Article
Multidisciplinary Sciences
Filippo Migliorini, Hanno Schenker, Nicola Maffulli, Joerg Eschweiler, Philipp Lichte, Frank Hildebrand, Christian David Weber
Summary: This study evaluated the outcomes of Autologous Matrix Induced Chondrogenesis (AMIC) as a revision procedure for failed AMIC surgery in treating talus osteochondral defects. The results showed that AMIC could be a viable option for revision surgery in recurrent symptomatic osteochondral defects of the talus. Patients were moderately satisfied with the procedure, and there was a significant improvement in the postoperative Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score. A deeper understanding of prognostic factors and patient selection is crucial to prevent surgery failures.
SCIENTIFIC REPORTS
(2022)
Article
Anatomy & Morphology
Piero Antonio Zecca, Marcella Reguzzoni, Marina Protasoni, Mario Raspanti
Summary: In the synovial joints, the transition between the soft articular cartilage and the subchondral bone is mediated by a calcified cartilage layer with similar characteristics to bone. This layer is not directly accessible and is visualized through histological sections of decalcified tissue. This study used conventional histology and scanning electron microscopy to discriminate between the calcified and uncalcified cartilage, revealing a high heterogeneity of the calcified layer and a different mineralization process compared to other hard tissues. Selective removal of the soft matrix allowed for a 3D view of the mineralization front.
Article
Nanoscience & Nanotechnology
Yan Lu, Yuxiang Wang, Hanjie Zhang, Zizhao Tang, Xiaolin Cui, Xing Li, Jie Liang, Qiguang Wang, Yujiang Fan, Xingdong Zhang
Summary: The study demonstrated that functionalizing collagen scaffolds with porcine decellularized extracellular matrix can promote neocartilage regeneration. Results showed that the solution form of ECM performed better in cell recruitment, proliferation, and chondrogenesis, quickly providing a favorable chondrogenic microenvironment for endogenous BMSCs.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Sprlakova-Pukova, Alena Stouracova, Martin Repko, Eva Koritakova, Jaroslav Tintera, Marek Dostal, Tomas Otasevic
Summary: The study found that there were no significant differences in the treatment effects of microfractures and scaffold implantation on cartilage defects at 6, 12, and 18 months. More substantial decrease in GAGs concentration was observed at month 6 with microfracture treatment, while the greatest decline was seen at month 12 with implantation. The decline in GAGs content and cartilage quality was also significant in the reference area and close surroundings.
ACADEMIC RADIOLOGY
(2021)
Review
Orthopedics
Hayden B. Schuette, Matthew J. Kraeutler, John B. Schrock, Eric C. McCarty
Summary: A systematic review comparing primary versus secondary autologous chondrocyte implantation (ACI) in knee joints found that patients undergoing secondary ACI have a significantly higher risk of treatment failure and may experience worse subjective outcomes compared to those undergoing primary ACI.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Engineering, Biomedical
Sunho Park, Ju Yong Na, Yonghyun Gwon, Woochan Kim, Ju Yeon Kang, Jong Keun Seon, Jangho Kim
Summary: This study proposes a transplantable stem cell nanobridge scaffold, which can reconstruct the defected cartilage with a structure and adhesive properties similar to native cartilage tissue through the synergistic effects of stem cells and nanotopography. This research represents a significant advancement in traditional cartilage treatment techniques.
Article
Engineering, Biomedical
Pawel Bakowski, Kamilla Grzywacz, Agnieszka Prusinska, Kinga Ciemniewska-Gorzela, Justus Gille, Tomasz Piontek
Summary: The study reports the medium-term follow-up results of patients treated with AMIC for focal chondral lesions, showing significant improvement in functional and subjective outcome measures within the first 2 years after intervention.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Biology
Filippo Migliorini, Jorg Eschweiler, Nicola Maffulli, Hanno Schenker, Alice Baroncini, Markus Tingart, Bjoern Rath
Summary: Several studies have compared the outcomes of AMIC and MFx for repairing focal unipolar chondral defects of the knee, with AMIC demonstrating superior results at midterm follow-up in terms of greater IKDC, Lysholm, and VAS scores, as well as higher level of sport activity and lower rates of failure and revision surgeries.
