Article
Materials Science, Multidisciplinary
Zunaira Huma Ghauri, Atif Islam, Muhammad Abdul Qadir, Abdul Ghaffar, Nafisa Gull, Maryam Azam, Azra Mehmood, Atif Ali Ghauri, Rafi Ullah Khan
Summary: The pH-sensitive hydrogels based on polyelectrolyte complex of chitosan/sodium alginate/PEG with 1,4-diaminobutane as a cross-linking agent were successfully prepared by solution casting method, exhibiting good hydrogel properties and drug release performance.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Pharmacology & Pharmacy
Ahmed M. Omer, Maha S. Ahmed, Gehan M. El-Subruiti, Randa E. Khalifa, Abdelazeem S. Eltaweil
Summary: Alg-CMCs@AmCs dual polyelectrolyte complexes were successfully employed as a pH-sensitive drug carrier for efficient encapsulation and release of diclofenac sodium. The developed microcapsules showed excellent stability and high encapsulation efficiency under colonic conditions, suggesting great potential for practical applications.
Article
Chemistry, Applied
Meng Cheng, Yingjun Cui, Yanli Guo, Peixin Zhao, Juan Wang, Rongfei Zhang, Xiangyou Wang
Summary: pH-responsive CC/SA/CA hydrogels were prepared using CC and SA as wall materials, with the hydrogel formation attributed to electrostatic interactions and hydrogen bonding. The hydrogels exhibited improved thermostability with increasing CC content, as well as increased swelling degree with higher pH of the buffer solution. CA release from the hydrogels was mainly controlled by Fickian diffusion, and the release rate was positively correlated with temperature and environmental pH, allowing for on-demand release of CA. The hydrogels also showed good storage stability, antioxidant and antibacterial activities, and biocompatibility, making them a promising platform for environmentally-responsive preservatives with precise release and intelligent preservation capabilities.
Article
Biochemistry & Molecular Biology
Nuo Wei, Ze Lv, Xiaohan Meng, Qianwei Liang, Tianzhen Jiang, Shaoyang Sun, Yan Li, Jianguo Feng
Summary: The development of controlled release formulations for agrochemicals has been driven by increasing concerns about environmental pollution. In this study, a convenient polysaccharide hydrogel was successfully prepared for the controlled release of a specific agrochemical. The hydrogel exhibited excellent agrochemical load capacity and encapsulation efficiency. It also showed promising protective properties for the encapsulated agrochemical, resulting in better control against a specific plant disease. Safety assessment studies further demonstrated the hydrogel's good biocompatibility with non-targeted organisms and the crop.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biophysics
Kun Yan, Feiyang Xu, Wei Wei, Chenguang Yang, Dong Wang, Xiaowen Shi
Summary: A novel nanocomposite coating was successfully fabricated on the stainless-steel needle electrode by coupling in situ electrochemical synthesis of silver nanoparticles with pre-deposited chitosan multilayer hydrogel. The coating exhibited considerable antibacterial property and a pH-dependent and staged release pattern of silver nanoparticles.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Tomasz Urbaniak, Gabriela S. Garcia-Briones, Alexander Zhigunov, Sviatoslav Hladysh, Edyta Adrian, Volodymyr Lobaz, Tereza Krunclova, Olga Janouskova, Ognen Pop-Georgievski, Dana Kubies
Summary: This study investigated layer-by-layer polyelectrolyte coatings with the ability to release heparin-binding proteins. The use of tannic acid as a physical crosslinker resulted in more stable films during assembly and increased protein release. The proteins released more when they were part of the heparin layers rather than as individual protein layers.
Article
Chemistry, Multidisciplinary
Jean Schoeller, Fabian Itel, Karin Wuertz-Kozak, Sandra Gaiser, Nicolas Luisier, Dirk Hegemann, Stephen J. Ferguson, Giuseppino Fortunato, Rene M. Rossi
Summary: Surface functionalization of electrospun nanofibers allows for the introduction of additional functionalities while retaining high porosity and surface-to-volume ratio. In this study, chitosan and alginate were sequentially deposited on PLGA nanofibers to form a polyelectrolyte complex for controlled release of ibuprofen. Chitosan with a positive surface charge regulated the interactions between the drug and the coating, resulting in slower release at acidic pH compared to neutral pH.
Article
Biochemistry & Molecular Biology
Jinglei Li, Haishan Wu, Kexin Jiang, Yuting Liu, Liu Yang, Hyun Jin Park
Summary: An effective delivery system for oral insulin administration was developed using alginate microbeads containing chitosan nanoparticles (CNP) for controlled release of insulin. The optimized CNP with a size around 150 nm and encapsulation efficiency of 23.70% showed promising potential for oral insulin delivery. The insulin-loaded alginate microbeads significantly lowered blood glucose level in hyperglycemia model mice in a controlled manner for up to 96 hours, demonstrating the potential for extended release of insulin.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Xiang Gao, Rui Huang, Yanpeng Jiao, Thomas Groth, Wufeng Yang, Chenlin Tu, Hailong Li, Fan Gong, Jiaqi Chu, Mingyan Zhao
Summary: In this study, bioactive coatings were developed using Michael addition reaction for sustained release of insulin on PLLA nanofibrous mats, showing superior wound healing effects in animal models.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Physical
Duangkamol Dechojarassri, Tomoki Okada, Hiroshi Tamura, Tetsuya Furuike
Summary: The cytotoxicity of hyaluronic acid/chitosan/bacterial cellulose-based (BC(CS/HA)) membranes was evaluated and compared to that of alginate/chitosan/bacterial cellulose-based (BC(CS/Alg)) membranes. Scanning electron microscopy showed that the fiber diameter in BC(CS/HA) membranes was larger than that in BC(CS/Alg) membranes. The BC(CS/HA)(5) membrane exhibited high biocompatibility and is a promising material for wound dressings.
