Article
Pharmacology & Pharmacy
Daniel Moldenhauer, Doan Chau Yen Nguyen, Lisa Jescheck, Franz Hack, Dagmar Fischer, Achim Schneeberger
Summary: This study utilized three-dimensional screen printing to fabricate oral dosage forms of different shapes and sizes, demonstrating high uniformity in size and mass of the tablets, as well as showing that drug release rate depends on the surface-area-to-volume ratio. The results indicate the potential of 3D screen printing for producing complex oral dosage forms with high reproducibility in mass production settings.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Nanoscience & Nanotechnology
Kshitis Chandra Baral, Rajiv Bajracharya, Sang Hoon Lee, Hyo-Kyung Han
Summary: Probiotics show potential in treating and preventing various diseases, but their clinical application is limited by biological and biopharmaceutical barriers due to their living nature. Stable formulations are needed to optimize their delivery and effectiveness.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Instruments & Instrumentation
Rabinarayan Parhi, Goutam Kumar Jena
Summary: Digital-based three-dimensional printing (3DP) is a powerful tool for fabricating personalized medicine by creating 3D printed pharmaceutical dosage forms with variable geometry. It has a significant impact on tailoring drug delivery systems for different patients and special populations.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Thermodynamics
Widson M. Santos, Fernanda P. Nobrega, Jessica C. Andrade, Lucas F. Almeida, Marta M. Conceicao, Ana Claudia D. Medeiros, Francinalva D. Medeiros
Summary: This study aimed to assess the compatibility of dexamethasone with solid pharmaceutical excipients. The results showed slight anticipations of decomposition and interactions with certain excipients, indicating caution should be taken when using heat-based manufacturing processes with these excipients in solid dosage forms.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Pharmacology & Pharmacy
Marcel Enke, Nicolle Schwarz, Franka Gruschwitz, Daniela Winkler, Felix Hanf, Lisa Jescheck, Stefan Seyferth, Dagmar Fischer, Achim Schneeberger
Summary: 3D printing allows for customized oral dosage forms, improving patient safety and care. The 3D screen printing (3DSP) technology can mass produce pharmaceuticals with high uniformity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Piotr Gadzinski, Anna Froelich, Barbara Jadach, Monika Wojtylko, Adam Tatarek, Antoni Bialek, Julia Krysztofiak, Michal Gackowski, Filip Otto, Tomasz Osmalek
Summary: Hydrogels, such as gellan gum, have a tridimensional structure and can absorb water or fluids without losing their structure. They can be used for encapsulation and targeted drug release. Gellan gum has unique features and is non-toxic, biocompatible, and biodegradable. Chemical crosslinking can modify the properties of gellan gum hydrogels and improve their three-dimensional structure.
Review
Pharmacology & Pharmacy
Muhammad Syakir Mohd Shahrizan, Zul Hadif Abd Aziz, Haliza Katas
Summary: Fluid gels, a suspension of gel particles, are widely used in the food industry and are being explored for pharmaceutical applications. Their tunable properties and ease of production make them promising for developing specific pharmaceuticals.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Michael E. E. Herbig, Dirk-Heinrich Evers, Sascha Gorissen, Melanie Koellmer
Summary: Specific aspects of semi-solid dosage forms for topical application include overcoming barriers, instability concerns, and sensory perception. Advances in understanding skin penetration and formulation design principles provide a foundation for rational design. This review analyzes the opportunities and constraints of rational formulation design approaches in developing topical drugs. Models for drug selection and the influence of skin penetration on formulation design are discussed. Rheological approaches and analytical methods for chemical stability characterization are explored. A combination of scientific understanding and regulatory compliance enables successful development of semi-solid formulations for topical application.
