Article
Infectious Diseases
Nuhamin Melaku Gebremariam, Adane Bitew, Estifanos Tsige, Daniel Woldesenbet, Mekdes Alemu Tola
Summary: The study revealed high levels of antimicrobial resistance and multi-drug resistance in Gram-positive cocci, highlighting the importance of ongoing monitoring of resistance patterns for selecting appropriate drugs for treatment and infection prevention.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Mar de Pablo-Miro, Sergi Pujol-Ruiz, Simona Iftimie, Maria del Mar Arenas-Miras, Inmaculada Lopez-Montesinos, Xavier Duran-Jorda, Albert Angles, Santiago Grau, Juan P. Horcajada
Summary: Dalbavancin, a new antibiotic effective against Gram-positive microorganisms, offers the possibility of weekly IV therapy in outpatient setting. A case-control study showed that Dalbavancin treatment reduced hospital stay and improved 30-day efficacy compared to other antibiotics.
Article
Infectious Diseases
Yongli Wei, He Zhang, Maowu Fu, Rui Ma, Ronghui Li, Lingti Kong
Summary: This study aimed to analyze the pharmacokinetics/pharmacodynamics (PK/PD) of linezolid in patients with intracerebral hemorrhage and provide recommendations for dosing and treatment regimens. The study found that linezolid had high target attainment probability (PTA) in plasma and sputum when the minimum inhibitory concentration (MIC) was <= 1 mg/L. Linezolid showed the highest cumulative fraction of response (CFR) against Streptococcus pneumoniae, followed by Enterococcus faecalis and Enterococcus faecium, with the lowest value for MRSA. This study provides valuable insights for selecting appropriate dosing regimens for linezolid in patients with intracerebral hemorrhage.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Chemistry, Applied
Le Wang, Xiaohong Pan, Shuzhi Tang, Yaqi Wang, Haixing Shi, Huanhuan Wang, Wenzhen Liu, Zhuo Chen
Summary: The skin microbiota is an important component of the skin barrier and plays a role in the stability of the barrier function and the development of skin diseases. Researchers have developed a negatively charged photosensitizer TPA-3NBA that can selectively stain and effectively kill Gram-positive cocci, allowing for quick identification of bacterial infections.
Article
Immunology
Richard G. Wunderink, Antoine Roquilly, Martin Croce, Daniel Rodriguez Gonzalez, Satoshi Fujimi, Joan R. Butterton, Natasha Broyde, Myra W. Popejoy, Jason Y. Kim, Carisa De Anda
Summary: Tedizolid demonstrated noninferiority to linezolid in terms of day 28 all-cause mortality in the treatment of gram-positive ventilated HABP/VABP, but noninferiority was not demonstrated for investigator-assessed clinical cure at test of cure. Both drugs were well tolerated.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Raquel Carbonell, Gerard Moreno, Ignacio Martin-Loeches, Frederic Gomez-Bertomeu, Carolina Sarvise, Josep Gomez, Maria Bodi, Emili Diaz, Elisabeth Papiol, Sandra Trefler, Mercedes Nieto, Angel Estella, Maria Jimenez Herrera, Pablo Vidal Cortes, Juan Jose Guardiola, Jordi Sole-Violan, Alejandro Rodriguez
Summary: A study on 1608 patients with severe influenza pneumonia found that patients with bacterial co-infection had significantly higher PCT and CRP levels, and deceased patients had higher PCT levels compared to survivors. However, these biomarkers were not significantly associated with mortality, and they did not have enough discriminatory power to predict the causative microorganism of the co-infection.
Article
Immunology
Xue Wan, Shuang Wang, Min Wang, Jinhua Liu, Yu Zhang
Summary: This study reports a case of Peptoniphilus harei bacteremia in an abdominal aortic aneurysm patient, highlighting the importance of including anaerobic blood cultures as part of blood culture procedures. Clinical microbiologists should be vigilant that the pathogenic potential of GPAC may be underestimated.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Min-Gyeong Seo, Kook-Young Han, Sang-Hyun Kim, Chang Keun Kang, Jong-Hyun Kim, Il-Hwa Hong
Summary: In this article, fibrinous pleuritis caused by Streptococcus canis infection in a leopard cat is described. It is noted that there is a lack of literature on S. canis in leopard cats.
