期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms18020280
关键词
low-dose radiation; hormesis; immune stimulating; immune therapy; autoimmune disease; cancer therapy
资金
- Key Project of Science and Technology Research of the Ministry of Education [311015]
- Bethune Program B of Jilin University [2012202]
- Science and Technology Project of Jilin Province [20140414014GH]
- Platform Construction Project of the Development and Reform Commission of Jilin Province [2014N147]
- Young Scholars Development Fund of the First Hospital of Jilin University [JDYY52015034]
- National Science Foundation of China [81502753, 81670221]
The interrelationship between ionizing radiation and the immune system is complex, multifactorial, and dependent on radiation dose/quality and immune cell type. High-dose radiation usually results in immune suppression. On the contrary, low-dose radiation (LDR) modulates a variety of immune responses that have exhibited the properties of immune hormesis. Although the underlying molecular mechanism is not fully understood yet, LDR has been used clinically for the treatment of autoimmune diseases and malignant tumors. These advancements in preclinical and clinical studies suggest that LDR-mediated immune modulation is a well-orchestrated phenomenon with clinical potential. We summarize recent developments in the understanding of LDR-mediated immune modulation, with an emphasis on its potential clinical applications.
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