colitis (UC) and may increase the risk of dysplasia through oncogenic traits. Moreover, the study also found that bacterial composition is associated with biofilms and dysplasia risk. The presence of biofilms is not significantly associated with dysplasia in UC, while ClbB is independently associated with dysplasia and FadA and Fusobacteriales are associated with a decreased risk of dysplasia in UC.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Medicine, General & Internal
Huan Ma, Ning Cheng, Caiyi Zhang
Summary: Schizophrenia is a severe psychiatric disorder with a complex etiology and is a leading cause of disability worldwide. Accurate diagnosis and effective treatment selection for schizophrenia are challenging due to the lack of objective indicators. Immunological biomarkers may be related to disease progression and treatment effectiveness.
MEDICINA-LITHUANIA
(2022)
Review
Oncology
Gregory Verghese, Jochen K. Lennerz, Danny Ruta, Wen Ng, Selvam Thavaraj, Kalliopi P. Siziopikou, Threnesan Naidoo, Swapnil Rane, Roberto Salgado, Sarah E. Pinder, Anita Grigoriadis
Summary: Computational pathology refers to the use of deep learning techniques and algorithms to analyze and interpret histopathology images. Despite its promising potential, the integration of computational pathology in clinical settings is hindered by various obstacles, including operational, technical, regulatory, ethical, financial, and cultural challenges.
JOURNAL OF PATHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Luca Gallelli, Rosa Terracciano, Alessandro Vatrella
Summary: TSLP is an innate cytokine that plays a key role in asthma pathogenesis, while tezepelumab is a fully human monoclonal antibody that prevents TSLP's interaction with receptors. Preliminary results indicate that tezepelumab has a good safety and efficacy profile in patients with severe, uncontrolled asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Rafi Haque, Caroline M. Watson, Jiaqi Liu, E. Kathleen Carter, Duc M. Duong, James J. Lah, Aliza P. Wingo, Blaine R. Roberts, Erik C. B. Johnson, Andrew J. Saykin, Leslie M. Shaw, Nicholas T. Seyfried, Thomas S. Wingo, Allan I. Levey
Summary: This study developed a reliable and high-throughput mass spectrometry assay to detect 48 key proteins in cerebrospinal fluid (CSF), and found that this panel of proteins performed at least as well as existing biomarkers in predicting clinical diagnosis, brain imaging results, cognitive decline, and dementia severity in Alzheimer's disease. Combining this panel with existing biomarkers significantly improved diagnostic accuracy and prediction of disease progression.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Murdaca, Alessandro Allegra, Francesca Paladin, Fabrizio Calapai, Caterina Musolino, Sebastiano Gangemi
Summary: This study examines the role of molecules such as high-mobility group box-1, heat shock proteins, and S100 proteins in the induction of neoangiogenesis in multiple myeloma, highlighting their significance in disease progression. The modulation of the host immune system and inhibition of neoangiogenesis may serve as potential therapeutic targets for MM treatment, aiming to improve survival outcomes and reduce the risk of relapsed/refractory disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Alexandra Laberko, Vasiliy Burlakov, Sarah Maier, Mario Abinun, Roderick Skinner, Anna Kozlova, Deepti Suri, Kai Lehmberg, Ingo Mueller, Dmitry Balashov, Galina Novichkova, Dirk Holzinger, Andrew R. Gennery, Anna Shcherbina
Summary: Allogeneic hematopoietic stem cell transplantation appears to be an effective option in curing cytopenia and severe autoinflammation in PAMI syndrome, and it may offer a curative option for other inflammatory disorders associated with proline-serine-threonine phosphatase-interacting protein 1.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Clinical Neurology
