Article
Medicine, General & Internal
Yves Cottin, Rany Issa, Mourad Benalia, Basile Mouhat, Alexandre Meloux, Laura Tribouillard, Florence Bichat, Luc Rochette, Catherine Vergely, Marianne Zeller
Summary: The study found an association between serum OPG levels and coronary lesion complexity in patients with acute myocardial infarction, which was not influenced by factors such as hypercholesterolemia, cardiovascular history, and reduced glomerular filtration rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Neil A. Zakai, Jessica Minnier, Monika M. Safford, Insu Koh, Marguerite R. Irvin, Sergio Fazio, Mary Cushman, Virginia J. Howard, Nathalie Pamir
Summary: The purpose of this study was to understand why CHD risk equations underperform in Black adults. The study found that low-density lipoprotein cholesterol and triglycerides play a role in predicting CHD risk in both Black and White adults, while low high-density lipoprotein cholesterol was associated with increased CHD risk in White adults but not in Black adults.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Genetics & Heredity
David Adlam, Takiy-Eddine N. Berrandou, Adrien Georges, Christopher Nelson, Eleni Giannoulatou, Josephine S. Henry, Lijiang Ma, Montgomery E. Blencowe, Tamiel L. Turley, Min-Lee Yang, Sandesh E. Chopade, Chris Finan, Peter Braund, Ines Sadeg-Sayoud, Siiri Iismaa, Matthew Kosel, Xiang Zhou, Stephen R. Hamby, Jenny Cheng, Lu Liu, Ingrid Tarr, David W. M. Muller, Valentina d'Escamard, Annette E. King, Liam R. Brunham, Ania A. Baranowska-Clarke, Stephanie G. Debette, Philippe Amouyel, Jeffrey W. Olin, Snehal Patil, Stephanie E. Hesselson, Keerat Junday, Stavroula Kanoni, Krishna G. Aragam, Adam S. Butterworth, Marysia Tweet, Rajiv Gulati, Nicolas Combaret, Daniella Kadian-Dodov, Jonathan M. Kalman, Diane Fatkin, Aroon D. Hingorani, Jacqueline Saw, Tom R. Webb, Sharonne N. Hayes, Xia Yang, Santhi K. Ganesh, Timothy M. Olson, Jason C. Kovacic, Robert M. Graham, Nilesh J. Samani, Nabila Bouatia-Naji
Summary: This study identifies 16 risk loci for spontaneous coronary artery dissection (SCAD) through a genome-wide association meta-analysis. Functional annotations suggest that these genes are likely to be regulated in vascular smooth muscle cells and artery fibroblasts and are involved in extracellular matrix biology. A locus containing the tissue factor gene F3 appears to be specific for SCAD risk. Several associated variants have opposite associations with coronary artery disease, suggesting shared biological processes but different mechanisms. High blood pressure is inferred to have a causal role in SCAD. These findings provide new pathophysiological insights and potential targets for specific therapeutics and preventions of SCAD.
Article
Multidisciplinary Sciences
Matthew T. Patrick, Qinmengge Li, Rachael Wasikowski, Nehal Mehta, Johann E. Gudjonsson, James T. Elder, Xiang Zhou, Lam C. Tsoi
Summary: This study identifies shared genetic loci between psoriasis and coronary artery disease through trans-disease meta-analysis, and prioritizes genes associated with inflammatory signaling. It also suggests that chronic systemic inflammation can increase the risk of psoriasis and cause coronary artery disease.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Ibrahim Al-Sawalha, Dalia Alzoubi
Summary: Coronary artery calcium score (CACs) is a method for measuring calcification in coronary arteries using a computed tomography scan, which can predict myocardial infarction. However, neglecting ethnicity in the study may affect the findings.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Multidisciplinary Sciences
Regitze Skals, Maria Lukacs Krogager, Emil Vincent R. Appel, Theresia M. Schnurr, Christian Theil Have, Gunnar Gislason, Henrik Enghusen Poulsen, Lars Kober, Thomas Engstrom, Steen Stender, Torben Hansen, Niels Grarup, Christina Ji-Young Lee, Charlotte Andersson, Christian Torp-Pedersen, Peter E. Weeke
Summary: Among patients referred for coronary angiography, only a strong genetic predisposition to insulin resistance was associated with risk of coronary artery disease and with a greater disease burden.
