Platelet Aggregometry Testing: Molecular Mechanisms, Techniques and Clinical Implications

A randomised trial on platelet function-guided de-escalation of antiplatelet treatment in ACS patients undergoing PCI

(2017) Claudius Jacobshagen et al.   THROMBOSIS AND HAEMOSTASIS

Comparison of SEER Sonorheometry With Rotational Thromboelastometry and Laboratory Parameters in Cardiac Surgery

(2016) Julie L. Huffmyer et al.   ANESTHESIA AND ANALGESIA

Contribution of whole platelet aggregometry to the endovascular management of unruptured aneurysms: an institutional experience

(2016) S G Aoun et al.   Journal of NeuroInterventional Surgery

Platelet function monitoring to adjust antiplatelet therapy in elderly patients stented for an acute coronary syndrome (ANTARCTIC): an open-label, blinded-endpoint, randomised controlled superiority trial

(2016) Guillaume Cayla et al.   LANCET

Regulation of integrins in platelets

(2015) Joel S. Bennett   BIOPOLYMERS

Relationship between low response to clopidogrel and periprocedural ischemic events with coil embolization for intracranial aneurysms

(2015) Takumi Asai et al.   Journal of NeuroInterventional Surgery

Clopidogrel resistance in cerebrovascular disease – results of one-year follow-up

(2015) László Szapáry et al.   ORVOSI HETILAP

Introduction of an algorithm for ROTEM-guided fibrinogen concentrate administration in major obstetric haemorrhage

(2014) S. Mallaiah et al.   ANAESTHESIA

Gender, race and diet affect platelet function tests in normal subjects, contributing to a high rate of abnormal results

(2014) Connie H. Miller et al.   BRITISH JOURNAL OF HAEMATOLOGY

Multiplexed phosphospecific flow cytometry enables large-scale signaling profiling and drug screening in blood platelets

(2014) B. E. J. Spurgeon et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Cytofluorimetric Platelet Analysis

(2014) Marco Gesi et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Global Thrombosis Test (GTT) can detect major determinants of haemostasis including platelet reactivity, endogenous fibrinolytic and thrombin generating potential

(2014) J. Yamamoto et al.   THROMBOSIS RESEARCH

Junctional adhesion molecule-A suppresses platelet integrin  IIb 3 signaling by recruiting Csk to the integrin-c-Src complex

(2013) M. U. Naik et al.   BLOOD

Five-minute parameter of thromboelastometry is sufficient to detect thrombocytopenia and hypofibrinogenaemia in patients undergoing liver transplantation

(2013) J.-G. Song et al.   BRITISH JOURNAL OF ANAESTHESIA

Thromboxane A2 Generation, in the Absence of Platelet COX-1 Activity, in Patients With and Without Atherothrombotic Myocardial Infarction

(2013) Andrew P. DeFilippis et al.   CIRCULATION JOURNAL

Flow Cytometry in Hematological Disorders

(2013) Hara Prasad Pati et al.   INDIAN JOURNAL OF PEDIATRICS

Differential Impact of Inflammation on Six Laboratory Assays Measuring Residual Arachidonic Acid-Inducible Platelet Reactivity During Dual Antiplatelet Therapy

(2013) Thomas Gremmel et al.   Journal of Atherosclerosis and Thrombosis

Management of Hemorrhage in Cardiothoracic Surgery

(2013) Klaus Görlinger et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Multiple electrode aggregometry in antiplatelet-related intracerebral haemorrhage

(2013) Christopher Beynon et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Consensus and Update on the Definition of On-Treatment Platelet Reactivity to Adenosine Diphosphate Associated With Ischemia and Bleeding

(2013) Udaya S. Tantry et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Recommendations for the standardization of light transmission aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC/ISTH

(2013) M. Cattaneo et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

State of the Art in Platelet Function Testing

(2013) Beate E. Kehrel et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Roles of Thrombelastography and Thromboelastometry for Patient Blood Management in Cardiac Surgery

