Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Review
Nutrition & Dietetics
Luca Dalle Carbonare, Monica Mottes, Maria Teresa Valenti
Summary: Osteonecrosis of the jaw is a severe clinical condition characterized by exposed bone that does not heal over time. Diagnosis is primarily clinical with imaging feedback playing a confirmatory role. Medication-related osteonecrosis of the jaw, particularly induced by bisphosphonates, has been widely discussed, but the exact mechanism remains debatable.
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
C. G. J. Monteiro, E. M. Vieira, C. Emerick, R. S. Azevedo, V. A. B. Pascoal, N. Homsi, R. X. Lins
Summary: The study aimed to evaluate the preventive effect of ozonated oil on the development of MRONJ-like lesions at tooth extraction sites in rats receiving zoledronic acid treatment. While there was no statistically significant difference in the average area of vital and necrotic bone between the groups, ozonated oil appeared to reduce osteonecrosis development. Further research is needed to confirm these findings.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Chemistry, Multidisciplinary
Salvatore D'Amato, Antonio Troiano, Giorgio Lo Giudice, Davide De Cicco, Mario Rusciano, Gianpaolo Tartaro, Giuseppe Colella
Summary: Surgical resection showed higher complete healing cases and statistically significant difference in recurrence rate compared to debridement. Debridement is an unfavorable prognostic factor when compared to surgical resection, with a 4.9 times higher risk of recurrence. Quality of life mean values improved significantly in the surgical resection group and slightly in the debridement group.
APPLIED SCIENCES-BASEL
(2021)
Article
Multidisciplinary Sciences
Yuki Sakamoto, Shunsuke Sawada, Yuka Kojima
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a refractory osteonecrosis caused by antiresorptive agents. In some recent cases, no abnormal findings were detected on computed tomography (CT), leading to the need for clarification of the characteristics of MRONJ without osteolysis.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Mario Dioguardi, Francesca Spirito, Mario Alovisi, Riccardo Aiuto, Daniele Garcovich, Vito Crincoli, Andrea Ballini, Giorgia Apollonia Caloro, Lorenzo Lo Muzio
Summary: Antiresorption drugs like bisphosphonates and monoclonal antibodies are used in the treatment of osteoporosis and other bone-related diseases. These drugs have been associated with cases of osteonecrosis of the jaws (MRONJ). Risk factors include extraction procedures in oral surgery, particularly in the mandible and maxilla. A systematic review and meta-analysis was conducted to determine if there is a greater risk of MRONJ in male or female subjects and to assess the involvement of osteonecrosis in different extraction sites. After analyzing 24 studies, the results showed a trend of higher risk in males and in the posterior mandibular sector, but further studies are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Zhiqiang Feng, Jingang An, Yang He, Yi Zhang
Summary: This study compared the clinical characteristics of patients with medication-related osteonecrosis of the jaw (MRONJ) and osteoporosis versus malignancy. The results showed differences between the osteoporosis and malignancy groups in terms of incubation periods, cumulative doses of bisphosphonates, and the proportion of patients receiving antiangiogenic agents. However, the two groups had similar surgical treatment outcomes.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Review
Endocrinology & Metabolism
L. dos Santos Ferreira, L. G. Abreu, C. B. Calderipe, M. D. Martins, L. F. Schuch, A. C. U. Vasconcelos
Summary: The study aimed to integrate data on the use of TPTD for MRONJ cases, finding that TPTD in combination with another therapy, especially antibiotic therapy, can be considered an effective protocol for MRONJ.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Immunology