Article
Orthopedics
Martyn Snow, Lee Middleton, Samir Mehta, Andrew Roberts, Richard Grey, James Richardson, Jan Herman Kuiper, ACTIVE Consortium
Summary: This study compared the long-term outcomes of autologous chondrocyte implantation (ACI) versus alternative forms of surgical cartilage management in patients with failed previous treatment. The results showed that there was no significant difference in Lysholm scores between ACI and alternative management after 5 years, indicating that both methods were equally effective. However, ACI had more adverse events compared to the alternatives.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Review
Orthopedics
Matthias R. Steinwachs, Justus Gille, Martin Volz, Sven Anders, Roland Jakob, Laura De Girolamo, Piero Volpi, Alfredo Schiavone-Panni, Sven Scheffler, Eric Reiss, Udo Wittmann
Summary: The systematic review and meta-analysis of Autologous Matrix-Induced Chondrogenesis (AMIC(R)) outcomes for grade III/IV chondral and osteochondral lesions of the knee treated with Chondro-Gide(R) demonstrated a significant improvement in clinical status and functional scoring in patients. The evidence supports the recommendation of AMIC procedure for knee chondral and osteochondral defects in a real-life treatment setting.
Article
Multidisciplinary Sciences
Filippo Migliorini, Nicola Maffulli, Alice Baroncini, Andreas Bell, Frank Hildebrand, Hanno Schenker
Summary: This study investigated the efficacy and safety of Autologous Matrix-Induced Chondrogenesis (AMIC) for focal chondral defects of the knee. The results showed that AMIC is effective in improving symptoms and outperforms microfracture (MFx) in terms of efficacy and revision rate.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
Dean Wang, Danyal H. Nawabi, Aaron J. Krych, Kristofer J. Jones, Joseph Nguyen, Ameer M. Elbuluk, Nadja A. Farshad-Amacker, Hollis G. Potter, Riley J. Williams
Summary: In this nonrandomized, retrospective comparison study, activity level and MRI appearance following treatment of cartilage lesions with the biphasic synthetic scaffold were superior to microfracture over time.
Article
Materials Science, Biomaterials
Jun Liu, Yan Lu, Fei Xing, Jie Liang, Qiguang Wang, Yujiang Fan, Xingdong Zhang
Summary: Microfracture surgery is popular for articular cartilage lesions but can lead to inferior tissue formation, prompting the introduction of ECM scaffolds. While effective, variability in natural tissue quality remains a challenge. This study developed composite scaffolds with cell-derived ECM, showing potential for clinical translation.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Engineering, Biomedical
David C. Browe, Ross Burdis, Pedro J. Diaz-Payno, Fiona E. Freeman, Jessica M. Nulty, Conor T. Buckley, Pieter A. J. Brama, Daniel J. Kelly
Summary: This study demonstrates that ECM derived biomaterials can successfully treat articular cartilage defects in a clinically relevant large animal model. In vivo, these scaffolds promote superior articular cartilage regeneration. Loading transforming growth factor (TGF)-β3 into the scaffolds can further improve the quality of repair.
MATERIALS TODAY BIO
(2022)
Article
Orthopedics
Qing-xin Han, Yi Tong, Lei Zhang, Jin Sun, Jia Ma, Xiaohua Liu, Sheng Zhang, Bo Jiang, Yan Li
Summary: This study systematically analyzed the postoperative outcomes of osteochondral autologous transplantation (OAT) and microfracture (MF) procedures. The results showed that patients in the OAT group had quicker return to sports, even returning to pre-injury level of activity, compared to the MF group. OAT was found to be better than MF procedure according to Lysholm score, Tegner score, ICRS score, and the rate of failure.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)