Article
Biochemistry & Molecular Biology
Ewelina A. Dziedzic, Jakub S. Gasior, Agnieszka Tuzimek, Justyna Paleczny, Miroslaw Kwasny, Marek Dabrowski, Piotr Jankowski
Summary: This study assessed the zinc nutritional status in patients with coronary artery disease using inductively coupled plasma optical emission spectrometry. The results showed no association between zinc and the severity of coronary artery disease, and there were no significant differences in zinc levels between patients with acute coronary syndrome and stable coronary artery disease. However, a significant negative correlation was observed between zinc content and serum triglyceride concentration, and patients with type 2 diabetes mellitus had lower hair zinc content.
Article
Nutrition & Dietetics
Yukihiko Momiyama, Yoshimi Kishimoto, Emi Saita, Masayuki Aoyama, Reiko Ohmori, Kazuo Kondo
Summary: Several cohort studies have shown that the Japanese diet is associated with reduced cardiovascular disease mortality, but the results are inconsistent and most studies were conducted in the 1990s. To further investigate this association, this study examined 802 patients undergoing coronary angiography and found that the intake of fish, soy products, vegetables, seaweed, fruits, and green tea was lower in patients with coronary artery disease (CAD), especially those with myocardial infarction (MI), compared to those without CAD. The Japanese diet score was significantly lower in CAD patients and the proportion of CAD and MI decreased with higher Japanese diet scores.
Article
Nutrition & Dietetics
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: The study found that higher levels of eicosapentaenoic acid and dihomo-gamma-linolenic acid are associated with a lower risk of coronary artery disease, while higher levels of linoleic acid are also linked to lower CAD risk. Arachidonic acid, on the other hand, showed significant causal estimates for a higher risk of CAD.
Article
Cell Biology
Chang Chen, Yequn Chen, Jiaxin Xiao, Yanhong Zhang, Zhaorui Yang, Peixuan Yang, Nan Lu, Kaihong Yi, Xiaojun Chen, Shaoxin Chen, Mary Clare O'Gara Msc, Michael O'Meara, Shu Ye, Xuerui Tan
Summary: There is an association between impaired fasting glucose level and a predisposition to severe coronary artery disease indicated by triple vessel disease or myocardial infarction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Audunn S. Snaebjarnarson, Anna Helgadottir, Gudny A. Arnadottir, Erna V. Ivarsdottir, Gudmar Thorleifsson, Egil Ferkingstad, Gudmundur Einarsson, Gardar Sveinbjornsson, Thorgeir E. Thorgeirsson, Magnus O. Ulfarsson, Bjarni V. Halldorsson, Isleifur Olafsson, Christian Erikstrup, Ole B. Pedersen, Mette Nyegaard, Mie T. Bruun, Henrik Ullum, Soren Brunak, Kasper Karmark Iversen, Alex Hoerby Christensen, Morten S. Olesen, Jonas Ghouse, Karina Banasik, Kirk U. Knowlton, David O. Arnar, Gudmundur Thorgeirsson, Lincoln Nadauld, Sisse Rye Ostrowski, Henning Bundgaard, Hilma Holm, Patrick Sulem, Kari Stefansson, Daniel F. Gudbjartsson
Summary: Sequence variants have both additive and non-additive effects on blood lipid levels, and interact with each other to affect lipid levels, variance, and correlations. These complex effects can translate into risk of coronary artery disease (CAD).
Review
Cardiac & Cardiovascular Systems
Samuel Heuts, Can Gollmann-Tepekoeylue, Ellen J. S. Denessen, Jules R. Olsthoorn, Jamie L. R. Romeo, Jos G. Maessen, Arnoud W. J. van't Hof, Otto Bekers, Ola Hammarsten, Leo Poelzl, Johannes Holfeld, Nikolaos Bonaros, Iwan C. C. van der Horst, Sean M. Davidson, Matthias Thielmann, Alma M. A. Mingels
Summary: The use of biomarkers in diagnosing myocardial infarction is well-established, but their value in identifying postoperative myocardial infarction after coronary artery bypass grafting is less understood. The release mechanisms of cardiac biomarkers, such as cTn, after CABG are not fully understood, making interpretation of postoperative increases in cTn concentrations complicated. Future studies are needed to determine the prognostic influence of biomarker release in general and postoperative myocardial infarction in particular.