Article
Pharmacology & Pharmacy
Mario A. Cano-Vega, Laura M. Arango-Salazar, Rodolfo Pinal
Summary: This study developed oral dosage forms with adjustable drug release profiles using progesterone as a model drug. The dosage forms were made up of stack assemblies of functional modules, which were PGR-carrying HPMC films cut into circular pieces. By adjusting the proportions of two types of modules, the drug release rate of the multi-layer assemblies could be fine-tuned to a wide range of profiles. This procedure is suitable for enhancing the bioavailability of poorly-soluble drugs and developing patient-centric formulations.
Article
Engineering, Chemical
Korinde A. van den Heuvel, Myrthe T. W. de Wit, Bastiaan H. J. Dickhoff
Summary: Understanding the relationship between powder blend characteristics and tablet characteristics is crucial for obtaining 3D powder bed printed tablets that meet pharmaceutical specifications. This study focused on the impact of different particle size distributions on key material attributes such as wettability, consolidation, and flowability. Optimizing the base formulation and print settings concurrently is essential for successfully formulating hydrophilic/hydrophobic APIs into 3D printed tablets.
Article
Chemistry, Medicinal
Paul Harmon
Summary: Nitrosamine impurities can be formed during drug substance manufacturing processes. This article focuses on the growth of nitrosamine impurity levels in oral drug products during long-term stability studies. The mechanisms of nitrosamine growth in oral dosage forms are typically attributed to nitrosating agents formed in nitrous acid solutions with a pH value of approximately pH 5 or below. The authors aim to raise awareness among pharmaceutical scientists about the catalytic effect of formaldehyde, commonly found in excipients of oral dosage forms, on the reaction between secondary amines and nitrite ions, leading to the formation of nitrosamine products. This mechanism occurs at higher pH values (>6) and is relevant to pharmaceutical solid dosage forms. Recent recalls of solid dosage form products are discussed as examples to demonstrate the formaldehyde-catalyzed nitrosation pathway in the solid state. (c) 2022 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Aljosa Bolje, Stanislav Gobec
Summary: Therapeutic proteins are crucial for treating many diseases, but their stability, particularly during drying and in solid state, is a key concern. The conformational stability of proteins is directly linked to their biological function, while denaturation as loss of higher order structure can lead to aggregation or chemical instability.
Article
Pharmacology & Pharmacy
Tingting Chen, Zhimin Ma, Zhenwen Qiu, Zhong Zhong, Lei Xing, Qiuping Guo, Dandong Luo, Zhiwei Weng, Fucheng Ge, Yating Huang, Xiubing Zhang, Hongling He, Xiaodong Zhuang, Qingguo Li, Tianhui Yuan
Summary: In this study, the impact of excipients on the pharmaceutical properties of sirolimus in the SAS-FB process was evaluated. Co-precipitation of excipients and sirolimus was found to affect the specific surface area of the carrier and drug yield. Among the tested excipients, the formulation containing polyvinylpyrrolidone K30 showed the highest drug yield and significantly improved oral bioavailability compared to the Rapamune tablet. Characterization of the processed API was conducted to understand the mechanism by which excipients contributed to drug dissolution properties.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Aron H. Blaesi, Nannaji Saka
Summary: This study investigates the use of expandable fibrous dosage forms for prolonged delivery of sparingly-soluble drugs. The dosage forms, containing water-absorbing and fiber-strengthening excipients, were found to expand at a similar rate upon immersion in a dissolution fluid and convert into a viscous gel. The release of the drug was dependent on the fiber volume fraction, with higher fractions resulting in slower release times.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Greta Frei, Adam Haimhoffer, Eniko Csapo, Krisztina Bodnar, Gabor Vasvari, Daniel Nemes, Istvan Lekli, Alexandra Gyongyosi, Ildiko Bacskay, Palma Feher, Liza Jozsa
Summary: The aim of this study was to formulate topical dosage forms containing curcumin for the treatment of certain inflammatory diseases. Self emulsifying drug delivery systems were used to increase the solubility and bioavailability of curcumin. Creams and gels were formulated using penetration-enhancing surfactants and gelling agents. The results showed that the curcumin-containing preparations were safe for skin application and had antioxidant effects. Animal experiments confirmed the effectiveness of the curcumin-containing topical preparations.