JOURNAL OF VETERINARY SCIENCE
(2023)
Article
Microbiology
Rohit Ruhal, Rashmi Kataria
Summary: Biofilms formed by Gram-positive and Gram-negative bacteria are the root cause of industrial biofouling and antimicrobial resistance during infections. To understand the mechanisms of biofilm formation better, it is essential to study common components and genetic regulations that are shared among the two types of bacteria.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Immunology
Qingliang Wang, Xiaojie Li, Wenting Tang, Xiaoling Guan, Zhiyong Xiong, Yong Zhu, Jiao Gong, Bo Hu
Summary: This study explored the gene differences between Gram-negative, Gram-positive, and mixed infections in sepsis using genome-wide techniques. The results showed molecular heterogeneity between Gram-negative and Gram-positive sepsis, which was confirmed in the validation dataset.共有40个共同的差异基因集识别. The findings offer new insights into investigating the pathophysiology of bacterial sepsis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Amit Ginzburg, Gal Goldstein, Dror Raviv, Hodaya Cohen, Sigal Weinreb, Dan Harlev, Adi Nitsan-Luques, Mohammad Yacoub Abou Saoud, Jacob Strahilevitz, Diana Averbuch
Summary: This retrospective study investigated the etiology and resistance patterns of pathogenic bacteria causing bacteremia in children with solid tumors in a pediatric hematology-oncology center in Jerusalem, Israel. The study found a high proportion of multidrug-resistant bacteria, with gram-negative rods being more prevalent than gram-positive cocci. Factors such as antibiotic choice and underlying diagnosis were associated with multidrug resistance, while shock, neutropenia, and PICU admission were associated with mortality.
MICROBIAL DRUG RESISTANCE
(2022)
Article
Microbiology
Reza Besharati, Hatef Ajoudanifar, Hamed Ghasemzadeh-Moghaddam, Amir Azimian
Summary: In the COVID-19 era, co-infections can lead to increased morbidity and mortality. This study evaluated the prevalence and antibiotic resistance of gram-positive cocci in nasal swabs from health care workers in the pre- and post-COVID-19 eras.
JUNDISHAPUR JOURNAL OF MICROBIOLOGY
(2023)
Article
Immunology
N. Kansak, R. Adaleti, Y. Nakipoglu, S. Aksaray
Summary: This study evaluated the compliance of rapid antibiotic susceptibility test (RAST) with conventional laboratory procedures. Results showed variations in categorical agreement of RAST across different strains and time points, but overall demonstrated a higher CA rate at the eighth hour.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Mehdi Zeinalizadeh, Roya Yazdani, Mohammad Mehdi Feizabadi, Maryam Shadkam, Arash Seifi, Seyed Ali Dehghan Manshadi, Alireza Abdollahi, Mohammadreza Salehi
Summary: This study aimed to compare the differences in clinical, laboratory features, and outcomes between post-neurosurgical meningitis caused by gram-negative bacilli (GNB) and gram-positive cocci (GPC). Results showed no correlation in various factors between the two groups, with only ESR and PCT levels being significantly higher in GNB cases. GNB antibiotic coverage should be carefully considered in post-neurosurgical meningitis, especially in patients with recent corticosteroid therapy and elevated inflammatory markers.
CASPIAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Infectious Diseases
Cristina Corsini Campioli, Natalia E. Castillo Almeida, John C. O'Horo, Walter R. Wilson, Edison Cano, Daniel C. DeSimone, Larry M. Baddour, M. Rizwan Sohail
Summary: This retrospective study investigated adult patients with monomicrobial brain abscesses caused by gram-positive and gram-negative bacteria. The study found that brain abscesses caused by gram-negative bacteria were more likely to occur in patients with a history of head and neck surgery. In terms of treatment failure, gram-negative bacteria had a higher rate compared to gram-positive bacteria.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Ana Belen Garcia-Martin, Thomas Roder, Sarah Schmitt, Friederike Zeeh, Remy Bruggmann, Vincent Perreten
Summary: This study provides insights into the genomic structure and variability of B. hyodysenteriae ST196, a predominant strain in Switzerland. The results reveal that Swiss B. hyodysenteriae isolates of the same ST may have evolved independently over time by point mutations and acquisition of larger genetic elements. The identification of a novel prophage, pphBhCH20, suggests that horizontal gene transfer events may drive changes in genomic structure.
