Article
Multidisciplinary Sciences
Irena Patsan, Amanda Tapley, Peter Davoren, Alison Fielding, Elizabeth Holliday, Jean Ball, Andrew Davey, Mieke van Driel, Rachel Turner, Katie Mulquiney, Neil Spike, Kristen FitzGerald, Parker Magin
Summary: This study aimed to describe the temporal trends and associations of Australian general practitioner registrars' prescription and initiation of "new" second-line oral agents compared to sulphonylureas. The results showed a significant increase in the prescription and initiation of "new" medications compared to sulphonylureas over time, with less prescribing for non-English-speaking patients and regional variation.
Article
Cardiac & Cardiovascular Systems
Benedicte Heegaard, Tania Deis, Kasper Rossing, Mads Ersboll, Caroline Kistorp, Finn Gustafsson
Summary: This study aims to investigate the impact of diabetes on hemodynamics in heart failure patients. It found that heart failure patients with diabetes have higher filling pressures, including pulmonary capillary wedge pressure, central venous pressure, cardiac index, and mean arterial pressure. Additionally, poor glycemic control in diabetic patients is associated with higher filling pressures. Therefore, diabetic cardiomyopathy may contribute to the increased mortality in heart failure patients with diabetes, but other unknown mechanisms beyond hemodynamic factors are also likely involved.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Muhammad Shahzeb Khan, Nikolaus Marx, Carolyn S. P. Lam, Sven Schnaidt, Anne Pernille Ofstad, Martina Brueckmann, Waheed Jamal, Edimar A. Bocchi, Piotr Ponikowski, Sergio Perrone, James L. Januzzi, Subodh Verma, Michael Boehm, Joao Pedro Ferreira, Stuart J. Pocock, Faiez Zannad, Milton Packer
Summary: In patients with chronic heart failure with reduced ejection fraction, empagliflozin significantly improved cardiovascular and renal outcomes, regardless of baseline diabetes status, and across the continuum of HbA1c.
Article
Medicine, General & Internal
Bertram Pitt, Gerasimos Filippatos, Rajiv Agarwal, Stefan D. Anker, George L. Bakris, Peter Rossing, Amer Joseph, Peter Kolkhof, Christina Nowack, Patrick Schloemer, Luis M. Ruilope
Summary: Finerenone therapy improved cardiovascular outcomes in patients with type 2 diabetes and stage 2 to 4 CKD with moderately elevated albuminuria or stage 1 or 2 CKD with severely elevated albuminuria, compared to placebo. The risk of the primary outcome event was significantly lower in the finerenone group, primarily driven by a reduction in hospitalization for heart failure.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Gerasimos Filippatos, Javed Butler, Dimitrios Farmakis, Faiez Zannad, Anne Pernille Ofstad, Joao Pedro Ferreira, Jennifer B. Green, Julio Rosenstock, Sven Schnaidt, Martina Brueckmann, Stuart J. Pocock, Milton Packer, Stefan D. Anker
Summary: In patients with heart failure and preserved ejection fraction, empagliflozin significantly reduces the risk of heart failure outcomes, regardless of diabetes status at baseline.
Article
Medicine, Research & Experimental
Fu-Shun Yen, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu, Chii-Min Hwu
Summary: This study compared cardiovascular risks among participants with T2DM and HTN, and found that both T2DM with subsequent HTN and HTN with subsequent diabetes were associated with higher risks of cardiovascular disease.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon
Summary: Diabetes mellitus is a significant risk factor for heart failure, with worse prognosis in diabetic patients. Early diagnosis and proper management of heart failure in diabetic patients are crucial. This review discusses the diagnosis criteria, screening tools, recommended pharmacological therapies, and effects of anti-diabetic medications on heart failure.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Endocrinology & Metabolism
Min Ye, Manting Choy, Xiao Liu, Peisen Huang, Yuzhong Wu, Yugang Dong, Wengen Zhu, Chen Liu
Summary: This study found that although obesity confers survival benefits in HFpEF patients, this effect disappears in patients with diabetes receiving insulin treatment. Insulin treatment may be a crucial confounder of the obesity paradox in HFpEF patients.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Cardiac & Cardiovascular Systems
Suzanne Arnold, Kamlesh Khunti, Fabrice Bonnet, Bernard Charbonnel, Hungta Chen, Javier Cid-Ruzafa, Andrew Cooper, Peter Fenici, Marilia B. Gomes, Niklas Hammar, Linong Ji, Gabriela Luporini-Saraiva, Jesus Medina, Antonio Nicolucci, Larisa Ramirez, Marina Shestakova, Iichiro Shimomura, Filip Surmont, Fengming Tang, Jiten Vora, Hirotaka Watada, Mikhail Kosiborod
Summary: In a global cohort of 14,057 patients with type 2 diabetes, 2.1% were diagnosed with heart failure at enrollment. The majority of incident cases of heart failure occurred in outpatients and in the absence of known coronary artery disease, highlighting the need for greater awareness of heart failure risk in patients with type 2 diabetes.
