期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 31, 期 -, 页码 124-139出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.04.002
关键词
-
资金
- National Institutes of Health [R01 GM55164]
- Philip Morris USA
- Philip Morris International
The structure of chromatin, affected by many factors from DNA linker lengths to posttranslational modifications, is crucial to the regulation of eukaryotic cells. Combined experimental and computational methods have led to new insights into its structural and dynamical features, from interactions due to the flexible core histone tails or linker histones to the physical mechanism driving the formation of chromosomal domains. Here we present a perspective of recent advances in chromatin modeling techniques at the atomic, mesoscopic, and chromosomal scales with a view toward developing multiscale computational strategies to integrate such findings. Innovative modeling methods that connect molecular to chromosomal scales are crucial for interpreting experiments and eventually deciphering the complex dynamic organization and function of chromatin in the cell.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据