期刊
ISRAEL JOURNAL OF CHEMISTRY
卷 57, 期 10-11, 页码 964-967出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ijch.201700044
关键词
C-H activation; Chelation assistance; Nickel; Benzylation; Benzyltrimethylammonium halide
资金
- JST Strategic Basic Research Programs Advanced Catalytic Transformation Program for Carbon Utilization (ACT-C) from the Japan Science and Technology Agency [JPMJCR12YS]
Nickel-catalyzed benzylation reactions of C-H bonds in aromatic amides with benzyltrimethylammonium halides are developed by using a 5-chloro-8-aminoquinoline derivative as a bidentate directing group. Benzylation occurs selectively at the ortho-C-H bonds in aromatic amides, and no methylation was detected. The presence of a 5-chloro-8aminoquinoline moiety is essential for the success of this reaction, in which a variety of functional groups can be tolerated.
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