Selective HDL-Raising Human Apo A-I Gene Therapy Counteracts Cardiac Hypertrophy, Reduces Myocardial Fibrosis, and Improves Cardiac Function in Mice with Chronic Pressure Overload

New perspectives on biological HDL-targeted therapies

(2017) Ilayaraja Muthuramu et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis

(2017) Ilayaraja Muthuramu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN JOURNAL OF HEART FAILURE

Apolipoprotein A-I gene transfer exerts immunomodulatory effects and reduces vascular inflammation and fibrosis in ob/ob mice

(2016) Frank Spillmann et al.   Journal of Inflammation-London

Physiological and pathological cardiac hypertrophy

(2016) Ippei Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

High-Density Lipoproteins Reduce Endothelial-to-Mesenchymal TransitionSignificance

(2015) Frank Spillmann et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High-density lipoprotein inhibits mechanical stress-induced cardiomyocyte autophagy and cardiac hypertrophy through angiotensin II type 1 receptor-mediated PI3K/Akt pathway

(2015) Li Lin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Selective homocysteine-lowering gene transfer attenuates pressure overload-induced cardiomyopathy via reduced oxidative stress

(2015) Ilayaraja Muthuramu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Pleiotropic Effects of HDL: Towards New Therapeutic Areas for HDL-Targeted Interventions

(2014) S.C. Gordts et al.   CURRENT MOLECULAR MEDICINE

Comparative Proteomic Analysis Reveals Sex and Estrogen Receptor β Effects in the Pressure Overloaded Heart

(2014) Georgios Kararigas et al.   JOURNAL OF PROTEOME RESEARCH

Novel aspects of ROS signalling in heart failure

(2013) Anne D. Hafstad et al.   BASIC RESEARCH IN CARDIOLOGY

Beneficial effects of selective HDL-raising gene transfer on survival, cardiac remodelling and cardiac function after myocardial infarction in mice

(2013) S C Gordts et al.   GENE THERAPY

Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond

(2013) Amy S. Shah et al.   JOURNAL OF LIPID RESEARCH

Tracking fatty acid kinetics in distinct lipoprotein fractions in vivo: a novel high-throughput approach for studying dyslipidemia in rodent models

(2012) David G. McLaren et al.   JOURNAL OF LIPID RESEARCH

Lipid Lowering and HDL Raising Gene Transfer Increase Endothelial Progenitor Cells, Enhance Myocardial Vascularity, and Improve Diastolic Function

(2012) Stephanie C. Gordts et al.   PLoS One

Usefulness of Electrocardiographic QT Interval to Predict Left Ventricular Diastolic Dysfunction

(2011) Jane E. Wilcox et al.   AMERICAN JOURNAL OF CARDIOLOGY

Gene Transfer for Inherited Metabolic Disorders of the Liver: Immunological Challenges

(2011) Stephanie C. Gordts et al.   CURRENT PHARMACEUTICAL DESIGN

Low-density lipoprotein receptor gene transfer in hypercholesterolemic mice improves cardiac function after myocardial infarction

(2011) E Van Craeyveld et al.   GENE THERAPY

Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies

(2011) Eline Van Craeyveld et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Reconstituted High-Density Lipoprotein Shortens Cardiac Repolarization

(2011) Hester M. Den Ruijter et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

(2011) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

High density lipoprotein downregulates angiotensin II type 1 receptor and inhibits angiotensin II-induced cardiac hypertrophy

(2010) Li Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene Therapy to Improve High-Density Lipoprotein Metabolism and Function

(2010) Eline Van Craeyveld et al.   CURRENT PHARMACEUTICAL DESIGN

Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale

(2010) Martin Lock et al.   HUMAN GENE THERAPY

Relations of Lipid Concentrations to Heart Failure Incidence

(2009) Raghava S. Velagaleti et al.   CIRCULATION

The impact of antigen expression in antigen-presenting cells on humoral immune responses against the transgene product

(2009) Y Feng et al.   GENE THERAPY

Apolipoprotein A-I and lecithin:cholesterol acyltransferase transfer induce cholesterol unloading in complex atherosclerotic lesions

(2009) E Van Craeyveld et al.   GENE THERAPY

Vascular-Protective Effects of High-Density Lipoprotein Include the Downregulation of the Angiotensin II Type 1 Receptor

(2009) Sophie Van Linthout et al.   HYPERTENSION

Critical role of scavenger receptor-BI-expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer

(2008) Y. Feng et al.   BLOOD

Human Apolipoprotein A-I Gene Transfer Reduces the Development of Experimental Diabetic Cardiomyopathy

(2008) Sophie Van Linthout et al.   CIRCULATION

Direct comparison of hepatocyte-specific expression cassettes following adenoviral and nonviral hydrodynamic gene transfer

(2008) F Jacobs et al.   GENE THERAPY

Wild-type apo A-I and apo A-IMilano gene transfer reduce native and transplant arteriosclerosis to a similar extent

(2008) Yingmei Feng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sex-specific pathways in early cardiac response to pressure overload in mice

(2008) Henning Witt et al.   JOURNAL OF MOLECULAR MEDICINE-JMM