Article
Veterinary Sciences
Jessica Quimby, Andrea Erickson, Shannon Mcleland, Rachel Cianciolo, David Maranon, Katharine Lunn, Jonathan Elliott, Jack Lawson, Ann Hess, Rene Paschall, Susan Bailey
Summary: This study found significantly increased renal cell senescence, telomere shortening, and nitrosative stress in cats with CKD, suggesting that these patients may benefit from senolytic therapy.
VETERINARY SCIENCES
(2021)
Review
Food Science & Technology
Bartu Eren Gunesliol, Esen Karaca, Duygu Agagunduz, Zeynep Alanur Acar
Summary: The aging of the population leads to a loss of ability to move independently, and the length of telomeres is associated with cell aging and death. Physical activity and nutrition can affect telomere length and slow down the aging process.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Chieh Ming Liao, Tianjiao Luo, Juliane von der Ohe, Blanca de Juan Mora, Roland Schmitt, Ralf Hass
Summary: Exosomes derived from MSC have been shown to promote proliferation and reduce senescence in kidney cells, suggesting their therapeutic potential in combating renal senescence. This study demonstrates that exosome treatment efficiently reduces senescence markers and SASP factors in kidney cells, indicating a promising approach for organ rejuvenation and regenerative therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anthony Lagnado, Jack Leslie, Marie-Helene Ruchaud-Sparagano, Stella Victorelli, Petra Hirsova, Mikolaj Ogrodnik, Amy L. Collins, Maria Grazia Vizioli, Leena Habiballa, Gabriele Saretzki, Shane A. Evans, Hanna Salmonowicz, Adam Hruby, Daniel Geh, Kevin D. Pavelko, David Dolan, Helen L. Reeves, Sushma Grellscheid, Colin H. Wilson, Sanjay Pandanaboyana, Madison Doolittle, Thomas von Zglinicki, Fiona Oakley, Suchira Gallage, Caroline L. Wilson, Jodie Birch, Bernadette Carroll, James Chapman, Mathias Heikenwalder, Nicola Neretti, Sundeep Khosla, Claudio Akio Masuda, Tamar Tchkonia, James L. Kirkland, Diana Jurk, Derek A. Mann, Joao F. Passos
Summary: The research shows that neutrophils cause oxidative damage to telomeres in non-immune cells, promoting cellular senescence. In aged liver, senescent cells recruit neutrophils, potentially leading to the spread of senescence.
Article
Behavioral Sciences
Ana Paula Mendes-Silva, Erica Leandro Marciano Vieira, Gabriela Xavier, Lucelia Scarabeli Silva Barroso, Laiss Bertola, Efrem Augusto Ribeiro Martins, Elisa Macedo Brietzke, Sintia Iole Nogueira Belangero, Breno Satler Diniz
Summary: The study found that older adults with late-life depression have shorter telomeres compared to healthy controls, especially those with more severe depressive symptoms. There was a negative correlation between telomere length and the severity of depressive symptoms and medical burden, but no significant correlation with cognitive performance.
BRAIN AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Hannah Froy, Sarah L. Underwood, Jennifer Dorrens, Luise A. Seeker, Kathryn Watt, Rachael V. Wilbourn, Jill G. Pilkington, Lea Harrington, Josephine M. Pemberton, Daniel H. Nussey
Summary: The study found that in wild Soay sheep, there was no significant association between telomere length and subsequent survival, suggesting that telomere length is not an important marker of biological aging or exposure to environmental stress in this study system. Instead, individual differences in average telomere length were associated with increased lifespan, indicating a genetic basis for this correlation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Natthakan Thongon, Feiyang Ma, Andrea Santoni, Matteo Marchesini, Elena Fiorini, Ashley Rose, Vera Adema, Irene Ganan-Gomez, Emma M. Groarke, Fernanda Gutierrez-Rodrigues, Shuaitong Chen, Pamela Lockyer, Sarah Schneider, Carlos Bueso-Ramos, Guillermo Montalban-Bravo, Caleb A. Class, Kelly A. Soltysiak, Matteo Pellegrini, Ergun Sahin, Alison A. Bertuch, Courtney D. DiNardo, Guillermo Garcia-Manero, Neal S. Young, Karen Dwyer, Simona Colla
Summary: The study reveals that telomere attrition leads hematopoietic stem cells towards differentiation into megakaryocytic lineage through upregulated innate immune signaling response, ultimately compromising their self-renewal capabilities and leading to depletion. Targeting the IFI16 signaling axis could potentially prevent functional decline of hematopoietic stem cells under conditions affecting telomere maintenance.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Ju Chang-Chien, Jing-Long Huang, Hui-Ju Tsai, Shih-Ling Wang, Ming-Ling Kuo, Tsung-Chieh Yao
Summary: Exposure to PM resulted in decreased cell viability, increased cellular uptake, shortening of telomere length, induction of G0/G1 phase arrest, and increased expression of senescence hallmarks in A549 cells. PM exposure induced upregulation of p21 and downregulation of PCNA and hTERT expression, leading to telomere shortening and the onset of cellular senescence in human lung epithelial cells. Overall, PM exposure may downregulate hTERT and PCNA through p53-independent induction of p21 expression.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Cell Biology
Jee Whu Lee, Eugene Boon Beng Ong
Summary: Cellular senescence, triggered by nucleic acid damage and genetic alterations, is one of the pathways leading to aging. Telomere erosion and ribosomal DNA instability can also result in cellular senescence. Lessons from budding yeast provide insights into the molecular mechanisms linking telomere length homeostasis and ribosomal DNA stability to cellular senescence and longevity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zehuan Liao, Han Lin Yeo, Siaw Wen Wong, Yan Zhao
Summary: Cellular senescence is a complex process affecting various biological processes, with characteristics including senescence-associated phenotype and cell cycle arrest. Persistent senescence is associated with aging pathologies, while transient senescence is linked to beneficial programs.
