MLN4924 and 2DG combined treatment enhances the efficiency of radiotherapy in breast cancer cells

MLN4924 therapy as a novel approach in cancer treatment modalities

(2016) Maryam Oladghaffari et al.   JOURNAL OF CHEMOTHERAPY

Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression

(2015) Lijun Jia et al.   NEOPLASIA

Disrupting Protein NEDDylation with MLN4924 Is a Novel Strategy to Target Cisplatin Resistance in Ovarian Cancer

(2013) S. T. Nawrocki et al.   CLINICAL CANCER RESEARCH

Protective autophagy induced byRBX1/ROC1knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis

(2012) Dongqin Yang et al.   Autophagy

Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells

(2012) Zhongguang Luo et al.   Autophagy

The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

(2012) Z. Luo et al.   CANCER RESEARCH

The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme

(2012) Dong Yang et al.   PLoS One

2-Deoxy-d-glucose and ferulic acid modulates radiation response signaling in non-small cell lung cancer cells

(2012) Venkata Reddy Bandugula et al.   TUMOR BIOLOGY

Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis

(2012) Y Zhao et al.   Cell Death & Disease

Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase

(2012) Yi Sun et al.   Protein & Cell

Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor

(2011) D. Wei et al.   CANCER RESEARCH

Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover

(2011) M. A. Milhollen et al.   CANCER RESEARCH

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

Emerging radiation techniques for early-stage breast cancer after breast-conserving surgery

(2011) Janice A Lyons et al.   Future Oncology

Targeted therapies for breast cancer

(2011) Michaela J. Higgins et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924

(2011) Hua Liao et al.   MOLECULAR & CELLULAR PROTEOMICS

mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR

(2011) Shanshan Duan et al.   MOLECULAR CELL

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia

(2010) R. T. Swords et al.   BLOOD

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

Invasive thymoma with intraorbital metastases

(2009) S Nirmala et al.   Journal of Cancer Research and Therapeutics

Enhancement of radiation and chemotherapeutic drug responses by 2-deoxy-D-glucose in animal tumors

(2009) BS Dwarakanath et al.   Journal of Cancer Research and Therapeutics

Modulation of cellular radiation responses by 2-deoxy-D-glucose and other glycolytic inhibitors: Implications for cancer therapy

(2009) VijayK Kalia et al.   Journal of Cancer Research and Therapeutics

Cytotoxicity,radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucoseIn vitro

(2009) BS Dwarakanath   Journal of Cancer Research and Therapeutics