期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 50, 期 3, 页码 753-767出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2017.3846
关键词
STAT3; gastrointestinal cancer; epithelial-mesenchymal transition
类别
资金
- Shanghai Health and Family Planning Commission [XYQ2013092]
- Shanghai Municipal Human Resources and Social Security Bureau [2012040, 13PJD024]
- Shanghai Municipal Science and Technology Commission [144119668]
- Shanghai Municipal Education Commission-Gaofeng Clinical Medicine [20161425]
Gastrointestinal (GI) cancer is characterized by its aggressiveness and tendency to metastasize at early stage. Epithelial-mesenchymal transition (EMT), commonly known as the preparing step of metastasis, may account for the aggressive phenotype of GI cancer cells. The process of EMT is finely orchestrated by multiple layers of regulators. Signal transducer and activator of transcription 3 (STAT3) is a transcription factor constitutively activated in diverse malignancies. Recent studies have suggested an involvement of STAT3 in GI cancer EMT. In this review, we first take an insight into the oncogenic functions of STAT3 in GI cancer, and then summarize the possible mechanisms by which STAT3 regulates the EMT process. Through the extensive interactions with EMT-inducing transcription factors and non coding RNAs, and crosstalk with other signaling pathways, STAT3 has been demonstrated to promote the mesenchymal and invasive phenotype of GI cancer, which provides ratio-nales for specifically targeting STAT3 to prevent and reverse the progression of GI cancer.
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