EUROPEAN HEART JOURNAL
(2023)
Article
Multidisciplinary Sciences
Lin Sun, Lin Zhao, Kunqi Yang, Zuozhi Li, Yan Wang, Tianjie Wang, Man Wang, Yan Zeng, Xianliang Zhou, Weixian Yang
Summary: This study evaluates the potential predictive value of total bilirubin (TBIL) for one-year prognosis in patients with coronary artery disease (CAD) and psoriasis. The results show that lower TBIL levels are associated with the severity of coronary artery calcification, and patients with lower TBIL levels have a significantly higher incidence of major adverse cardiac and cerebrovascular events (MACCEs) in one-year follow-up.
Review
Medicine, General & Internal
Anna Kablak-Ziembicka, Rafal Badacz, Tadeusz Przewlocki
Summary: MicroRNAs (miRs) play important roles in the diagnosis, prognosis and treatment of atherosclerotic cardiovascular disease, a globally significant condition affecting a wide range of clinical cases. Studying the expression of miRs in CAD and ACS can provide clinicians with vital information.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ziyang Wang, Yueying Wang, Yuke Cui, Zhiyong Chen, Lei Yi, Zhengbin Zhu, Jingwei Ni, Run Du, Xiaoqun Wang, Jinzhou Zhu, Fenghua Ding, Weiwei Quan, Ruiyan Zhang, Jian Hu, Xiaoxiang Yan
Summary: This study suggests that higher BAFF levels in the acute phase are an independent predictor of the incidence of MACEs in patients with STEMI. The impact of high BAFF on MACEs development is stronger in patients without dyslipidemia. BAFF can also improve the predictive value of traditional risk factors and cardiac troponin I in predicting MACEs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Shuai Yuan, Susanna C. Larsson
Summary: This study conducted a bidirectional Mendelian randomization to explore the association between serum 25-hydroxyvitamin D and NAFLD. It found that increased vitamin D levels may play a role in preventing NAFLD in European populations.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Geriatrics & Gerontology
Snehal M. Pinto Pereira, Victoria Garfield, Thomas Norris, Stephen Burgess, Dylan M. Williams, Richard Dodds, Avan A. Sayer, Sian M. Robinson, Rachel Cooper
Summary: This study found a nonlinear relationship between circulating vitamin D concentration and grip strength, with higher vitamin D levels associated with stronger grip. Mendelian randomization analysis also showed a modest positive effect of higher vitamin D concentration on grip strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Jie Chen, Xixian Ruan, Yuhao Sun, Xue Li, Shuai Yuan, Susanna C. Larsson
Summary: This study used Mendelian randomization analysis and found potential causal associations between high levels of plasma phospholipid AA and the risk of NAFLD and cirrhosis, based on data from three different sources.
Article
Biology
Ashish Patel, Dipender Gill, Paul Newcombe, Stephen Burgess
Summary: This paper proposes a method for cis-MR inference that uses many correlated variants to make robust inferences even in situations with weak effects. This method can be used for drug target validation and provides genetic evidence for cholesterol-lowering drug targets aimed at preventing coronary heart disease.
Article
Endocrinology & Metabolism
Jie Chen, Shuai Yuan, Tian Fu, Xixian Ruan, Jie Qiao, Xiaoyan Wang, Xue Li, Dipender Gill, Stephen Burgess, Edward L. Giovannucci, Susanna C. Larsson
Summary: We conducted an MR study to examine the associations between type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs). It was found that genetic liability to type 2 diabetes was associated with an increased risk of 12 GDs.
