期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms18122659
关键词
lncRNA structure; epigenetic regulation; RNA-protein binding motif; regulation protein recruit
资金
- National Natural Science Foundation of China [31501062, 91746113]
- Research Projects of Education Department of Heilongjiang Province [1254G041, 12511273]
- Fundamental Research Funds for the Provincial Universities [2017JCZX50]
The rapid development of new generation sequencing technology has deepened the understanding of genomes and functional products. RNA-sequencing studies in mammals show that approximately 85% of the DNA sequences have RNA products, for which the length greater than 200 nucleotides (nt) is called long non-coding RNAs (lncRNA). LncRNAs now have been shown to play important epigenetic regulatory roles in key molecular processes, such as gene expression, genetic imprinting, histone modification, chromatin dynamics, and other activities by forming specific structures and interacting with all kinds of molecules. This paper mainly discusses the correlation between the structure and function of lncRNAs with the recent progress in epigenetic regulation, which is important to the understanding of the mechanism of lncRNAs in physiological and pathological processes.
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