Article
Biochemistry & Molecular Biology
Darshan R. Telange, Shirish P. Jain, Anil M. Pethe, Prashant S. Kharkar, Nilesh R. Rarokar
Summary: A novel nanocarrier system FAPLC CNPs was developed to improve the oral bioavailability and antioxidant potential of FA. Characterization studies showed that FAPLC CNPs exhibited lower particle size, higher solubility, dissolution, and permeation rate compared to traditional FA. In vivo studies demonstrated significant enhancement of oral bioavailability and antioxidant activity of FA from FAPLC CNPs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Heng Chen, Xiao Duan, Jianbin Xu, Biao Wang, Sihan Xiang, Xin Wang
Summary: A water-soluble safe antioxidant, ferulic acid-chitosan complex, was easily prepared in water with mild-temperature heating. The complex exhibits improved water solubility and higher antioxidative property compared to its precursors. This approach enables the development of chitosan-based functional biomaterials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Jianghao Yan, Min Li, Huifang Wang, Xiaojie Lian, Yanying Fan, Zhigao Xie, Baolong Niu, Wenfeng Li
Summary: Novel biodegradable composite packages based on biodegradable materials show enhanced performances in terms of tensile strength, water resistance, and antioxidant activity. The addition of Cu2O@NCs further improves the properties of the films, making them suitable for functional food packaging with great potential.
Article
Food Science & Technology
Haishan Xu, Xincheng Fu, Hui Kong, Fei Chen, Xia Chang, Zemin Ding, Rongrong Wang, Yang Shan, Shenghua Ding
Summary: Ultrasonication-assisted Fenton-system (US-Fenton) was used to synthesize chitosan-ferulic acid conjugates, and the effect of different ultrasonication times on the conjugates was investigated. The conjugate obtained after 1 minute of ultrasonication (FUS1) showed the highest grafting ratio and had improved structural and functional properties compared to the Fenton-grafted method. The FUS1 conjugate also exhibited strong antioxidant and antibacterial activities. A film made from FUS1 showed decreased viscosity, improved barrier properties, and increased water solubility and tensile strength compared to a chitosan film.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Parichehr Hassanzadeh, Elham Arbabi, Fatemeh Rostami
Summary: Nanotechnology-based approaches are utilized to enhance the pharmacological properties of the phenolic compound ferulic acid, demonstrating therapeutic potential in acute pancreatitis by targeted delivery.
Article
Food Science & Technology
Guotian Wang, Yunpeng Liu, Huimin Yong, Shuai Zong, Changhai Jin, Jun Liu
Summary: The use of ferulic acid-g-CS coating was found to effectively extend the shelf life of refrigerated pork and improve its quality by providing strong antioxidant and antimicrobial activities.
Article
Chemistry, Physical
Chen Li, Kun Fang, Wei He, Kai Li, Yi Jiang, Jianbin Li
Summary: In this study, bovine serum albumin was loaded onto chitosan-ferulic acid conjugants as a model protein drug carrier. The conjugates exhibited high thermal stability and superior in vitro sustained release property, making them suitable for oral carrier in functional foods and drug delivery systems.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Materials Science, Coatings & Films
Muhammad Asim Akhtar, Camilla E. Mariotti, Bice Conti, Aldo R. Boccaccini
Summary: In this study, chitosan-bioactive glass-ferulic acid composite coatings were successfully fabricated using AC-EPD technique. The coatings exhibited good biocompatibility and antibacterial properties, enhancing the viability of MG-63 human osteoblast-like cells. Furthermore, the coatings formed a hydroxyapatite surface layer after incubation in simulated body fluid.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Agricultural Engineering
Qun Zhang, Yangyang Sun, Yu Liu
Summary: In this study, chitosan (CS) and phytic acid (PA) polymers and nanoparticles were synthesized and characterized for the preparation of materials with dye adsorption and drug delivery properties. The CS-PA polymers and nanoparticles were prepared through a simple one-step ionic cross-linking protocol, with their formation depending on solution pH, CS and PA molecular weight, and concentration. The materials exhibited different morphologies and sizes based on the experimental conditions, and showed good stability under specific conditions. The study provides insights for the construction and application of CS-based materials.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Nanoscience & Nanotechnology
Vijay Kumar Pal, Sangita Roy
Summary: In this study, a bio-nano construct with dual functionality and stimuli-responsive assembly behavior was fabricated for wound healing applications. The spherical nano-particles formed by the collagen-inspired peptide amphiphile underwent a shape transition and released a hydrophobic drug when exposed to the basic chronic wound environment.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Emilli Antonio, Osmar dos Reis Antunes Junior, Rossana Gabriela Del Jesus Vasquez Marcano, Camila Diedrich, Juliane da Silva Santos, Christiane Schineider Machado, Najeh Maissar Khalil, Rubiana Mara Mainardes
Summary: Nanoparticles containing UA with chitosan modification were developed to improve oral bioavailability, showing potential application for cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Lili Zheng, Minghan She, Binling Ai, Yang Yang, Xiaoyan Zheng, Shenwan Wang, Dao Xiao, Zhiguo Jiang, Zhanwu Sheng
Summary: A double network hydrogel (DN) was synthesized by forming protein and polysaccharide micronetworks, and then inducing cross-links using genipin. The DN showed improved controlled release ability and increased load rate due to its higher structural complexity and mechanical integrity. The addition of polysaccharide network increased the proportion of beta-sheet structures, resulting in higher storage modulus and lower solubility.