Article
Medicine, General & Internal
Evan M. Murray, David J. Whellan, Haiying Chen, Alain G. Bertoni, Pamela Duncan, Amy M. Pastva, Dalane W. Kitzman, Robert J. Mentz
Summary: Diabetes status had minimal impact on the response to rehabilitation intervention in heart failure patients, with diabetic patients showing slightly less improvement in physical function compared to non-diabetic patients.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Se Yong Jang, Jieun Jang, Dong Heon Yang, Hyun-Jai Cho, Soo Lim, Eun-Seok Jeon, Sang Eun Lee, Jae-Joong Kim, Seok-Min Kang, Sang Hong Baek, Myeong-Chan Cho, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Sue K. Park, Hae-Young Lee
Summary: Patients with diabetes mellitus and heart failure have a higher risk of mortality. Insulin therapy was found to be associated with increased mortality in acute heart failure patients, especially in those with low levels of glycated hemoglobin.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Nutrition & Dietetics
Christina Chrysohoou, Christos Fragoulis, Ioannis Leontsinis, Ioannis Gastouniotis, Dimitra Fragouli, Maximos Georgopoulos, Emmanouil Mantzouranis, Marina Noutsou, Konstantinos P. Tsioufis
Summary: The mechanisms leading to the development of heart failure in diabetes mellitus patients are multifactorial. Assessing the risk of heart failure development in diabetic patients is valuable for identifying high-risk subgroups and defining low-risk subpopulations. Both imaging parameters and biomarkers are important tools for recognizing diabetic patients at risk of heart failure manifestation and arrhythmogenic risk, and for improving patients' outcomes utilizing drugs and non-pharmaceutical cardioprotective tools such as diet modification.
Review
Biology
Panagiotis Theofilis, Evangelos Oikonomou, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: Diabetes mellitus (DM) and heart failure (HF) have a common pathophysiologic background. HF can be caused by various pathways, including inflammation, oxidative stress, endothelial dysfunction, fibrosis, autonomic neuropathy, and alterations in substrate utilization. DM may aggravate myocardial inflammation, fibrosis, autonomic dysfunction, and lipotoxicity. The interaction between DM and HF is critical, and the new treatment approach, SGLT2 inhibitors (SGLT2i), may have beneficial effects in reversing the pathophysiology of these conditions and improving HF outcomes.
Article
Cardiac & Cardiovascular Systems
Stefano Ghio, Valentina Mercurio, Andrea Attanasio, Gaetano Asile, Carlo Gabriele Tocchetti, Stefania Paolillo
Summary: There is a strong bidirectional relationship between diabetes mellitus (DM) and heart failure (HF), with DM activating multiple molecular and pathophysiological mechanisms that can damage the heart in the long term. However, the prognostic role of DM in chronic and acute HF is still unclear, with gaps in evidence due to the heterogeneity of patient phenotypes and the necessity to better characterize individual patients and their comorbidities. This review aims to summarize the negative impact of DM on HF and analyze available data on the prognostic implications in both chronic and acute HF.