Ann-Kristin Struckmeier, Falk Wehrhan, Raimund Preidl, Melanie Mike, Tina Moench, Lea Eilers, Jutta Ries, Leah Trumet, Rainer Lutz, Carol Geppert, Marco Kesting, Manuel Weber
Summary: The aim of this study was to compare macrophage populations in the craniofacial and extracranial skeleton and investigate the changes induced by Zol application and surgical interventions. The results showed that there were significantly more macrophages and a heightened pro-inflammatory environment in the jaw bones compared to the tibia. Tooth extraction increased the number of macrophages and worsened the inflammatory environment in the jaw bones, which was amplified by Zol application. The study suggests that targeting macrophages could be an attractive strategy to prevent MRONJ.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Kazumitsu Aoki, Satoru Matsunaga, Shinichirou Ito, Takahiko Shibahara, Takeshi Nomura, Hideo Matsuzaki, Shinichi Abe, Akira Yamaguchi
Summary: BRONJ is characterized by numerous bone resorption lacunae on the necrotic bone surface, which is distinct from the limited resorption lacunae in DRONJ and suppurative osteomyelitis. The histopathological diagnosis of BRONJ can be distinguished based on the unique persistence of bone resorption lacunae on the necrotic bone surface.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Medicine, General & Internal
Gianluca Colapinto, Funda Goker, Riccardo Nocini, Massimo Albanese, Pier Francesco Nocini, Salvatore Sembronio, Francesca Argenta, Massimo Robiony, Massimo Del Fabbro
Summary: The aim of this randomized study was to evaluate the effect of pentoxifylline and tocopherol in patients that had developed MRONJ after tooth extractions. The study showed that patients who received pharmacological treatment had better mucosal healing after 1 month and clinical and radiographic healing of the bone lesion after 6 months.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Kun-Jung Hsu, Szu-Yu Hsiao, Ping-Ho Chen, Han-Sheng Chen, Chun-Ming Chen
Summary: The study investigated maxillary MRONJ in elderly patients through a meta-analysis, revealing specific characteristics such as female-to-male ratio, average age, and clinical efficacy of surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Daigo Yoshiga, Izumi Yoshioka, Manabu Habu, Masaaki Sasaguri, Kazuhiro Tominaga
Summary: This study aimed to investigate the benefits of adjuvant daily or weekly teriparatide injections in treating exposed bony MRONJ lesions. The results showed that TPTD treatment helped in the coverage of exposed bone, shortened the healing period, and did not increase the risk of complications.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2022)
Article
Multidisciplinary Sciences
Takuma Watanabe, Keita Asai, Shizuko Fukuhara, Ryuji Uozumi, Kazuhisa Bessho
Summary: This study evaluated the variables associated with treatment outcomes in patients with ARONJ at a single center, finding that surgery and HBO therapy were effective treatment approaches for both stage 2 and 3 ARONJ. Extensive surgery was more effective in healing than conservative surgery for stage 2 ARONJ, while >= 46 sessions of HBO therapy was less associated with healing in the same stage.
Article
Dentistry, Oral Surgery & Medicine
Oliver Ristow, Gregor Schnug, Maximilian Smielowksi, Julius Moratin, Maximilian Pilz, Michael Engel, Christian Freudlsperger, Jurgen Hoffmann, Thomas Ruckschloss
Summary: This study compared the diagnostic accuracy of orthopantomography (OPT) and cone-beam computed tomography (CBCT) in detecting early non-vital bone changes before tooth extractions in patients with antiresorptive (AR) intake. The results showed that CBCT had higher sensitivity and specificity in detecting non-vital bone changes compared to OPT.
