Review
Medicine, General & Internal
Tania T. T. Herrera, Idalina Cubilla-Batista, Amador Goodridge, Tiago V. V. Pereira
Summary: The aim of this study was to evaluate the accuracy of prenatal imaging for diagnosing congenital Zika syndrome. After a comprehensive analysis of 18 studies, it was found that ultrasound can improve the diagnostic accuracy of Zika virus infection in pregnant women. However, the current evidence is still uncertain and larger, properly conducted studies are needed.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Eric Osoro, Irene Inwani, Cyrus Mugo, Elizabeth Hunsperger, Jennifer R. Verani, Victor Omballa, Dalton Wamalwa, Chulwoo Rhee, Ruth Nduati, John Kinuthia, Hafsa Jin, Lydia Okutoyi, Dufton Mwaengo, Brian Maugo, Nancy A. Otieno, Harriet Mirieri, Mufida Shabibi, Peninah Munyua, M. Kariuki Njenga, Marc-Alain Widdowson
Summary: The incidence of Zika virus infection was high in a pregnancy cohort in coastal Kenya, but there was little evidence of Zika virus transmission. The prevalence of severe microcephaly among newborns was higher compared to estimates from facility-based studies in Europe and Latin America.
Article
Immunology
Nicholas P. Krabbe, Elaina Razo, Hunter J. Abraham, Rachel V. Spanton, Yujia Shi, Saswati Bhattacharya, Ellie K. Bohm, Julia C. Pritchard, Andrea M. Weiler, Ann M. Mitzey, Jens C. Eickhoff, Eric Sullivan, John C. Tan, Matthew T. Aliota, Thomas C. Friedrich, David H. O'Connor, Thaddeus G. Golos, Emma L. Mohr
Summary: The magnitude and breadth of the maternal antibody response do not seem to impact maternal virologic control. However, higher antibody titers may be associated with poor control of infection and could be used as a biomarker.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Susannah Hopkins Leisher, Arin A. Balalian, Hanna Reinebrant, Stephanie Shiau, Vicki Flenady, Louise Kuhn, Stephen S. Morse
Summary: Studies have not provided enough evidence to determine whether there is a higher risk of foetal death in Zika-affected pregnancies, but suggest that the quality of reporting on foetal deaths needs improvement.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2021)
Article
Virology
Rita T. Patel, Brennan M. Gallamoza, Praveen Kulkarni, Morgan L. Sherer, Nicole A. Haas, Elise Lemanski, Ibrahim Malik, Khan Hekmatyar, Mark S. Parcells, Jaclyn M. Schwarz
Summary: A rat model of maternal Zika virus infection with MRI imaging was used to study the long-term neurological consequences of prenatal Zika virus infection. The study found altered brain development in Zika virus-infected rats and suggested that maternal immune activation may play a role in altered brain growth. The introduction of manual and automated atlas-based segmentation for neonatal and juvenile rat brains is effective in detecting significant changes in neurodevelopment.
Review
Oncology
Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang
Summary: Zika virus is a newly emerging pathogen associated with neurological complications, but there are currently no approved drugs or vaccines for its treatment. Repurposing clinically approved drugs could be an effective and efficient approach to combat Zika virus infections.
FRONTIERS OF MEDICINE
(2021)
Article
Infectious Diseases
Pamela Joyce Previdelli Da Conceicao, Lucas Rodrigues De Carvalho, Bianca Lara Venancio De Godoy, Mauricio Lacerda Nogueira, Ana Carolina Bernardes Terzian, Moacir Fernandes de Godoy, Marilia Freitas Calmon, Cintia Bittar, Paula Rahal
Summary: The study revealed that 11% of urine samples from outpatients without a clinical diagnosis of arbovirus tested positive for ZIKV-RNA. This highlights the effectiveness of urine as a non-invasive sample for detecting ZIKV infection. Additionally, a significant percentage of ZIKV-RNA-positive individuals were completely asymptomatic.