Editorial Material
Biochemistry & Molecular Biology
Chrisna Gouws, Josias H. Hamman
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2020)
Article
Pharmacology & Pharmacy
Mark Fensham, Jan Steenekamp, Adriaan Jacobs, Josias Hamman
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2020)
Article
Chemistry, Medicinal
Tanya Smit, Carlemi Calitz, Clarissa Willers, Hanna Svitina, Josias Hamman, Stephen J. Fey, Chrisna Gouws, Krzysztof Wrzesinski
ACS MEDICINAL CHEMISTRY LETTERS
(2020)
Review
Pharmacology & Pharmacy
Jannes van der Merwe, Jan Steenekamp, Dewald Steyn, Josias Hamman
Article
Biology
Morne Fouche, Clarissa Willers, Sias Hamman, Christiaan Malherbe, Jan Steenekamp
Review
Pharmacology & Pharmacy
Anja Haasbroek-Pheiffer, Suzanne Van Niekerk, Frank van der Kooy, Theunis Cloete, Jan Steenekamp, Josias Hamman
Summary: The intranasal route of administration is a noninvasive method to deliver drugs into the systemic circulation and/or directly into the brain. In vitro and ex vivo models provide a means to investigate physiological and pharmaceutical factors that affect drug delivery across the nasal epithelium. Developing cost-effective pharmacokinetic models for intranasal drug delivery can improve drug product development and reduce the need for animal studies.
BIOPHARMACEUTICS & DRUG DISPOSITION
(2023)
Article
Chemistry, Multidisciplinary
Cassandra Kirby-Smith, Jan Steenekamp, Dewald Steyn, Anja Haasbroek-Pheiffer, Hannlie Hamman, Josias Hamman
Summary: This study investigated the effectiveness of microparticle formulations prepared from Aloe vera polysaccharides for nasal delivery of insulin across excised sheep olfactory and respiratory nasal epithelial tissues. The microparticle formulations significantly improved nasal insulin delivery compared to that of the control group. Therefore, Aloe vera polysaccharide containing microparticles showed high potential to enhance systemic bioavailability and delivery into the brain of macromolecular drugs such as insulin after intranasal administration.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Anja Haasbroek-Pheiffer, Alvaro Viljoen, Jan Steenekamp, Weiyang Chen, Josias Hamman
Summary: The intranasal route of drug administration allows direct delivery into the brain by bypassing the blood-brain barrier. Medicinal plants like Centella asiatica and Mesembryanthemum tortuosum have shown scientific evidence in treating conditions like anxiety and depression. Permeation studies on asiaticoside and mesembrine, as well as crude extracts of C. asiatica and M. tortuosum, have demonstrated their potential for direct nose-to-brain delivery of psychoactive phytochemicals.
Article
Plant Sciences
Anri Hattingh, Jean-Pierre Laux, Clarissa Willers, Josias Hamman, Dewald Steyn, Hannlie Hamman
Summary: The study found that combining Aloe vera gel with Bulbine frutescens aqueous extract can enhance the wound healing properties of Aloe vera gel.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Plant Sciences
Neil Miller, Christiaan Johannes Malherbe, Werner Gerber, Josias H. Hamman, Marietader van der Rijst, Marique Aucamp, Elizabeth Joubert
Summary: The study found that fractions enriched in xanthones and benzophenones exhibited high efflux ratios in excised porcine jejunal tissue, suggesting that these compounds mainly act in the intestine and are effectively concentrated at the target site (gut lumen).
Article
Polymer Science
Morne Weyers, Bianca Peterson, Josias H. Hamman, Jan H. Steenekamp
Summary: This study aimed to enhance the delivery of macromolecular drugs across ovine nasal epithelial tissues by incorporating piperine into chitosan microparticle formulations. Two distinct sizes of chitosan microparticles were prepared using ionic gelation, demonstrating a promising approach for nasal drug delivery of poorly bioavailable drugs.