HEART FAILURE REVIEWS
(2023)
Article
Multidisciplinary Sciences
Eiichiro Kanda, Atsushi Suzuki, Masaki Makino, Hiroo Tsubota, Satomi Kanemata, Koichi Shirakawa, Toshitaka Yajima
Summary: A novel machine learning model was developed to predict the risk of developing CKD/HF in early-stage T2DM patients, showing good predictive performance in external validation. Early diagnosis and intervention based on ML models may improve the prognosis of high-risk patients.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Amgad Mentias, Eric D. Peterson, Neil Keshvani, Dharam J. Kumbhani, Clyde W. Yancy, Alanna A. Morris, Larry A. Allen, Saket Girotra, Gregg C. Fonarow, Randall C. Starling, Paulino Alvarez, Milind Y. Desai, Peter Cram, Ambarish Pandey
Summary: This study found that using race-specific risk adjustment models can more accurately represent hospital performance for patients of Black and other races in terms of heart failure hospitalization and 30-day risk-standardized readmission rate and risk-standardized mortality rate.
Editorial Material
Cardiac & Cardiovascular Systems
Javed Butler, Khawaja M. Talha, Gregg C. Fonarow
Editorial Material
Cardiac & Cardiovascular Systems
Brian R. Lindman, Gregg C. Fonarow, Gary Myers, Heather M. Alger, Christine Rutan, Katie Troll, Angeline Aringo, Melanie Shahriary, Mariell Jessup, Suzanne V. Arnold, Pinak B. Shah, Wilson Y. Szeto, Clyde W. Yancy, Catherine M. Otto
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gregg C. Fonarow, Harriette G. C. Van Spall, James L. Januzzi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Hubert B. Haywood, Gregg C. Fonarow, Muhammad Shahzeb Khan, Michael E. Nassif, Javed Butler, Stephen J. Greene
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Muhammad Shahzeb Khan, Sumitabh Singh, Matthew W. Segar, Muhammad Shariq Usman, Neil Keshvani, Andrew P. Ambrosy, Mona Fiuzat, Harriette G. C. Van Spall, Gregg C. Fonarow, Faiez Zannad, G. Michael Felker, James L. Januzzi, Christopher O'Connor, Javed Butler, Ambarish Pandey
Summary: This study aimed to evaluate the impact of polypharmacy on the receipt of optimal guideline-directed medical therapy (GDMT) among patients with heart failure with reduced ejection fraction (HFrEF) over time.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Neil Keshvani, Vinayak Subramanian, Christopher A. Wrobel, Nicole Solomon, Brooke Alhanti, Stephen J. Greene, Adam D. DeVore, Clyde W. Yancy, Larry A. Allen, Gregg C. Fonarow, Ambarish Pandey
Summary: This study aimed to investigate the referral and participation rates in cardiac rehabilitation (CR) among patients with heart failure with reduced ejection fraction and evaluate the impact on survival and readmission. The results showed that referral rates have increased from 2010 to 2020, but only one in four patients were referred to CR. The participation rate in CR was low. Patients referred to CR had a lower risk of 1-year death compared to those not referred.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Hubert B. Haywood, Gregg C. Fonarow, Muhammad Shahzeb Khan, Harriette G. C. Van Spall, Alanna A. Morris, Michael E. Nassif, Michelle M. Kittleson, Javed Butler, Stephen J. Greene
Summary: Hospital at home is an innovative care model that is particularly suitable for heart failure patients. It provides a patient-centered and effective alternative to traditional outpatient and inpatient care. Current research supports its safety and cost-effectiveness, and new payment structures are being introduced to support its development.