Review
Biochemistry & Molecular Biology
Erika Csekes, Lucia Rackova
Summary: This article discusses the impact of skin aging and cellular senescence on the skin, as well as the role of natural polyphenols in preventing and delaying aging. It also summarizes the latest research on the anti-senescent mechanisms of polyphenols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Dries S. Martens, Charlotte Van der Stukken, Catherine Derom, Evert Thiery, Esm Ee M. Bijnens, Tim S. Nawrot
Summary: The study found that there is a correlation between telomere length at birth and later in life in both children and adults. The ranking of telomere length tends to be stable over time, indicating the importance of understanding the initial setting of newborn telomere length and its significance for later life. Additionally, longer maternal telomere length is associated with lower telomere attrition in the next generation.
Article
Environmental Sciences
Haktan Bagis Erdem, Taha Bahsi, Mehmet Ali Ergun
Summary: Telomeres are specialized non-coding DNA repeat sequences that play a crucial role in maintaining genome integrity. Short telomeres have been associated with age-related diseases, but factors influencing telomere length are not well understood. Future research is expected to lead to clinical applications of telomere length analysis.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Review
Cell Biology
Jing Yang, Mengmeng Liu, Dongchun Hong, Musheng Zeng, Xing Zhang
Summary: Cellular senescence in cancer presents a dual role, acting as both a preventative measure and a promoter of tumor development. Senescent cells contribute to oncogenesis through their secretory phenotype, both inhibiting tumor growth and creating an environment conducive to tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fernanda Hernandez-Gonzalez, Rosa Faner, Mauricio Rojas, Alvar Agusti, Manuel Serrano, Jacobo Sellares
Summary: Fibrosing interstitial lung diseases are chronic and fatal lung diseases characterized by the irreversible accumulation of scar tissue in the lung tissue. Cellular senescence, defined as a cell fate decision caused by unrepairable cellular damage, plays an important role in the initiation and progression of pulmonary fibrosis, likely by promoting molecular and cellular changes in chronic fibrosing processes. Targeting cellular senescence may be a potential therapeutic approach for treating fibrosing ILDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
J. Volkmann, J. Schmitz, J. Nordlohne, L. Dong, A. Helmke, P. Sen, S. Immenschuh, W. M. Bernhardt, W. Gwinner, J. H. Braesen, R. Schmitt, H. Haller, S. von Vietinghoff
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2020)
Article
Urology & Nephrology
Payel Sen, Alexandra Helmke, Chieh Ming Liao, Inga Soerensen-Zender, Song Rong, Jan-Hinrich Braesen, Anette Melk, Hermann Haller, Sibylle von Vietinghoff, Roland Schmitt
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Immunology
Kirill Kreimann, Mi-Sun Jang, Song Rong, Robert Greite, Sibylle von Vietinghoff, Roland Schmitt, Jan Hinrich Braesen, Lena Schiffer, Jessica Gerstenberg, Vijith Vijayan, Oliver Dittrich-Breiholz, Li Wang, Christian M. Karsten, Wilfried Gwinner, Hermann Haller, Stephan Immenschuh, Faikah Gueler
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Urology & Nephrology
George Haddad, Malte Kolling, Urs A. Wegmann, Angela Dettling, Harald Seeger, Roland Schmitt, Inga Soerensen-Zender, Hermann Haller, Andreas D. Kistler, Anne Dueck, Stefan Engelhardt, Thomas Thum, Thomas F. Mueller, Rudolf P. Wuethrich, Johan M. Lorenzen
Summary: The study found that H19 is upregulated in kidney biopsies of patients with AKI, in murine ischemic kidney tissue, and in cultured and ex vivo sorted hypoxic endothelial cells (ECs) and tubular epithelial cells (TECs). The overexpression of H19 promotes angiogenesis both in vitro and in vivo, and it confers protection against renal injury by stimulating proangiogenic signaling.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Tabea Stocklassa, Bianca Borchert-Morlins, Nima Memaran, Gunilla Einecke, Roland Schmitt, Nicolas Richter, Florian Wr Vondran, Elena Bauer, Sabrina Markefke, Anette Melk, Bernhard M. W. Schmidt
Summary: The study found that women have better cardiovascular disease outcomes and blood pressure control after transplantation, and CCB treatment has a positive impact on LVMI and PWV in women, indicating the need for further research on the effects of gender on cardiovascular risk in transplant recipients and the use of CCBs.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Cell Biology
