期刊
CURRENT OPINION IN PLANT BIOLOGY
卷 24, 期 -, 页码 17-23出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2015.01.005
关键词
-
资金
- National Science Foundation [MCB0923640, MCB1412948]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1412948] Funding Source: National Science Foundation
Sequencing of complete plant genomes has become increasingly more routine since the advent of the next-generation sequencing technology. Identification and annotation of large amounts of noncoding but functional DNA sequences, including cis-regulatory DNA elements (CREs), have become a new frontier in plant genome research. Genomic regions containing active CREs bound to regulatory proteins are hypersensitive to DNase I digestion and are called DNase I hypersensitive sites (DHSs). Several recent DHS studies in plants illustrate that DHS datasets produced by DNase I digestion followed by next-generation sequencing (DNase-seq) are highly valuable for the identification and characterization of CREs associated with plant development and responses to environmental cues. DHS-based genomic profiling has opened a door to identify and annotate the 'dark matter' in sequenced plant genomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据