期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms18061185
关键词
zebrafish; visual behaviors; visual motor response; drug screening; retinal degeneration; retinitis pigmentosa; night blindness
资金
- Indiana Clinical and Translational Sciences Institute from the National Institutes of Health, National Center for Advancing Translational Sciences [TL1 TR001107, UL1 TR001108]
- Schlumberger Foundation
- Medical Panel, The Chinese University of Hong Kong [2041771]
- Research Grants Council of Hong Kong [2140694]
- National Scientific Foundation of China [81486126]
- Provincial Natural Scientific Foundation of China [8151503102000019]
Zebrafish are a popular vertebrate model in drug discovery. They produce a large number of small and rapidly-developing embryos. These embryos display rich visual-behaviors that can be used to screen drugs for treating retinal degeneration (RD). RD comprises blinding diseases such as Retinitis Pigmentosa, which affects 1 in 4000 people. This disease has no definitive cure, emphasizing an urgency to identify new drugs. In this review, we will discuss advantages, challenges, and research developments in using zebrafish behaviors to screen drugs in vivo. We will specifically discuss a visual-motor response that can potentially expedite discovery of new RD drugs.
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