Katie J. Mylonas, Eoin D. O'Sullivan, Duncan Humphries, David P. Baird, Marie-Helena Docherty, Sarah A. Neely, Paul J. Krimpenfort, Anette Melk, Roland Schmitt, Sofia Ferreira-Gonzalez, Stuart J. Forbes, Jeremy Hughes, David A. Ferenbach
Summary: This study demonstrated the impact of senescent cells on functional loss in human aging, chronic kidney disease, and radiation nephropathy, as well as the causative role of senescence in enhanced fibrosis in aged and irradiated murine kidneys after injury. Treatments targeting senescent cells, such as the B cell lymphoma 2/w/xL inhibitor ABT-263, were shown to reduce senescent cell numbers and restore regenerative capacity in kidneys, leading to improved function and reduced fibrosis after injury, suggesting a potential therapeutic option for protecting aging and vulnerable kidneys.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Doerte Huscher, Natalie Ebert, Inga Soerensen-Zender, Nina Mielke, Elke Schaeffner, Roland Schmitt
Summary: A study developed new prediction models for mortality or cardiovascular events using serum AZGP1 in older adults, finding that increased levels of AZGP1 predict lower risk of death and the composite endpoint in this population. However, no associations or correlations were found between AZGP1 and other candidate variables.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Chieh Ming Liao, Vera Christine Wulfmeyer, Maxine Swallow, Christine Susanne Falk, Hermann Haller, Ron Korstanje, Anette Melk, Roland Schmitt
Summary: This study examined the impact of genetic differences between mouse inbred strains on stress-induced cellular senescence in primary tubular epithelial cells. Significant differences were found in senescence values among PTEC from different strains, highlighting the importance of genetic diversity in senescence research and providing new insights for future investigations.
Article
Urology & Nephrology
Roland Schmitt
Summary: This article reviews the pathomechanistic principles of RAAS-mediated renal damage and the pharmaceutical possibilities for inhibition of the RAAS, summarizes the evidence from clinical studies on nephroprotection, and discusses international guideline recommendations.
Article
Biochemistry & Molecular Biology
Inga Soerensen-Zender, Song Rong, Hermann Haller, Roland Schmitt
Summary: This study investigated the therapeutic potential of increasing AZGP1 in treating fibrotic kidney disease. Both systemic treatment with recombinant AZGP1 and conditional overexpression of AZGP1 in proximal tubular cells showed beneficial effects, including reduced collagen deposition and improved lipid metabolism in tubular cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chieh Ming Liao, Tianjiao Luo, Juliane von der Ohe, Blanca de Juan Mora, Roland Schmitt, Ralf Hass
Summary: Exosomes derived from MSC have been shown to promote proliferation and reduce senescence in kidney cells, suggesting their therapeutic potential in combating renal senescence. This study demonstrates that exosome treatment efficiently reduces senescence markers and SASP factors in kidney cells, indicating a promising approach for organ rejuvenation and regenerative therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Vera Christine Wulfmeyer, Roland Schmitt
Summary: Autosomal dominant polycystic kidney disease typically presents with cystic transformation of the kidneys and liver, affecting 1 in 400-1 in 1000 individuals. Currently, there is no targeted treatment for all patients, but unspecific measures such as controlling blood pressure, fluid, and salt intake may benefit all patients. Research on targeted therapies and gene therapy for this disease is ongoing.
Article
Urology & Nephrology
Anke Schwarz, Roland Schmitt, Gunilla Einecke, Frieder Keller, Ulrike Bode, Hermann Haller, Hans Heinrich Guenter
Summary: After kidney transplantation, the course of pregnancy and graft function may have reciprocal interactions. Pre-pregnancy graft function plays a key role in pregnancy outcomes and graft function. Women with a low pre-pregnancy eGFR experience a significant decline in graft function during pregnancy.
Editorial Material
Urology & Nephrology
Sibylle von Vietinghoff, Roland Schmitt
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Physiology
Arpita Baisantry, Birgit Berkenkamp, Song Rong, Raj Bhayadia, Inga Soerensen-Zender, Roland Schmitt, Anette Melk
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)