Review
Biochemistry & Molecular Biology
Anderson Luiz-Ferreira, Teresa Pacifico, Alefe Cardoso Cruz, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: TRAIL is a promising anticancer agent that selectively induces apoptosis in transformed cells, while flavonoids, natural compounds found in plants, have shown competence in enhancing TRAIL-induced apoptosis. However, bioavailability issues are the main limitations for the clinical use of flavonoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Rosario Yerbes, Rocio Mora-Molina, F. Javier Fernandez-Farran, Laura Hiraldo, Abelardo Lopez-Rivas, Carmen Palacios
Summary: This study reveals a previously unknown cell death mechanism triggered in glutamine-addicted tumor cells in response to glutamine metabolism limitation. The mechanism is regulated by GCN2 activation induced by glutamine starvation and involves the activation of the extrinsic apoptotic pathway mediated by TRAIL-R2.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
So Rae Song, Seung Un Seo, Seon Min Woo, Ji Yun Yoon, Simmyung Yook, Taeg Kyu Kwon
Summary: In this study, the research focused on the effect of traditional Chinese medicinal herb, Tubeimoside-1 (TBMS-1), on the sensitization of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). The results showed that combination therapy using TBMS-1 and TRAIL increased apoptotic cell death. Mechanistically, TBMS-1 destabilized c-FLIP expression by downregulating STAMBPL1, a deubiquitinase (DUB). Moreover, knockdown of STAMBPL1 enhanced TRAIL-mediated apoptosis via c-FLIP downregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Oliver H. Voss, Daniel Arango, Justin C. Tossey, Miguel A. Villalona Calero, Andrea Doseff
Summary: Apigenin sensitizes primary lung cancer cells to TRAIL-induced apoptosis through reprogramming alternative splicing of key TRAIL/DISC components and directly binding heat shock protein 70 to promote cell death. These findings emphasize the synergies between diet and cancer treatments, providing new avenues for improved cancer therapies.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Valeria Coppola, Ilaria Marino, Uwe Warnken, Mario Falchi, Luca Pasquini, Mauro Biffoni, Ruggero De Maria, Tobias Longin Haas
Summary: We have identified FYCO1 as a protein that promotes the transport of autophagic and endosomal vesicles. It interacts with activated CASP8 and its loss leads to increased sensitivity of cells to apoptosis and impaired transport of TNFRSF10B/TRAIL-R2/DR5.
Article
Biochemistry & Molecular Biology
Rui Zhang, Teng Xue, Anwen Shao, Yue Lang, Chao Qin, Mingliang Zhao, Yu Kuang, Zhengquan Yu, Yunyun Geng, Chenyang Zhao, Jun Tang
Summary: TNF stimulation generates pro-survival signals by activating NF-kappa B and restricting death signaling. Bclaf1 has been identified as a novel component of TNF anti-apoptotic program, promoting CFLAR transcription downstream of NF-kappa B activation. The depletion of Bclaf1 sensitizes cells to TNF-induced apoptosis and exacerbates small intestine injury in mice.
Article
Biochemistry & Molecular Biology
Rutambhara Purohit, Amal Kanti Bera
Summary: Panx1 protein plays a crucial role in cell activities, and mutations can affect channel function. The R217H mutation reduces channel currents and impacts cell death processes, but does not affect when CT is completely removed.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Zhi-Qiang Bai, Xiaofang Ma, Bin Liu, Tao Huang, Kaifeng Hu
Summary: This study provides a structural basis for understanding the interaction between c-FLIP and procaspase-8 and the molecular mechanisms of c-FLIP in regulating cell death.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Greta Del Mistro, Shamala Riemann, Sebastian Schindler, Stefan Beissert, Roland E. Kontermann, Aurelien Ginolhac, Rashi Halder, Luana Presta, Lasse Sinkkonen, Thomas Sauter, Dagmar Kulms
Summary: Malignant melanoma (MM) is a life-threatening disease that often develops resistance to targeted kinase inhibition. In this study, the researchers found that inhibiting focal adhesion kinase (FAK) could restore sensitivity to treatment in previously resistant MM cells.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Yang Cao, Ying He, Litao Yang, Zhou Luan
Summary: Studies have shown that CR-31 treatment can counter the resistance to TRAIL in GBC cells, increase sensitivity to apoptosis, and may serve as a novel therapeutic strategy.