FOOD HYDROCOLLOIDS
(2023)
Article
Nanoscience & Nanotechnology
Zi Chao Wu, Xin Yu Liu, Jia Yan Liu, Jing Shu Piao, Ming Guan Piao
Summary: This study investigates the use of betulinic acid-loaded galactosylated chitosan nanoparticles (BA-GC-NPs) for liver protection in the treatment of liver fibrosis. The results demonstrate that BA-GC-NPs have a small diameter and a core-shell structure, and can consistently and continuously release betulinic acid. In vitro and in vivo studies show that BA-GC-NPs have good biocompatibility and liver-targeting potential, reducing the degree of liver injury in a mouse model of liver fibrosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Danni Feng, Renyin Zhang, Mengting Zhang, Ashe Fang, Feng Shi
Summary: In this study, silver nanoparticles were synthesized using glycyrrhizin as a reducing agent and stabilizer. The synthesized nanoparticles showed high antibacterial activity against Escherichia coli and Staphylococcus aureus, and low cytotoxicity to human kidney epithelial cells. The results suggest that glycyrrhizin-reduced silver nanoparticles have potential applications in antibacterial treatments.
Article
Acoustics
Nairah Noor, Adil Gani, Faiza Jhan, Mohammad Ashraf Shah, Zanoor ul Ashraf
Summary: The use of starch-based nanoparticles in stabilizing pickering emulsions has gained popularity due to its various advantages. In this study, resistant starch nanoparticles (RSN) were isolated from lotus stem and used to stabilize flax seed-oil water mixture to form pickering emulsions. Ferulic acid (FA) was nanoencapsulated using ultrasonication, and the resulting emulsions were lyophilized to form FA-loaded lyophilized pickering emulsion (FA-LPE). The FA-LPE was characterized using various techniques, and it was found to have controlled release of FA and higher bioactivity compared to FA-LPE with lower concentrations. This study demonstrates the potential of pickering emulsions for nutraceutical delivery in food and supplement products.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Rania M. Hathout, AbdelKader A. Metwally, Timothy J. Woodman, John G. Hardy
Article
Pharmacology & Pharmacy
Nermine V. Fares, Hend Abd-Allah, Ahmed E. Sobaih, Hind Atta, Nada Ramekh, Hala Khaled, Mina William, Jailan Adel, Ali Waheed, Yasmeena Hisham, Omar Mostafa, Dina Sharbek, Mohamed Samir, Rania M. Hathout
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Adrian Magaz, Mark D. Ashton, Rania M. Hathout, Xu Li, John G. Hardy, Jonny J. Blaker
Article
Chemistry, Inorganic & Nuclear
Heba A. Gad, Rania M. Hathout
Summary: The study explores the possibility of using molecular dynamics and docking experiments to select a suitable natural bio-macromolecule for loading doxorubicin into nanoparticles, aiming at improving drug loading efficiency and release rate. The results of docking experiments are highly correlated with the loading data obtained from literature, demonstrating the reliability and effectiveness of docking experiments in selecting drug carriers.
JOURNAL OF CLUSTER SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Nada M. El Hoffy, Engy A. Abdel Azim, Rania M. Hathout, Marwa A. Fouly, Seham A. Elkheshen
Summary: Glaucoma, a worldwide cause of irreversible vision loss, is often asymptomatic in late stage. Targeted smart delivery systems in the field of glaucoma treatment have attracted interest for their potential to overcome treatment challenges.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
John G. Hardy, Stephanie Sdepanian, Alison F. Stowell, Amal D. Aljohani, Michael J. Allen, Ayaz Anwar, Dik Barton, John Baum, David Bird, Adam Blaney, Liz Brewster, David Cheneler, Olga Efremova, Michael Entwistle, Reza N. Esfahani, Melike Firlak, Alex Foito, Leandro Forciniti, Sydney A. Geissler, Feng Guo, Rania M. Hathout, Richard Jiang, Punarja Kevin, David Leese, Wan Li Low, Sarah Mayes, Masoud Mozafari, Samuel T. Murphy, Hieu Nguyen, Chifundo N. M. Ntola, George Okafo, Adam Partington, Thomas A. K. Prescott, Stephen P. Price, Sherif Soliman, Papri Sutar, David Townsend, Patrick Trotter, Karen L. Wright
Summary: Multidisciplinary teaching improves learners' affective and cognitive learning abilities, and the inclusion of chemistry as a discipline in higher education is increasingly important.