Article
Microbiology
Jennifer Eleonora Keller, Sybille Schwendener, Gudrun Overesch, Vincent Perreten
Summary: Gram-positive coccoid bacteria were isolated from the nasal cavities and skin regions of pigs and calves. Phylogenetic analysis revealed that these strains belonged to the genus Macrococcus, specifically a novel species called Macrococcus armenti sp. nov. These strains showed similarities to other Macrococcus species, but DNA analysis confirmed their distinctness.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Infectious Diseases
Jens Becker, Vincent Perreten, Gertraud Schuepbach-Regula, Dimitri Stucki, Adrian Steiner, Mireille Meylan
Summary: This study investigated the association between the use of antimicrobial drugs during the fattening period of veal calves and antimicrobial susceptibility shortly before slaughter. The results showed that the use of antimicrobial drugs was associated with the occurrence of antimicrobial resistance in the calves.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Hatice Akarsu, Anne Liljander, Mario Younan, Isabelle Brodard, Gudrun Overesch, Ilona Glucks, Fabien Labroussaa, Peter Kuhnert, Vincent Perreten, Stefan Monecke, Jan Felix Drexler, Victor Max Corman, Laurent Falquet, Joerg Jores
Summary: This study conducted genome sequencing and analysis of 84 Staphylococcaceae strains collected from camels and cattle in Somalia and Kenya, revealing potentially novel species, antimicrobial resistances, and virulence traits. The first multidrug-resistant camel S. epidermidis strain of sequence type 1136 in East Africa was identified.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Infectious Diseases
Jacqueline Findlay, Vincent Perreten, Laurent Poirel, Patrice Nordmann
Summary: OXA-48-type β-lactamases are the most common carbapenemase-type in Enterobacterales in Switzerland, mainly found in Escherichia coli and Klebsiella pneumoniae. Bacteria producing OXA-48-type enzymes are endemic in certain regions, including Europe and North Africa, and frequently cause hospital-acquired infections. Despite the emergence of multiple OXA-48-type variants, the original variant, OXA-48, remains the most prevalent in E. coli. This study describes the epidemiology of OXA-48-producing E. coli isolates submitted to the Swiss National Reference Center for Emerging Antibiotic Resistance (NARA) between January 2019 and December 2020.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Correction
Infectious Diseases
Edgar I. Campos-Madueno, Aline I. Moser, Geraldine Jost, Carola Maffioli, Thomas Bodmer, Vincent Perreten, Andrea Endimiani
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Microbiology
Javier E. Fernandez, Helena M. B. Seth-Smith, Patrice Nordmann, Adrian Egli, Andrea Endimiani, Vincent Perreten
Summary: This study discovered a novel multidrug resistance plasmid pJEF1-OXA-181, which carries carbapenemase and aminoglycoside resistance genes. It highlights the risk of multidrug resistance plasmids spreading in the healthcare system and calls for continuous monitoring of multidrug-resistant bacteria in high-risk patients.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Juliana Menezes, Joana Moreira da Silva, Sian-Marie Frosini, Anette Loeffler, Scott Weese, Vincent Perreten, Stefan Schwarz, Luis Telo da Gama, Andreia Jesus Amaral, Constanca Pomba
Summary: This study detected colistin-resistant E. coli strains carrying the mcr-2 gene in dogs, cats, and humans in Lisbon, Portugal. The findings indicate the potential sharing of these bacteria between companion animals and their cohabiting humans, highlighting their role in disseminating clinically important resistance genes in the community setting.