Article
Oncology
Ann-Kristin Struckmeier, Anne Radermacher, Michael Fehrenz, Tamara Bellin, Dalia Alansary, Philipp Wartenberg, Ulrich Boehm, Mathias Wagner, Anja Scheller, Jochen Hess, Julius Moratin, Christian Freudlsperger, Juergen Hoffmann, Lorenz Thurner, Klaus Roemer, Kolja Freier, Dominik Horn
Summary: IDO1-expressing immune cells, especially macrophages, are more abundant in advanced stages of oral squamous cell carcinoma (OSCC) and are associated with reduced progression-free survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Reinald Kuehle, Medea Kuebler, Jennifer Fuchs, Frederic Weichel, Julius Moratin, Kolja Freier, Michael Engel, Juergen Hoffmann, Oliver Ristow, Christian Freudlsperger
Summary: Prebent reconstruction plates on 3D printed models can improve the accuracy of condylar position after mandibular resection. However, the recent changes in the European Medical Device Regulation affect the use of 3D printing in hospitals, raising the need for discussion on its legitimization. This retrospective observational case-control study found that prefabricated osteosynthesis significantly reduced rotational deviations in the coronal and sagittal planes, with Jewer class-L defects benefiting more.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Medicine, General & Internal
Claudius Steffen, Katharina Duda, Dag Wulsten, Jan O. O. Voss, Steffen Koerdt, Susanne Nahles, Max Heiland, Sara Checa, Carsten Rendenbach
Summary: This study evaluates a new bite force measuring device and its feasibility in patients after mandibular resection. The device shows high accuracy and reproducibility, providing new opportunities for quantifying perioperative oral function after reconstructive surgery of the mandible.
Article
Clinical Neurology
C. Maier, N. Thieme, B. Beck-Broichsitter, N. L. Beetz, T. C. Walter-Rittel, K. Rubarth, M. Heiland, K. Kreutzer, S. Koerdt, J. O. Voss
Summary: Orbital compartment syndrome is a sight-threatening emergency characterized by proptosis, optic nerve stretching, and decreased posterior globe angle. This study systematically evaluated the imaging features of orbital compartment syndrome and found that the pathophysiology involves an expanding pathology within the orbit.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Claudius Steffen, Margrit Welter, Heilwig Fischer, Maximilian Goedecke, Christian Doll, Steffen Koerdt, Kilian Kreutzer, Max Heiland, Carsten Rendenbach, Jan O. Voss
Summary: This retrospective observational study aimed to characterize patients who required revision surgery after mandibular fractures and evaluate the impact of treatment quality on complications. The results showed that most cases of revision surgery were due to osteomyelitis or pseudarthrosis, with risk factors including drug-related immune suppression, local infection, and substance abuse. The study also highlighted discrepancies in treatment quality assessments. The findings suggest the need for careful observation and individualized treatment for patients with risk factors, as well as a re-evaluation of current treatment guidelines.
CRANIOMAXILLOFACIAL TRAUMA & RECONSTRUCTION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Kilian Kreutzer, Philipp Lampert, Christian Doll, Jan O. Voss, Steffen Koerdt, Max Heiland, Claudius Steffen, Carsten Rendenbach
Summary: This study compared the clinical outcomes and complication rates of patient-specific 3D-printed miniplates and reconstruction plates for mandibular reconstruction. The results showed that the use of miniplates reduced the occurrence of fistula and non-union compared to reconstruction plates, and the procedures were performed more easily. In general, patient-specific 3D-printed miniplates have lower complication rates in immediate mandibular reconstruction.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Article
Medicine, General & Internal
Sven Zittel, Julius Moratin, Sinclair Awounvo, Thomas Rueckschloss, Kolja Freier, Oliver Ristow, Michael Engel, Juergen Hoffmann, Christian Freudlsperger, Dominik Horn
Summary: Salvage surgery can improve health-related quality of life (HRQoL) in patients with recurrent oral squamous cell carcinoma (OSCC), despite a decrease in swallowing function. Significant pain relief can be observed as early as 3 months after surgery in patients with advanced recurrent tumors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Reinald Kuehle, Mats Scheurer, Frederic Bouffleur, Jennifer Fuchs, Michael Engel, Juergen Hoffmann, Christian Freudlsperger