Review
Genetics & Heredity
Lavinia Schuler-Faccini, Miguel del Campo, Alfredo Garcia-Alix, Liana O. Ventura, Juliano Andre Boquett, Vanessa van der Linden, Andre Pessoa, Helio van der Linden Junior, Camila V. Ventura, Mariana Carvalho Leal, Thayne Woycinck Kowalski, Lais Rodrigues Gerzson, Carla Skilhan de Almeida, Lucelia Santi, Walter O. Beys-da-Silva, Andre Quincozes-Santos, Jorge A. Guimaraes, Patricia P. Garcez, Julia do Amaral Gomes, Fernanda Sales Luiz Vianna, Andre Anjos da Silva, Lucas Rosa Fraga, Maria Teresa Vieira Sanseverino, Alysson R. Muotri, Rafael Lopes da Rosa, Alberto Mantovani Abeche, Clairton Marcolongo-Pereira, Diogo O. Souza
Summary: This article reviews the identification of Zika virus as a human teratogen and its effects on congenital Zika syndrome (CZS). This syndrome is characterized by severe motor, cognitive, and language impairments, particularly in the form of cerebral palsy. However, some children may exhibit milder deficits, and those born without brain or eye abnormalities can have normal neurodevelopment. Vertical transmission and disruption in brain development are less frequent when maternal infection occurs in the second half of pregnancy. Experimental studies indicate the possibility of other behavioral outcomes in prenatally infected children, as well as in postnatal and adult infections. The development of CZS is influenced by various factors, including genetics, environment, nutrition, and social determinants.
FRONTIERS IN GENETICS
(2022)
Article
Developmental Biology
Jennifer L. Watts, Amy Ralston
Summary: This article evaluates the consequences of Zika virus (ZIKV) infection in mouse embryos during early embryogenesis. The results show that different strains of ZIKV can infect the fetal lineage and cause developmental arrest, raising concerns about the developmental consequences of sexual transmission of ZIKV.
Article
Pharmacology & Pharmacy
Qin Hui Li, Kenneth Kim, Sujan Shresta
Summary: Seven years after the onset of the Zika virus epidemic, longitudinal studies have shown that children infected in utero without severe birth defects exhibit motor skill deficits at up to 3 years of age. The long-term health and socioeconomic impacts of fetal Zika virus infection seem inevitable. In the absence of vaccines or antivirals, small animal models of Zika virus transmission are essential to test antiviral strategies and understand the mechanisms of immunity at the maternal-fetal interface. The review discusses the current state of Zika virus transplacental transmission models, highlights key unanswered questions, and sets goals for the next generation of mouse models.
ANTIVIRAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Xianlong Zhang, Guoliang Li, Guang Chen, Niu Zhu, Di Wu, Yongning Wu, Tony D. James
Summary: Zika virus is a particularly notorious mosquito-borne flavivirus with devastating effects on both fetuses and adults. Researchers worldwide are working tirelessly to develop effective detection strategies and vaccines to combat ZIKV infection.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Multidisciplinary Sciences
Sumit Sen Santara, Angela C. Crespo, Sachin Mulik, Cristian Ovies, Selma Boulenouar, Jack L. Strominger, Judy Lieberman
Summary: Zika virus infection during pregnancy can lead to placental damage and fetal birth defects, with limited understanding of the cellular immune response at the maternal-fetal interface. Research has shown that dNK cells in the first trimester are able to kill Zika virus-infected trophoblasts, indicating that certain immune cells protect the fetus by eliminating infected cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Judith Estevez-Herrera, Silvia Perez-Yanes, Romina Cabrera-Rodriguez, Daniel Marquez-Arce, Rodrigo Trujillo-Gonzalez, Jose-David Machado, Ricardo Madrid, Agustin Valenzuela-Fernandez
Summary: Zika virus infection and its associated disorders remain a Public Health Emergency of International Concern, with pathogenicity involving immune evasion as a critical factor.
