Article
Endocrinology & Metabolism
Lydia Coulter Kwee, Olga Ilkayeva, Michael J. Muehlbauer, Nathan Bihlmeyer, Bruce Wolfe, Jonathan Q. Purnell, F. Xavier Pi-Sunyer, Haiying Chen, Judy Bahnson, Christopher B. Newgard, Svati H. Shah, Blandine Laferrere
Summary: Analysis of metabolic markers identified two metabolite factors associated with weight loss and type 2 diabetes remission in individuals with severe obesity, but the results were not significant after multiple testing. Inclusion of these factors in clinical models led to modest improvements in model fit and performance.
NUTRITION & DIABETES
(2021)
Article
Endocrinology & Metabolism
Malini Prasad, Victoria Mark, Chanel Ligon, Roxanne Dutia, Nandini Nair, Ankit Shah, Blandine Laferrere
Summary: The study found that improvements in beta-cell function after RYGB surgery, such as weight loss, decreased fat mass, reduced waist circumference, and improved insulin resistance, were significant at 12 and 24 months but were not related to diabetes remission status. However, changes in beta-cell glucose sensitivity after oral glucose intake differed by remission status, with more significant and sustained improvements in those with full remission compared to those with partial or no remission.
Article
Endocrinology & Metabolism
Malini Prasad, Victoria Mark, Chanel Ligon, Roxanne Dutia, Nandini Nair, Ankit Shah, Blandine Laferrere
Summary: This study investigates the role of gut in diabetes remission after Roux-en-Y gastric bypass (RYGB). The results show that the improvement in beta-cell function, but not changes in weight loss or insulin sensitivity, drives diabetes remission.
Review
Nutrition & Dietetics
Dimitra Vasdeki, Theocharis Koufakis, Georgios Tsamos, Luca Busetto, Pantelis Zebekakis, Kalliopi Kotsa
Summary: Type 2 diabetes mellitus is a progressive disease that can potentially be managed through lifestyle changes, obesity surgery, and glucose-lowering therapy, but there are still some unknowns regarding its long-term effects on diabetic complications.
Article
Endocrinology & Metabolism
Rinki Murphy, Lindsay D. Plank, Michael G. Clarke, Nicholas J. Evennett, James Tan, David D. W. Kim, Richard Cutfield, Michael W. C. Booth
Summary: SR-LRYGB provided superior diabetes remission and weight loss compared with LSG at 5 years, with similar low risks of complications.
Article
Endocrinology & Metabolism
Laura J. Corbin, David A. Hughes, Caroline J. Bull, Emma E. Vincent, Madeleine L. Smith, Alex McConnachie, Claudia-Martina Messow, Paul Welsh, Roy Taylor, Michael E. J. Lean, Naveed Sattar, Nicholas J. Timpson
Summary: Through metabolomics analysis, we found that a weight management intervention was associated with decreases in branched-chain amino acids, sugars, and LDL triglycerides, and increases in sphingolipids, plasmalogens, and metabolites related to fatty acid metabolism. Among individuals who lost more than 9 kg between baseline and 12 months, those who achieved diabetes remission experienced greater reductions in glucose, fructose, and mannose compared to those who did not achieve remission.
Article
Medicine, General & Internal
Karen J. Coleman, Anirban Basu, Lee J. Barton, Heidi Fischer, David E. Arterburn, Douglas Barthold, Anita Courcoulas, Cecelia L. Crawford, Benjamin B. Kim, Peter N. Fedorka, Edward C. Mun, Sameer B. Murali, Kristi Reynolds, Robert E. Zane, Sami Alskaf
Summary: This study compared the effectiveness of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) in the long-term management of dyslipidemia, revealing that RYGB had higher remission rates after 4 years but required close monitoring to prevent relapse.
