Article
Neurosciences
Jingsong Xiao, Qifu Zhang, Yaohui Shan, Feng Ye, Xi Zhang, Jin Cheng, Xiaogang Wang, Yuanpeng Zhao, Guorong Dan, Mingliang Chen, Yan Sai
Summary: In this study, it was found that MOTS-c could directly interact with Nrf2 to activate the Nrf2/HO-1/NQO1 signal pathway, thus protecting dopaminergic neurons from oxidative stress and neurotoxicity induced by rotenone.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Zhao-Hui Yao, Jing Wang, Jing-Ping Yuan, Kai Xiao, Shao-Feng Zhang, Yan-Chun Xie, Jun-Hua Mei
Summary: EGB761 treatment may improve cognitive function impairment induced by CCH by affecting synaptic plasticity, synaptic degeneration, and axon demyelination.
Article
Environmental Sciences
Yuri Lee, Sooji Choi, Kyung Won Kim
Summary: This study investigated the neurotoxic effects of the fungicide Dithianon and its underlying cellular and molecular mechanisms using the model organism Caenorhabditis elegans. Chronic exposure to Dithianon caused significant degeneration of dopaminergic neurons in a concentration-dependent manner. The study also found that Dithianon induced oxidative stress and mitochondrial fragmentation, which are associated with cellular stress. These findings contribute to a better understanding of the neurotoxic potential of Dithianon.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Neurosciences
Ruihua Sun, Junkui Shang, Xi Yan, Jingran Zhao, Wan Wang, Wenjing Wang, Wei Li, Chenhao Gao, Fengyu Wang, Haohan Zhang, Yanliang Wang, Huixia Cao, Jiewen Zhang
Summary: Chronic cerebral hypoperfusion (CCH) is associated with neuronal loss and blood-brain barrier (BBB) impairment in vascular dementia (VaD). This study aimed to explore the relationship and molecular mechanisms between BBB dysfunction and neuronal loss. Using a rat model, the authors observed the pathological changes of cortical neurons and BBB following CCH. Transcriptome analysis of cortical microvessels revealed that vascular inflammation-related processes mainly occurred in the chronic phase, and the adhesion molecule VCAM1 played an important role.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Ifat Alsharif, Loubna Boukhzar, Benjamin Lefranc, David Godefroy, Juliette Aury-Landas, Jean-Luc do Rego, Jean-Claude do Rego, Frederic Naudet, Arnaud Arabo, Abdeslam Chagraoui, David Maltete, Abdelhamid Benazzouz, Catherine Bauge, Jerome Leprince, Abdel G. Elkahloun, Lee E. Eiden, Youssef Anouar
Summary: PSELT, derived from SELENOT, shows promise as a therapeutic candidate for Parkinson's disease by targeting oxidative stress at multiple intracellular levels.
Article
Neurosciences
Shao-Hua Su, Ming Chen, Yi-Fang Wu, Qi Lin, Da-Peng Wang, Jun Sun, Jian Hai
Summary: This study explores the role of gut microbiota and SCFAs in chronic cerebral ischemia-induced neuronal injury. Fecal microbiota transplantation and SCFAs treatment can reverse these effects and improve cognitive function by modulating the gut microbiota and inflammatory responses in the brain.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Plant Sciences
Qiao Xiao, Huina Liu, Chao Yang, Yi Chen, Yueyue Huang, Xiaoxia Xiao, Yaru Pan, Jinyang He, Qun Du, Qi Wang, Yifan Zhang
Summary: This study aimed to investigate the therapeutic effects and underlying mechanisms of the traditional Chinese medicine formula Bushen-Yizhi (BSYZ) on chronic cerebral hypoperfusion (CCH) in rats. The results showed that BSYZ attenuated oxidative stress and neuronal apoptosis through inhibiting excessive mitophagy, thus improving cognitive and memory abilities in CCH-injured rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Xiaodong Wang, Xudong Yang, Fang Han, Ling Gao, Yi Zhou
Summary: The study investigated the effects of propofol on cognitive dysfunction and brain injury in a rat model of chronic cerebral hypoperfusion. Results showed that propofol treatment increased antioxidant enzyme activity, decreased oxidative stress levels, and reduced inflammatory responses in rat brain tissue, thereby improving cognitive function and alleviating brain damage.
FOOD SCIENCE & NUTRITION
(2021)
Article
Medicine, Research & Experimental
Shinrye Lee, Yu-Mi Jeon, Myungjin Jo, Hyung-Jun Kim
Summary: The study demonstrated that SIRT3 expression is increased under oxidative stress in dopaminergic neuronal cells and its overexpression enhances mitochondrial activity, protecting against oxidative stress-induced cell death. The research also showed the protective role of SIRT3 in a Drosophila model, further supporting its importance in mitochondrial function and cell survival.
EXPERIMENTAL NEUROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yefei Wang, Ying Wang, Shixin Li, Huihui Jin, Jiayu Duan, Xiyue Lu, Yinglin Qin, Jiale Song, Xiaoshan Li, Xianglan Jin
Summary: Chronic cerebral hypoperfusion (CCH) is associated with cognitive impairment, and mitochondrial dysfunction plays a crucial role in CCH-induced neurovascular pathology. Chinese herbal medicine has been proven effective in improving mitochondrial dysfunction and neurovascular pathology after CCH, and it also shows potential therapeutic value in combating neurodegenerative diseases by targeting mitochondrial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xingrui Ji, Shaocong Zhou, Nana Wang, Jingwen Wang, Yue Wu, Yuhan Duan, Penghao Ni, Jingzhong Zhang, Shuang Yu
Summary: The exosomes released by cerebral organoids have potential neuroprotective effects and can promote the differentiation of induced pluripotent stem cells into dopaminergic neurons. This study provides insights into the biological properties of cerebral organoids and highlights the potential of exosomes from cerebral organoids in the treatment of neurodegenerative diseases such as Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Chia-Cheng Wei, Nien-Chieh Yang, Chi-Wei Huang
Summary: This study conducted in vivo ZEN neurotoxicity assessment using Caenorhabditis elegans and found that ZEN exposure induced dopaminergic neuron damage and abnormal behaviors, as well as increased mitochondrial fragmentation. Moreover, upregulation of mitochondrial fission and apoptosis-related genes by ZEN exposure revealed the crucial role of DRP-1 on ZEN-induced neurotoxicity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Geriatrics & Gerontology
Miao Zhang, Yuan Hu, Jiahui Zhang, Junjian Zhang
Summary: The study showed that FTY720 can improve chronic cerebral hypoperfusion-induced spatial memory loss, possibly through the regulation of mitochondrial function and neuroinflammation. This provides new insights into the pathological mechanisms of cognitive impairment caused by chronic cerebral hypoperfusion.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sibylle Frase, Franziska Loeffler, Jonas A. Hosp
Summary: This study demonstrates the facilitating effect of substance P (SP) treatment on motor rehabilitation after stroke, especially if administered prior to training. SP also prevents delayed dopaminergic degeneration and preserves physiological endogenous SPergic innervation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Phakkawat Thangwong, Pranglada Jearjaroen, Piyarat Govitrapong, Chainarong Tocharus, Jiraporn Tocharus
Summary: Melatonin shows therapeutic effects on CCH-induced AD pathology, ER stress, and synaptic plasticity by reducing oxidative stress, ER stress, and apoptosis, thus ameliorating cognitive impairment.
BIOCHEMICAL PHARMACOLOGY
(2022)