CIRCULATION-HEART FAILURE
(2023)
Article
Endocrinology & Metabolism
Alessandra Dei Cas, Raffaella Aldigeri, Valentina Ridolfi, Angela Vazzana, Anna Vittoria Ciardullo, Valeria Manicardi, Alessandra Sforza, Franco Tomasi, Donatella Zavaroni, Ivana Zavaroni, Riccardo C. Bonadonna
Summary: This study assessed the efficacy of a structured educational intervention for health professionals in improving the appropriateness of inpatient diabetes care and clinical outcomes. The results showed that the intervention did not improve the appropriateness of diabetes care or clinical outcomes. In-hospital hypoglycemia was found to be an independent indicator of death risk.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Stephen J. Greene, Gregg C. Fonarow
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Nicholas K. Brownell, Gregg C. Fonarow
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gregg C. Fonarow, Reza Mohebi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mohamed B. Jalloh, Tauben Averbuch, Prashanth Kulkarni, Christopher B. Granger, James L. Januzzi, Faiez Zannad, Robert W. Yeh, Clyde W. Yancy, Gregg C. Fonarow, Khadijah Breathett, Michael Gibson, Harriette G. C. Van Spall
Summary: Heart failure is a leading cause of death and disability in older adults, but the implementation of guideline-directed medical therapies to reduce the burden of the disease has been suboptimal. This review discusses interventions that increase the uptake of these therapies, barriers and facilitators of implementation, conceptual frameworks in implementation science, and trial design suggestions. An evidence-to-care conceptual model is proposed to generate evidence and promote long-term implementation. By applying principles of implementation science, policymakers, researchers, and clinicians can help alleviate the burden of heart failure worldwide.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Harsh Patolia, Muhammad Shahzeb Khan, Gregg C. Fonarow, Javed Butler, Stephen J. Greene
Summary: Despite the availability of effective medical therapy for heart failure with reduced ejection fraction, there are major gaps in its utilization. This review discusses various strategies for improving the use of these therapies and emphasizes the urgent need for better provision of appropriate treatment.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Revanth S. Kosaraju, Gregg C. Fonarow, Michael K. Ong, Paul A. Heidenreich, Donna L. Washington, Xiaoyan Wang, Boback Ziaeian
Summary: The burden of heart failure is increasing, and there is geographic variation in the quality of care for heart failure with reduced ejection fraction. This study evaluates the prescription of guideline-directed medical therapies (GDMT) within the Veterans Health Administration and finds significant variation across regions. Targeted strategies are needed to improve GDMT prescription in lower-performing regions, especially those affected by income inequality and poverty.
JACC-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Gary Tse, Quinncy Lee, Oscar Hou In Chou, Cheuk To Chung, Sharen Lee, Jeffrey Shi Kai Chan, Guoliang Li, Narinder Kaur, Leonardo Roever, Haipeng Liu, Tong Liu, Jiandong Zhou
Summary: Routinely collected electronic health records (EHRs) data provide valuable information for epidemiological studies, and the use of big data and artificial intelligence (AI) has rapidly increased in Hong Kong since 2015. The advantages of big data include generalizability, simultaneous determination of multiple outcomes, ease of cross-validation, analysis of numerous variables, analysis of static and dynamic variables, capturing non-linear and latent interactions, and enhancing prediction models with AI approaches.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Sneha Annie Sebastian, Edzel Lorraine Co, Atiyah Tidd-Johnson, Selia Chowdhury, Esha Jain, Michael Davidson, Gurpreet Johal
Summary: Carotid ultrasound screening plays a contributory role in cardiovascular risk stratification and prevention of CVD, aiding in early detection of subclinical atherosclerosis.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Anas Alsughayer, Abdulmajeed Alharbi, Momin Shah, Michelle Cherian, Rohit Vyas, Ragheb Assaly
Summary: This study investigates the relationship between myocardial bridging (MB) and hypertrophic cardiomyopathy (HCM) and their impact on percutaneous coronary intervention (PCI) outcomes. The findings indicate that HCM patients have a higher risk of post-PCI complications, including atrial fibrillation and acute kidney injury, while MB is associated with increased occurrences of acute heart failure and post-PCI bleeding.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Junsu Lee, Hyunmin Lee, Adham El Sherbini, Leili Baghaie, Fleur Leroy, Husam Abdel-Qadir, Myron R. Szewczuk, Mohammad El-Diasty
Summary: Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery and can increase the risk for adverse outcomes. Current literature suggests that miRNAs may play a role in predicting the development of atrial fibrillation after cardiac surgery, but more robust clinical data are needed to justify their use in routine clinical practice.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Umael Khan, Usman Afzal, Lauri Kask, Nasir Saeed, Ronak Rajani, Eivind Solheim, Sahrai Saeed
