Oxidative Stress in Cardiovascular Diseases: Involvement of Nrf2 Antioxidant Redox Signaling in Macrophage Foam Cells Formation

Urolithin A shows anti-atherosclerotic activity via activation of class B scavenger receptor and activation of Nef2 signaling pathway

(2018) Guang-Hao Cui et al.   Pharmacological Reports

The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells

(2017) Kaipeng Huang et al.   EXPERIMENTAL CELL RESEARCH

Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control

(2017) Jenny Jongstra-Bilen et al.   JOURNAL OF IMMUNOLOGY

Omega-3 polyunsaturated fatty acids improve the antioxidative defense in rat astrocytes via an Nrf2-dependent mechanism

(2017) Emilia Zgórzyńska et al.   Pharmacological Reports

Peroxiredoxin 1 have protective role in the vascular disease by regulating macrophages

(2016) S. Kim et al.   ATHEROSCLEROSIS

Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

(2016) Liping Xie et al.   DIABETES

The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells

(2016) Giuseppe Maltese et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lipoicmethylenedioxyphenol Reduces Experimental Atherosclerosis through Activation of Nrf2 Signaling

(2016) Zhekang Ying et al.   PLoS One

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural basis of Keap1 interactions with Nrf2

(2015) Peter Canning et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of Nrf2 in oxidative stress-induced endothelial injuries

(2015) B. Chen et al.   JOURNAL OF ENDOCRINOLOGY

Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice

(2015) LinZhang Huang et al.   JOURNAL OF LIPID RESEARCH

NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages

(2015) Min-gu Song et al.   PLoS One

Myeloid Cell–Specific ATP-Binding Cassette Transporter A1 Deletion Has Minimal Impact on Atherogenesis in Atherogenic Diet–Fed Low-Density Lipoprotein Receptor Knockout Mice

(2014) Xin Bi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo

(2014) Alexander Akhmedov et al.   EUROPEAN HEART JOURNAL

Adenovirus-Mediated Prothymosin α Gene Transfer Inhibits the Development of Atherosclerosis in Apoe-Deficient Mice

(2014) Meng-Ya Chang et al.   International Journal of Biological Sciences

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Biological Relevance of Inflammation and Oxidative Stress in the Pathogenesis of Arterial Diseases

(2013) David P. Hajjar et al.   AMERICAN JOURNAL OF PATHOLOGY

The absence of macrophage Nrf2 promotes early atherogenesis

(2013) Anna-Kaisa Ruotsalainen et al.   CARDIOVASCULAR RESEARCH

Tertiary-Butylhydroquinone Upregulates Expression of ATP-Binding Cassette Transporter A1 via Nuclear Factor E2-Related Factor 2/Heme Oxygenase-1 Signaling in THP-1 Macrophage-Derived Foam Cells

(2013) Qian Lu et al.   CIRCULATION JOURNAL

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice

(2013) Marit Westerterp et al.   CIRCULATION RESEARCH

Foam cells in atherosclerosis

(2013) Xiao-Hua Yu et al.   CLINICA CHIMICA ACTA

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1

(2013) Zhiping Liu et al.   JOURNAL OF LIPID RESEARCH

Nrf2and Cardiovascular Defense

(2013) Reuben Howden   Oxidative Medicine and Cellular Longevity

Ginkgolide B Reduces LOX-1 Expression by Inhibiting Akt Phosphorylation and Increasing Sirt1 Expression in Oxidized LDL-Stimulated Human Umbilical Vein Endothelial Cells

(2013) Lina Ma et al.   PLoS One

Myeloid Deletion of Nuclear Factor Erythroid 2−Related Factor 2 Increases Atherosclerosis and Liver Injury

(2012) Alan R. Collins et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation

(2012) Nobuhiko Harada et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells

(2012) Chao-Ke Tang   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Caveolin-1 Inhibits Expression of Antioxidant Enzymes through Direct Interaction with Nuclear Erythroid 2 p45-related Factor-2 (Nrf2)

(2012) Wen Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Laminar Flow Activation of ERK5 Protein in Vascular Endothelium Leads to Atheroprotective Effect via NF-E2-related Factor 2 (Nrf2) Activation

(2012) Miso Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice

(2012) Kazunobu Ishikawa et al.   International Journal of Hypertension

The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis

(2011) Illiana Meurs et al.   ATHEROSCLEROSIS

Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E–Deficient Mice

(2011) Jong-Gil Park et al.   CIRCULATION RESEARCH

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

(2011) Stefan Freigang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antioxidant signaling via Nrf2 counteracts lipopolysaccharide-mediated inflammatory responses in foam cell macrophages

(2011) Anne-Marie Kuhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

TGF-β1 Up-Regulates Expression of ABCA1, ABCG1 and SR-BI through Liver X Receptor α Signaling Pathway in THP-1 Macrophage-Derived Foam Cells

(2011) Yan-Wei Hu et al.   Journal of Atherosclerosis and Thrombosis

The Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 and its Soluble Form: Cardiovascular Implications

(2011) Teresa Navarra et al.   Journal of Atherosclerosis and Thrombosis

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

(2010) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection

(2010) Berenice Barajas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors

(2010) P. I. Makinen et al.   CARDIOVASCULAR RESEARCH

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls

(2010) Zuzana Majkova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State

(2009) Mustafa Zakkar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development

(2009) Bart Lammers et al.   ATHEROSCLEROSIS

Palmitic acid enhances lectin-like oxidized LDL receptor (LOX-1) expression and promotes uptake of oxidized LDL in macrophage cells

(2009) Junichi Ishiyama et al.   ATHEROSCLEROSIS

Heme Oxygenase 1 Determines Atherosclerotic Lesion Progression Into a Vulnerable Plaque

(2009) Caroline Cheng et al.   CIRCULATION

LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma

(2009) David F. Schaeffer et al.   JOURNAL OF LIPID RESEARCH

Loss of SR-A and CD36 Activity Reduces Atherosclerotic Lesion Complexity Without Abrogating Foam Cell Formation in Hyperlipidemic Mice

(2008) Jennifer J. Manning-Tobin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages

(2008) Tzi-Wei Lian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

(2008) Q.-j. Zhang et al.   CARDIOVASCULAR RESEARCH

Peroxiredoxin1 Prevents Excessive Endothelial Activation and Early Atherosclerosis

(2008) Janka Kisucka et al.   CIRCULATION RESEARCH

Nrf2 Regulates Antioxidant Gene Expression Evoked by Oxidized Phospholipids in Endothelial Cells and Murine Arteries In Vivo

(2008) Henna-Kaisa Jyrkkänen et al.   CIRCULATION RESEARCH

Antioxidants and Phase 2 Enzymes in Macrophages: Regulation by Nrf2 Signaling and Protection Against Oxidative and Electrophilic Stress

(2008) Hong Zhu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

(2008) Thomas E. Sussan et al.   PLoS One

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

(2008) K. J. Pearson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters A1 and G1

(2007) Ruud Out et al.   CIRCULATION RESEARCH