Review
Chemistry, Analytical
Wang Li, Xiaoyue Zhang, Tingting Li, Yibing Ji, Ruijun Li
Summary: The integration of molecularly imprinted polymers with paper-based analytical devices (MIP-PADs) offers advanced analytical devices with enhanced selectivity and sensitivity, as well as reduced assay time and cost. This technology has wide applications in biomedical diagnostics, environmental analysis, and food safety monitoring.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Narges Shaabani, Nora W. C. Chan, Abebaw B. Jemere
Summary: An electrochemical sensor for selective and sensitive detection of the drug naloxone was developed using molecular imprinting and sol-gel techniques. The sensor showed excellent linear response and detection limit for NLX, as well as good selectivity and reproducibility. It demonstrated successful application in measuring NLX in synthetic urine samples with high recoveries.
Article
Nanoscience & Nanotechnology
Alessandra Maria Bossi, Alessio Bucciarelli, Devid Maniglio
Summary: Nanosized biomimetics prepared by molecular imprinting are showing potential as plastic antibodies in medicine for cell imaging and targeted therapies. Utilizing natural polymer silk fibroin to synthesize biocompatible MIP SF-NPs demonstrates high affinity recognition sites and biocompatibility.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemical Research Methods
Noman Nawaz, Nor Kartini Abu Bakar, Habibun Nabi Muhammad Ekramul Mahmud, Nazzatush Shimar Jamaludin
Summary: Molecularly imprinted polymers (MIPs) are promising materials for biological sensing, with advantages such as ease of synthesis, low cost, high recognition ability, and long-term durability. They can be employed in drug delivery, biosensor technology, and nanotechnology, and offer potential for improved recognition of biomacromolecules.
ANALYTICAL BIOCHEMISTRY
(2021)
Review
Environmental Sciences
Diana Samantha Villarreal-Lucio, Karla Ximena Vargas-Berrones, Lorena Diaz de Leon-Martinez, Rogelio Flores-Ramiez
Summary: Molecular imprinting polymers (MIPs) are synthetic materials that selectively retain molecules or analytes. They are widely used as extraction materials due to their low cost, easy preparation, reversible adsorption and desorption, and stability. MIPs are considered as a promising approach for the quantification and monitoring of emerging pollutants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Chemistry, Analytical
Birgit Brauer, Christine Unger, Martin Werner, Peter A. Lieberzeit
Summary: MIP-based sensors have the potential for applications in medical, environmental, and food quality control fields, but research focusing on real-life biological samples needs to be expanded. The design of sensors using MIPs is still in the research stage and not widely commercialized.
Review
Chemistry, Analytical
Simonas Ramanavicius, Inga Morkvenaite-Vilkonciene, Urte Samukaite-Bubniene, Vilma Ratautaite, Ieva Plikusiene, Roman Viter, Arunas Ramanavicius
Summary: This review focuses on the development of molecularly imprinted polymers (MIPs) and their application in sensor design. MIP-based conducting polymers, such as polypyrrole, are frequently used in sensor design due to their unique properties. The review also provides an overview of other materials that can be molecularly imprinted and discusses methods for designing MIP-based sensing structures and transducing analytical signals. Furthermore, it explores expected new trends and horizons in the application of MIP-based structures.
Review
Polymer Science
Chengya Dong, Hongxing Shi, Yuanrui Han, Yuanyuan Yang, Ruixin Wang, Jiying Men
Summary: Surface molecular imprinting technology (SMIT) has attracted extensive attention and been applied in various fields due to its desired selectivity and fast mass transfer rate, but faces challenges such as obtaining pure templates and high cost of using noble metals.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Materials Science, Multidisciplinary
Ernesto Paruli, Olivier Soppera, Karsten Haupt, Carlo Gonzato
Summary: Molecularly imprinted polymers (MIPs) have become highly attractive materials for biomimetic molecular recognition due to their excellent affinity and specificity, as well as their robustness and competitive costs. Control over size, morphology, and physical form of MIPs has led to defined micro- and nanostructures, crucial for modern applications. Light as a stimulus for structuring MIPs has emerged as a powerful tool, offering new possibilities for their development and application.
ACS APPLIED POLYMER MATERIALS
(2021)
Review
Polymer Science
Simonas Ramanavicius, Arunas Jagminas, Arunas Ramanavicius
Summary: This review outlines the important directions and applications of polymer-based semiconducting materials in affinity sensors, focusing on the bioanalytical application of conducting polymers such as polypyrrole and polyaniline. It also discusses advancements in polymerization techniques and analytical signal transduction methods applied in affinity sensors. Additionally, the review highlights the development and application of molecularly imprinted polymer-based structures as potential replacements for expensive affinity reagents.
Review
Polymer Science
Roberta Del Sole, Giuseppe Mele, Ermelinda Bloise, Lucia Mergola
Summary: Molecular Imprinting Polymer (MIP) technology, focusing on the design of artificial receptors with predetermined selectivity, has gained attention in recent years, especially in the context of green synthesis. Research efforts have been directed towards utilizing biomass waste for preparing MIPs, showing promise as a sustainable alternative source for high-value carbon-based materials.
Article
Chemistry, Multidisciplinary
Jaroslava Bezdekova, Francesco Canfarotta, Fabiana Grillo, Hasan Yesilkaya, Marketa Vaculovicova, Sergey Piletsky
Summary: In this study, molecularly imprinted nanoparticles (nanoMIPs) were synthesized using a solid-phase approach to target pathogen surface monosaccharides. These nanoMIPs function as artificial lectins that selectively bind to specific monosaccharides. Evaluation of their binding capabilities against bacterial cells demonstrated the potential use of nanoMIPs for pathogen detection and imaging.
