Ginsenoside Rh2 Improves Cardiac Fibrosis via PPARδ–STAT3 Signaling in Type 1-Like Diabetic Rats

Understanding STAT3 signaling in cardiac ischemia

(2016) K. E. O’Sullivan et al.   BASIC RESEARCH IN CARDIOLOGY

Telmisartan improves cardiac fibrosis in diabetes through peroxisome proliferator activated receptor δ (PPARδ): from bedside to bench

(2016) Wei-Ting Chang et al.   Cardiovascular Diabetology

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Ramipril restores PPARβ/δ and PPARγ expressions and reduces cardiac NADPH oxidase but fails to restore cardiac function and accompanied myosin heavy chain ratio shift in severe anthracycline-induced cardiomyopathy in rat

(2016) Hana Cernecka et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lung damage induced by hyperglycemia in diabetic rats: The role of signal transducer and activator of transcription 3 (STAT3)

(2016) Ching-Min Wang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells

(2016) Rajeshwary Ghosh et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Finding and Producing Probiotic Glycosylases for the Biocatalysis of Ginsenosides: A Mini Review

(2016) Seockmo Ku   MOLECULES

Plant Natural Product Formononetin Protects Rat Cardiomyocyte H9c2 Cells against Oxygen Glucose Deprivation and Reoxygenation via Inhibiting ROS Formation and Promoting GSK-3βPhosphorylation

(2016) Yuanyuan Cheng et al.   Oxidative Medicine and Cellular Longevity

Roles and mechanisms of ginsenoside in cardiovascular diseases: progress and perspectives

(2016) Yingying Sun et al.   Science China-Life Sciences

STAT3, a key regulator of cell-to-cell communication in the heart

(2014) Arash Haghikia et al.   CARDIOVASCULAR RESEARCH

The impact of 1,25-dihydroxyvitamin D3 on the expression of connective tissue growth factor and transforming growth factor-β1 in the myocardium of rats with diabetes

(2014) Lingling Wang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Cryptotanshinone Attenuates Cardiac Fibrosis via Downregulation of COX-2, NOX-2, and NOX-4

(2014) Yunzi Ma et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Signals for increase of μ-opioid receptor expression in muscle by hyperglycemia

(2014) Meng Ching Yeh et al.   NEUROSCIENCE LETTERS

Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways

(2014) Karina Huynh et al.   PHARMACOLOGY & THERAPEUTICS

A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases

(2014) Chang Ho Lee et al.   Journal of Ginseng Research

Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats

(2014) Cheng-Chia Tsai et al.   Biomed Research International

Naringin Inhibits ROS-activated MAPK Pathway in High Glucose-induced Injuries in H9c2 Cardiac Cells

(2013) Jingfu Chen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation

(2013) Yan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac Peroxisome Proliferator-Activated Receptor δ (PPARδ) as a New Target for Increased Contractility without Altering Heart Rate

(2013) Zhih-Cherng Chen et al.   PLoS One

Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid

(2012) Chun-jun Li et al.   Cardiovascular Diabetology

Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced CardiotoxicityIn VitroandIn Vivo

(2012) Hongbo Wang et al.   Evidence-based Complementary and Alternative Medicine

Diabetic cardiomyopathy

(2012) BR Goyal et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice

(2012) Hui-Ting Wang et al.   Journal of Translational Medicine

Allicin protects against myocardial apoptosis and fibrosis in streptozotocin-induced diabetic rats

(2012) Yang Liu et al.   PHYTOMEDICINE

Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARδ) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity

(2012) Heidi E. Kocalis et al.   PLoS One

Characterization of the mechanisms of the increase in PPARδ expression induced by digoxin in the heart using the H9c2 cell line

(2011) Zhih-Cherng Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

JAK-STAT signaling in hepatic fibrosis

(2011) Markus Mair   Frontiers in Bioscience-Landmark

Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment

(2011) Inês Falcão-Pires et al.   HEART FAILURE REVIEWS

Janus Kinase 2/Signal Transducers and Activators of Transcription Signal Inhibition Regulates Protective Effects of Probucol on Mesangial Cells Treated with High Glucose

(2010) Juan Du et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53

(2010) Binghui Li et al.   CANCER LETTERS

Cardiac-Specific IGF-1 Receptor Transgenic Expression Protects Against Cardiac Fibrosis and Diastolic Dysfunction in a Mouse Model of Diabetic Cardiomyopathy

(2010) K. Huynh et al.   DIABETES

Oxidative stress and inflammation modulate peroxisome proliferator-activated receptors with regional discrepancy in diabetic heart

(2010) Ting-I. Lee et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-β/δ ATTENUATES MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN THE RAT

(2010) Amar Kapoor et al.   SHOCK

Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases

(2009) Claudio Napoli et al.   ARCHIVES OF PHARMACAL RESEARCH

Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: formulation, pharmacokinetics, biodistribution and efficacy

(2009) Alain G. Musende et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cardiac Fibroblast

(2009) Colby A. Souders et al.   CIRCULATION RESEARCH

Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs

(2009) Yi Gu et al.   FOOD AND CHEMICAL TOXICOLOGY

Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions

(2009) Kay-Dietrich Wagner et al.   PHARMACOLOGY & THERAPEUTICS

Catheter replacement of the needle in percutaneous arteriography

(2008) Sven Ivar Seldinger   ACTA RADIOLOGICA

New insights into form and function of fibronectin splice variants

(2008) ES White et al.   JOURNAL OF PATHOLOGY