Letter
Public, Environmental & Occupational Health
Yu Hao, Jinyu Xiao, Yu Liang, Xueyao Wu, Haoyu Zhang, Chenghan Xiao, Li Zhang, Stephen Burgess, Nan Wang, Xunying Zhao, Peter Kraft, Jiayuan Li, Xia Jiang
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Maddalena Ardissino, Eric A. W. Slob, Paul Carter, Tormod Rogne, Joanna Girling, Stephen Burgess, Fu Siong Ng
Summary: This study used Mendelian randomization to explore the causal relevance of reproductive factors on cardiovascular disease in women. The results showed that earlier genetically predicted age at first birth, higher genetically predicted number of live births, and earlier genetically predicted age at menarche were associated with increased risk of cardiovascular disease. These findings support the role of reproductive factors in the development of cardiovascular disease in women and identify potential modifiable mediators for clinical intervention.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Psychiatry
Xixian Ruan, Jie Chen, Yuhao Sun, Yao Zhang, Jianhui Zhao, Xiaoyan Wang, Xue Li, Shuai Yuan, Susanna C. C. Larsson
Summary: The study used Mendelian randomization analysis to explore the association between depression and 24 gastrointestinal diseases. It was found that genetic variations associated with depression were linked to several gastrointestinal diseases, including irritable bowel syndrome, non-alcoholic fatty liver disease, and ulcerative colitis.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Elias Bjornson, Martin Adiels, Marja-Riitta Taskinen, Stephen Burgess, Aidin Rawshani, Jan Boren, Chris J. Packard
Summary: In this study, the association between triglyceride-rich lipoproteins (TRL) and coronary heart disease (CHD) was investigated using population data from the UK Biobank. The results suggest that TRL/remnant cholesterol has a stronger and independent association with CHD compared to LDL cholesterol. Moreover, different genetic clusters impact TRL/remnants and LDL differentially, with TRL/remnants exhibiting a higher atherogenicity per particle than LDL.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Maddalena Ardissino, Alec P. Morley, Eric A. W. Slob, Art Schuermans, Bilal Rayes, Zahra Raisi-Estabragh, Antonio de Marvao, Stephen Burgess, Tormod Rogne, Michael C. Honigberg, Fu Siong Ng
Summary: This study found that natural birth weight, independent of the intrauterine environment, is associated with cardiovascular disease and adverse cardiac structure and function.
EUROPEAN HEART JOURNAL
(2023)
Article
Multidisciplinary Sciences
Yordi van de Vegte, Ruben P. Eppinga, M. Yldau van der Ende, Yanick Hagemeijer, Yuvaraj V. Mahendran, Elias Y. Salfati, Albert E. Smith, Vanessa Tan, Dan V. Arking, Ioanna Ntalla, Emil A. Appel, Claudia Schurmann, Jennifer Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina U. Mononen, Kirsi F. Auro, Anne Jackson, Lawrence Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Mueller-Nurasyid, Carolina E. Roselli, Weihua Zhang, Marcus J. Kleber, Xiuqing Guo, Henry E. Lin, Francesca Pavani, Tessel Galesloot, Raymond E. Noordam, Yuri Milaneschi, Katharina Schraut, Marcel den Hoed, Frauke E. Degenhardt, Stella Trompet, Marten van den Berg, Giorgio Pistis, Yih-Chung S. Tham, Stefan L. Weiss, Xueling J. Sim, Hengtong M. Li, Peter van der Most, Ilja Nolte, Leo-Pekka R. Lyytikaeinen, M. Abdullah Said, Daniel Witte, Carlos M. Iribarren, Lenore S. Launer, Susan Ring, Paul de Vries, Peter P. Sever, Allan Linneberg, Erwin M. Bottinger, Sandosh Padmanabhan, Bruce Psaty, Nona Sotoodehnia, Ivana Kolcic, Delnaz D. Roshandel, Andrew O. Paterson, David F. Arnar, Daniel Gudbjartsson, Hilma Holm, Beverley T. Balkau, Claudia H. Silva, Christopher Newton-Cheh, Kjell Nikus, Perttu L. Salo, Karen A. Mohlke, Patricia Peyser, Heribert Schunkert, Mattias Lorentzon, Jari C. Lahti, Dabeeru C. Rao, Marilyn D. Cornelis, Jessica A. Faul, Jennifer Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie F. Waldenberger, Moritz