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Biochemistry & Molecular Biology
Laura Francesca Pisani, Gian Eugenio Tontini, Carmine Gentile, Beatrice Marinoni, Isabella Teani, Nicoletta Nandi, Pasquale Creo, Emanuele Asti, Luigi Bonavina, Maurizio Vecchi, Luca Pastorelli
Summary: IL-33 has antiproliferative and proapoptotic effects on gastric cancer cell lines, while it stimulates proliferation and reduces apoptosis in normal epithelial cell lines. These effects may be mediated through the regulation of cell cycle gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Qian Zhang, Jun Dan, Shuang Meng, Yingjie Li, Jing Li
Summary: This study investigated the role of Toll-like receptor 4 (TLR4) in autophagy and proliferation in gastric cancer (GC) cells. The levels of TLR4 were determined in different stages of GC cells/tissues using RT-qPCR and WB, along with the levels of autophagy-related proteins (ARPs) and the underlying signaling mechanism. Proliferation was assessed using the CCK-8 assay. The results revealed that modulation of the PI3K/AKT/mTOR pathway was induced by the overexpression and knockdown of TLR4, leading to inhibition/induction of autophagy, and TLR4 played a vital role in GC progression.
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Cell Biology
Zilu Chen, Liyue Yuan, Xiaopeng Li, Junhui Yu, Zhengshui Xu
Summary: This study demonstrates that BMP2 acts as a tumor suppressor in gastric cancer cells by downregulating EZH2 and H3K27me3 through the non-SMAD BMP pathway, suggesting that BMP2 might be a potential therapeutic target for gastric cancer treatment.
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Oncology
Dakui Luo, Hao Fan, Xiang Ma, Chao Yang, Yu He, Yugang Ge, Mingkun Jiang, Zekuan Xu, Li Yang
Summary: Existing evidence strongly suggests that miR-1301-3p plays a significant role in the tumorigenesis and progression of gastric cancer. The overexpression of miR-1301-3p in GC tissues and cells accelerates cell proliferation, cell cycle progression, and tumorigenesis. SIRT1 is identified as a direct target of miR-1301-3p, and knockdown of SIRT1 enhances the proliferative ability of GC cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Juan An, Yan Liu, Shenglan Duo, Xiaoming Ma, Ling An, Yunfei Yan, Dongde Ji, Yupeng Yan, Qiliang Cheng, Zhanhai Su
Summary: In this study, it was found that podofilox can inhibit gastric cancer cell proliferation by preventing cell cycle progression and regulating the c-Myc/ATG10 signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Tomoyuki Fukami, Atsushi Shiozaki, Toshiyuki Kosuga, Michihiro Kudou, Hiroki Shimizu, Takuma Ohashi, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Yukiko Morinaga, Eiichi Konishi, Eigo Otsuji
Summary: ANO5 is a key regulator in tumor progression and a potential prognostic biomarker for gastric cancer. Knockdown of ANO5 inhibits cell proliferation, induces apoptosis, and affects cell cycle progression, invasion, and migration. High expression of ANO5 is associated with poor prognosis in patients with GC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chieh-Hsin Lin, Hsin-Han Chang, Chien-Rui Lai, Hisao-Hsien Wang, Wen-Chiuan Tsai, Yu-Ling Tsai, Chih-Ying Changchien, Yu-Chen Cheng, Sheng-Tang Wu, Ying Chen
Summary: Bladder cancer (BC) recurrence can be reduced by targeting fatty acid binding protein 6 (FABP6), which plays an important role in cell growth, migration, cell cycle, autophagy, and gene expression in BC cells. Inhibition of FABP6 leads to decreased cell viability, reduced tumor progression and cell motility, and altered signaling pathways. These findings highlight the potential of targeting FABP6 for the treatment of BC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Solbi Kim, Sang-Il Lee, Nayoung Kim, Mina Joo, Kyung-Ha Lee, Myung-Won Lee, Heung Jin Jeon, Hyewon Ryu, Jin-Man Kim, Ji-Young Sul, Gyu-Yong Song, Ji-Yeon Kim, Hyo Jin Lee
Summary: Decursin inhibits cell growth and cell cycle progression in gastric cancer by blocking autophagic flux, suggesting its potential as a therapeutic agent for simultaneously inhibiting cell growth and autophagy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Plant Sciences
Ruli Li, He Li, Jie Lan, Dongmei Yang, Xinjing Lin, Hongling Xu, Bin Han, Ming Yang, Bo Su, Fu Liu, Wei Jiang
Summary: Damnacanthal inhibits the growth of ovarian cancer via the ERK/mTOR/autophagy signaling cascade, indicating its potential as a therapeutic candidate for ovarian cancer.
