Article
Oncology
Anna Faldt Beding, Peter Larsson, Khalil Helou, Zakaria Einbeigi, Toshima Z. Parris
Summary: Our study suggests that BIRC5 overexpression is associated with the initiation and progression of several cancer types, and therefore holds promise as a prognostic biomarker.
Article
Oncology
Kazuki Mori, Tomofumi Hamada, Mahiro Beppu, Hiroki Tsuchihashi, Yuichi Goto, Kenichi Kume, Hiroshi Hijioka, Keitaro Nishi, Yumiko Mishima, Tsuyoshi Sugiura
Summary: Using gargle fluid as a noninvasive screening tool can accurately diagnose early-stage oral cancer and distinguish it from oral potentially malignant disorders (OPMDs). The methylation panel of genes in gargle fluid is a reliable and noninvasive method for early cancer detection.
Article
Oncology
Stephanie P. L. Saw, Win Pin Ng, Siqin Zhou, Gillianne G. Y. Lai, Aaron C. Tan, Mei -Kim Ang, Wan-Teck Lim, Ravindran Kanesvaran, Quan Sing Ng, Amit Jain, Wan Ling Tan, Tanujaa Rajasekaran, Johan W. K. Chan, Yi Lin Teh, Mengyuan Pang, Jia-Chi Yeo, Angela Takano, Boon-Hean Ong, Eng-Huat Tan, Sze Huey Tan, Anders J. Skanderup, Daniel S. W. Tan
Summary: The aim of this study was to compare the prognostic value of programmed death-ligand 1 (PD-L1) score in early-stage epidermal growth factor receptor (EGFR)-mutated and EGFR-wildtype non-small cell lung cancer (NSCLC). The results showed that PD-L1 > 1% was an independent predictor of worse prognosis in EGFR-mutated NSCLC and was associated with inferior disease-free survival (DFS) regardless of EGFR status. Therefore, PD-L1 score should be evaluated as a risk stratification factor in prospective adjuvant studies among EGFR-mutated NSCLC.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Medical Laboratory Technology
Qian Fang, Chuandou Ni, Zhun Cai, Wangyong Li, Jianjin Xie
Summary: This study found that hsa_circ_0048122 may serve as a potential predictor for liver metastasis in early-stage CRC cases. High expression of hsa_circ_0048122 is associated with increased risk of liver metastasis and poor prognosis in stage IV CRC patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Jacqueline I. Keenan, Frank A. Frizelle
Summary: Colorectal cancer is a leading cause of mortality worldwide, highlighting the need for better early detection techniques. The use of noninvasive biomarkers can accurately determine which patients should undergo clinical investigation, ultimately improving the survival rate of those with curable-stage colorectal cancer.
Review
Otorhinolaryngology
Amr Elseragy, Ibrahim O. Bello, Awais Wahab, Ricardo D. Coletta, Antti A. Makitie, Ilmo Leivo, Alhadi Almangush, Tuula Salo
Summary: This study summarizes the histopathological markers with prognostic value in early oral tongue squamous cell carcinoma (OTSCC), highlighting their importance in pathology reports.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Dentistry, Oral Surgery & Medicine
Cheng Wang, Zhengxian Huang, Ming Zhang, Gan Xiong, Xiaohua Chen, Nan Xie
Summary: This study found that tertiary lymphoid structures (TLS) are frequently observed in oral tongue squamous cell carcinoma (OTSCC), and are associated with a favorable prognosis in early clinical stage OTSCC patients. TLS can serve as an independent prognostic factor for overall and disease-free survival, and may also be used to predict immunotherapy sensitivity.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Immunology
Xin Hua, Fangfang Duan, Wenyu Zhai, Chenge Song, Chang Jiang, Li Wang, Jiajia Huang, Huanxin Lin, Zhongyu Yuan
Summary: The study investigated the prognostic value of baseline inflammatory and nutritional biomarkers in early-stage breast cancer patients and developed the INPS scoring system. Four biomarkers were selected to construct INPS using the LASSO Cox analysis, and a prognostic nomogram incorporating INPS and other clinical factors showed excellent discrimination for overall survival prediction.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Oncology
C. Phanthunane, R. Wijers, M. de Herdt, T. P. M. Langeveld, S. Koljenovic, S. Dasgupta, S. Sleijfer, R. J. Baatenburg de Jong, J. Hardillo, H. E. Balcioglu, R. Debets
Summary: In early oral-tongue cancer, the presence of stromal B-cell clusters at the invasive margin, in conjunction with CD4 T cells, is associated with a favorable prognosis.
