Article
Chemistry, Organic
Austin D. Marchese, Andrew G. Durant, Mark Lautens
Summary: A simple and modular approach using palladium catalysis to synthesize bis-heterocyclic spirocycles is reported. The method leverages a Mizoroki-Heck-type reaction to generate neopentylpalladium species, allowing for intramolecular C-H activation on a wide array of C-H bonds to produce a variety of spirocycles. The reaction is scalable, allowing for easy incorporation of biologically relevant heterocycles without the need for flash column chromatography.
Review
Chemistry, Organic
Yilin Kong, Kangning Wei, Guobing Yan
Summary: This review focuses on recent radical coupling reactions via photochemical and electrochemical strategies, as well as the discussion of their mechanisms.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Emilien Le Saux, Eleni Georgiou, Igor A. Dmitriev, Will C. Hartley, Paolo Melchiorre
Summary: A photochemical method for the functionalization of pyridines using radicals derived from allylic C-H bonds is reported. The reaction exhibits distinct positional selectivity and employs a dithiophosphoric acid as a multi-functional catalyst.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Xiao Xiao, Puren Han, Jie-Ping Wan, Jianchao Liu
Summary: An efficient and general method for the synthesis of indolyl-C-glycosides has been developed. The method exhibits excellent stereoselectivity, a wide range of substrate applicability, and mild reaction conditions. It has also been successfully applied to large-scale reactions and diversified synthetic transformations.
Article
Chemistry, Multidisciplinary
Yin-Xia Wang, Feng-Ping Zhang, Hao Chen, Yue Li, Jiang-Fei Li, Mengchun Ye
Summary: In this study, enantioselective Ni-catalyzed aliphatic C(sp(3))-H activation of formamides was achieved using a phosphine oxide-ligated Ni-Al bimetallic catalyst, providing a series of chiral N-containing heterocycles in yields of 40-95% and ee values of 70-95%.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Long Li, Jiao-Zhe Li, Yong-Bin Sun, Chun-Mei Luo, Hui Qiu, Keqi Tang, Hongxin Liu, Wen-Ting Wei
Summary: A novel visible-light-catalyzed tandem radical addition/1,5-hydrogen atom transfer/cyclization cascade reaction was developed for the synthesis of sulfonylfunctionalized dihydrobenzofurans. This reaction relies on unique energy transfer and solvent-radical relay strategies, enabling the generation of sulfonyl radicals under photocatalyst-and additive-free conditions.
Article
Chemistry, Organic
Min Seo Park, Kyeongwon Moon, Harin Oh, Ji Yoon Lee, Prithwish Ghosh, Ju Young Kang, Jung Su Park, Neeraj Kumar Mishra, In Su Kim
Summary: The Rh(III)-catalyzed C-H functionalization and subsequent intramolecular cyclization between azobenzenes and vinylene carbonate leads to the formation of different compounds, such as (2H)-indazoles or dihydrocinnolin-4-ones. Vinylene carbonate surprisingly acts as an acetaldehyde or acetyl surrogate, enabling [4 + 1] or [4 + 2] annulation reaction. This transformation stands out for its mild reaction conditions, simplicity, and excellent functional group compatibility.
Article
Chemistry, Organic
Garrit Wicker, Roland Schoch, Jan Paradies
Summary: The borane-catalyzed synthesis of dihydroquinoline-4-ones has been developed, with high yields and excellent diastereoselectivity. The reaction mechanism is investigated through kinetic, isotope labeling, and computational experiments.
Review
Chemistry, Organic
Zhanghong Wang, Yu Sun, Liu-Yu Shen, Wen-Chao Yang, Fei Meng, Pinhua Li
Summary: In summary, the activation and functionalization of C-F bonds are important tools for organic synthesis. Recent developments using photochemical or electrochemical methods have shown significant progress in this field, providing alternative approaches to traditional chemical methods.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Applied
Monica Oliva, Guglielmo A. Coppola, Erik V. Van der Eycken, Upendra K. Sharma
Summary: This review discusses recent advances in benzylic C-H functionalization using organic radical strategies involving photochemistry and electrochemistry as sustainable tools. The potential and prospects of this field are highlighted, along with mechanistic details of typical reactions to aid researchers in exploring new discoveries and opportunities.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Dattatraya H. Dethe, Vimlesh Kumar, Manmohan Shukla
Summary: Here, we report the first palladium/MPAA catalyzed enantioselective C-H activation/[4 + 1] annulation of diarylmethyltriflamide and olefins to construct chiral cis-1,3-disubstituted isoindoline derivatives. The use of a readily accessible mono-N-protected amino acid as a chiral ligand improves the efficiency and enantioselectivity of the catalytic transformation, enabling the synthesis of both enantiomers of the product.