Article
Microbiology
Edgar I. I. Campos-Madueno, Aline I. I. Moser, Peter M. M. Keller, Vincent Perreten, Laurent Poirel, Patrice Nordmann, Andrea Endimiani
Summary: KoC species overproduce OXY beta-lactamases, leading to reduced susceptibility to piperacillin-tazobactam, expanded-spectrum cephalosporins, and aztreonam. Whole-genome sequencing and susceptibility testing were used to characterize 44 KoC strains, showing phenotypic differences between ESBL producers and hyperproducers of OXYs. Only cefepime/cefepime-clavulanate combination disk tests or the double-disk synergy test could accurately distinguish between these two groups.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Letter
Infectious Diseases
Jennifer Eleonora Keller, Sybille Schwendener, Dana Novakova, Roman Pantucek, Vincent Perreten
MICROBIAL DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Ervin Albert, Rita Sipos, Vincent Perreten, Akos Toth, Erika Ungvari, Marton Papp, Adam Dan, Imre Biksi
Summary: In Hungary, a study found that 83% of pig farms and 70% of swine professionals were carriers of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA). The study highlights the significant increase in the occurrence of LA-MRSA in the swine industry in Hungary, calling for a reassessment of the risk it poses to public health.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Genetics & Heredity
Aitana Neves, Daniel Walther, Trinidad Martin-Campos, Valerie Barbie, Claire Bertelli, Dominique Blanc, Gerard Bouchet, Frederic Erard, Gilbert Greub, Hans H. Hirsch, Michael Huber, Laurent Kaiser, Stephen L. Leib, Karoline Leuzinger, Vladimir Lazarevic, Mirjam Mausezahl, Jorge Molina, Richard A. Neher, Vincent Perreten, Alban Ramette, Tim Roloff, Jacques Schrenzel, Helena M. B. Seth-Smith, Roger Stephan, Dillenn Terumalai, Fanny Wegner, Adrian Egli
Summary: The SPSP is a secure platform that enables surveillance and monitoring of pathogens in human, veterinary, environmental, and foodborne sources. It utilizes whole genome sequencing data and metadata to quickly track and monitor the transmission and outbreak of pathogens. It provides controlled data access, complex dynamic queries, dedicated dashboards, and automated data sharing with international repositories, aiming to improve public health and societal well-being.
MICROBIAL GENOMICS
(2023)
Article
Microbiology
Andrew F. Brown, Judith Pfister, Javier E. Fernandez, Valentina Dona, Victor Rodriguez, Gina Retschnig, Alexandra Collaud, Peter Neumann, Vincent Perreten
Summary: The complete genome sequence of Lactobacillus melliventris strain IBH004, isolated from the gut of a honeybee worker (Apis mellifera) and containing two plasmids and a temperate phage, was determined using hybrid assembly of Oxford Nanopore and Illumina reads. Phage-sequence relationships were identified from the coding sequences, and a proteomic tree was constructed.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Microbiology
Emma Marchionatti, Vincent Perreten
Summary: A novel 23S ribosomal RNA methylase gene erm(56) flanked by insertion sequence IS6100 was identified in a Trueperella pyogenes isolated from the abscess of a dog and was also present in another T. pyogenes and in Rothia nasimurium from livestock. It was shown to confer resistance to macrolide, lincosamide, streptogramin B antibiotics in T. pyogenes and E. coli, indicating functionality in both Gram-positive and Gram-negative bacteria. The detection of erm(56) on different elements in unrelated bacteria from different animal sources and geographical origins suggests that it has been independently acquired and likely selected by the use of antibiotics in animals.
Article
Infectious Diseases
Valentina Dona, Patrice Nordmann, Sonja Kittl, Simone Schuller, Maxime Bouvier, Laurent Poirel, Andrea Endimiani, Vincent Perreten
Summary: A study in Switzerland found that Enterobacter hormaechei producing the carbapenemase OXA-48 was identified in companion animals and human patients. The study analyzed the genetic relatedness of these strains and their mobile genetic elements and found a connection between antimicrobial resistance in E. hormaechei and animals and humans in the same environment.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