Claire G. Salter, Yiying Cai, Bernice Lo, Guy Helman, Henry Taylor, Amber McCartney, Joseph S. Leslie, Andrea Accogli, Federico Zara, Monica Traverso, James Fasham, Joshua A. Lees, Matteo P. Ferla, Barry A. Chioza, Olivia Wenger, Ethan Scott, Harold E. Cross, Joanna Crawford, Ilka Warshawsky, Matthew Keisling, Dimitris Agamanolis, Catherine Ward Melver, Helen Cox, Mamoun Elawad, Tamas Marton, Matthew N. Wakeling, Dirk Holzinger, Stephan Tippelt, Martin Munteanu, Deyana Valcheva, Christin Deal, Sara Van Meerbeke, Catherine Walsh Vockley, Manish J. Butte, Utkucan Acar, Marjo S. van der Knaap, G. Christoph Korenke, Urania Kotzaeridou, Tamas Balla, Cas Simons, Holm H. Uhlig, Andrew H. Crosby, Pietro De Camilli, Nicole Wolf, Emma L. Baple
Summary: Biallelic PI4KA sequence alterations in humans are associated with neurological disease, particularly hypomyelinating leukodystrophy, as well as potentially causing inflammatory bowel disease, multiple intestinal atresia, and combined immunodeficiency. These phenotypical outcomes are likely due to impaired organ-specific functions of the PI4KIII alpha-TTC7-FAM126 complex resulting from defective catalytic activity or altered intra-complex functional interactions. The data defines PI4KA gene alteration as a cause of a variable phenotypical spectrum and provides new insight into the biology of the PI4KIII alpha-FAM126-TTC7-EFR3 molecular complex.
Article
Allergy
David Egg, Ina Caroline Rump, Noriko Mitsuiki, Jessica Rojas-Restrepo, Maria-Elena Maccari, Charlotte Schwab, Annemarie Gabrysch, Klaus Warnatz, Sigune Goldacker, Virginia Patino, Daniel Wolff, Satoshi Okada, Seiichi Hayakawa, Yoshiaki Shikama, Kenji Kanda, Kohsuke Imai, Manabu Sotomatsu, Makoto Kuwashima, Takahiro Kamiya, Tomohiro Morio, Kazuaki Matsumoto, Takeshi Mori, Yuri Yoshimoto, Ingunn Dybedal, Maria Kanariou, Zeynep Yesim Kucuk, Hugo Chapdelaine, Lenka Petruzelkova, Hanns-Martin Lorenz, Kathleen E. Sullivan, Jennifer Heimall, Michel Moutschen, Jiri Litzman, Mike Recher, Michael H. Albert, Fabian Hauck, Suranjith Seneviratne, Jana Pachlopnik Schmid, Antonios Kolios, Gary Unglik, Christian Klemann, Scott Snapper, Lisa Giulino-Roth, Michael Svaton, Craig D. Platt, Sophie Hambleton, Olaf Neth, Geraldine Gosse, Steffen Reinsch, Dirk Holzinger, Yae-Jean Kim, Shahrzad Bakhtiar, Faranaz Atschekzei, Reinhold Schmidt, Georgios Sogkas, Shanmuganathan Chandrakasan, William Rae, Beata Derfalvi, Hanne Vibeke Marquart, Ahmet Ozen, Ayca Kiykim, Elif Karakoc-Aydiner, Pavlina Kralickova, Godelieve de Bree, Dimitra Kiritsi, Markus G. Seidel, Robin Kobbe, Jennifer Dantzer, Laia Alsina, Thais Armangue, Vassilios Lougaris, Philipp Agyeman, Sofia Nystrom, David Buchbinder, Peter D. Arkwright, Bodo Grimbacher
Summary: Heterozygous germline mutations in cytotoxic T lymphocyte-associated antigen-4 (CTLA4) can lead to life-threatening autoimmune and lymphoproliferative complications. Treatment options include systemic immunosuppressants, immunoglobulin replacement, and stem cell transplantation for potential cure.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Axel Schmidt, Sophia Peters, Alexej Knaus, Hemmen Sabir, Frauke Hamsen, Carlo Maj, Julia Fazaal, Sugirthan Sivalingam, Oleksandr Savchenko, Aakash Mantri, Dirk Holzinger, Ulrich Neudorf, Andreas Mueller, Kerstin U. Ludwig, Peter M. Krawitz, Hartmut Engels, Markus M. Noethen, Soyhan Bagci
Summary: A 3.5-year-old girl with an autoinflammatory disorder of unknown etiology and severe COVID-19 symptoms died, with gene sequencing revealing variants associated with severe COVID-19 and common variable immunodeficiency, possibly predisposing to lethal COVID-19 in this case.