Article
Chemistry, Organic
Yuxin Ding, Huihui Yan, Rener Chen, Xuqiong Xiao, Zhiming Wang, Lei Wang, Yongmin Ma
Summary: The paper discusses a novel one-pot cascade reaction catalyzed/oxidized by the [Pd]/[Ag] system, involving two C-N bond and one C-C bond formations during the double annulation process to yield the desired products. The method is applicable to a wide range of readily available substrates and provides high yields.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Matthew R. Lasky, Tolani K. Salvador, Sukrit Mukhopadhyay, Matthew S. Remy, Thomas P. Vaid, Melanie S. Sanford
Summary: This report describes the development of a photochemical method for C(sp(2))-H pyridination that leverages the photoexcitation of electron donor-acceptor (EDA) complexes. The reaction results in aryl radical cation intermediates that can be trapped with pyridine nucleophiles under aerobic conditions. This approach eliminates the need for an exogenous photocatalyst and is cost-effective.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Yuki Yoshida, Haruka Takeuchi, Kohei Nakagawa, Toshiki Fujii, Norihito Arichi, Shinya Oishi, Hiroaki Ohno, Shinsuke Inuki
Summary: In this study, it was found that simple biphenyl substrates derived from amino acids can participate in a radical cascade reaction under visible light irradiation in the presence of [Ir{dF(CF3)ppy}(2)(dtbpy)]PF6, enabling the direct construction of bicyclo[2.2.2]octene structures. Isotopic labeling experiments suggested that intramolecular hydrogen atom transfer is involved in the cascade processes.
Article
Chemistry, Organic
Dong-Fang Jiang, Xing-Xing Zeng, De-Feng Li, Si-Miaomiao Wen, Ming-Hua Hu
Summary: A tandem oxidative aryl migration/carbonyl formation reaction mediated by K2S2O8 and visible-light photoredox catalysis has been discovered, which enables the synthesis of important alpha-allenic aldehyde/ketone derivatives in a regioselective manner through 1,4-aryl shift concomitant with carbonyl formation. The operational simplicity and broad substrate scope demonstrate the great potential of this method for the synthesis of highly functional alpha-allenic aldehyde/ketone derivatives.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Dermatology
Rajna Ogrin, Mohammod A. Motin, Behzad Aliahmad, Kylie Elder, Jacinta Anderson, Dinesh Kumar
Summary: This study investigated the effectiveness of using thermal imaging to predict venous leg ulcer healing in the homes of participants. The results showed that thermal imaging could not predict the healing progression of ulcers when taken in home settings.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Review
Cardiac & Cardiovascular Systems
Muhammad Umer, Manish Motwani, John L. Jefferies, Sherif F. Nagueh, Dinesh K. Kalra
Summary: Fabry disease is a rare X-linked disorder that affects glycosphingolipid metabolism. It is caused by alpha-galactosidase A enzyme deficiency, leading to the accumulation of GL3 in lysosomes. Multiple systems are affected, with cardiac involvement being a significant manifestation. Early symptoms include neuropathic pain, skin lesions, anhidrosis, corneal changes, and gastrointestinal symptoms. Later stages may involve strokes, hearing loss, and life-threatening complications. This review focuses on the cardiac manifestations of Fabry disease and the role of multimodality imaging in diagnosis and monitoring.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Suresh C. C. Tyagi, Sathnur Pushpakumar, Utpal Sen, Sri Prakash L. Mokshagundam, Dinesh K. K. Kalra, Mohamed A. A. Saad, Mahavir Singh
Summary: Although the mechanisms underlying respiratory failure in Duchenne muscular dystrophy (DMD) and long-COVID are unclear, there is evidence of neopterin (NPT) involvement in both conditions. Studies have shown increased levels of NPT and other inflammatory markers in lung tissue, leading to fibrosis of the diaphragm. Understanding the epigenetic regulation and generation of NPT in long-COVID patients is of interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Muhammad Umer, Dinesh K. Kalra
