Article
Pharmacology & Pharmacy
Abdul Ahad, Yousef A. Bin Jardan, Mohd Zaheen Hassan, Mohammad Raish, Ajaz Ahmad, Abdullah M. Al-Mohizea, Fahad Al-Jenoobi
Summary: The aim of this study was to improve the solubility and dissolution rate of eprosartan mesylate by preparing an inclusion complex with beta-cyclodextrin using microwave technique. The inclusion complex showed better drug release profile compared to the physical mixture or pure drug, indicating its potential to improve the solubility and bioavailability of eprosartan. Molecular modeling study confirmed the good affinity of eprosartan to beta-cyclodextrin. This research provides valuable insights into enhancing the solubility of eprosartan.
Article
Biochemistry & Molecular Biology
Mattanun Sangkhawasi, Khanittha Kerdpol, Abbas Ismail, Bodee Nutho, Chonnikan Hanpiboon, Peter Wolschann, Kuakarun Krusong, Thanyada Rungrotmongkol, Supot Hannongbua
Summary: Alpha-tocopherol is the most biologically active form of vitamin E, but its low water solubility limits its potential use in various industries. This study explores the use of large-ring cyclodextrins (LR-CDs) to enhance its solubility. The results suggest that a 1:2 ratio of CD26 to alpha-tocopherol is the most suitable stoichiometry for improving solubility and stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Irene Degrassi, Ilaria Leonardi, Elisabetta Di Profio, Chiara Montanari, Gianvincenzo Zuccotti, Elvira Verduci
Summary: This review identifies the current indications and gaps in the management of fat-soluble vitamins in pediatric patients with cholestasis. A comprehensive literature review was conducted, and relevant studies published in the past 20 years were selected. The causes of malabsorption, recommended methods of supplementation, and monitoring complications were discussed. The literature suggests that children with cholestasis are at a higher risk of fat-soluble vitamin deficiency, but there is no uniform validated treatment for vitamin deficiency.
Article
Chemistry, Applied
Wei Chen, Haiying Yu, Ruijie Shi, Chenglong Ma, Munkh-Amgalan Gantumur, Abdul Qayum, Akhunzada Bilawal, Guizhao Liang, Kwang-Chol Oh, Zhanmei Jiang, Juncai Hou
Summary: This study investigates the interaction mechanisms between alpha-lactalbumin (ALa) and three fat-soluble vitamins (VA, VD3, VE), showing that VD3 has the highest binding affinity for ALa. The addition of VA and VD3 increases the zeta potential and surface hydrophobicity of ALa, while VE initially increases and then decreases it. Molecular simulation suggests that VA and VE bind at the same site in ALa, while VD3 binds in a hydrophobic pocket with binding forces being hydrophobic interaction and hydrogen bond.
FOOD HYDROCOLLOIDS
(2021)
Article
Food Science & Technology
Srujana Mekala, Eric Keven Silva, Marleny D. A. Saldana
Summary: This study investigated the chemical stability of a vitamin complex in emulsion-filled hydrogels produced using high-intensity ultrasound as the homogenization technique. The hydrogels showed shear-thinning behavior and the addition of ascorbic acid had no significant effect on the rheological properties. Samples processed under specific conditions had maximum retention capacity and the presence of ascorbic acid improved antioxidant activity and reduced lipid oxidation.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Article
Spectroscopy
Vimalasruthi Narayanan, Manawwer Alam, Naushad Ahmad, Suganya Bharathi Balakrishnan, Vigneshkumar Ganesan, Esakkimuthu Shanmugasundaram, Brindha Rajagopal, Stalin Thambusamy
Summary: In this study, solid inclusion complexes of CA/CDs were incorporated into PVA nanofibers using electrospinning technique to enhance solubility and antibacterial activity. The physical properties of CA/CDs were examined and the formation of ICs was confirmed. PVA/CA/CDs demonstrated promising performance in terms of antibacterial activity and solubility enhancement.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Agriculture, Multidisciplinary
Chuan Cao, Dongmei Wei, Li Xu, Jinwei Hu, Jun Qi, Yibin Zhou
Summary: In this study, LR-CDs complexed with TTO were prepared by co-precipitation methods. The complexation efficiency was up to 86.23%, enhancing the solubility and thermal stability of TTO, while maintaining its volatile characteristics.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Polymer Science
Ine Suharyani, Muchtaridi Muchtaridi, Ahmed Fouad Abdelwahab Mohammed, Khaled M. Elamin, Nasrul Wathoni, Marline Abdassah
Summary: The study aimed to enhance the solubility of alpha-Mangostin in water by forming a complex with Cyclodextrin, resulting in a significant increase in solubility and potential for water-based preparation for clinical applications.