Article
Endocrinology & Metabolism
G. Thom, C. -M. Messow, W. S. Leslie, A. C. Barnes, N. Brosnahan, L. McCombie, A. Al-Mrabeh, S. Zhyzhneuskaya, P. Welsh, N. Sattar, R. Taylor, M. E. J. Lean
Summary: The study aimed to identify predictors of type 2 diabetes remission, and found that weight loss was the strongest predictor of remission at both 12 and 24 months. Other predictors included being prescribed fewer medications, lower triglyceride and gamma-glutamyl transferase levels, and reporting better quality of life.
Review
Endocrinology & Metabolism
Jianping Ye, Yangxi Hu, Chengming Wang, Hongkai Lian, Zigang Dong
Summary: Bariatric surgery is an effective treatment for type 2 diabetes in obese patients. Surgery improves insulin sensitivity by inducing an energy deficit, correcting mitochondrial overload, and leading to diabetes remission.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Endocrinology & Metabolism
Maryna Chumakova-Orin, Carolina Vanetta, Dimitrios P. Moris, Alfredo D. Guerron
Summary: Obesity rates have continued to rise, in parallel with increasing rates of type 2 diabetes mellitus. Bariatric surgery provides better T2DM resolution in obese patients, with Biliopancreatic diversion and Roux-en-Y gastric bypass showing higher rates of T2DM resolution compared to other procedures.
WORLD JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Lucia Rehackova, Angela Margarete Rodrigues, George Thom, Naomi Brosnahan, Alison C. Barnes, Louise McCombie, Wilma S. Leslie, Sviatlana Zhyzhneuskaya, Carl Peters, Ashley J. Adamson, Michael E. J. Lean, Roy Taylor, Falko F. Sniehotta
Summary: The DiRECT intervention has shown that sustained remission of type 2 diabetes through weight loss is achievable in primary care. Participants found adherence to TDR easier than expected, with some choosing to extend the program. Rapid weight loss and changes in diabetes markers provided ongoing motivation, while additional support and maintenance strategies were important for long-term success. The adaptation process identified in this study demonstrates the need for flexibility and tailoring of behavioral support to individual needs.
Review
Endocrinology & Metabolism
Pushpa Singh, Nicola J. Adderley, Jonathan Hazlehurst, Malcolm Price, Abd A. Tahrani, Krishnarajah Nirantharakumar, Srikanth Bellary
Summary: A systematic review was conducted on models predicting remission of type 2 diabetes following bariatric surgery, with the ABCD and DiaRem models being the most widely validated and showing good performance. While existing models perform well in the short term, more research is needed on long-term remission.
Article
Surgery
Wissam Ghusn, Kayla Ikemiya, Karim Al Annan, Andres Acosta, Barham K. Abu Dayyeh, Edmund Lee, Kostantinos Spaniolas, Michael Kendrick, Kelvin Higa, Pearl Ma, Omar M. Ghanem
Summary: In this study, the long-term remission of type 2 diabetes (T2DM) in patients with BMI >= 50 kg/m(2) who underwent Roux-En-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) was investigated. Among 279 T2DM patients who underwent RYGB or SG, 47% achieved long-term remission (>= 5 years), with duration, medication usage, and weight loss being identified as independent factors for long-term remission.
Article
Obstetrics & Gynecology
K. Johansson, A-k Wikstrom, J. Soderling, I Naslund, J. Ottosson, M. Neovius, O. Stephansson
Summary: A nationwide matched cohort study in Sweden involving over 843,000 singleton pregnancies found that gastric bypass surgery before pregnancy is associated with a reduced risk of pre-eclampsia, with the largest absolute risk reduction observed in nulliparous women.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Medicine, General & Internal
Roy Taylor
Summary: The twin cycle hypothesis suggests that excess liver fat can lead to dysfunction of both the liver and pancreas in type 2 diabetes. Calorie restriction can help normalize liver glucose handling and restore beta-cell function, resulting in remission. Achieving significant weight loss is crucial for remission, with the duration of diabetes and baseline beta-cell function being important factors.
JOURNAL OF INTERNAL MEDICINE
(2021)