Article
Biology
Joshua D. Greenlee, Maria Lopez-Cavestany, Nerymar Ortiz-Otero, Kevin Liu, Tejas Subramanian, Burt Cagir, Michael R. King
Summary: This study demonstrates that oxaliplatin-resistant CRC cells become more sensitive to TRAIL-mediated apoptosis due to increased DR4 expression, palmitoylation, and translocation. The alteration of DR4/raft colocalization and TRAIL sensitivity by raft perturbation via nystatin and resveratrol is significant. Additionally, treatment with TRAIL liposomes in blood samples from metastatic CRC patients results in a reduction of viable CTCs, with increased DR4/lipid raft colocalization corresponding to increased oxaliplatin resistance and efficacy of TRAIL liposomes.
Article
Chemistry, Medicinal
Gunya Sittithumcharee, Ryusho Kariya, Teerapich Kasemsuk, Rungnapha Saeeng, Seiji Okada
Summary: Acanthoic acid (AA) extracted from the traditional plant Croton oblongifolius Roxb. in Thailand is found to effectively inhibit the proliferation of PEL cells, demonstrating potential as a new treatment option for PEL.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chiara Musiu, Simone Caligola, Alessandra Fiore, Alessia Lamolinara, Cristina Frusteri, Francesco Domenico Del Pizzo, Francesco De Sanctis, Stefania Cane, Annalisa Adamo, Francesca Hofer, Roza Maria Barouni, Andrea Grilli, Serena Zilio, Paolo Serafini, Evelina Tacconelli, Katia Donadello, Leonardo Gottin, Enrico Polati, Domenico Girelli, Ildo Polidoro, Piera Amelia Iezzi, Domenico Angelucci, Andrea Capece, Ying Chen, Zheng-Li Shi, Peter J. Murray, Marco Chilosi, Ido Amit, Silvio Bicciato, Manuela Iezzi, Vincenzo Bronte, Stefano Ugel
Summary: Research has shown that FLIP can control cytokine release syndrome (CRS) by activating a STAT3-dependent inflammatory program. Expression of a viral FLIP homolog in myeloid cells can trigger a fatal inflammatory syndrome in mice, characterized by increased cytokine output, lymphopenia, lung injury, and multiple organ dysfunctions. Targeting the STAT3 pathway may help alleviate inflammation, immune disorders, and organ failures associated with CRS.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Chemistry, Medicinal
Sayyed Jalil Mahdizadeh, Melissa Thomas, Leif A. Eriksson
Summary: The DISC is a complex composed of multiple proteins that trigger the extrinsic apoptosis pathway. This study used a new protein-protein docking meta-approach to reconstruct the DISC structure, revealing that the formation of DISC starts with the dimerization of adjacent Fas DD trimers followed by recruitment of FADD through homotypic DD interactions with the oligomerized death receptor.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Pathology
Handy Riantana, Orawan Waenphimai, Panupong Mahalapbutr, Kun Karnchanapandh, Kulthida Vaeteewoottacharn, Sopit Wongkham, Kanlayanee Sawanyawisuth
Summary: PLK1 is an essential mitotic checkpoint protein that plays a key role in cell cycle division and its overexpression is associated with poor prognosis in various cancers. In this study, the PLK1 inhibitors BI6727 and GSK461364A effectively suppressed cholangiocarcinoma cell proliferation, induced G2/M arrest, and triggered mitotic catastrophe and cell apoptosis, suggesting that they could be potential drugs for cholangiocarcinoma therapy at the clinical level.
PATHOLOGY RESEARCH AND PRACTICE
(2023)