NPJ GENOMIC MEDICINE
(2021)
Article
Allergy
Miriam Gross, Carsten Speckmann, Annette May, Tania Gajardo-Carrasco, Katharina Wustrau, Sarah Lena Maier, Marcus Panning, Daniela Huzly, Abbas Agaimy, Yenan T. Bryceson, Sharon Choo, C. W. Chow, Gregor Dueckers, Anders Fasth, Sylvie Fraitag, Katja Graewe, Sabine Haxelmans, Dirk Holzinger, Ole Hudowenz, Judith M. Huebschen, Claudia Khurana, Korbinian Kienle, Roman Klifa, Klaus Korn, Heinz Kutzner, Tim Laemmermann, Svea Ledig, Dan Lipsker, Marie Meeths, Nora Naumann-Bartsch, Jelena Rascon, Anne Schaenzer, Maximilian Seidl, Bianca Tesi, Christelle Vauloup-Fellous, Beate Vollmer-Kary, Klaus Warnatz, Claudia Wehr, Benedicte Neven, Pablo Vargas, Fernando E. Sepulveda, Kai Lehmberg, Annette Schmitt-Graeff, Stephan Ehl
Summary: This study investigated the defective effector mechanism allowing rubella vaccine virus persistence in granulomas by studying patients with cytotoxicity defects and granuloma. The results suggest a critical role of T cells in rubella elimination.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Carolin Park, Maria Miranda-Garcia, Rainer Berendes, Gerd Horneff, Jasmin Kuemmerle-Deschner, Gerd Ganser, Hans-Iko Huppertz, Kirsten Minden, Johannes-Peter Haas, Annette F. Jansson, Michael Borte, Catharina Schuetz, Prasad Oommen, Michael Frosch, Bernhard Schlueter, Annette Richter-Unruh, Christoph Kessel, Claas Hinze, Helmut Wittkowski, Johannes Roth, Dirk Foell, Dirk Holzinger
Summary: This study validated the usefulness of MRP8/14 serum analyses in supporting the diagnosis of SJIA in febrile children. The results could be confirmed with commercial ELISA and LFIA, enabling a rapid diagnostic point-of-care screening test.
Article
Agronomy
Marko Ocepek, Anja Znidar, Miha Lavric, Dejan Skorjanc, Inger Lise Andersen
Summary: The goal of this study was to develop an automated monitoring system for the detection of pigs' bodies, heads and tails. By using machine learning algorithms and neural network analysis, the study achieved accurate recognition of pigs' bodies and tail postures, with human-level precision.
Article
Rheumatology
Joachim Gerss, Monika Tedy, Ariane Klein, Gerd Horneff, Maria Miranda-Garcia, Christoph Kessel, Dirk Holzinger, Valda Stanevica, Joost F. Swart, David A. Cabral, Hermine Brunner, Dirk Foell
Summary: This study investigates the use of high-sensitivity C-reactive protein (hsCRP) and S100A12 as predictive biomarkers for successful drug withdrawal in children with clinical remission of juvenile idiopathic arthritis (JIA). The results show that using these predictive markers of subclinical inflammation is a promising tool in the decision-making process of therapy withdrawal, resulting in direct benefit for patients.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Emma J. Sumner, Beverley Almeida, Jason Palman, Peter Bale, Clare Heard, Dirk Holzinger, Johannes Roth, Dirk Foell, Emily Robinson, Simona Ursu, Chris Wallace, Kimberly Gilmour, Lucy R. Wedderburn, Elizabeth Ralph
Summary: The objective of this study was to determine the effectiveness of MRP8/14 as a predictor of disease flare in patients with juvenile idiopathic arthritis (JIA) following the withdrawal of methotrexate (MTX) in a routine clinical setting. The study found that there was no significant difference in flares between patients with an elevated or low MRP8/14 value. However, in those who stopped MTX, no patients with a low MRP8/14 result flared.
