Article
Immunology
Rui Tada, Akira Hidaka, Yuya Tanazawa, Akari Ohmi, Shoko Muto, Miki Ogasawara, Momoko Saito, Akihiro Ohshima, Naoko Iwase, Emi Honjo, Hiroshi Kiyono, Jun Kunisawa, Yoichi Negishi
Summary: The study demonstrates that intranasal administration of cationic liposomes can induce interleukin-6 (IL-6) expression at the administration site, promoting the production of IL-6 in nasal passages and splenocytes in mice. IL-6, produced by the nasally administered cationic liposomes, plays a crucial role in inducing antigen-specific IgA responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Mona Yazdani, Amin Reza Nikpoor, Zahra Gholizadeh, Nema Mohamadian Roshan, Alexander Seifalian, Mahmoud Reza Jaafari, Ali Badiee
Summary: The study compared the efficacy of different approaches in DC-based vaccine delivery for melanoma treatment, indicating that ex vivo pulsed DC vaccination was more effective than in vivo administration, resulting in delayed tumor growth and improved survival rate.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Polymer Science
Yunys Perez-Betancourt, Bianca de Carvalho Lins Fernandes Tavora, Eliana L. Faquim-Mauro, Ana Maria Carmona-Ribeiro
Summary: In this study, biocompatible lipid polymer nanoparticles were investigated as immuno-adjuvants and found to induce both humoral and cellular antigen-specific immune responses, demonstrating high biocompatibility and antigen adsorption capability.
Article
Nanoscience & Nanotechnology
Yun Hu, Zongmin Zhao, Marion Ehrich, Chenming Zhang
Summary: Nicotine vaccines have been studied for smoking cessation, and the combination of lipid-PLA and lipid-PLGA nanoparticles has shown potential for achieving long-lasting immunity against nicotine. The results suggest that the stability and combination of vaccines play a crucial role in their long-term efficacy, with the lipid-PLA vaccine inducing more sustained antibody production. Additionally, the study indicated that the vaccines were safe for use in mice based on body weight and histopathology assessments.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biophysics
Vincenzo De Leo, Anna Maria Maurelli, Livia Giotta, Lucia Catucci
Summary: The rapid development of nanotechnology has enabled the production of a variety of nanomaterials with outstanding properties, and the combination with liposomes has shown great potential in the fields of biology and biomedicine.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Xing Duan, Yi Zhang, Mengran Guo, Na Fan, Kepan Chen, Shugang Qin, Wen Xiao, Qian Zheng, Hai Huang, Xiawei Wei, Yuquan Wei, Xiangrong Song
Summary: mRNA vaccines have advantages of high efficiency, low side effects, and ease of manufacture. However, most mRNA delivery carriers have limitations such as high toxicity and low efficiency. This study developed a negatively charged SA@DOTAP-mRNA nanovaccine that overcame these limitations. The coated mRNA showed improved transfection efficiency, enhanced antigen-presenting ability, and better antitumor effects, suggesting the potential clinical application prospects.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Rui Tada, Emi Honjo, Shoko Muto, Noriko Takayama, Hiroshi Kiyono, Jun Kunisawa, Yoichi Negishi
Summary: Mucosal vaccines have advantages over conventional parenteral vaccines, but few have been developed. This study found that intranasal administration of CpG ODN-loaded cationic liposomes can induce IL-6 release in nasal tissues, which promotes antigen-specific IgA responses.
Article
Chemistry, Multidisciplinary
Yi-Fang Chen, Yan Wang, Yue Wang, Ying-Li Luo, Zi-Dong Lu, Xiao-Jiao Du, Cong-Fei Xu, Jun Wang
Summary: In this study, researchers screened an optimized cationic lipid-assisted nanoparticle (CLAN) to effectively deliver CpG ODNs into plasmacytoid dendritic cells (pDCs) and conventional dendritic cells (cDCs), serving as a therapeutic vaccine adjuvant for treating HBV infection.
PHARMACEUTICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Gabriel Talaia, Joseph Amick, Shawn M. Ferguson
Summary: This study reveals the mechanism of WDR41-PQLC2 interaction, showing that the interaction is mediated by a short peptide motif in a flexible loop extended from the WDR41 beta-propeller. This finding helps to understand how substrate transport regulates the impact of the protein complex on lysosome function.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Chemical
Yanan Sheng, Jiangxue Wei, Zhengjun Li, Zhiguo Su, Guanghui Ma, Songping Zhang
Summary: In this study, ferritin nanoparticles were used as a carrier for influenza vaccine by chemically conjugating M2e and HA antigens on the outer surface. The dual-antigen vaccine candidate showed high levels of antigen-specific antibodies in immunized mice and provided effective protection against both homologous and heterologous influenza virus strains.
Article
Pharmacology & Pharmacy
Takashi Nakano, Shakila B. Rizwan, David M. A. Myint, Jason Gray, Sean M. Mackay, Paul Harris, Christopher G. Perk, Brian I. Hyland, Ruth Empson, Eng Wui Tan, Keshav M. Dani, John N. J. Reynolds, Jeffery R. Wickens
Summary: This study demonstrates a novel drug delivery system based on hollow-gold nanoparticles tethered to liposomes, which can release drugs in high concentration to inhibit neurons and suppress seizure activity when activated by optical or acoustic stimulation. The system allows precise temporal control over drug exposure.
Article
Pharmacology & Pharmacy
Ponien Kou, Elizabeth S. Levy, An D. Nguyen, Donglu Zhang, Shu Chen, Yusi Cui, Xing Zhang, Fabio Broccatelli, Jennifer Pizzano, Jennifer Cantley, Elizabeth Bortolon, Emma Rousseau, Michael Berlin, Peter Dragovich, Vijay Sethuraman
Summary: PROTACs, including monovalent and bivalent protein degraders, are a promising technology in drug development. The market entry of bivalent PROTACs has been limited due to their complex physicochemical properties. Encapsulation in liposome systems can improve the pharmacokinetics of PROTACs, as shown in studies of two bivalent PROTAC molecules.
Article
Pharmacology & Pharmacy
Debra Wu, Douglas Vogus, Vinu Krishnan, Marta Broto, Anusha Pusuluri, Zongmin Zhao, Neha Kapate, Samir Mitragotri
Summary: The study introduced a prodrug 5FUR-W for improved loading in liposomes, showing significant anti-tumor effects in a breast cancer model.
Article
Pharmacology & Pharmacy
Ming Xia, Pengwei Huang, Ming Tan
Summary: This study developed a promising non-replicating, parenteral vaccine candidate against the most prevalent rotaviruses using S-60-VP8* pseudovirus nanoparticles.
Article
Chemistry, Multidisciplinary
Yue Li, Laren Lofchy, Guankui Wang, Hanmant Gaikwad, Mayumi Fujita, Dmitri Simberg
Summary: Studies have shown that PEGylated liposomes predominantly accumulate in areas of the skin subject to mechanical stress/pressure, with leaky blood vessels in foot skin leading to extravasation. The use of confocal microscopy and labeled liposomes revealed different modes of extravasation. These findings enhance our understanding of the extravasation pathways of nanocarriers in skin pathological areas.
Article
Cardiac & Cardiovascular Systems
Isabella Leo, Eleni Nakou, Jessica Artico, Emmanouil Androulakis, Joyce Wong, James C. Moon, Ciro Indolfi, Chiara Bucciarelli-Ducci
Summary: Structural and functional abnormalities of coronary microvasculature are common in clinical settings and associated with worse clinical outcomes. Traditional invasive methods for assessment of coronary microvascular function have limitations and risks. Recent advances in non-invasive imaging techniques provide alternative approaches for evaluating coronary microvascular function.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Instruments & Instrumentation
Emeka B. Okeke, Cameron Louttit, Caitlin M. Snyder, James J. Moon
Summary: Neutrophils and NETs play significant roles in cancer progression and metastasis and are associated with adverse patient outcomes. New drug delivery approaches targeting and modulating neutrophils and NETs have become a research focus in cancer therapeutics.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Louise A. E. Brown, Gaurav S. Gulsin, Sebastian C. Onciul, David A. Broadbent, Jian L. Yeo, Alice L. Wood, Christopher E. D. Saunderson, Arka Das, Nicholas Jex, Amrit Chowdhary, Sharmaine Thirunavukarasu, Noor Sharrack, Kristopher D. Knott, Eylem Levelt, Peter P. Swoboda, Hui Xue, John P. Greenwood, James C. Moon, David Adlam, Gerry P. McCann, Peter Kellman, Sven Plein
Summary: This study aimed to establish sex- and age-specific normal values for myocardial blood flow (MBF) in healthy volunteers. The results showed differences in MBF between males and females, and a decrease in MBF and myocardial perfusion reserve with advancing age.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Chemistry, Multidisciplinary
Xiaoqi Sun, Xingwu Zhou, Yu Leo Lei, James J. Moon
Summary: The STING pathway is an important innate immune pathway involved in cancer immunity. Recent developments in molecules and drug delivery systems have made systemic STING agonist immunotherapy possible, showing promising tumor eradication in preclinical studies. This article discusses the potential mechanisms of STING agonism as a multifaceted anti-cancer therapy and the pharmacological challenges associated with systemic delivery of STING agonists at different levels. Drug delivery strategies to overcome these challenges are also presented and discussed. Advances in this field may unlock the potential of systemic STING agonists as effective and safe cancer immunotherapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Cheng Xu, Hannah E. Dobson, Mengjie Yu, Wang Gong, Xiaoqi Sun, Kyung Soo Park, Andrew Kennedy, Xingwu Zhou, Jin Xu, Yao Xu, Andrew W. Tai, Yu Leo Lei, James J. Moon
Summary: This study developed a manganese-silica nanoplatform (MnOx@HMSN) that enhances the adjuvant effects of CDNs for vaccination against cancer and SARS-CoV-2. The nanoplatform efficiently co-loaded CDNs and antigens, resulting in robust immune responses and therapeutic efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel A. Jones, Anne-Marie Beirne, Matthew Kelham, Krishnaraj S. Rathod, Mervyn Andiapen, Lucinda Wynne, Thomas Godec, Nasim Forooghi, Rohini Ramaseshan, James C. Moon, Ceri Davies, Christos V. Bourantas, Andreas Baumbach, Charlotte Manisty, Andrew Wragg, Amrita Ahluwalia, Francesca Pugliese, Anthony Mathur, BYPASS-CTCA Trial Comm Investigators
Summary: This study assessed the benefit of computed tomography cardiac angiography (CTCA) in patients with previous coronary artery bypass grafting referred for invasive coronary angiography (ICA). The results showed that CTCA before ICA led to reductions in procedure time and contrast-induced nephropathy, with improved patient satisfaction.
Article
Cardiac & Cardiovascular Systems
George Joy, Christopher I. Kelly, Matthew Webber, Iain Pierce, Irvin Teh, Louise Mcgrath, Paula Velazquez, Rebecca K. Hughes, Huafrin Kotwal, Arka Das, Fiona Chan, Athanasios Bakalakos, Massimiliano Lorenzini, Konstantinos Savvatis, Saidi A. Mohiddin, Peter W. Macfarlane, Michele Orini, Charlotte Manisty, Peter Kellman, Rhodri H. Davies, Pier D. Lambiase, Christopher Nguyen, Jurgen E. Schneider, Maite Tome, Gabriella Captur, Erica Dall'Armellina, James C. Moon, Luis R. Lopes
Summary: In patients with hypertrophic cardiomyopathy, alterations in myocardial microstructure and microvascular disease have been found to occur early in the disease process. These changes serve as potential early phenotype biomarkers for disease detection and management.
Article
Cardiac & Cardiovascular Systems
Adam Ioannou, Aldostefano Porcari, Rishi K. K. Patel, Yousuf Razvi, Giulio Sinigiani, Ana Martinez-Naharro, Lucia Venneri, James Moon, Muhammad U. U. Rauf, Helen Lachmann, Ashutosh Wechelakar, Philip N. N. Hawkins, Julian D. D. Gillmore, Marianna Fontana
Summary: AApoAI and AApoAIV are rare but increasingly recognized causes of cardiac amyloidosis (CA). This study aimed to define the cardiac phenotype in AApoAI and AApoAIV using multimodality imaging. The results showed that both AApoAI and AApoAIV were associated with a good prognosis and a lower risk of mortality.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Chemistry, Applied
Keara T. Saud, Jin Xu, Sabina Wilkanowicz, Yue He, James J. Moon, Michael J. Solomon
Summary: Recent studies have shown that inulin has a prebiotic effect by selectively promoting bacteria in the colon, modulating the gut microbiome, and generating beneficial effects on gastrointestinal inflammation, diabetes, and cancer. However, the water-soluble nature of inulin limits its prebiotic effect due to low delivery efficiency and short retention time in the colon. This study aimed to produce inulin microparticles (MPs) using the electrospray method and evaluate their material properties and bioavailability.
FOOD HYDROCOLLOIDS
(2023)
Article
Cardiac & Cardiovascular Systems
Francisco Gama, Pedro Custodio, Aliki Tsagkridi, James Moon, Guy Lloyd, Thomas A. Treibel, Sanjeev Bhattacharyya
Summary: High-definition blood flow imaging is a feasible technique that significantly improves the diagnostic accuracy and grading of left ventricular function compared to 2D echocardiography.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Oncology
Constantin-Cristian Topriceanu, Eesha Dev, Mahmood Ahmad, Rebecca Hughes, Hunain Shiwani, Matthew Webber, Kenan Direk, Andrew Wong, Martin Ugander, James C. Moon, Alun D. Hughes, Jane Maddock, Todd T. Schlegel, Gabriella Captur
Summary: This study investigates the relationship between DNAm age and A-ECG heart age, and finds that DNAm AgeAccel is associated with cardiovascular risk factors. The results suggest that participants with accelerated DNA methylation at the age of 60 may have older, weaker, and more electrically impaired hearts. Furthermore, the harmful effects of cardiovascular risk factors on cardiac age and health may be partially mediated by DNAm AgeAccel.
CLINICAL EPIGENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Rebecca K. Hughes, Joao B. Augusto, Kristopher Knott, Rhodri Davies, Hunain Shiwani, Andreas Seraphim, James W. Malcolmson, Shafik Khoury, George Joy, Saidi Mohiddin, Luis R. Lopes, William J. McKenna, Peter Kellman, Hui Xue, Maite Tome, Sanjay Sharma, Gabriella Captur, James C. Moon
Summary: This study found that apical perfusion defects are universally present in ApHCM patients, suggesting that ischemia may play a disease-defining role in ApHCM, which is supported by characteristic ECG results.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Jessica Artico, Hunain Shiwani, James C. Moon, Miroslawa Gorecka, Gerry P. McCann, Giles Roditi, Andrew Morrow, Kenneth Mangion, Elena Lukaschuk, Mayooran Shanmuganathan, Christopher A. Miller, Amedeo Chiribiri, Sanjay K. Prasad, Robert D. Adam, Trisha Singh, Chiara Bucciarelli-Ducci, Dana Dawson, Daniel Knight, Marianna Fontana, Charlotte Manisty, Thomas A. Treibel, Eylem Levelt, Ranjit Arnold, Peter W. Macfarlane, Robin Young, Alex McConnachie, Stefan Neubauer, Stefan K. Piechnik, Rhodri H. Davies, Vanessa M. Ferreira, Marc R. Dweck, Colin Berry, John P. Greenwood
Summary: This study aimed to assess the presence, nature, and extent of myocardial damage in hospitalized patients with troponin elevation and COVID-19. The study found that patients with COVID-19 and elevated cardiac troponin levels had more ventricular impairment and myocardial scar compared to the control group. However, the proportion of myocarditis was low and scar pathogenesis was diverse.
Article
Cardiac & Cardiovascular Systems
Constantin-Cristian Topriceanu, Massimiliano Fornasiero, Han Seo, Matthew Webber, Kathryn E. E. Keenan, Karl F. F. Stupic, Ruediger Bruehl, Bernd Ittermann, Kirsty Price, Louise McGrath, Wenjie Pang, Alun D. D. Hughes, Reza Nezafat, Peter Kellman, Iain Pierce, James C. C. Moon, Gabriella Captur
Summary: A phantom dedicated to the quality assurance of T-2 mapping in CMR was fabricated and assessed. The phantom was able to mimic clinically relevant myocardial T-2 and demonstrated excellent structural integrity, magnetic field uniformity, and reproducibility. This device can now be mass-produced to support the quality assurance of T-2 mapping in CMR.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Article
Cardiac & Cardiovascular Systems
Adam Ioannou, Rishi K. Patel, Ana Martinez-Naharro, Yousuf Razvi, Aldostefano Porcari, Muhammad U. Rauf, Roos E. Bolhuis, Jacob Fernando-Sayers, Ruta Virsinskaite, Francesco Bandera, Tushar Kotecha, Lucia Venneri, Daniel Knight, Charlotte Manisty, James Moon, Helen Lachmann, Carol Whelan, Peter Kellman, Philip N. Hawkins, Julian D. Gillmore, Ashutosh Wechalekar, Marianna Fontana
Summary: This study evaluated the effectiveness of native T1 mapping in measuring cardiac treatment response in patients with cardiac light-chain amyloidosis and found that changes in native T1 were associated with changes in traditional markers of cardiac response and mortality.