Article
Chemistry, Physical
Liyuan Chen, Waixiang Yang, Chuanzhu Gao, Xiali Liao, Jing Yang, Bo Yang
Summary: In this study, two bridged cyclodextrin dimers were designed and synthesized for the encapsulation of CBD, leading to significantly improved water solubility and antioxidant activity without compromising its anti-tumor activity.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Engineering, Chemical
Abdul Ahad, Yousef A. Bin Jardan, Mohammad Raish, Abdullah M. Al-Mohizea, Fahad Al-Jenoobi
Summary: The aim of this study was to enhance the solubility and dissolution rate of sinapic acid (SA) by formulating a binary inclusion complex with hydroxypropyl-beta-cyclodextrin (HP beta CD) using solvent evaporation technology. The results showed that the inclusion complex significantly improved the solubility of SA and exhibited stronger antioxidant activity compared to pure SA.
Article
Pharmacology & Pharmacy
Anna A. Kravtsova, Anna A. Skuredina, Alexander S. Malyshev, Irina M. Le-Deygen, Elena V. Kudryashova, Ekaterina M. Budynina
Summary: In this study, the water solubility of biologically active spiro[cyclopropane-1,3'-oxindoles] (SCOs) was improved through complexation with different beta-cyclodextrins (beta-CDs), and a possible mechanism of complex formation was proposed. Beta-CDs significantly increased the water solubility of SCOs (up to fourfold), and the nature of the substituents in the beta-CDs influenced the solubility of the guest molecule. The complexation occurred via the inclusion of aromatic moieties of SCOs into the hydrophobic cavity of beta-CDs, forming stable supramolecular systems.
Article
Biochemistry & Molecular Biology
Arantza Zornoza, Itziar Velaz, Gustavo Gonzalez-Gaitano, Maria Cristina Martinez-Oharriz
Summary: This study investigated the complexation of GEM with β-CD and its derivatives under different conditions. Stable constants were determined using multiple techniques, and the advantages and drawbacks of each analytical technique were discussed. Additionally, the thermodynamic parameters of complexation were studied, and the complexation of solid dispersions was evaluated using X-ray diffraction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Pooja Suvarna, Pinal Chaudhari, Sumit Birangal, Lakshmi Sruthi Mallela, Sanhita Roy, Ananthamurthy Koteshwara, Jesil Mathew Aranjani, Shaila Angela Lewis
Summary: The study demonstrated that the formation of cyclodextrin-based ternary complexes and incorporation into mucoadhesive films improved the solubility, transcorneal permeation, and antifungal activity of voriconazole, offering a promising strategy for the management of fungal keratitis.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Marius Fuchs, Christian Viel, Alina Lehto, Helene Lau, Jochen Klein
Summary: Antioxidants such as vitamin C and vitamin E have protective effects in the brain, reducing oxidative damage caused by seizures. Other antioxidants tested in this study were ineffective.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Maryam Ghahremani-nasab, Naeimeh Akbari-Gharalari, Azizeh Rahmani Del Bakhshayesh, Armita Ghotaslou, Abbas Ebrahimi-kalan, Mahdi Mahdipour, Ahmad Mehdipour
Summary: The study provides evidence that 3D CA/AA/TP composite hydrogels seeded by rMSCs in hypoxic conditions have great potential to improve wound healing.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Oncology
Parijat Pandey, Hitesh Chopra, Deepak Kaushik, Ravinder Verma, Deepika Purohit, Jatin Parashar, Vineet Mittal, Md. Habibur Rahman, Saurabh Bhatia, Pradeep Kumar, Tanima Bhattacharya, Priti Tagde, Ahmed Al-Harrasi