(2013) Daniel Bolliger et al.   TRANSFUSION MEDICINE REVIEWS

Antiplatelet Therapy: Targeting the TxA2 Pathway

(2013) P. Fontana et al.   Journal of Cardiovascular Translational Research

Early thromboelastometric variables reliably predict maximum clot firmness in patients undergoing cardiac surgery: a step towards earlier decision making

(2012) D. DIRKMANN et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Clopidogrel Hyper-Response and Bleeding Risk in Neurointerventional Procedures

(2012) C. Goh et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Clopidogrel Resistance Is Associated with Thromboembolic Complications in Patients Undergoing Neurovascular Stenting

(2012) J.T. Fifi et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

High-Sensitivity Flow Cytometry Provides Access to Standardized Measurement of Small-Size Microparticles—Brief Report

(2012) Stéphane Robert et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fast interpretation of thromboelastometry in non-cardiac surgery: reliability in patients with hypo-, normo-, and hypercoagulability

(2012) K. Görlinger et al.   BRITISH JOURNAL OF ANAESTHESIA

Rotational Thromboelastometry (ROTEM)-Based Coagulation Management in Cardiac Surgery and Major Trauma

(2012) Kenichi A. Tanaka et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

A Randomized Trial of Prasugrel Versus Clopidogrel in Patients With High Platelet Reactivity on Clopidogrel After Elective Percutaneous Coronary Intervention With Implantation of Drug-Eluting Stents

(2012) Dietmar Trenk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Phenotyping vs. genotyping for prediction of clopidogrel efficacy and safety: the PEGASUS-PCI study

(2012) J. M. SILLER-MATULA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Perioperative assessment of platelet function by Thromboelastograph® Platelet Mapping™ in cardiovascular patients undergoing non-cardiac surgery

(2012) Davide Cattano et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Residual Platelet Reactivity, Bleedings, and Adherence to Treatment in Patients Having Coronary Stent Implantation Treated With Prasugrel

(2011) Guido Parodi et al.   AMERICAN JOURNAL OF CARDIOLOGY

Patients With Severe Aortic Valve Stenosis and Impaired Platelet Function Benefit From Preoperative Desmopressin Infusion

(2011) Barbara Steinlechner et al.   ANNALS OF THORACIC SURGERY

Guidelines for the laboratory investigation of heritable disorders of platelet function

(2011) Paul Harrison et al.   BRITISH JOURNAL OF HAEMATOLOGY

Platelet Reactivity and Cardiovascular Outcomes After Percutaneous Coronary Intervention

(2011) Matthew J. Price et al.   CIRCULATION

Good Short-Term but not Long-Term Reproducibility of the Antiplatelet Efficacy Laboratory Assessment

(2011) Hana Sevcikova et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

The EFFect of hIgh-dose ClopIdogrel treatmENT in patients with clopidogrel resistance (The EFFICIENT Trial)

(2011) Hasan Ari et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Assessment of coagulation in the obstetric population using ROTEM® thromboelastometry

(2011) S. Armstrong et al.   INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA

Prospective Evaluation of On-Clopidogrel Platelet Reactivity Over Time in Patients Treated With Percutaneous Coronary Intervention

(2011) Gianluca Campo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comparison of different procedures to prepare platelet-rich plasma for studies of platelet aggregation by light transmission aggregometry

(2011) Eti Alessandra Femia et al.   PLATELETS

Evaluation of the INNOVANCE PFA P2Y test cartridge: Sensitivity to P2Y12blockade and influence of anticoagulant

(2011) Abbie Edwards et al.   PLATELETS

Light Transmittance Aggregometry Induced by Different Concentrations of Adenosine Diphosphate to Monitor Clopidogrel Therapy: A Methodological Study

(2011) Rita Paniccia et al.   THERAPEUTIC DRUG MONITORING

Platelet Function Analyzer (PFA-100) as a Useful Tool for the Prediction of Transfusion Requirements during Aortic Valve Replacement

(2011) C. Sucker et al.   THORACIC AND CARDIOVASCULAR SURGEON

Reference values for rotation thromboelastometry (ROTEM®) parameters following non-haemorrhagic deliveries. Correlations with standard haemostasis parameters

(2011) Myriam Oudghiri et al.   THROMBOSIS AND HAEMOSTASIS

Predictive value of post-treatment platelet reactivity for occurrence of post-discharge bleeding after non-ST elevation acute coronary syndrome.