Sinner, Konstantin E. Strauch, Graciela D. Delgado, Kent Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renee de Mutsert, Eco J. C. de Geus, Asa K. Johansson, Peter K. Joshi, Lars Lind, Andre W. Franke, Peter V. Macfarlane, Kirill Tarasov, Nicholas B. Tan, Stephan Felix, E-Shyong Q. Tai, Debra Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia P. Lindgren, Andrew T. Morris, Olli Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur J. Gudnason, Nicholas C. Timpson, Alanna B. Morrison, Patricia P. Munroe, David Strachan, Niels Grarup, Ruth J. F. R. Loos, Susan Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif J. Groop, Nicholas M. Wareham, Cornelia F. van Duijn, Mary J. Feitosa, Christopher O'Donnell, Mika Kaehoenen, Markus Perola, Michael Boehnke, Sharon L. R. Kardia, Jeanette Erdmann, Colin N. A. Palmer, Claes J. Ohlsson, David G. Porteous, Johan Eriksson, Claude Bouchard, Susanne Moebus, Peter R. Kraft, David Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kaeaeb, Annette C. Peters, John S. Chambers, Jaspal Kooner, Winfried I. Maerz, Jerome A. Rotter, Andrew Hicks, J. Gustav Smith, Lambertus A. L. M. O. Kiemeney, Dennis Mook-Kanamori, Brenda W. J. H. Penninx, Ulf F. Gyllensten, James Wilson, Stephen Burgess, Johan Sundstroem, Wolfgang Lieb, J. Wouter Jukema, Mark Eijgelsheim, Edward L. M. Lakatta, Ching-Yu Cheng, Marcus Doerr, Tien-Yin Wong, Charumathi J. Sabanayagam, Albertine Oldehinkel, Harriette Riese, Terho Lehtimaeki, Niek Verweij, Pim van der Harst
Summary: This study identifies new genetic variants associated with resting heart rate (RHR) and demonstrates that higher genetically predicted RHR is associated with a decreased risk of atrial fibrillation and ischemic stroke. Genome-wide analysis reveals multiple genetic variants in cardiomyocyte-related genes and provides insights into their electrocardiogram (ECG) signature. Mendelian randomization analyses indicate that higher genetically predicted RHR increases the risk of dilated cardiomyopathy, but reduces the risk of atrial fibrillation, ischemic stroke, and cardio-embolic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Qi Feng, Andrew J. Grant, Qian Yang, Stephen Burgess, Jelena Besevic, Megan Conroy, Wemimo Omiyale, Yangbo Sun, Naomi Allen, Ben Lacey, Peter Pribis
Summary: This study used Mendelian randomization to investigate the associations between cooked and raw vegetable intake with cardiovascular diseases. The study found null evidence for significant associations between genetically predicted vegetable intake and coronary heart disease, heart failure, atrial fibrillation, and cardiometabolic risk factors in a meta-analysis of 1.2 million participants.
Article
Nutrition & Dietetics
Alice Giontella, Roxane de la Harpe, Helene T. Cronje, Loukas Zagkos, Benjamin Woolf, Susanna C. Larsson, Dipender Gill
Summary: Genetically predicted plasma caffeine levels are associated with a decrease in kidney function, while genetically predicted caffeine intake is associated with an improvement in kidney function.
Article
Genetics & Heredity
Haodong Tian, Amy M. Mason, Cunhao Liu, Stephen Burgess
Summary: Non-linear Mendelian randomization is an extension of standard Mendelian randomization that explores the causal relationship between an exposure and outcome using an instrumental variable. The current stratification method, referred to as the residual method, relies on strong parametric assumptions and can yield misleading results. We propose a new stratification method, called the doubly-ranked method, that relaxes these assumptions and provides unbiased estimates even in non-linear or heterogeneous scenarios.
Review
Cardiac & Cardiovascular Systems
Susanna C. Larsson, Adam S. Butterworth, Stephen Burgess
Summary: Mendelian randomization utilizes genetic variation as a natural experiment to improve causal inferences from observational data. It can determine whether a putative risk factor likely has a causal effect on the disease.
EUROPEAN HEART JOURNAL
(2023)