Summary: Cancer remains a leading cause of death worldwide, and while there are treatment options available, their adverse effects often outweigh their therapeutic benefits. Nanotechnology shows promise in addressing these issues, but further development is needed. Stimuli-responsive nanomedicine, dendrimers, micelles, and lipid-based nano-formulations have been explored for their efficacy in cancer treatment. This review paper highlights significant patents granted/applied globally that utilize nanotechnology for cancer treatment, with focus on enhancing the ADME profile of therapeutic molecules.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Sunaina Indermun, Pradeep Kumar, Mershen Govender, Yahya E. E. Choonara
Summary: Tyrosine kinase inhibitors (TKIs) are effective drug molecules for treating various cancers. Nanomedicinal interventions and approaches can enhance the efficacy of TKIs by providing carrying capacities and potentially targeting tumor-specific environments and cellular compartments. Different nanosystems have been developed for TKI delivery in cancer treatment, with each having their own preparation methods and physicochemical properties. This review discusses the applicability of nano-interventions for combination therapies, dose reduction, and improved treatment outcomes, highlighting the efficacy of developed nanosystems against different cancer cell lines and models.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Polymer Science
Sindy P. Ndlovu, Thierry Y. Fonkui, Pradeep Kumar, Yahya E. Choonara, Derek T. Ndinteh, Blessing A. Aderibigbe
Summary: A major challenge in treating burn wounds is bacteria invasion which prolongs the wound healing process. To address the issue of skin tears caused by removal of wound dressings, researchers designed dissolvable wound dressings that can be easily removed without causing tears, while also exhibiting desirable antibacterial activity and absorption capability.
Article
Pharmacology & Pharmacy
Mumuni Sumaila, Pradeep Kumar, Philemon Ubanako, Samson A. Adeyemi, Yahya E. Choonara
Summary: This research reports the design and characterization of rifampicin (RIF) and isoniazid (INH) loaded hybrid lipid-polysaccharide nanoparticles using the solvent injection method, and demonstrated the influence of conjugated mannosyl residue on macrophage targeting and intracellular drug delivery capacity.
CURRENT DRUG DELIVERY
(2023)
Article
Biochemistry & Molecular Biology
Z. Feketshane, S. A. Adeyemi, P. Ubanako, D. T. Ndinteh, S. S. Ray, Y. E. Choonara, B. A. Aderibigbe
Summary: This study developed dissolvable antibacterial wound dressing patches for the treatment of infected wounds in patients with highly sensitive skin. These patches exhibited good tensile strength, appropriate thickness, and good flexibility suitable for the skin. They also displayed good biodegradability and low moisture uptake to prevent microbial invasion and demonstrated sustained release of the drug to inhibit bacterial infection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Hillary Mndlovu, Lisa C. du Toit, Pradeep Kumar, Yahya E. Choonara
Summary: This study developed scaffolds using polymers and peptides for wound healing and skin tissue regeneration. The scaffolds showed improved mechanical properties through crosslinking with tannic acid and transformed physicochemical and morphological features through the use of RGD. The superior performance of these scaffolds in promoting wound healing and tissue regeneration was demonstrated.
