Article
Ophthalmology
Zhang Zhang, Xinrong Zou, Wenwen Xue, Pei Zhang, Shanshan Wang, Haidong Zou
Summary: The study investigated the ocular surface commensal bacteria profiles of patients with diabetes mellitus and dry eye disease, revealing differences in microbial composition between the groups. Patients with diabetes mellitus and dry eye disease had a more complex microbial composition compared to other groups, with unique core genera identified in each group. The findings provide insights into the microbial profile of dry eye disease in patients with diabetes mellitus.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Noriaki Nagai, Shunsuke Sakurai, Ryotaro Seiriki, Misa Minami, Mizuki Yamaguchi, Saori Deguchi, Eiji Harata
Summary: The MPC polymer prepared in this study showed hydrating effects without causing corneal damage, promoting tear film maintenance and improvement in dry eye symptoms.
Article
Biochemistry & Molecular Biology
Chang Ho Yoon, Jin Suk Ryu, Jung Hwa Ko, Joo Youn Oh
Summary: This study revealed that aberrant fucosylation plays a crucial role in the pathogenesis of dry eye disease (DED) and may serve as a novel target for DED therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Shuo Yang, Yaying Wu, ChunYang Wang, Xiuming Jin
Summary: This review summarizes the various ion-channels related to dry eye, their functions, and distribution. It also discusses the research results of different compounds targeting these channels. Further understanding the relationship between ion-channels and dry eye is crucial for targeted drug therapy.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Benjamin Paik, Louis Tong
Summary: This study suggests that topical omega-3 is a promising treatment for dry eye, with evidence from human trials showing improvements in ocular surface staining and tear break-up time. However, further research is needed to confirm the effects on other aspects of dry eye.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Ilenia Abbate, Cristina Zappulla, Manuela Santonocito, Santa Viola, Luca Rosario La Rosa, Giuseppe De Pasquale, Elisa Caviola, Marisa Meloni, Maria Cristina Curatolo, Maria Grazia Mazzone
Summary: This study suggests that a matrix based on sodium hyaluronate, xanthan gum, glycine, and betaine can promote the repair and protection of the ocular surface through synergistic effects, reducing inflammation and oxidative damage. It has the potential to be a new approach for treating dry eye disease.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Medicine, General & Internal
Matias Soifer, Nadim S. Azar, Hazem M. Mousa, Victor L. Perez
Summary: Ocular surface inflammatory disorders (OSID) are inflammatory reactions in the ocular adnexal connective tissues caused by systemic disorders, resulting in inflammatory dry eye. The lack of available biomarkers for detecting and quantifying inflammation in the conjunctiva and lacrimal gland is a major limitation in managing these conditions. OSID and dry eye syndrome involve different immune cells and understanding the potential role of inflammation and immune phenotype in ocular tissues is crucial.
