Article
Microbiology
Boram Seo, Kyungchan Jeon, Inwoo Baek, Yung Mi Lee, Kiwoon Baek, GwangPyo Ko
Summary: Strain SNUG30386(T) is an obligately anaerobic, Gram-stain-positive and spore-forming bacterium belonging to the family Lachnospiraceae. Phylogenetic analysis based on 16S rRNA gene sequences suggests that it represents a novel species within the genus Clostridium, which has been proposed as Clostridium fessum sp. nov.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Andrea Piccioni, Federico Rosa, Federica Manca, Giulia Pignataro, Christian Zanza, Gabriele Savioli, Marcello Covino, Veronica Ojetti, Antonio Gasbarrini, Francesco Franceschi, Marcello Candelli
Summary: The composition of the human microbiome plays a crucial role in health, and alterations in the microbiota can lead to Clostridium difficile infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carlos J. Garcia, Vit Kosek, David Beltran, Francisco A. Tomas-Barberan, Jana Hajslova
Summary: This study evaluated the diversity of microbially conjugated bile acids (MCBAs) produced by the gut microbiota through a metabolomics approach. The results showed that the gut microbiota can produce various MCBAs and re-conjugate hydroxyls on the sterol backbone as well as generate esters at the C24 acyl site of bile acids.
Article
Biology
Brandon H. Schlomann, Raghuveer Parthasarathy
Summary: By studying the formation of three-dimensional bacterial clusters experimentally and theoretically, it was found that the distribution of gut bacterial cluster sizes follows a power law decay, with the decay trend of larger clusters being strain-dependent.
Article
Biology
Nuria Mach, Cedric Midoux, Sebastien Leclercq, Samuel Pennarun, Laurence Le Moyec, Olivier Rue, Celine Robert, Guillaume Salle, Eric Barrey
Summary: Recent evidence shows that the gut microbiome has an impact on endurance exercise performance. Using elite endurance horses as a model, scientists have built a comprehensive horse gut gene catalog and found an association between gut microbiome composition and gene function with endurance performance. The findings suggest potential nutritional interventions that could benefit horse athletes.
COMMUNICATIONS BIOLOGY
(2022)
Article
Microbiology
Disha Bhattacharjee, Clara Flores, Christine Woelfel-Monsivais, Anna M. M. Seekatz
Summary: Clostridia are medically important anaerobes in the human gastrointestinal tract that significantly impact metabolism and functioning. C. innocuum is a highly prevalent and diverse species, demonstrating clade-specific differences in metabolism and potential virulence.
Review
Gastroenterology & Hepatology
Bingqian Zhou, Xiaoqi Pang, Jingyi Wu, Tianyu Liu, Bangmao Wang, Hailong Cao
Summary: The COVID-19 epidemic is a global health threat with gastrointestinal symptoms being common manifestations. Alterations in the gut microbiota are associated with COVID-19 progression and severity, as well as post-COVID-19 syndrome. Therapeutic strategies such as diet, probiotics/prebiotics, herb, and fecal microbiota transplantation have shown positive effects. Understanding the connections between gut microbiota and COVID-19 could provide new insights for COVID-19 management in the future.
Review
Biochemistry & Molecular Biology
Aleksandra Sedzikowska, Leszek Szablewski
Summary: The majority of our body's epithelial surfaces and various systems are colonized by diverse microorganisms, which play crucial roles in digestion, metabolism, and vitamin synthesis. The composition of these microbiota is influenced by internal and external factors, with dysbiosis potentially leading to various diseases. The close relationship between the gut microbiota and human health highlights the potential role of these microorganisms in disease prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Concetta Panebianco, Annacandida Villani, Adele Potenza, Enrica Favaro, Concetta Finocchiaro, Francesco Perri, Valerio Pazienza
Summary: Cancer cachexia is a complex syndrome characterized by weight loss, anorexia, inflammation, and metabolic alterations, which negatively impact cancer patients. Studies have shown a link between gut microbiota and cancer cachexia, suggesting a role for dysbiosis in its pathogenesis. Different manipulation tools of gut microbiota have shown promising improvements in cachexia outcomes, paving the way for future research and clinical interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Dongxu Ji, Hao Sun, Weichao Yang, Mingfu Gao, Hui Xu
Summary: Laboratory animals with human microbiome have been used to study the interaction between bacteria and host. In this study, the human gut microbiome was successfully transferred to drosophila using antibiotic therapy and fecal exposure strategy. The male drosophila inherited more microbiota from the donor and showed improved lifespan and climbing ability. Differential gene expression patterns were observed between male and female drosophila recipients.
Review
Food Science & Technology
Chunhua Chen, Xiaojun Huang, Hui Wang, Fang Geng, Shaoping Nie
Summary: Dietary intervention in regulating gut microbiota can improve the pathophysiological indicators and gut health of metabolic diseases. This review focuses on the effects of (3-glucan on the development of metabolic diseases and the role of gut microbiota in modulating these diseases.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Review
Food Science & Technology
Jorge Armando Jimenez-Avalos, Gerardo Arrevillaga-Boni, Lorena Gonzalez-Lopez, Zaira Yunuen Garcia-Carvajal, Marisela Gonzalez-Avila
Summary: A healthy Human Gut Microbial Ecosystem (HGME) is essential for the proper functioning of the body, with dysbiosis potentially leading to various disorders. Different methods such as diet, probiotics, antibiotics, and Fecal Microbiota Transplantation (FMT) can help restore or maintain the balance of Gut Microbiota (GM) populations. New approaches such as engineered nanomaterials, phagotherapy, antimicrobial peptides, non-antibiotic drugs, vaccines, and immunoglobulins are promising strategies for modulating HGME.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Martin F. Laursen, Anurag K. Sinha, Mikael Pedersen, Henrik M. Roager
Summary: The development and composition of gut microbiota play a crucial role in the metabolism, neuronal, and immunological development in early life. This study investigates the dynamics of microbiota-derived metabolites, such as short-chain fatty acids (SCFAs) and aromatic amino acid (AAA) catabolites, and identifies the key bacterial taxa responsible for their production in 25 Danish infants. The results reveal individual variations in the gut microbiota composition and metabolism, with significant changes over time. Specific bacterial taxa, including Bifidobacterium, Peptostreptococcus anaerobius, Ruminococcus gnavus, and Enterococcus species, are identified as the main producers of AAA catabolites in the infants' gut.
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Review
Biochemistry & Molecular Biology
Dahai Yu, Xin Meng, Willem M. de Vos, Hao Wu, Xuexun Fang, Amit K. Maiti
Summary: Throughout the human life cycle, gut microbes play a significant role in health, affected by factors such as environment, lifestyle, and age. Studies show that regulating gut microbes through diet, prebiotics, antibiotics can treat various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)