BIOMEDICAL MATERIALS
(2023)
Review
Medicine, Research & Experimental
Simisola Ayodele, Pradeep Kumar, Armorel van Eyk, Yahya E. Choonara
Summary: Tuberculosis remains a major threat to global health, mainly due to drug resistance and immune compromise. Repurposing drugs as host-directed therapies can improve clinical outcomes by enhancing antimicrobial activity and reducing treatment duration, while minimizing the risk of drug resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mduduzi N. Sithole, Pradeep Kumar, Lisa C. Du Toit, Kennedy H. Erlwanger, Philemon N. Ubanako, Yahya E. Choonara
Summary: This research utilized a 3D-printed biomaterial scaffold to enhance bone tissue regeneration. The scaffold exhibited essential biomineral trace elements and supported cell adhesion and proliferation. The protein-embedded scaffolds showed higher bone formation potential compared to the control group. It provides a potential platform for functional regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Ahmed Abdelgader, Mershen Govender, Pradeep Kumar, Yahya E. Choonara
Summary: Locally delivered estrogens, administered via tablets, capsules, rings, pessaries, and creams, are highly recommended for treating the genitourinary syndrome of menopause (GSM). Among these, estradiol, either alone or in combination with progestins, effectively alleviates moderate to severe menopausal symptoms. This review compares different commercially available and non-commercial vaginal estradiol formulations in terms of absorption, efficacy, safety, and patient satisfaction.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Polymer Science
Mershen Govender, Thankhoe A. Rants'o, Yahya E. Choonara
Summary: A micro-in-macro gastroretentive and gastrofloatable drug delivery system (MGDDS) loaded with ciprofloxacin was developed to overcome the limitations of narrow-absorption window (NAW) drug delivery. The system, consisting of microparticles loaded in a gastrofloatable macroparticle, successfully modified the release of ciprofloxacin and increased drug absorption. This study demonstrates the potential of the MGDDS in delivering other NAW drugs.
Article
Biochemistry & Molecular Biology
Divesha Essa, Pierre P. D. Kondiah, Pradeep Kumar, Yahya E. E. Choonara
Summary: In this study, quercetin-loaded PLGA nanoparticles were prepared and optimized. It was found that coating with chitosan increased the cellular uptake of the nanoparticles and folic acid targeting provided selective toxicity and enhanced uptake in LnCap prostate cancer cells. The targeted nano-system exhibited sustained, pH-dependent quercetin release, higher cytotoxicity, and cellular uptake in LnCap cells compared to non-targeted nano-system.
Review
Biochemistry & Molecular Biology
Divya Thirumal, Rakesh K. Sindhu, Shuchi Goyal, Aayush Sehgal, Ashok Kumar, Marianesan Arockia Babu, Pradeep Kumar
Summary: Psoriasis is an inflammatory skin condition that causes various diseases and significantly affects patients' quality of life. It not only impairs the skin but also affects other parts of the body. Many variables can directly or indirectly impact the etiology of psoriasis. Psoriasis affects approximately 2% of the world's population, and significant progress has been made in understanding and treating alternative forms of psoriasis.
Review
Pharmacology & Pharmacy
Pavan Walvekar, Pradeep Kumar, Yahya E. Choonara
Summary: Bolus vaccines are often administered multiple times due to inadequate activation of T and B lymphocytes. Recent research focuses on developing long-acting vaccine delivery systems that can enhance antigen presentation in lymph nodes and achieve robust immune responses. Various polymers and lipids have been explored to develop effective biomaterial-based vaccine strategies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Mashudu T. Mphaphuli, Mduduzi N. Sithole, Pradeep Kumar, Pierre P. D. Kondiah, Mostafa Mabrouk, Yahya E. Choonara
Summary: This review examines the current use of nanotechnology as a drug delivery system for anti-TB drugs and explores the potential of integrating these nanoparticle systems into bioactive three-dimensional biomaterial scaffolds. This innovative approach has the potential to revolutionize the treatment of bone TB and CNS-TB.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Plant Sciences
Arvind Sharma, Harapriya Mohapatra, Kanika Arora, Ritchu Babbar, Rashmi Arora, Poonam Arora, Pradeep Kumar, Evren Algin Yapar, Kailash Rani, Maninder Meenu, Marianesan Arockia Babu, Maninderjit Kaur, Rakesh K. Sindhu
Summary: This review provides insights into plant and herbal formulations for preventing hair loss and stimulating new hair growth, focusing on the molecular mechanisms of hair growth and loss, hair growth-promoting phytoconstituents, and the application of nanoarchitectonic technologies.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