Summary: Fabry disease is a rare genetic disorder caused by a deficiency in the alpha-galactosidase A enzyme, leading to the accumulation of globotriaosylceramide in various organs. Fabry cardiomyopathy is characterized by abnormalities in the heart, including increased ventricular wall thickness, valvular disease, arrhythmias, and heart failure. Early diagnosis and treatment are crucial to prevent complications and improve patient outcomes. This review focuses on the role of cardiovascular magnetic resonance imaging in the diagnosis, decision-making, and monitoring of treatment efficacy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Aangi J. Shah, Taylor Beckmann, Mounica Vorla, Dinesh K. Kalra
Summary: Pulmonary arterial hypertension (PAH) is a chronic and progressive disorder that affects the pulmonary vasculature and leads to pulmonary and cardiac remodeling. Despite improved life expectancy through targeted therapies, PAH still remains a progressive disease with significant morbidity and mortality. Current vasodilator therapies do not target the underlying pathogenesis of the disease, highlighting the need for the development of new drugs and interventional therapies. This review focuses on newer targets, drugs, and interventional therapies that modify various pathways involved in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sathnur Pushpakumar, Mahavir Singh, Yuting Zheng, Oluwaseun E. Akinterinwa, Sri Prakash L. Mokshagundam, Utpal Sen, Dinesh K. Kalra, Suresh C. Tyagi
Summary: Renal denervation (RDN) protects against hypertension, hypertrophy, and heart failure (HF) but it is unclear whether RDN preserves ejection fraction (EF) during HFpEF. By creating an aorta-vena cava fistula (AVF) in mice, this study demonstrated that RDN is cardioprotective during HFpEF via preservation of eNOS and endocardial-endothelial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Muhammad Umer, Dinesh K. K. Kalra
Summary: Fabry disease is a rare genetic disorder that affects the metabolism of glycosphingolipids. It results in the accumulation of globotriaosylceramide in lysosomes due to a deficiency of the alpha-galactosidase A enzyme. This disease affects multiple organs, mainly the kidneys, heart, and cerebrovascular system. Early diagnosis and treatment are crucial in preventing irreversible tissue damage, organ failure, and life-threatening complications that can significantly impact life expectancy. This review focuses on the current and emerging treatment options for Fabry disease.
Article
Cardiac & Cardiovascular Systems
Amit Rout, Sanchit Duhan, Muhammad Umer, Miranda Li, Dinesh Kalra
Review
Cardiac & Cardiovascular Systems
Dinesh K. Kalra, Mounica Vorla, Erin D. Michos, Anandita Agarwala, Salim Virani, Bart Duell, Frederick J. Raal
Summary: With the improvement of antiretroviral therapy, the life expectancy of people living with HIV has increased, but cardiovascular disease has become a major cause of morbidity and mortality in this aging population. Therefore, it is crucial to assess and treat cardiovascular disease risk factors, including dyslipidemia, in this population. However, there is limited evidence regarding the pathogenesis and management of dyslipidemia in people living with HIV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Medicine, General & Internal
U. Sagheer, M. K. Shotwell, M. Umer, W. Furtado, J. Joshi, D. K. Kalra
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
S. Hammad Jafri, Maya Guglin, Roopa Rao, Onyedika Ilonze, Kareem Ballut, Zulfiqar Qutrio Baloch, Mohammed Qintar, Joel Cohn, Matthew Wilcox, Andrew M. Freeman, Dinesh K. Kalra, Wen-Chih Wu
Summary: This study found that patients with heart failure (HF) were able to achieve similar or even better functional and psychosocial outcomes after intensive cardiac rehabilitation (ICR), despite their lower baseline functional status and psychosocial scores compared to non-HF patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Nachiket Apte, Dinesh K. Kalra
Summary: Ventricular ectopy is a common cardiac arrhythmia that can be managed with antiarrhythmic drugs. However, the use of these drugs should be done cautiously due to potential side effects.
Article
Mechanics
Tejaswini Kumari, Dinesh Kumar, K. N. Rai, S. K. Singh
Summary: This paper presents a mathematical heat transfer model for predicting the temperature profile at the tumor position during hyperthermia treatment in multi-layer skin tissue. It combines the dual-phase-lag model with a Gaussian heat source term and discusses the effects of various parameters and boundary conditions. The study concludes with a discussion on a better approach to treat tumor cells during hyperthermia treatment without harming neighboring healthy tissues.