FRONTIERS IN MEDICINE
(2022)
Review
Microbiology
Qingyu An, Haidong Zou
Summary: People with diabetes mellitus are at a higher risk of developing dry eye disease (DED). The ocular surface microbiota (OSM) differs significantly between patients with DED and healthy people, indicating that OSM dysbiosis may contribute to the pathogenesis of DED. The high-glucose environment and subsequent pathological changes can cause OSM dysbiosis, leading to ocular surface inflammation and tear composition alterations.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Immunology
Yun Qi, Yong Wan, Tianhui Li, Ming Zhang, Yu Song, Yaguang Hu, Yining Sun, Li Li
Summary: In this study, differences in the composition and function of the ocular microbiome were observed between patients with dry eye concomitant with autoimmune disease and those without autoimmune disease, suggesting potential variations in pathogenesis and disease severity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alba Ramos-Llorca, Camilla Scarpellini, Koen Augustyns
Summary: This review examines the implications of proteases in the development and severity of dry eye disease and discusses the progress in utilizing protease inhibitors as potential therapeutic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Youssof Eshac, Rachel L. Redfern, Vinay Kumar Aakalu
Summary: The ocular surface is responsible for maintaining a clear moist refractive surface and protecting the eye from exogenous pathogens, with antimicrobial peptides playing a crucial role in the immune response during both healthy states and dry eye diseases. These peptides have various functions such as neutralizing microbial threats, promoting wound healing, and modulating immunity, making them potential therapeutic targets for ocular surface diseases and dry eye.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Shangkun Ou, Mani Vimalin Jeyalatha, Yi Mao, Junqi Wang, Chao Chen, Minjie Zhang, Xiaodong Liu, Minghui Liang, Sijie Lin, Yiming Wu, Yixuan Li, Wei Li
Summary: Ectodysplasin A (EDA), a ligand of the TNF family, is crucial for maintaining the homeostasis of the ocular surface. Mutation of EDA can lead to ocular surface abnormalities and various eye disorders. Experimental studies have demonstrated the potential of using recombinant EDA protein to prevent and treat ocular surface abnormalities. Thus, EDA-based therapy holds promise as a novel approach for the treatment of ocular surface disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Ophthalmology
Archana Padmanabhan Nair, Sharon D'Souza, Pooja Khamar, Rudy M. M. A. Nuijts, Swaminathan Sethu, Rohit Shetty
Summary: Dry eye disease (DED) is a chronic ocular surface inflammatory condition, and the severity of the disease is directly related to the immune-inflammatory status of the ocular surface. The presence of various immune cells on the ocular surface plays a role in DED, with increased proportions of neutrophils, dendritic cells, macrophages, and certain T cell subsets, and a decrease in T regulatory cells. These cells have shown a causal association with ocular surface health parameters. Interventions targeting specific immune cell subsets have been studied to reduce DED severity.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Maria Carmen Sanchez-Gonzalez, Raul Capote-Puente, Marta-C Garcia-Romera, Concepcion De-Hita-Cantalejo, Maria-Jose Bautista-Llamas, Carmen Silva-Viguera, Jose-Maria Sanchez-Gonzalez
Summary: This study describes the role of OSA as a new non-invasive diagnostic device for dry eye disease. OSA provides accurate and non-invasive parameters to interpret distinct functions of the tear film. A complete examination protocol for OSA and OSA Plus devices is presented. These devices represent a renewal in dry eye disease diagnosis and have the potential to replace invasive techniques.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Jasmine Andersson, Josef K. Vogt, Marlene D. Dalgaard, Oluf Pedersen, Kim Holmgaard, Steffen Heegaard
Summary: The study found that patients with aqueous tear-deficient dry eye have decreased diversity and altered composition of ocular surface microbiota compared to controls, with a few bacterial genera being present in the majority of study participants.
Article
Pathology
Jinghua Bu, Jingwen Yu, Yang Wu, Xiaoxin Cai, Kechun Li, Liying Tang, Nan Jiang, M. Vimalin Jeyalatha, Minjie Zhang, Huimin Sun, Hui He, Andrew J. Quantock, Yongxiong Chen, Zuguo Liu, Wei Li
AMERICAN JOURNAL OF PATHOLOGY
(2020)
Article
Ophthalmology
Yun Han, Nan Jiang, Ting Su, Qi-Chen Yang, Cong-Cong Yan, Lei Ye, Qing Yuan, Pei-Wen Zhu, Wei Li, Zu-Guo Liu, Yi Shao
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Chengchao Chu, Jingwen Yu, En Ren, Shangkun Ou, Yunming Zhang, Yiming Wu, Han Wu, Yang Zhang, Jing Zhu, Qixuan Dai, Xiaoyong Wang, Qingliang Zhao, Wei Li, Zuguo Liu, Xiaoyuan Chen, Gang Liu
Article
Ophthalmology
Jia He, Shangkun Ou, Jun Ren, Huimin Sun, Xin He, Zhongyang Zhao, Han Wu, Yangluowa Qu, Tingting Liu, Vimalin Jeyalatha, Liying Zhang, Qiyuan Li, Peter Sol Reinach, Andrew Quantock, Jie Hao, Zuguo Liu, Wei Li
Article
Biotechnology & Applied Microbiology
Yi Mao, Sijie Lin, Chengfang Zhu, Xiaodong Liu, Huping Wu, Shangkun Ou
Summary: This retrospective study investigates the correlation between cytokine levels and virus status in Fuchs heterochromic iridocyclitis patients. The results show that rubella virus presence is associated with higher levels of IL-6 and IL-8, and lower levels of bFGF in the aqueous humor. Additionally, VCAM-1 and IL-10 levels were higher, while VEGF levels were lower in the virus-positive group compared to the virus-negative group.