CLINICAL RHEUMATOLOGY
(2022)
Article
Hematology
Laura M. Moser, Julia Fekadu, Andre Willasch, Eva Rettinger, Jan Soerensen, Andrea Jarisch, Marta Kirwil, Adrian Lieb, Dirk Holzinger, Gabriele Calaminus, Peter Bader, Shahrzad Bakhtiar
Summary: This study reports on the successful treatment of inborn errors of immunity (IEI) patients with treatment-refractory inflammatory bowel disease (IBD) using allogeneic hematopoietic stem cell transplantation (alloHSCT). The patients achieved stable engraftment, immune reconstitution, and resolution of gastrointestinal symptoms. The overall survival rate was 100% over a median follow-up of 34.7 months.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Immunology
Rensheng Wan, Johannes Faender, Ia Zakaraia, Min Ae Lee-Kirsch, Christine Wolf, Nadja Lucas, Lisa Isabel Olfe, Corinna Hendrich, Danny Jonigk, Dirk Holzinger, Mathis Steindor, Gunnar Schmidt, Claudia Davenport, Christian Klemann, Nicolaus Schwerk, Matthias Griese, Brigitte Schlegelberger, Florian Stehling, Christine Happle, Bernd Auber, Doris Steinemann, Martin Wetzke, Sandra von Hardenberg
Summary: This study reports four novel cases and eight historic cases of autosomal recessive SAVI caused by c.841C>T homozygosity. Comprehensive clinical data and treatment regimens are provided, and the study aims to raise awareness for autosomal recessive inheritance in this rare, severe disease, which may aid in early diagnosis and development of optimized treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Prasad T. Oommen, Timmy Strauss, Karen Baltruschat, Ivan Foeldvari, Christoph Deuter, Gerd Ganser, Johannes-Peter Haas, Claas Hinze, Dirk Holzinger, Anton Hospach, Hans-Iko Huppertz, Arnold Illhardt, Michael Jung, Tilmann Kallinich, Ariane Klein, Kirsten Minden, Kirsten Monkemoller, Sonja Mrusek, Ulrich Neudorf, Gregor Dueckers, Tim Niehues, Matthias Schneider, Philipp Schoof, Angelika Thon, Michael Wachowsky, Norbert Wagner, Susanne Bloedt, Michael Hofer, Klaus Tenbrock, Catharina Schuetz
Summary: This article summarizes the recent update of the interdisciplinary, consensus-based German guidelines on the management of juvenile idiopathic arthritis (JIA). Through multi-disciplinary and consensus participation, therapeutic principles and recommendations were proposed, providing physicians with evidence-based tailored treatment approaches.
CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Julia Kuehn, Susanne Schleifenbaum, Michaela Hendling, Sandra Siebenhandl, Julie Krainer, Sabrina Fuehner, Antje Hellige, Carolin Park, Claas Hinze, Helmut Wittkowski, Dirk Holzinger, Lorenz Thurner, Andreas Weinhaeusel, Dirk Foell, Christoph Kessel
Summary: This study found that aberrant or incomplete polarization of T helper cells may contribute to the pathological processes in systemic juvenile idiopathic arthritis (sJIA).