Article
Pharmacology & Pharmacy
Xu Liu, Qiaoyu Zheng, Qiongfang Yu, Yan Hu, Yanmin Cheng, Zhaozhao Shao, Li Chen, Wenjie Ding, Dian Gao
Summary: The study demonstrates that Apatinib inhibits the proliferation of GC cells by promoting apoptosis and autophagy, altering cell cycle distribution, and inhibiting invasion and migration capacities of GC cells.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wei Yang, Jiaqi Su, Mingjing Li, Tiantian Li, Xu Wang, Mingdong Zhao, Xuemei Hu
Summary: Myricetin inhibits the proliferation of HCC cells by downregulating MARCH1 and affecting the p38 MAPK and Stat3 signaling pathways, ultimately suppressing HCC growth. This natural flavonol also induces autophagy and cell cycle arrest in HCC cells, demonstrating its anticancer properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying Zhou, Rishun Fu, Mei Yang, Weihuang Liu, Zan Tong
Summary: Lycopene, a natural carotenoid, inhibits the growth and induces apoptosis in gastric cancer cells. It decreases CCNE1 expression and increases the levels of TP53, making it a potential target therapy reagent for gastric cancer.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Jakub Rok, Justyna Kowalska, Zuzanna Rzepka, Dominika Stencel, Anna Skorek, Klaudia Banach, Dorota Wrzesniok
Summary: Melanoma is the most dangerous form of skin cancer due to its high mortality, aggressiveness, and low effectiveness of therapy. Previous studies have shown the therapeutic potential of minocycline, doxycycline, and chlortetracycline on melanoma cells. This study aimed to evaluate the cytotoxicity of tigecycline, a third-generation tetracycline, on melanotic and amelanotic melanoma cell lines. The results demonstrated that tigecycline efficiently inhibited the proliferation of both types of melanoma cells, accompanied by dysregulation of the cell cycle, depolarization of the mitochondrial membrane, and alterations in various molecular levels. However, the drug induced apoptosis only in melanotic melanoma cells, while amelanotic cells exhibited resistance and showed increased autophagy marker levels.
Article
Oncology
Chuanzhi Chen, Haili Bao, Wu Lin, Xiangliu Chen, Yingying Huang, Haohao Wang, Yan Yang, Jin Liu, Xiadong Lv, Lisong Teng
Summary: This study reveals the upregulation of ASF1b in gastric cancer tissues, which is significantly correlated with disease stage, histological grade, and prognosis. ASF1b is found to promote the proliferation, migration, and invasion of gastric cancer cells through regulation of cell cycle and the PI3K/AKT/mTOR signaling pathway.
Article
Genetics & Heredity
Hui Zhang, Yidan Lin, Minxue Zhuang, Lin Zhu, Yongmei Dai, Mengbo Lin
Summary: The study identified the cell cycle pathway and CNIH4 as key regulators of cell viability in gastric cancer through CRISPR-cas9 screening. CNIH4 showed significant prognostic value and can serve as a novel therapeutic target for gastric cancer patients.
Article
Oncology
Chenfei Zhou, Liangjun Zhu, Jun Ji, Fangmi Ding, Chao Wang, Qu Cai, Yingyan Yu, Zhenggang Zhu, Jun Zhang
CURRENT CANCER DRUG TARGETS
(2017)
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Oncology
Chao Wang, Wenqi Xi, Jinling Jiang, Jun Ji, Yingyan Yu, Zhenggang Zhu, Jun Zhang
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Oncology
Xusheng Ding, Wenqi Xi, Jun Ji, Qu Cai, Jinling Jiang, Min Shi, Yingyan Yu, Zhenggang Zhu, Jun Zhang
Article
Cell Biology
Xusheng Ding, Jun Ji, Jinling Jiang, Qu Cai, Chao Wang, Min Shi, Yingyan Yu, Zhenggang Zhu, Jun Zhang
CELL DEATH & DISEASE
(2018)
Article
Multidisciplinary Sciences
Chao Wang, Jinling Jiang, Jun Ji, Qu Cai, Xuehua Chen, Yingyan Yu, Zhenggang Zhu, Jun Zhang
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Chenfei Zhou, Xiaojing Feng, Fei Yuan, Jun Ji, Min Shi, Yingyan Yu, Zhenggang Zhu, Jun Zhang
CANCER MANAGEMENT AND RESEARCH
(2018)
Review
Oncology
Chenfei Zhou, Jun Zhang
FRONTIERS OF MEDICINE
(2019)
Article
Medicine, Research & Experimental
Qian-Fu Zhao, Jun Ji, Qu Cai, Chao Wang, Min Shi, Chen-Fei Zhou, Zheng-Gang Zhu, Jun Zhang
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2020)
Article
Medicine, General & Internal
Jun Ji, Chenfei Zhou, Junwei Wu, Qu Cai, Min Shi, Huan Zhang, Yingyan Yu, Zhenggang Zhu, Jun Zhang
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2019)