期刊
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
卷 38, 期 11, 页码 857-863出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0043-113042
关键词
exercise; Natural Killer Cells; Serotonin; migration; cytotoxcity
Increased serotonin (5-HT) levels have been shown to influence natural killer cell (NK cell) function. Acute exercise mobilizes and activates NK cells and further increases serum 5-HT concentrations in a dose-dependent manner. The aim of this study was to investigate the impact of different serum 5-HT concentrations on NK cell migratory potential and cytotoxicity. The human NK cell line KHYG-1 was assigned to 4 conditions, including 3 physiological concentrations of 5-HT (100, 130 or 170 mu g/l 5-HT) and one control condition. NK cells were analyzed regarding cytotoxicity, migratory potential and expression of adhesion molecules. No treatment effect on NK cell cytotoxicity and expression of integrin subunits was detected. Migratory potential was increased in a dose dependent manner, indicating the highest protease activity in cells that were incubated with 170 mu g/l 5-HT (170 mu g/l vs. control, p < 0.001, 170 mu g/l vs. 100 mu g/l, p < 0.001; 170 mu g/l vs. 130 mu g/l, p = 0.003; 130 mu g/l vs. control, p < 0.001, 130 mu g/l vs. 100 mu g/l, p < 0.001). These results suggest that elevated 5-HT serum levels play a mediating role in NK cell function. As exercise has been shown to be involved in NK cell mobilization and redistribution, the influence of 5-HT should be investigated in ex vivo and in vivo experiments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据