NANOSCALE ADVANCES
(2023)
Article
Biochemical Research Methods
Francesca Torrini, Laura Caponi, Andrea Bertolini, Pasquale Palladino, Francesca Cipolli, Alessandro Saba, Aldo Paolicchi, Simona Scarano, Maria Minunni
Summary: An original biomimetic enzyme-linked immunoassay (BELISA) has been developed for quantification of gonadorelin, a peptide hormone recently banned in sports. The assay involves the growth of a polynorepinephrine (PNE)-based molecularly imprinted polymer (MIP) on microwells. It utilizes a colorimetric indirect competitive bioassay and achieves a detection limit of 277 pmol L-1 with good reproducibility. The selectivity of the assay is suitable for biological specimens and non-specific control peptides, and the analytical figures of merit are validated by mass spectrometry.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wiebke Derz, Melita Fleischmann, Paul W. Elsinghorst
Summary: This study demonstrates the use of pharmacophore modeling to guide MIP design for the extraction of citrinin from cereals using MISPE, resulting in a promising MIP derived from rhodizonic acid. The developed protocol was compared to immunoaffinity chromatography for clean-up efficiency and recovery.
Article
Materials Science, Multidisciplinary
Ming Guo, Rui Wang, Zhicheng Jin, Xinyu Zhang, Jesse Jokerst, Yuting Sun, Liping Sun
Summary: This research successfully synthesized fluorescent and amine-terminated hyperbranched polymers (AT-HP) and AT-HP/TR-MIPs, and extensively characterized their structures and compositions. The results showed that AT-HP/TR-MIPs exhibited excellent selectivity and resistance to interference towards tetracycline molecules.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Jian-Ping Lu, Jiao Zhang, Kwonseop Kim, Thomas C. Case, Robert J. Matusik, Yan-hua Chen, Michael Wolfe, Jongdee Nopparat, Qun Lu
Article
Biochemistry & Molecular Biology
J. Nopparat, J. Zhang, J-P Lu, Y-H Chen, D. Zheng, P. D. Neufer, J. M. Fan, H. Hong, C. Boykin, Q. Lu
Article
Multidisciplinary Sciences
Jongdee Nopparat, Aekkaraj Nualla-ong, Amornrat Phongdara
Article
Medicine, Research & Experimental
Manaras Komolkriengkrai, Jongdee Nopparat, Uraporn Vongvatcharanon, Vipavee Anupunpisit, Wipapan Khimmaktong
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Article
Instruments & Instrumentation
Faisal Usman, Jongdee Nopparat, Ibrahim Javed, Teerapol Srichana
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Mingchuan Li, Jongdee Nopparat, Byron J. Aguilar, Yan-hua Chen, Jiao Zhang, Jie Du, Xin Ai, Yong Luo, Yongguang Jiang, Christi Boykin, Qun Lu
Review
Pharmacology & Pharmacy
Quangang Zhu, Zhongjian Chen, Pijush Kumar Paul, Yi Lu, Wei Wu, Jianping Qi
Summary: Oral administration of proteins and peptides has been a big demand in clinical use, and research has focused on developing new technologies to overcome GI barriers, such as enteric coating, enzyme inhibitors, permeation enhancers, nanoparticles, and intestinal microdevices. Some new technologies have been under clinical trials or even on the market.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pharmacology & Pharmacy
Teerapol Srichana, Ekawat Thawithong, Titpawan Nakpheng, Pijush Kumar Paul
Summary: Levofloxacin-proliposomes prepared by the spray drying technique showed high-performance in aerosol dispersion parameters and a uniform distribution of levofloxacin. The proliposomes exhibited good safety and demonstrated significant reduction in the viability of M. bovis, making them a potential modality for tuberculosis treatment. Confocal laser scanning microscopy and holotomographic imaging confirmed the efficient phagocytosis of the formulations by NR8383 cells, resulting in morphological and biological changes in the macrophages.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Munir Ahmad Khan, Abul Kalam Azad, Muhammad Safdar, Asif Nawaz, Muhammad Akhlaq, Pijush Paul, Md. Kamal Hossain, Md. Habibur Rahman, Roua S. Baty, Attalla F. El-kott, Mohamed Kamel, Simona G. Bungau, Mohamed M. Abdel-Daim
Summary: This study aimed to synthesize and characterize pH-sensitive hydrogels loaded with 5-fluorouracil and investigate their controlled release properties. The formulations exhibited different swelling and release behaviors at different pH conditions, suggesting their potential as oral controlled colon drug delivery carriers.
Meeting Abstract
Oncology
Mingchuan Li, Jongdee Nopparat, Jiao Zhang, Byron J. Aguilar, Yan-Hua Chen, Jie Du, Xin Ai, Yong Luo, Yongguang Jiang, Christi Boykin, Qun Lu
Article
Pharmacology & Pharmacy
Pijush Kumar Paul, Alongkot Treetong, Roongnapa Suedee
ACTA PHARMACEUTICA
(2017)
Meeting Abstract
Medicine, Research & Experimental
Jongdee Nopparat, Jiao Zhang, Yan-Hua Chen, Yi Zhu, Christi Boykin, Qun Lu
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2014)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)