Anti-Fibrotic Effect of Losartan, an Angiotensin II Receptor Blocker, Is Mediated through Inhibition of ER Stress via Up-Regulation of SIRT1, Followed by Induction of HO-1 and Thioredoxin

Losartan attenuates renal interstitial fibrosis and tubular cell apoptosis in a rat model of obstructive nephropathy

(2014) PING HE et al.   Molecular Medicine Reports

Endoplasmic Reticulum Stress Induces Epithelial-Mesenchymal Transition through Autophagy via Activation of c-Src Kinase

(2014) Soo Young Moon et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of sirtuins in kidney disease

(2013) Munehiro Kitada et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease

(2013) Xian-Si Zeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic Reticulum Stress Is Involved in Cardiac Damage and Vascular Endothelial Dysfunction in Hypertensive Mice

(2012) Modar Kassan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endoplasmic reticulum stress as a pro-fibrotic stimulus

(2012) Harikrishna Tanjore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice

(2012) Asuka Shiota et al.   Cardiovascular Diabetology

The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis

(2012) Stefania Lenna et al.   CURRENT OPINION IN RHEUMATOLOGY

Insulin-Like Growth Factor-1 Inhibits 6-Hydroxydopamine-Mediated Endoplasmic Reticulum Stress-Induced Apoptosis via Regulation of Heme Oxygenase-1 and Nrf2 Expression in PC12 Cells

(2012) Yumi Kim et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Losartan Alleviates Renal Fibrosis by Down-Regulating HIF-1αand Up-Regulating MMP-9/TIMP-1 in Rats with 5/6 Nephrectomy

(2012) Wencheng Fu et al.   RENAL FAILURE

Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice

(2012) Jian-Qing Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

(2012) P Menu et al.   Cell Death & Disease

Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders

(2011) Lale Ozcan et al.   Annual Review of Medicine

Aliskiren and Valsartan Reduce Myocardial AT1 Receptor Expression and Limit Myocardial Infarct Size in Diabetic Mice

(2011) Yumei Ye et al.   CARDIOVASCULAR DRUGS AND THERAPY

Modulation of AT-1R/CHOP-JNK-Caspase12 pathway by olmesartan treatment attenuates ER stress-induced renal apoptosis in streptozotocin-induced diabetic mice

(2011) Arun Prasath Lakshmanan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol

(2011) Pedro Ayala et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

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(2011) Chih-Kang Chiang et al.   MOLECULAR MEDICINE

Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: Involvement of ACE2-Ang (1–7)-mas axis

(2011) Somasundaram Arumugam et al.   TOXICOLOGY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Angiotensin AT1 receptor activation mediates high glucose-induced epithelial-mesenchymal transition in renal proximal tubular cells

(2010) Li Zhou et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum

(2010) Fabio Martinon et al.   CURRENT OPINION IN IMMUNOLOGY

HLA-B35 Upregulates Endothelin-1 and Downregulates Endothelial Nitric Oxide Synthase via Endoplasmic Reticulum Stress Response in Endothelial Cells

(2010) S. Lenna et al.   JOURNAL OF IMMUNOLOGY

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

(2010) Jane C. Goodall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfhydryl Angiotensin-Converting Enzyme Inhibitor Promotes Endothelial Cell Survival through Nitric-Oxide Synthase, Fibroblast Growth Factor-2, and Telomerase Cross-Talk

(2009) S. Donnini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Endoplasmic reticulum stress in proteinuric kidney disease

(2009) Andrey V. Cybulsky   KIDNEY INTERNATIONAL

Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-β inductionvia X-box binding protein 1

(2008) Judith A. Smith et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE