期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 12, 期 -, 页码 2749-2758出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S131304
关键词
metallodrugs; nanotechnology; cancer treatment; cell apoptosis; DNA damage; toxicity
资金
- R&D Program for Society of the National Research Foundation (NRF) - Ministry of Science, ICT & Future Planning [2015M3A9E2031372]
- National Research Foundation of Korea [2015M3A9E2031372] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In recent years, the field of metal-based drugs has been dominated by other existing precious metal drugs, and many researchers have focused their attention on the synthesis of various ruthenium (Ru) complexes due to their potential medical and pharmaceutical applications. The beneficial properties of Ru, which make it a highly promising therapeutic agent, include its variable oxidation states, low toxicity, high selectivity for diseased cells, ligand exchange properties, and the ability to mimic iron binding to biomolecules. In addition, Ru complexes have favorable adsorption properties, along with excellent photochemical and photophysical properties, which make them promising tools for photodynamic therapy. At present, nanostructured materials functionalized with Ru complexes have become an efficient way to administer Ru-based anticancer drugs for cancer treatment. In this review, the recent developments in the nanostructured materials functionalized with Ru complexes for targeted drug delivery to tumors are discussed. In addition, information on traditional (ie, non-nanostructured) Ru-based cancer therapies is included in a precise manner.
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