ARTHRITIS & RHEUMATOLOGY
(2023)
Meeting Abstract
Oncology
Kai Lehmberg, Svea Ledig, Katharina Wustrau, Udo Kontny, Silke Westphal, Patrick Hundsdoerfer, Norbert Jorch, Johanna Scheer-Preiss, Dominik Schneider, Sujal Ghosh, Nora Naumann-Bartsch, Dirk Holzinger, Shahrzad Bakhtiar, Christine Mauz-Koerholz, Christof Kramm, Rita Beier, Wolfgang Behnisch, Monika Streiter, Alfred Laengler, Rhoikos Furtwaengler, Bernd Gruhn, Michaela Nathrath, Uemmueguel Behr, Meinolf Siepermann, Lars Fischer, Antje Redlich, Alexandra Russo, Matthias Duerken, Fabian Hauck, Martina Ahlmann, Martin Irnich, Heiko-Manuel Teltschik, Peter Lang, Manfred Hoenig, Ansgar Schulz, Sharon Choo, Bruce Crooks, Renata Formankova, Marianne Ifversen, Thais Murciano-Carrillo, Itziar Astigarraga, Juana Gil Herrera, Tal Ben-Ami, Joanne Yacobovich, Iwona Malinowska, Michael Jordan, Melissa Hines, Julie-An Talano, Jana Pachlopnik Schmid, Stephan Ehl
PEDIATRIC BLOOD & CANCER
(2023)
Article
Immunology
Maria Elena Maccari, Sebastian Fuchs, Patrick Kury, Geoffroy Andrieux, Simon Volkl, Bertram Bengsch, Myriam Ricarda Lorenz, Maximilian Heeg, Jan Rohr, Sabine Jagle, Carla N. Castro, Miriam Gross, Ursula Warthorst, Christoph Koenig, Ilka Fuchs, Carsten Speckmann, Julian Thalhammer, Friedrich G. Kapp, Markus G. Seidel, Gregor Duckers, Stefan Schoenberger, Catharina Schuetz, Marita Fuhrer, Robin Kobbe, Dirk Holzinger, Christian Klemann, Petr Smisek, Stephen Owens, Gerd Horneff, Reinhard Kolb, Nora Naumann-Bartsch, Maurizio Miano, Julian Staniek, Marta Rizzi, Tomas Kalina, Pascal Schneider, Anika Erxleben, Rolf Backofen, Arif Ekici, Charlotte M. Niemeyer, Klaus Warnatz, Bodo Grimbacher, Hermann Eibel, Andreas Mackensen, Andreas Philipp Frei, Klaus Schwarz, Melanie Boerries, Stephan Ehl, Anne Rensing-Ehl
Summary: The identification and characterization of a population of FAS-controlled TCR alpha beta(+) T cells in autoimmune lymphoproliferative syndrome show numerous unique features, including a distinct molecular signature, high proliferation rates, noncytotoxicity, and IL-10 cytokine bias. Mechanistically, the regulation of this population involves FAS and CTLA4 signaling, as well as mTOR and STAT3 signals, and genetic alterations in these pathways can lead to significant lymphoproliferative disease.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Rheumatology
Maria Chiara Maccarone, Daniele Coraci, Gianluca Regazzo, Nicola Sarandria, Anna Scanu, Stefano Masiero
Summary: Long COVID syndrome refers to the new, returning, or persistent symptoms after the initial SARS-CoV-2 infection. Musculoskeletal symptoms have a significant impact on the quality of life in many patients. A literature review was conducted to explore the evolution of musculoskeletal symptoms in Long COVID syndrome. The findings highlight the need for interdisciplinary management and timely rehabilitative interventions.
Review
Rheumatology
Alexis Mathian, Renaud Felten, Marta E. Alarcon-Riquelme, Antony Psarras, Philippe Mertz, Francois Chasset, Edward M. Vital, Laurent Arnaud
Summary: Improved understanding of the molecular basis of innate immunity has led to the recognition of type I interferons (IFNs) as key mediators in the development of immunemediated inflammatory diseases (IMIDs). Pharmacological targeting of IFNs and their downstream signaling pathways, such as JAK1 and Tyk2, holds promise for the treatment of IMIDs.