Summary: This case study demonstrates the ECG changes in a patient with severe hypokalemia caused by diarrhea. It highlights the distinguishing features of bifid T-waves in hypokalemia compared to other conditions, such as coronary artery disease or pericarditis. Furthermore, it shows the gradual reversal of ECG changes when potassium levels are normalized.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Jessica Hernandez-Duran, Laura Valentina Lopez-Gutierrez, Maria Isabel Palacio-Mejia, Luisa Aguilera, Lucrecia Burgos, Clara Ines Saldarriaga Giraldo
Summary: This article examines the current situation of heart failure in Latin American women and identifies the need for future research.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Salman Salehin, Wissam Harmouch, Maha Yaqub, Umer Khan, Anwar Merie, Shahran Salehin, Syed Mustajab Hasan, Wissam Khalife, Muhie Dean Sabayon, Khaled Chatila, Muhammad Raja
Summary: Heart failure is a significant global health issue with high mortality rates. While guideline-directed medical therapy and device-based therapies have improved outcomes, not all advanced heart failure patients benefit from these treatments. Cardiac contractility modulation is an innovative therapy that aims to improve functional outcomes and quality of life for these patients.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Letter
Cardiac & Cardiovascular Systems
Muhammad Hamza Shafiq, Maham Jabeen, Izza Shakeel, Erum Zaidi
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Guang-Gui Zeng, Qiong Lei, Wan-Li Jiang, Xing-Xing Zhang, Liluo Nie, Xianghao Gong, Kang Zheng
Summary: This research paper uses bibliometric analysis to examine the historical evolution, current areas of interest, and future development trends of ABCG1. It reveals that research on ABCG1 has remained active over the past two decades and has started to expand into other fields such as cancer research. This study provides insights into the research status and emerging trends of ABCG1, and offers potential areas of focus for future studies.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Guillermo Cueto-Robledo, Leslie-Marisol Gonzalez-Hermosillo, Mateo Porres-Aguilar, Dulce-Iliana Navarro-Vergara, Marisol Garcia-Cesar, Maria-Berenice Torres-Rojas, Alma Daniela Martinez-Carrillo, Hector R. Cajigas
Summary: This study evaluated the indications for performing RHC and the occurrence of adverse events related to the procedure in patients aged >= 70 years in a Mexican Tertiary Care Center. The findings suggest that RHC can be safely performed in patients aged >= 70 years without significant major complications.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Hritvik Jain, Mohammed Dheyaa Marsool Marsool, Aman Goyal, Samia Aziz Sulaiman, Laveeza Fatima, Muhammad Idrees, Bhavya Sharma, Vamsikalyan Borra, Prakash Gupta, Abdullah Nadeem, Jyoti Jain, Hassam Ali, Amir H. Sohail
Summary: Dysbiosis of the gut microbiota may play a role in the development of heart failure, and exploring this role could lead to the discovery of new biomarkers, preventive measures, and therapeutic targets.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Letter
Cardiac & Cardiovascular Systems
Siraj Memon, Kashifa Qureshi
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Lanlan Zhang, Yanmin Zhang, Jing Wang, Shengjun Ta, Jia Zhao, Lu Yao, Chao Han, Jiao Liu, Xueli Zhao, Jiarui Yuan, Ruoxuan Li, Bo Shan, Yue Wang, Yuze Qin, Bo Wang, Liwen Liu
Summary: This study analyzed the clinical characteristics of 1023 unrelated hypertrophic cardiomyopathy (HCM) patients carrying the MYH7-R143Q variant. It was found that patients carrying this variant were often diagnosed between the ages of 31-40, with moderate hypertrophy and fibrosis concentrated in the anterior and inferior septum, indicating a moderate risk of sudden cardiac death (SCD). Moreover, this variant exhibited different genetic characteristics, including incomplete penetrance of autosomal dominant inheritance and polygenic cumulative effect.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Akanimo Antia, Chinonso Ndukauba, Ruth Pius, Oghenetejiri Gbegbaje, Kenneth Ong
Summary: Weekend admissions for cardiogenic shock (CS) are associated with worse outcomes, including higher mortality and cardiac arrest rates. This situation has persisted for years and may be related to physician dissatisfaction, understaffing, or burnout.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Ruben Lopez-Bueno, Lin Yang, Joaquin Calatayud, Lars Louis Andersen, Borja del Pozo Cruz
Summary: This study examined the dose-response association between cardiovascular health (CVH) and all-cause, cardiovascular disease (CVD), and cancer mortality among cancer survivors. The findings showed that higher CVH levels were associated with a lower risk of all-cause mortality and a curvilinear relationship with CVD deaths. However, no significant association was found between CVH and cancer deaths.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)