(2011) Thomas Cuisset et al.   EuroIntervention

Randomized comparison of platelet function monitoring to adjust antiplatelet therapy versus standard of care: Rationale and design of the Assessment with a double Randomization of (1) a fixed dose versus a monitoring-guided dose of aspirin and Clopidogrel after DES implantation, and (2) Treatment Interruption versus Continuation, 1 year after stenting (ARCTIC) study

(2010) Jean-Philippe Collet et al.   AMERICAN HEART JOURNAL

Development of North American Consensus Guidelines for Medical Laboratories That Perform and Interpret Platelet Function Testing Using Light Transmission Aggregometry

(2010) Catherine P.M. Hayward et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Multiple Electrode Whole-Blood Aggregometry and Bleeding in Cardiac Surgery Patients Receiving Thienopyridines

(2010) Marco Ranucci et al.   ANNALS OF THORACIC SURGERY

Platelet function testing in clinical diagnostics

(2010) A. R. Rechner   Hamostaseologie

Comparison of Platelet Function Tests in Predicting Clinical Outcome in Patients Undergoing Coronary Stent Implantation

(2010) Nicoline J. Breet   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Evaluation of Platelet Inhibition by Tirofiban in Patients Stratified According to Aspirin and Clopidogrel Responsiveness

(2010) Gianluca Campo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comparison of methods for monitoring residual platelet reactivity after clopidogrel by point-of-care tests on whole blood in high-risk patients

(2010) Emilia Antonucci et al.   THROMBOSIS AND HAEMOSTASIS

Relationship between platelet reactivity inhibition and non-CABG related major bleeding in patients undergoing percutaneous coronary intervention

(2010) Omar Ait Mokhtar et al.   THROMBOSIS RESEARCH

Thromboelastography-Guided Transfusion Decreases Intraoperative Blood Transfusion During Orthotopic Liver Transplantation: Randomized Clinical Trial

(2010) S.-C. Wang et al.   TRANSPLANTATION PROCEEDINGS

Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometry

(2009) N. RAHE-MEYER et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Laboratory Diagnosis and Molecular Classification of von Willebrand Disease

(2009) Alain Gadisseur et al.   ACTA HAEMATOLOGICA

Predictive Values of Post-Treatment Adenosine Diphosphate–Induced Aggregation and Vasodilator-Stimulated Phosphoprotein Index for Stent Thrombosis After Acute Coronary Syndrome in Clopidogrel-Treated Patients

(2009) Thomas Cuisset et al.   AMERICAN JOURNAL OF CARDIOLOGY

Assessment of Platelet Function on Whole Blood by Multiple Electrode Aggregometry in High-Risk Patients With Coronary Artery Disease Receiving Antiplatelet Therapy

(2009) Rita Paniccia et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays

(2009) Teresa Quiroga et al.   BRITISH JOURNAL OF HAEMATOLOGY

High Residual Platelet Reactivity After Clopidogrel Loading and Long-Term Clinical Outcome After Drug-Eluting Stenting for Unprotected Left Main Coronary Disease

(2009) Angela Migliorini et al.   CIRCULATION

Intensifying Platelet Inhibition With Tirofiban in Poor Responders to Aspirin, Clopidogrel, or Both Agents Undergoing Elective Coronary Intervention

(2009) Marco Valgimigli et al.   CIRCULATION

Cardiovascular Death and Nonfatal Myocardial Infarction in Acute Coronary Syndrome Patients Receiving Coronary Stenting Are Predicted by Residual Platelet Reactivity to ADP Detected by a Point-of-Care Assay

(2009) Rossella Marcucci et al.   CIRCULATION

The genetics of antiplatelet drug resistance

(2009) G Feher et al.   CLINICAL GENETICS

Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial

(2009) Alan D. Michelson et al.   EUROPEAN HEART JOURNAL

Early but not late stent thrombosis is influenced by residual platelet aggregation in patients undergoing coronary interventions