Review
Rheumatology
Marie Robert, Marc Scherlinger
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and organ injury, involving the active role of platelets in the pathogenesis and disease progression. Platelets in SLE patients show intrinsic differences and can perpetuate inflammation by interacting with immune cells, thereby participating in organ damage and heightened cardiovascular mortality.
Review
Rheumatology
Jean Sibilia, Fabrice Berna, Jean-Gerard Bloch, Marc Scherlinger
Summary: Mind-body practices, such as mindfulness meditation, yoga, and Tai Chi, show promise in improving patient-reported outcomes in chronic rheumatic diseases, but their impact on inflammation and structural progression remains unclear.
Review
Rheumatology
Anne Tournadre, Marine Beauger
Summary: Obesity alters the characteristics of adipose tissue, leading to chronic low-grade inflammation, increased risk of chronic inflammatory diseases, and impact on treatment efficacy. Dietary and weight adjustments have a positive effect on improving inflammatory rheumatic diseases.
Article
Rheumatology
Romain Fore, Eric Liozon, Stephanie Dumonteil, Thomas Sene, Emmanuel Heron, Valentin Lacombe, Mathilde Leclercq, Julie Magnant, Clement Beuvon, Alexis Regent, Donatienne de Mornac, Maxime Samson, Perrine Smets, Jean-Francois Alexandra, Brigitte Granel, Pierre-Yves Robert, Muhammad Faiz Curumthaullee, Simon Parreau, Sylvain Palat, Holy Bezanahary, Kim Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
Summary: This study aimed to evaluate whether the use of intravenous pulse of methylprednisolone reduces the risk of bilateral visual ischemia in patients with giant cell arteritis. The results showed no significant difference in the incidence of bilateral visual ischemia between the group receiving intravenous pulse of methylprednisolone and the group receiving direct prednisone.
Review
Rheumatology
Florent Eymard, Judith Aron-Wisnewsky
Summary: Obesity is a major modifiable risk factor for osteoarthritis (OA) and is associated with poorer outcomes in terms of pain, functional limitations, and response to treatments. Bariatric surgery (BS) can significantly reduce symptoms and improve function in patients with symptomatic knee OA, but its impact on long-term complications of arthroplasties appears to be disappointing. Overall, BS shows promise in reducing OA symptoms and potentially slowing disease progression.
Review
Rheumatology
Georges Marouna, Christina Fissouna, Marina Villaverde, Jean-Marc Brondelloa, Yves-Marie Pers
Summary: Recent discoveries have shown that the presence of senescent cells in osteoarticular tissues plays a crucial role in the development of osteoarthritis (OA). However, the senescence-regulatory factors associated with OA still need to be identified. Additionally, there is a lack of diagnostic and prognostic biomarkers currently used in clinics to evaluate OA patients. In the future, detecting senescence-regulatory biomarkers in patient fluids, along with imaging and clinical examination, could become a promising method for diagnosing, monitoring, assessing progression, and predicting prognosis in OA patients.
Article
Rheumatology
Patrick Yousif, Vicky Nahra, Muhammad A. Khan, Marina Magrey
Summary: Axial psoriatic arthritis (axPsA) has unique clinical and radiographic features compared to axial spondyloarthritis (axSpA). IL-23 inhibitors may be effective in treating axPsA, but further clinical trials are needed. Developing classification criteria and assessment tools for axPsA is also necessary.
Review
Rheumatology
Baptiste Gerard, Florian Bailly, Anne-Priscille Trouvin
Summary: This review aims to critically evaluate the effectiveness and safety of pharmacological treatments for chronic pain in rheumatic diseases, providing guidance for clinicians in selecting appropriate treatment options. The recommended pharmacological treatments vary depending on the specific rheumatic disease.