MECHANICS BASED DESIGN OF STRUCTURES AND MACHINES
(2023)
Article
Mathematics, Applied
D. L. Suthar, Dinesh Kumar, Haile Habenom
Summary: This article discusses the possible solutions of the fractional kinetic equation associated with the generalized multiindex Bessel function using the Laplace transform method. Numerical results and graphical solutions of the main theorems are also provided.
DIFFERENTIAL EQUATIONS AND DYNAMICAL SYSTEMS
(2023)
Article
Astronomy & Astrophysics
P. Abratenko, J. Anthony, L. Arellano, J. Asaadi, A. Ashkenazi, S. Balasubramanian, B. Baller, C. Barnes, G. Barr, J. Barrow, V Basque, L. Bathe-Peters, O. Benevides Rodrigues, S. Berkman, A. Bhanderi, M. Bhattacharya, M. Bishai, A. Blake, B. Bogart, T. Bolton, J. Y. Book, L. Camilleri, D. Caratelli, I. Caro Terrazas, F. Cavanna, G. Cerati, Y. Chen, J. M. Conrad, M. Convery, L. Cooper-Troendle, J. Crespo-Anadon, M. Del Tutto, S. R. Dennis, P. Detje, A. Devitt, R. Diurba, R. Dorrill, K. Duffy, S. Dytman, B. Eberly, A. Ereditato, J. J. Evans, R. Fine, O. G. Finnerud, W. Foreman, B. T. Fleming, N. Foppiani, D. Franco, A. P. Furmanski, D. Garcia-Gamez, S. Gardiner, G. Ge, S. Gollapinni, O. Goodwin, E. Gramellini, P. Green, H. Greenlee, W. Gu, R. Guenette, P. Guzowski, L. Hagaman, O. Hen, R. Hicks, C. Hilgenberg, G. A. Horton-Smith, R. Itay, C. James, X. Ji, L. Jiang, J. H. Jo, R. A. Johnson, Y-J Jwa, D. Kalra, N. Kamp, N. Kaneshige, G. Karagiorgi, W. Ketchum, M. Kirby, T. Kobilarcik, I Kreslo, M. B. Leibovitch, I Lepetic, J-Y Li, K. Li, Y. Li, K. Lin, B. R. Littlejohn, W. C. Louis, X. Luo, K. Manivannan, C. Mariani, D. Marsden, J. Marshall, D. A. Martinez Caicedo, K. Mason, A. Mastbaum, N. McConkey, V Meddage, K. Miller, J. Mills, K. Mistry, A. Mogan, T. Mohayai, M. Mooney, A. F. Moor, C. D. Moore, L. Mora Lepin, J. Mousseau, S. Mulleriababu, D. Naples, A. Navrer-Agasson, N. Nayak, M. Nebot-Guinot, D. A. Newmark, J. Nowak, M. Nunes, N. Oza, O. Palamara, N. Pallat, V Paolone, A. Papadopoulou, V Papavassiliou, H. B. Parkinson, S. F. Pate, N. Patel, Z. Pavlovic, E. Piasetzky, I. D. Ponce-Pinto, S. Prince, X. Qian, J. L. Raaf, V Radeka, A. Rafique, M. Reggiani-Guzzo, L. Ren, L. C. J. Rice, L. Rochester, J. Rodriguez Rondon, M. Rosenberg, M. Ross-Lonergan, C. Rudolf von Rohr, G. Scanavini, D. W. Schmitz, A. Schukraft, W. Seligman, M. H. Shaevitz, R. Sharankova, J. Shi, A. Smith, E. L. Snider, M. Soderberg, S. Soldner-Rembold, J. Spitz, M. Stancari, J. St John, T. Strauss, S. Sword-Fehlberg, A. M. Szelc, W. Tang, N. Taniuchi, K. Terao, C. Thorpe, D. Torbunov, D. Totani, M. Toups, Y-T Tsai, J. Tyler, M. A. Uchida, T. Usher, B. Viren, M. Weber, H. Wei, A. J. White, Z. Williams, S. Wolbers, T. Wongjirad, M. Wospakrik, K. Wresilo, N. Wright, W. Wu, E. Yandel, T. Yang, L. E. Yates, H. W. Yu, G. P. Zeller, J. Zennamo, C. Zhang
Summary: In this study, a search for long-lived Higgs portal scalars (HPS) and heavy neutral leptons (HNL) was conducted using data collected in the MicroBooNE liquid-argon time projection chamber. The results provide constraints on the mixing parameter and scalar-Higgs mixing angle, with improved sensitivity compared to previous studies.