(2009) T. Geisler et al.   EUROPEAN HEART JOURNAL

Platelet Reactivity After Clopidogrel Treatment Assessed With Point-of-Care Analysis and Early Drug-Eluting Stent Thrombosis

(2009) Dirk Sibbing et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Calcium signaling in platelets

(2009) D. VARGA-SZABO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments

(2009) C. P. M. HAYWARD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placement

(2009) D. SIBBING et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Multiple electrode aggregometry predicts stent thrombosis better than the vasodilator-stimulated phosphoprotein phosphorylation assay

(2009) J. M. SILLER-MATULA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet Adhesion under Flow

(2009) Zaverio M. Ruggeri   MICROCIRCULATION

Clopidogrel response status assessed with Multiplate point-of-care analysis and the incidence and timing of stent thrombosis over six months following coronary stenting

(2009) D. Sibbing et al.   THROMBOSIS AND HAEMOSTASIS

Optical platelet aggregation versus thromboxane metabolites in healthy individuals and patients with stable coronary artery disease after low-dose aspirin administration

(2009) Sofie S. Hedegaard et al.   THROMBOSIS RESEARCH

Coagulation Monitoring: Current Techniques and Clinical Use of Viscoelastic Point-of-Care Coagulation Devices

(2008) Michael T. Ganter et al.   ANESTHESIA AND ANALGESIA

Cell Adhesion Mechanisms in Platelets

(2008) David Varga-Szabo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tailoring Treatment with Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clopidogrel (3T/2R). Rationale for the Study and Protocol Design

(2008) Marco Valgimigli et al.   CARDIOVASCULAR DRUGS AND THERAPY

Assessing the Current Role of Platelet Function Testing

(2008) Eugene Braunwald et al.   CLINICAL CARDIOLOGY

Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation

(2008) Matthew J. Price et al.   EUROPEAN HEART JOURNAL

Assessment of aspirin resistance varies on a temporal basis in patients with ischaemic heart disease

(2008) A R Muir et al.   HEART

The clopidogrel resistance can be attenuated with triple antiplatelet therapy in patients undergoing drug-eluting stents implantation

(2008) Chi Young Shim et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Clopidogrel 150 mg/day to Overcome Low Responsiveness in Patients Undergoing Elective Percutaneous Coronary Intervention

(2008) Boris Aleil et al.   JACC-Cardiovascular Interventions

Glycoprotein IIb/IIIa Inhibitors Improve Outcome After Coronary Stenting in Clopidogrel Nonresponders

(2008) Thomas Cuisset et al.   JACC-Cardiovascular Interventions

The Antiplatelet Effect of Higher Loading and Maintenance Dose Regimens of Clopidogrel

(2008) Patrick Gladding et al.   JACC-Cardiovascular Interventions

Aspirin Resistance: Focus on Clinical Endpoints

(2008) Gabriella Pusch et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Incidence and Clinical Impact of Dual Nonresponsiveness to Aspirin and Clopidogrel in Patients With Drug-Eluting Stents

(2008) Anna Maria Gori et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adjusted Clopidogrel Loading Doses According to Vasodilator-Stimulated Phosphoprotein Phosphorylation Index Decrease Rate of Major Adverse Cardiovascular Events in Patients With Clopidogrel Resistance

(2008) Laurent Bonello et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Some hemostasis variables at the end of the population distributions are risk factors for severe postpartum hemorrhages

(2008) C. CHAULEUR et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Use of the PFA-100™ closure time to predict cardiovascular events in aspirin-treated cardiovascular patients: a systematic review and meta-analysis

(2008) J.-L. RENY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Key Role of Platelet Procoagulant Activity in Tissue Factor-and Collagen-Dependent Thrombus Formation in Arterioles and VenulesIn VivoDifferential Sensitivity to Thrombin Inhibition

(2008) Marijke J.E. Kuijpers et al.   MICROCIRCULATION

Lack of reproducibility of assessment of aspirin responsiveness by optical aggregometry and two platelet function tests

(2008) Paul Harrison et al.   PLATELETS