Summary: This retrospective study compared the positioning and fixation effects of traditional miniplates and patient-specific implants in virtually planned segmental maxillary osteotomy. The results showed that the patient-specific implant group had lower deviation differences and positive influences on pitch and inward rotation of the lateral segments compared to the conventional group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Julius Moratin, Sven Zittel, Dominik Horn, Rouven Behnisch, Oliver Ristow, Michael Engel, Juergen Hoffmann, Kolja Freier, Christian Freudlsperger
Summary: This study evaluated the oncological outcome and quality of life in patients with early oral squamous cell carcinoma treated with surgical resection and free-flap reconstruction, and concluded that free-flap reconstruction is a safe and effective procedure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Julius Moratin, Philip Dao Trong, Karl Semmelmayer, Jan Mrosek, Sven Zittel, Moritz Bleymehl, Oliver Ristow, Christian Freudlsperger, Juergen Hoffmann, Michael Engel
Summary: This study compared the use of antero-lateral thigh flaps (ALT) and vastus lateralis muscle flaps for the reconstruction of extensive scalp defects. The study found no significant differences in flap success rate, complication rate, or duration of hospitalization between the two groups. Both ALT flaps and vastus lateralis flaps are suitable options for large scalp defect closure, with high success rates and short surgery times.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Julius Moratin, Dominik Horn, Karl Semmelmayer, Oliver Ristow, Michael Engel, Juergen Hoffmann, Moritz Bleymehl, Thomas Held, Sven Zittel, Christian Freudlsperger
Summary: Carcinomas of the minor salivary glands of the oral cavity are a rare and heterogeneous group of malignant tumors. In this study, we compared clinical and pathological features and oncological outcomes in patients with different kinds of minor salivary gland cancer who received primary surgical therapy. We found different rates of cervical metastases and disease recurrence in dependence on the tumor entity, suggesting the need for different treatment approaches for each tumor entity.
Article
Oncology
Christian Freudlsperger, Reinald Kuehle, Sebastian Adeberg, Julius Moratin, Jennifer Fuchs, Sameena Sandhu, Sebastian Regnery, Jochen Hess, Juergen Hoffmann
Summary: Personalized oncologic therapy of head and neck tumours can achieve remarkable therapeutic success through interdisciplinary collaboration between surgeons, pathologists, and radiation oncologists. Virtual surgical planning, prefabricated surgical guides, and patient-specific implants improve accuracy and predict reconstructive outcomes. Intraoperative assistance systems enhance safe oncological resection and navigation data sets contribute to individualized postoperative radiotherapy. The determination of molecular characteristics enables personalized adjuvant therapy. Overall, the importance of this approach in optimizing therapy management is rated 8 out of 10.
Article
Dentistry, Oral Surgery & Medicine
Norbert Neckel, Daniel Troeltzsch, Dario Zocholl, Steffen Koerdt, Yvonne Motzkus, Andrej Trampuz, Jan-Dirk Raguse, Max Heiland, Susanne Nahles
Summary: The purpose of this study was to compare different assessment methods for peri-implant inflammation, evaluate potential risk factors, and establish a comprehensive algorithm for clinical staging, treatment, and evaluation of success in periorbital implants. The results showed that probing depth and skin reaction to be valuable quick assessment tools, which can be complemented with sulcus fluid flow rate for improved accuracy. Patient-specific factors did not have a significant impact on peri-implant inflammation.
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Christian Freudlsperger, Frederic Weichel, Mats Scheurer, Reinald Kuehle, Juergen Hoffmann
Summary: Recent decades have witnessed significant advancements in orthognathic surgery techniques and the application of new osteosynthesis methods. Virtual 3D planning has become a routine practice in clinics, offering higher accuracy compared to conventional planning, particularly for patients with asymmetry. Soft tissue simulation has greatly influenced the planning process and improved communication between practitioners and patients. The trend is shifting towards orthofacial surgery, emphasizing facial harmony as well as function. The use of patient-specific implants enables precise implementation of the 3D plan without the need for positioning splints. However, close cooperation between orthodontists and surgeons remains crucial for successful treatment.