Article
Virology
Rosa Estela Gazeta, Ana Paula Antunes Pascalicchio Bertozzi, Rita de Cassia de Aguirre Bernardes Dezena, Andrea Cristina Botelho Silva, Thamirys Cosmo Gillo Fajardo, Daniel T. Catalan, Maria de Fatima Valente Rizzo, Antonio Fernandes Moron, Antoni Soriano-Arandes, Nuria Sanchez Clemente, Tania Quintella, Dora Fix Ventura, Francisco Max Damico, Valtenice de Cassia Rodrigues de Matos Franca, Juliana Paula Gomes de Almeida, Ana Laura de Sene Amancio Zara, Lucas Castro Pires, Cohort Zika virus Jundiai, Saulo Duarte Passos
Summary: Congenital Zika virus infection can result in a wide range of clinical manifestations, including developmental delays and neurological abnormalities. Longitudinal study of high-risk pregnant women and their newborns showed that some patients may continue to experience developmental delays beyond the age of three, highlighting the importance of long-term follow-up.
Review
Biochemistry & Molecular Biology
Jonathan Turpin, Daed El Safadi, Gregorie Lebeau, Morgane Krejbich, Camille Chatelain, Philippe Despres, Wildriss Viranaicken, Pascale Krejbich-Trotot
Summary: Cell death by apoptosis is a major cellular response in the control of tissue homeostasis and viral clearance. This study focuses on the interplay between Zika virus (ZIKV) infection and apoptosis in different cell types, and how the virus deals with this cellular response. The effects of ZIKV-controlled apoptosis are dual, depending on the timing and context, and understanding this interplay may have implications for ZIKV-related therapies and the use of ZIKV as an oncolytic agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Avelino Nunez-Delgado, Warish Ahmed, Jesus L. Romande, Kuldeep Dhama, Jose L. Domingo
Summary: This article introduces a virtual special issue on the origin of the SARS-CoV-2 virus, aiming to shed light on the matter through high-quality scientific research papers. The special issue received 50 submissions, and the most outstanding papers were accepted for publication after careful peer-review. The editors believe that these papers provide valuable contributions to the scientific community and society.
ENVIRONMENTAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Mahmoud Alagawany, Rana Muhammad Bilal, Shaaban S. S. Elnesr, Hamada A. M. Elwan, Mayada R. R. Farag, Kuldeep Dhama, Mohammed A. E. Naiel
Summary: Scientists around the world are interested in developing alternative technologies and materials to replace antibiotics in poultry farming. These efforts include substituting antibiotic growth promoters in poultry feeds and reducing the overall use of veterinary antibiotics for organic products. One approach is the use of beneficial bacteria and medicinal herbs, with probiotics becoming a common practice in commercial poultry production. Yeast-based products are being considered as alternative supplements in poultry feed due to their health and nutritional advantages, as their inclusion has shown to enhance nutrient utilization and increase egg production in layer chickens.
WORLDS POULTRY SCIENCE JOURNAL
(2023)
Article
Immunology
Chiranjib Chakraborty, Manojit Bhattacharya, Srijan Chatterjee, Ashish Ranjan Sharma, Rudra P. Saha, Kuldeep Dhama, Govindasamy Agoramoorthy
Summary: Pattern recognition is crucial in integrative bioinformatics to determine the structural patterns of proteins in viruses such as SARS-CoV-2. This study identifies the patterns of SARS-CoV-2 proteins to understand the structure-function relationships. Various models and algorithms were used, and the functionality of proteins was found to be unique.
