Review
Pharmacology & Pharmacy
Mehran Alavi, Ali Nokhodchi
Summary: In this article, we provide an overview of micro- and nanoformulations of paclitaxel (PTX) based on micelles, liposomes, cubosomes, and lipid nanoparticles (LNPs) to improve the therapeutic effects of this drug both in vitro and in vivo.
DRUG DISCOVERY TODAY
(2022)
Article
Materials Science, Biomaterials
Yun Li, Zhi Cai, Yihua Yin, Ying Yi, Weiquan Cai, Shengxiang Tao, Mengting Du, Jingli Zhang, Ruyu Cao, Yijing Luo, Wenjin Xu
Summary: In this study, a photoactivated bactericide nanosystem was developed using hematoporphyrin as a photosensitizer and pectin as a carrier. The nanosystem showed good water solubility and demonstrated high photodynamic activity upon esterase stimulation. It exhibited potent antibacterial effects and good adherence to leaves with no apparent toxic effects on plants. This research provides a new strategy for obtaining a photoactivated bactericide nanosystem with high utilization rate, good photostability, and targeting ability.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Pharmacology & Pharmacy
Shradha Dattani, Xiaoling Li, Charina Lampa, David Lechuga-Ballesteros, Amanda Barriscale, Behzad Damadzadeh, Bhaskara R. Jasti
Summary: The purpose of this study was to compare LDV-targeted lipid-based micelles, liposomes, and solid lipid nanoparticles (SLN) in vitro and in vivo to investigate their therapeutic potential. The nanocarriers were characterized for their physicochemical properties, drug loading efficiency, release behavior, stability, and antitumor efficacy in a melanoma xenograft model. Results showed that SLN had the slowest drug release rate and highest stability, and demonstrated a statistically significant delay in tumor growth compared to the other two formulations. This study highlights the potential of SLN as drug delivery vehicles for anticancer therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Ayesha Younas, Hongzhou Gu, Yongxing Zhao, Nan Zhang
Summary: The knee joint is susceptible to injuries due to activities, diseases, or accidents. Various drug delivery systems like nanoparticles have been used to treat knee joint injuries by improving function and alleviating symptoms.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Ana Claudia Lima, Rui L. Reis, Helena Ferreira, Nuno M. Neves
Summary: This study aimed to assess the internalization rates of different NPs under normal and proinflammatory states in three types of cells, revealing the importance of surface charge and chemistry in determining NP internalization levels. The study also identified different cellular uptake and internalization pathways, providing guidance for designing functional NPs for therapeutic purposes.
MOLECULAR PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Shubham A. Salunkhe, Deepak Chitkara, Ram Mahato, Anupama Mittal
Summary: Non-alcoholic fatty liver disease (NAFLD) encompasses a range of liver diseases that can progress to liver cancer, with diabetes mellitus being a key factor in its development. Liver fibrosis treatment involves the use of lipid nanoparticles, while the effects of elevated free fatty acids, insulin resistance, and diabetes on pathogenesis are also important considerations. Targeting hepatic stellate cells has been explored as a strategy for treating liver fibrosis.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Flavia Laffleur, Alexander Heinz Mayer
Summary: Oral drug delivery is a popular method, but it is limited by physiological and physicochemical barriers in the gastrointestinal tract. Nanoparticulate drug delivery systems based on lipids or polymers have shown promising results in improving bioavailability and treating diseases such as intestinal bowel disease and colorectal cancer.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Multidisciplinary Sciences
Xuexiang Han, Ningqiang Gong, Lulu Xue, Margaret M. Billingsley, Rakan El-Mayta, Sarah J. Shepherd, Mohamad-Gabriel Alameh, Drew Weissman, Michael J. Mitchell
Summary: By synthesizing AA-lipidoids with high delivery efficiency and selectivity, and validating in a preclinical model of liver fibrosis, the potential of AA-lipidoids for targeted RNA delivery to activated fibroblasts has been demonstrated.
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Pratik Kakade, Arkasubhro Chatterjee, Anjali Pandya, John Disouza, Vandana Patravale
Summary: Nanotechnology is an important field for formulation scientists, and lipidic nanosystems with surface modification using carbohydrates have attracted attention in drug delivery. These systems offer interesting properties and can be developed using various methods.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Thi-Thao-Linh Nguyen, Van-An Duong, Han-Joo Maeng
Summary: P-glycoprotein (P-gp) plays a crucial role in the active transport of substrates out of cells, leading to poor intestinal permeation. Utilizing P-gp inhibitors and pharmaceutically inert excipients can help enhance the oral absorption and bioavailability of P-gp substrates. Different formulations with inherent P-gp inhibitory activity have been developed, offering a promising strategy to bypass P-gp and improve drug delivery.