JOURNAL OF CHEMICAL EDUCATION
(2021)
Article
Pharmacology & Pharmacy
Muhammed Ossama, Rania M. Hathout, Dalia A. Attia, Nahed D. Mortada
Summary: The physically adsorbed Poloxamer 188 coating polymer enhanced the cytotoxicity of allicin-loaded gelatin nanoparticles, making them suitable for cancer-targeting therapies. The prepared nanoparticles were stable to gamma-sterilisation and had a storage life of 12 months.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Shaymaa A. Abd-algaleel, Hend M. Abdel-Bar, Abdelkader A. Metwally, Rania M. Hathout
Summary: This review summarizes different trials for modeling and predicting drug payload in lipid and polymeric nanocarriers. It discusses the evolution of the field from early attempts using solubility and Flory-Huggins models to the emergence of molecular dynamic simulations and docking studies, and finally to the successful era of artificial intelligence and machine learning. Key aspects are reviewed through sequential examples that highlight both matching and poorly matching studies with wet lab-dry lab results.
Article
Chemistry, Medicinal
Sara Zaher, Mahmoud E. Soliman, Mahmoud Elsabahy, Rania M. Hathout
Summary: In this study, sesamol-loaded albumin nanoparticles showed a better protective effect against oxidative stress induced by anthracyclines. The nanoparticles were prepared using the desolvation technique and freeze-dried with trehalose as a cryoprotectant. The optimized nanoparticles had a spherical shape, smaller particle diameter, longer half-life, and mean residence time compared to the free drug. In vivo experiments demonstrated that the sesamol-loaded albumin nanoparticles significantly ameliorated biochemical markers and histopathological changes.
Article
Pharmacology & Pharmacy
Maria B. Sokol, Margarita Chirkina, Nikita G. Yabbarov, Mariia R. Mollaeva, Tatyana A. Podrugina, Anna S. Pavlova, Viktor V. Temnov, Rania M. Hathout, Abdelkader A. Metwally, Elena D. Nikolskaya
Summary: In this study, a combination of molecular dynamics simulation and in vitro experiments was used to improve the design of polymer-based nanoparticles for cancer treatment. The results showed that nanoparticles loaded with novel carboplatin derivatives exhibited high antitumor activity and hemocompatibility, indicating the potential for optimizing encapsulation and antitumor efficacy in drug delivery system design.
Article
Biotechnology & Applied Microbiology
Rania M. Hathout, Eman M. El-Marakby
Summary: The intranasal route is a highly promising route for drug delivery to the brain, but also one of the most difficult and complex. Scientists are continuously searching for new drug delivery vehicles, and in this study, the superiority of nanocarriers, with lipid nanoparticles in particular, was confirmed.
BIOENGINEERING-BASEL
(2022)
Article
Pharmacology & Pharmacy
Merna H. Emam, Reham S. Elezaby, Shady A. Swidan, Samah A. Loutfy, Rania M. Hathout
Summary: In this study, cerium oxide nanoparticles were successfully incorporated into polyacrylonitrile nanofibers for the fabrication of antiviral filters. These nanofibers showed excellent bacterial filtration efficiency and were non-toxic to cells. Furthermore, the cerium oxide nanoparticles exhibited antiviral activity. Therefore, this nanofiber can effectively reduce virus transmission.
Article
Polymer Science
Rania M. Hathout
Summary: This study confirms the ability of polymeric nanoparticulate systems to enhance the absorption and bioavailability of orally administered drugs through systematic review and meta-analysis. Polymeric nanoparticles significantly increase the area under the curve compared to conventional formulations. Furthermore, there are no significant differences between synthetic polymeric nanoparticles and their naturally-based counterparts.
Review
Pharmacology & Pharmacy
Salma M. Abdel-Hafez, Rania M. Hathout, Omaima A. Sammour
Summary: Curcumin has attracted attention from scientists in oncology and therapeutics, but its delivery faces limitations. Researchers have made efforts to deliver curcumin through the transdermal route, which may offer a new platform for targeting solid tumors like breast carcinoma.
ADVANCES IN TRADITIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Rania M. Hathout, Dina H. Kassem
Summary: The article introduces a new method for preventing COVID-19 by reducing the viral load at body entrances, using formulations containing viral electrostatic repulsive nanofibers. ε-poly-L-lysine was prepared using the electrospinning technique.
SCIENTIA PHARMACEUTICA
(2021)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
