Article
Entomology
Haihao Ma, Xiumei Yan, Lin Yan, Jingyan Zhao, Jiping Song, Rong Peng, Yongbo Yang, Jianxin Peng, Kaiyu Liu
Summary: Apoptosis is essential in the development and cell elimination of lepidopteran insects. This study characterized the apoptotic protease activating factor-1 (Apaf-1) from Spodoptera litura, showing similarities to mammalian Apaf-1. The function of Sl-Apaf-1 in mediating apoptosis is evolutionarily conserved, indicating a conserved apoptosis pathway between lepidopteran insects and mammals.
Article
Medicine, Research & Experimental
Xizhu Fang, Yeon-Hwa Lee, Jeong-Hoon Jang, Su-Jung Kim, Seong Hoon Kim, Do-Hee Kim, Hye-Kyung Na, Kyung-Ok Kim, Jeong-Heum Baek, Young-Joon Surh
Summary: This study found that ARD1 stabilizes NRF2 by increasing its acetylation levels, thereby enhancing the oncogenic function of NRF2 in human colon cancer.
Article
Cell Biology
Pietro Carotenuto, Alessia Romano, Anna Barbato, Paola Quadrano, Simona Brillante, Mariagrazia Volpe, Luigi Ferrante, Roberta Tammaro, Manuela Morleo, Rossella De Cegli, Antonella Iuliano, Marialuisa Testa, Fabrizio Andreone, Gennaro Ciliberto, Eduardo Clery, Giancarlo Troncone, Giuseppe Palma, Claudio Arra, Antonio Barbieri, Mariaelena Capone, Gabriele Madonna, Paolo A. Ascierto, Luisa Lanfrancone, Alessia Indrieri, Brunella Franco
Summary: This study identifies the MITF/APAF-1 axis as a molecular driver of MAPK inhibitor resistance in melanoma, and quinacrine and methylbenzethonium as potent activators of apoptosis and suppressors of MITF function, demonstrating their potential as therapeutic approaches for resistant melanoma.
Article
Pharmacology & Pharmacy
Bin He, Wenkan Zhang, Jiaming He
Summary: The study demonstrated that fraxinellone (FRA) isolated from the D. dasycarpus plant inhibited the proliferation and migration of osteosarcoma cells, induced cell apoptosis, and increased autophagy flux. The pro-apoptotic effect of FRA was achieved through excessive autophagy flux, providing new ideas for future osteosarcoma treatment and offering theoretical support for the anti-cancer mechanism of FRA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Fisheries
Xue Qiao, Lilin Hou, Jihan Wang, Yuhao Jin, Ning Kong, Jialuo Li, Sicong Wang, Lingling Wang, Linsheng Song
Summary: The study identified a homologue of AIF, CgAIF1, in oysters, which shares a similarity of 35.44% to 79.22% with AIF1s from other species. Upon LPS and Poly (I:C) stimulation, the mRNA transcripts of CgAIF1 in gills significantly increased.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Cell Biology
Wei Chen, Zhiyi Wang, Junfeng Ji, Tao Shi, Hong ye Jiao, You Cheng, Li Xu, Rui Wang
Summary: This study found that the regulatory role of HSP70 in ER level has different significance in pepsin-treated laryngeal epithelial cells and LC cells. Inhibition of HSP70 reduces the expression of GRP78 in pepsin-stimulated laryngeal epithelial cells and LC cells, and only inhibits apoptosis-related pathways in laryngeal epithelial cells. Inhibition of HSP70 and ER can promote apoptosis and inhibit tumor growth.
Article
Pharmacology & Pharmacy
Xiaocong Xiang, Yunhong Tian, Jiani Hu, Rong Xiong, Matthew Bautista, Li Deng, Qiuju Yue, Yuqi Li, Wei Kuang, Junfeng Li, Kang Liu, Chunlei Yu, Gang Feng
Summary: Fangchinoline (Fan) induces apoptosis and autophagy in colorectal cancer cells by activating the AMPK/mTOR/ULK1 signaling pathway, inhibiting tumor growth both in vitro and in vivo, and showing potential as a promising anticancer agent.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Environmental Sciences
Miaoling Lin, Rui Hua, Jing Ma, Yao Zhou, Pei Li, Xiya Xu, Zhiqiang Yu, Song Quan
Summary: This study demonstrated that BPA exposure could significantly decrease human ovarian functions and lead to abnormal folliculogenesis by activating autophagy in GCs through the AMPK/mTOR/ULK1 pathway.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Cell Biology
Zonghao Tang, Renfeng Xu, Zhenghong Zhang, Congjian Shi, Yan Zhang, Hongqin Yang, Qingqiang Lin, Yiping Liu, Fengping Lin, Baorong Geng, Zhengchao Wang
Summary: Hypoxia drives the activation of HIF-1 alpha/BNIP3 signaling, inducing an increase in autophagy, which protects GCs from apoptosis during follicular development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Yu-Ting Zhou, Rui Li, Si-Hong Li, Xiang Ma, Lu Liu, Dong Niu, Xing Duan
Summary: Perfluorooctanoic acid (PFOA) exposure during gestation was found to have potential toxic effects on ovarian function and resulted in higher meiotic defects in female offspring. PFOA exposure disrupted early embryonic cleavage and blastocyst formation by impacting spindle assembly and chromosome alignment. Moreover, PFOA exposure caused mitochondrial dysfunction, oxidative stress, DNA damage, autophagy, and apoptosis in 2-cell stage embryos.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Mingfei Wu, Yan Cong, Kailu Wang, Haiyang Yu, Xuan Zhang, Mingyue Ma, Zhiwen Duan, Xiucong Pei
Summary: This study investigates the effects of BPA on macrophages and its mechanism of action. The results show that BPA decreases cell viability and disrupts macrophage function by inhibiting autophagy and inducing apoptosis. Activation of autophagy and inhibition of apoptosis can ameliorate the damage caused by BPA on macrophages.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Wenfeng Gou, Na Luo, Bing Yu, Hongying Wu, Shaohua Wu, Chen Tian, Jianghong Guo, Hongxin Ning, Changfen Bi, Huiqiang Wei, Wenbin Hou, Yiliang Li
Summary: UA232, a derivative of ursolic acid, demonstrates anti-tumor effects against breast and cervical cancer cells by inducing apoptosis and promoting autophagy. The compound exerts its pharmacological effects through triggering endoplasmic reticulum stress and lysosomal dysfunction, making it a promising candidate for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Raheleh Shakeri, Asma Kheirollahi, Jamshid Davoodi
Summary: Apaf-1 plays a crucial role in cancer and neurodegenerative diseases, but its specific contribution is complex due to diverse mechanisms and involvement of other factors.
Article
Biochemistry & Molecular Biology
Jingnan Zhang, Fan Yang, Xiyu Mei, Rui Yang, Bin Lu, Zhengtao Wang, Lili Ji
Summary: Toosendanin (TSN) and isotoosendanin (ITSN) are natural triterpenoids that inhibit the growth of triple-negative breast cancer (TNBC) by inducing necrosis, apoptosis, and autophagy in tumor cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Pharmacology & Pharmacy
Qingqing Shao, Fan Wu, Tong Liu, Wenjia Wang, Tianli Liu, Ximing Jin, Lijun Xu, Yonggui Ma, Guangying Huang, Zhuo Chen
Summary: This study aimed to investigate the protective effects of JieZe-1 (JZ-1) against HSV-2 infection-induced genital herpes and its underlying mechanisms. The results demonstrated that JZ-1 inhibits cell apoptosis by inducing autophagy, alleviates histological damage, improves inflammatory responses, and downregulates the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)