Article
Chemistry, Applied
Charanjit Kaur Surjit Singh, Hui-Peng Lim, Beng-Ti Tey, Eng-Seng Chan
Summary: In this study, a multi-functional Pickering emulsion powder was developed using chitosan as a Pickering emulsifier and alginate as a coating material. The powder exhibited good oxidative stability, pH-responsiveness, mucoadhesivity, and controlled lipid digestibility, making it a potential delivery system for applications in the food industry.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Dilara Gundogdu, Cemre Alemdar, Cagri Turan, H. Hazal Husnugil, Sreeparna Banerjee, Irem Erel-Goktepe
Summary: This study aimed to enhance the stimuli-responsive properties of physical alginate (ALG) hydrogels through layer-by-layer (LbL) modification and explore their potential as dual responsive, dual drug releasing platforms for antibacterial applications. It was found that LbL modification imparted temperature and pH responsiveness to ALG hydrogel, and enhanced the release of CIP. The LbL-coated hydrogels exhibited strong antibacterial activity, particularly at pH 7.4.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Nanoscience & Nanotechnology
Ishtpreet Kaur, Shekhar Agnihotri, Dinesh Goyal
Summary: In this study, insecticide cartap hydrochloride was fabricated as nanospheres using a two-step method. The nanospheres showed good stability and encapsulation efficiency. The release experiments indicated that the nanospheres had controlled release properties.
Review
Multidisciplinary Sciences
Yedi Herdiana, Nasrul Wathoni, Shaharum Shamsuddin, Muchtaridi Muchtaridi
Summary: This article summarizes the relationship between modification in chitosan-based drug nanoparticles (CSNPs) as multifunctional delivery systems and drug release properties and kinetics. The study found that almost all CSNPs show biphasic release, with an initial burst release followed by controlled release as expected.
Article
Chemistry, Physical
Kyung Hee Park, Yeon Woo Choi, Heejoo Ryu, Hyoung Jae Lee, Jae-Hak Moon, Ho-Jun Song, Yeong-Joon Park
Summary: This study developed improved multi-component beads for controlled and sustained delivery of antibiotics. Single and multi-component beads were prepared using chitosan, calcium chloride, alginate, and citric acid, and the release of antibiotics was controlled by crosslinking. The crosslinked beads showed efficient sustained-release of gentamicin.
Article
Engineering, Biomedical
Daniel J. Hickey, Batur Ercan, Linlin Sun, Thomas J. Webster
ACTA BIOMATERIALIA
(2015)
Article
Materials Science, Biomaterials
Luting Liu, Batur Ercan, Linlin Sun, Katherine S. Ziemer, Thomas J. Webster
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2016)
Article
Materials Science, Biomaterials
Luting Liu, Batur Ercan, Linlin Sun, Katherine S. Ziemer, Thomas J. Webster
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2016)
Article
Nanoscience & Nanotechnology
Fang Li, Chunli Zheng, Junbo Xin, Fangcheng Chen, Hua Ling, Linlin Sun, Thomas J. Webster, Xin Ming, Jianping Liu
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2016)
Review
Nanoscience & Nanotechnology
Linlin Sun, Chunli Zheng, Thomas J. Webster
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2017)
Article
Biotechnology & Applied Microbiology
Fujuan Chai, Linlin Sun, Yafei Ding, Xiaoqing Liu, Yajie Zhang, Thomas J. Webster, Chunli Zheng
Article
Chemistry, Multidisciplinary
Junyan Zhang, Linlin Sun, Paola A. Zapata, Monica Arias, Lucia Atehortuac, Thomas J. Webster
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2017)
Article
Nanoscience & Nanotechnology
Yanan Li, Yong Zhang, Pengmei Li, Gujie Mi, Jiasheng Tu, Linlin Sun, Thomas J. Webster, Yan Shen
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2017)
Review
Nanoscience & Nanotechnology
Chunmeng Sun, Yang Ding, Li Zhou, Di Shi, Linlin Sun, Thomas J. Webster, Yan Shen
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2017)
Review
Nanoscience & Nanotechnology
Yujia Wang, Ming Gao, Danquan Wang, Linlin Sun, Thomas J. Webster
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Correction
Nanoscience & Nanotechnology
Yanan Li, Yong Zhang, Pengmei Li, Gujie Mi, Jiasheng Tu, Linlin Sun, Thomas J. Webster, Yan Shen
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Materials Science, Multidisciplinary
Bingyi Lu, Qiuzhi Gao, Hailian Zhang, Qingshuang Ma, Huijun Li, Ziyun Liu, Linlin Sun
Summary: The strengthening and fracture mechanisms of Fe-20Ni-14Cr-2Cu alumina-forming austenitic (AFA) steel during creeping at 973 K/130 MPa were investigated. The presence of Laves and B2-NiAl phases was found to contribute to the creep properties of AFA steel, while the coarsening of sigma phase in the delta-ferrite region was the main reason for creep failure. The Fe-20Ni-14Cr-2Cu AFA steel aged for 1000 hours displayed excellent creep property at 973 K with a minimum steady-state creep rate of 7.64 x 10(-6) s(-1) and the longest creep life of 329.5 hours.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Ming Gao, Run Chang, Danquan Wang, Yuan Li, Linlin Sun, Steven R. Lustig, Thomas J. Webster
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Meeting Abstract
Chemistry, Multidisciplinary
Ming Gao, Kanny Chang, Danquan Wang, Yuan Li, Linlin Sun, Steven Lustig, Thomas Webster
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)