期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 50, 期 4, 页码 1439-1447出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2017.3877
关键词
matrix stiffness; laryngeal squamous cancer cells; chemoresistance; Sox2; ABCG2
类别
资金
- Natural Science Foundation of Liaoning Province of China [201202287]
Increasing evidence shows that matrix stiffness plays a critical role in affecting the phenotype and behavior of tumor cells. We report that matrix stiffness significantly regulated the proliferation and chemotherapeutic response of Hep-2 cells. Increasing substrate stiffness promotes the proliferation of Hep-2 cells. When cultured on soft gels, Hep-2 cells expressed higher level of stem cell markers. Following treatment with cisplatin or 5-FU, we observed reduced apoptosis in Hep-2 cells cultured on soft supports. Sox2 is essential for the chemoresistance of Hep-2 cells cultured in soft stiffness. Our results demonstrated that Sox2 promotes chemoresistance of Hep-2 cells in soft stiffness via upregulating the expression of ABCG2. Our findings will provide a new platform for the future design of anticancer drugs based on the biophysical properties of the tumor site.
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