Article
Oncology
Alexandre Prieur, Andrew Harper, Momtafin Khan, Berengere Vire, Dominique Joubert, Lea Payen, Karen Kopciuk
Summary: Circulating progastrin or hPG(80) can serve as a potential prognostic biomarker for breast cancer, as it is associated with survival outcomes. This study found that higher levels of hPG(80) at diagnosis are significantly associated with an increased risk of recurrence or death in women with breast cancer.
Article
Oncology
John K. Chan, Chunqiao Tian, Joshua P. Kesterson, Michael T. Richardson, Ken Lin, Krishnansu S. Tewari, Thomas Herzog, Daniel S. Kapp, Bradley J. Monk, Yovanni Casablanca, Parviz Hanjani, Robert M. Wenham, Joan Walker, Leah McNally, Larry J. Copeland, Sharon Robertson, Samuel Lentz, Nick M. Spirtos, Jeffery G. Bell
Summary: This study aims to investigate the clinical and prognostic significance of CA-125 trends during chemotherapy in high-risk early-stage epithelial ovarian cancer patients. The results showed that normalization of CA-125 after the first cycle of chemotherapy was associated with better survival.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Genetics & Heredity
Hui-Ching Wang, Chien-Jung Chiang, Ta-Chih Liu, Chun-Chieh Wu, Yi-Ting Chen, Jan-Gowth Chang, Grace S. Shieh
Summary: This study identified novel immunohistochemical (IHC) prognostic markers for Asian oral squamous cell carcinoma (OSCC). Through multivariate analysis, significant IHC marker pairs were identified, improving the current state-of-the-art for identification of IHC markers.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Diogo J. Silva, Goncalo Miranda, Teresina Amaro, Matilde Salgado, Alexandra Mesquita
Summary: Tumor budding (TB) is a dynamic process associated with the epithelial-mesenchymal transition and has been proven to be a significant prognostic biomarker for colorectal cancer. This study aimed to investigate the clinical applicability and prognostic value of TB in patients with early breast cancer (EBC). The results showed a significant association between high TB score and aggressive clinicopathological features, as well as poor prognosis. The findings suggest that TB could serve as a valuable prognostic biomarker for EBC.
Review
Oncology
Siamack Sabrkhany, Marijke J. E. Kuijpers, Mirjam G. A. Oude Egbrink, Arjan W. Griffioen
Summary: Platelets play a crucial role in tumor angiogenesis, growth, and metastasis, with interactions between cancer and platelets leading to changes in platelet characteristics. Researchers are investigating whether analyzing these platelet features could offer a new strategy in the search for biomarkers of cancer.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Oncology
Pablo Azcue, David Guerrero Setas, Ignacio Encio, Berta Ibanez-Beroiz, Maria Mercado, Ruth Vera, Maria Luisa Gomez-Dorronsoro
Summary: The study proposed a biomarker panel consisting of PD-L1, GLUT-1, dMMR, and potentially CDX2 that divided patients into low, medium, and high risk groups in terms of overall survival or disease-free survival. Medium-risk patients had almost twice the risk of death compared to low-risk patients, while high-risk patients had nearly four times the risk. The findings provide a critical foundation for the future development of an immunohistochemical assessment tool that can personalize treatment and improve survival outcomes for patients with early-stage colon cancer.