Editorial Material
Infectious Diseases
Jaffar A. Al-Tawfiq, Hitesh Chopra, Kuldeep Dhama, Ranjit Sah, Patricia Schlagenhauf, Ziad A. Memish
NEW MICROBES AND NEW INFECTIONS
(2023)
Letter
Surgery
Sirwan K. Ahmed, Rabab G. A. El-Kader, Salar O. Abdulqadir, Ardalan J. Abdullah, Nahed A. El-Shall, Deepak Chandran, Abhijit Dey, Talha B. Emran, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Hitesh Chopra, Md. Aminul Islam, Deepak Chandran, Talha B. Emran, Ebad Ur Rehman Mohammad, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Madhumita Pal, Smita Parija, Ganapati Panda, Snehasish Mishra, Ranjan K. Mohapatra, Kuldeep Dhama
Summary: Global public health is overwhelmed by COVID-19. This study aims to use deep learning approaches to classify chest X-ray images of COVID-19 cases. The findings show that computer-aided analysis could help address health emergency situations with limited resources and improve early screening.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Akriti Goel, Garima, Navidha Aggarwal, Garima Kapoor, Hitesh Chopra, Mamta Naagar, Aishwarya Gangwar, Prachi Singh, Kuldeep Dhama
Summary: Skin and soft tissue infections (SSTIs) occur when microbes invade the skin and underlying tissues, leading to various shapes and high severity levels. Distinguishing between SSTIs that require immediate attention and intervention from those that don't is challenging. SSTIs are most common in emergency rooms, affecting 7% to 10% of hospitalized patients. They are characterized by inflammation, fever, rapidly growing lesions, and bullae. Developing a severity categorization approach for appropriate empirical treatment would enhance SSTI management. Antibiotic medication is chosen based on the patient's condition and knowledge of potential infections. Oral antibiotics are sufficient for simple mild-to-moderate infections, while intravenous antibiotics are required for complicated severe infections.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2023)
Editorial Material
Medicine, Research & Experimental
Chiranjib Chakraborty, Abinit Saha, Manojit Bhattacharya, Kuldeep Dhama, Govindasamy Agoramoorthy
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Biochemistry & Molecular Biology
Nirmala Sehrawat, Mukesh Yadav, Sunil Kumar, Ashwanti Devi, Rajbir Singh, Varruchi Sharma, Kuldeep Dhama, Jose M. Lorenzo, Anil Kumar Sharma
Summary: Cancer remains a major challenge for humans. Researchers have turned their attention to plant-based metabolites, such as those found in mung beans, as a safe and cost-effective strategy for preventing carcinogenesis. Mung beans are nutritionally important legumes that contain bioactive phytochemicals and easily digestible proteins, providing various health benefits. Regular consumption of mung beans can regulate metabolism and have anti-inflammatory, antioxidant, antiproliferative, and immunomodulatory effects, which may help prevent cancer.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Bimal Kumar Sarkar, Manojit Bhattacharya, Govindasamy Agoramoorthy, Kuldeep Dhama, Chiranjib Chakraborty
Summary: This study uses entropy-driven bioinformatics to analyze the global spread of monkeypox virus (mpox), finding that it likely originated from African countries and spread to non-African countries. The results provide important insights into the evolution and pathogenicity of mpox and can help inform preventive measures to halt the spread of the virus.
MOLECULAR BIOTECHNOLOGY
(2023)
Letter
Medicine, General & Internal
Ramadan Abdelmoez Farahat, Abubakar Nazir, Sidhant Ochani, Sheharyar Hassan Khan, Annama Mahjabin, Saleh Mohammed, Israt Jahan, Khadizatul Kubra, Sarya Swed, Kuldeep Dhama
EGYPTIAN JOURNAL OF INTERNAL MEDICINE
(2023)
Letter
Surgery
Shopnil Akash, Talha B. Emran, Hitesh Chopra, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Sirwan Khalid Ahmed, Deepak Chandran, Safin Hussein, S. Praveen, Sandip Chakraborty, Md. Rabiul Islam, Kuldeep Dhama
Summary: Two powerful earthquakes in Turkey and Syria resulted in tens of thousands of deaths and hundreds of thousands of injuries. The immediate physical impact was severe, but the long-term health consequences, including strain on healthcare services and the potential for disease outbreaks, were also concerning. This article outlines approaches to reducing health risks for the victims of these earthquakes.
ENVIRONMENTAL HEALTH INSIGHTS
(2023)
Review
Chemistry, Multidisciplinary
Hardeep Singh Tuli, Ruchira Joshi, Ginpreet Kaur, Vivek Kumar Garg, Katrin Sak, Mehmet Varol, Jagjit Kaur, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Diwakar Aggarwal, Kuldeep Dhama, Vivek Sheel Jaswal, Sonam Mittal, Gautam Sethi
Summary: Nanotechnology has led to the development of new materials (metal nanoparticles) that have specific applications in healthcare, particularly in the diagnosis and treatment of cancer. Metal nanoparticles can modulate molecular expression in the tumor microenvironment and have anti-cancer effects by inducing apoptosis and cell cycle arrest. They can also inhibit tumor angiogenesis, metastasis, and inflammation, thus preventing cancer proliferation.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)