Article
Rheumatology
Yixuan Li, Shangkun Ou, Sijie Lin, Hongyan Qian, Zhongyang Zhao, Mengqin Zhang, Siyang Li, Yuan Liu, Guixiu Shi
Summary: This study investigated the alteration of meibomian gland (MG) in patients with systemic lupus erythematosus (SLE). The findings suggest that examinations of MGs can help diagnose or infer ocular diseases in SLE patients at an early stage.
Review
Medicine, General & Internal
Liying Zhang, Zhirong Lin, Huping Wu, Shangkun Ou
Summary: This case report highlights a rare case of corneal perforation caused by eyelid margin trichilemmal carcinoma (TLC), emphasizing the importance of considering TLC in the differential diagnosis of eyelid lesions and ensuring complete excision for prevention of recurrence.
FRONTIERS IN MEDICINE
(2022)
Article
Cell & Tissue Engineering
Yi Mao, Shangkun Ou, Chengfang Zhu, Sijie Lin, Xiaodong Liu, Minghui Liang, Jingwen Yu, Yiming Wu, Hui He, Rongrong Zong, Zhirong Lin, Zuguo Liu, Wei Li
Summary: The downregulation of the p38 MAPK signaling pathway is essential for maintaining the stemness and preventing the terminal differentiation and abnormal differentiation of corneal epithelial cells during the construction of tissue-engineered corneal epithelium. Small molecules that modulate this pathway can improve the quality of tissue-engineered corneal epithelium. Transplantation of tissue-engineered corneal epithelium treated with SB203580 in a rabbit LSCD model showed faster wound healing and improved epithelial quality.
TISSUE ENGINEERING PART A
(2022)
Review
Biochemistry & Molecular Biology
Shangkun Ou, Mani Vimalin Jeyalatha, Yi Mao, Junqi Wang, Chao Chen, Minjie Zhang, Xiaodong Liu, Minghui Liang, Sijie Lin, Yiming Wu, Yixuan Li, Wei Li
Summary: Ectodysplasin A (EDA), a ligand of the TNF family, is crucial for maintaining the homeostasis of the ocular surface. Mutation of EDA can lead to ocular surface abnormalities and various eye disorders. Experimental studies have demonstrated the potential of using recombinant EDA protein to prevent and treat ocular surface abnormalities. Thus, EDA-based therapy holds promise as a novel approach for the treatment of ocular surface disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yujie Zhang, Xie Fang, Zhirong Lin, Zhiwen Xie, Huping Wu, Shangkun Ou
Summary: This case report presents a rare coexistence of Mooren's ulcer (MU) and pterygium, highlighting the diagnostic challenges. Through various examinations and histopathological examination, MU concealed beneath the pterygium was diagnosed, leading to appropriate treatment.
JOURNAL OF HISTOTECHNOLOGY
(2022)
Meeting Abstract
Ophthalmology
Shangkun Ou, Jingwen Yu, Yuli Guo, Hui He, Yixuan Li, Sijie Lin, Minghui Liang, Yi Mao, Zuguo Liu, Wei Li
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Meeting Abstract
Ophthalmology
Xin He, Zhongyang Zhao, JingHua Bu, Minjie Zhang, Jie Kang, Yixuan Li, Kechun Li, Zuguo Liu, Wei Li
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