Article
Polymer Science
Qunli Yu, Nan Sun, Dengwen Hu, Yaping Wang, Xiaohua Chang, Nan Yan, Yutian Zhu, Yongjin Li
Summary: The proposed method effectively encapsulates large size inorganic nanoparticles into polymeric vesicles through 3D confined co-assembly within organic emulsion droplets. The encapsulation of nanoparticles into vesicle walls is mainly influenced by the ratio of nanoparticle diameter to the layer thickness of affinitive blocks.
Article
Chemistry, Multidisciplinary
Sandrine Lteif, Neda A. Nosratabad, Sisi Wang, Yan Xin, Steven J. Weigand, Hedi Mattoussi, Joseph B. Schlenoff
Summary: To stabilize and transport nanoparticles, polymeric nanocarriers are often used. This study encapsulates hydrophobic metal and metal oxide nanoparticles within PDMS nanodroplets using flash nanoprecipitation, resulting in stable nanocomposite nanodroplets in aqueous salt solutions without the use of surfactants.
Article
Pharmacology & Pharmacy
Mar Gil, Lareen Khouri, Imma Raurell, Diana Rafael, Fernanda Andrade, Ibane Abasolo, Simo Schwartz, Maria Martinez-Gomez, Maria Teresa Salcedo, Juan Manuel Pericas, Diana Hide, Mingxing Wei, Norman Metanis, Joan Genesca, Maria Martell
Summary: In this study, functionalized polymeric micelles (FPMs) loaded with simvastatin were developed as a drug delivery system to target liver sinusoidal endothelial cells (LSECs) and preserve liver function in chronic liver disease (CLD). The functionalized micelles showed greater in vivo internalization in LSECs compared to non-functionalized micelles. Treatment with FPM-Sim reduced toxicity and moderately lowered portal pressure in bile duct ligation (BDL) rats. In a less severe model of TAA-induced cirrhosis, treatment with FPM-CD32b-Sim significantly decreased portal pressure, reduced liver fibrosis, and stimulated nitric oxide synthesis.
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Parisa Abbasi, Mohammad Mahdi Eshaghi, Ali Bakhshi, Amanda-Lee Ezra Manicum, Abbas Rahdar, Sadanand Pandey, Sapana Jadoun, Ana M. Diez-Pascual
Summary: This review explores different types of nanostructures that can be used as drug delivery systems for curcumin, a biologically active polyphenol with high anticancer potential. Different approaches recently developed to solve issues such as poor solubility, short biological half-life, and high metabolism rate are described. Furthermore, co-delivery systems involving curcumin and other anticancer drugs are reviewed.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Changning Xue, Lifen Zhang, Yuman Zhang, Yao Yu, Chenlu Xu, Zhi Li
Summary: A H2O2-responsive and self-fluorescence prodrug-nanosystem has been constructed to release lovastatin in the liver, effectively reversing nonalcoholic fatty liver disease (NAFLD).
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Reju George Thomas, Afeesh Rajan Unnithan, Myeong Ju Moon, Suchithra Poilil Surendran, Tumurbaatar Batgerel, Chan Hee Park, Cheol Sang Kim, Yong Yeon Jeong
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Review
Biochemistry & Molecular Biology
Suchithra Poilil Surendran, Myeong Ju Moon, Rayoung Park, Yong Yeon Jeong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chung-Man Moon, Sang-Soo Shin, Suk-Hee Heo, Hyo-Soon Lim, Myeong-Ju Moon, Suchithra Poilil Surendran, Ga-Eon Kim, Il-Woo Park, Yong-Yeon Jeong
MOLECULAR IMAGING AND BIOLOGY
(2019)
Review
Pharmacology & Pharmacy
Subin Kim, Myeong Ju Moon, Suchithra Poilil Surendran, Yong Yeon Jeong
Article
Multidisciplinary Sciences
Suchithra Poilil Surendran, Reju George Thomas, Myeong Ju Moon, Rayoung Parke, Doo Hyun Kim, Kyun Hwan Kim, Yong Yeon Jeong
Article
Engineering, Biomedical
Suchithra Poilil Surendran, Reju George Thomas, Myeong Ju Moon, Rayoung Park, Jae Hyuk Lee, Yong Yeon Jeong
ACTA BIOMATERIALIA
(2020)
Review
Biochemistry & Molecular Biology
Reju George Thomas, Suchithra Poilil Surendran, Yong Yeon Jeong
FRONTIERS IN MOLECULAR BIOSCIENCES
(2020)
Article
Nanoscience & Nanotechnology
Athira Raveendran, Suchithra Poilil Surendran, Jinhui Ser, Khurshed Alam, Hoonsung Cho, Yong Yeon Jeong
Summary: The study successfully synthesized paclitaxel-MHI-148 conjugates (PTX-MHI), demonstrating superior performance in tumor cells, even without light treatment. PTX-MHI shows promising potential in specific drug delivery to tumor cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)