Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li
Summary: The study demonstrates that SVHRP can inhibit neuroinflammation and microglia activation, potentially explaining the therapeutic effects of BmK-derived materials and suggesting that BmK venom could be a potential source for CNS drug development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jiayuan Wu, Xinqin Xu, Li Zheng, Juanfen Mo, Xiuhui Jin, Yi Bao
Summary: Nilotinib has been shown to suppress microglia-mediated neuroinflammatory response and protect DA neurons from inflammatory damage, suggesting its potential application in further clinical trials.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dewei He, Guiqiu Hu, Ang Zhou, Yanting Liu, Bingxu Huang, Yingchun Su, Hefei Wang, Bojian Ye, Yuan He, Xiyu Gao, Shoupeng Fu, Dianfeng Liu
Summary: This study found that Echinocystic acid (EA) inhibits neuroinflammation by activating the PI3K/Akt pathway and inhibiting the NF-kappa B and MAPK pathways, and exhibits neuroprotective effects in vivo and in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Han Zhu, Gaorui Wang, Yuyan Bai, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: Bear bile powder (BBP) has been used to treat neuroinflammation, and its mechanism of action may involve the TGR5/AKT/NF-κB signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Dong Zhao, Li Jun Zhang, Tian Qi Huang, Joonki Kim, Ming-Yao Gu, Hyun Ok Yang
Summary: Narciclasine (NA) inhibits pro-inflammatory factors in LPS-induced microglial cells but increases anti-inflammatory cytokines. The study suggests that NA may relieve neuroinflammation by down-regulating the Akt/IKK/NF-kappa B and JNK signaling pathways.
Review
Geriatrics & Gerontology
Mobina Fathi, Kimia Vakili, Shirin Yaghoobpoor, Mohammad Sadegh Qadirifard, Mohammadreza Kosari, Navid Naghsh, Afsaneh Asgari Taei, Andis Klegeris, Mina Dehghani, Ashkan Bahrami, Hamed Taheri, Ashraf Mohamadkhani, Ramtin Hajibeygi, Mostafa Rezaei Tavirani, Fatemeh Sayehmiri
Summary: Parkinson's disease is characterized by neuroinflammation, and several protein factors and pathways are implicated in the development of PD and other neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Plant Sciences
Shou-Kai Wang, Ting-Xiao Chen, Wei Wang, Ling-Ling Xu, Yu-Qing Zhang, Zhen Jin, You -Bin Liu, You-Zhi Tang
Summary: Aesculetin exhibits potent anti-inflammatory effect both in vitro and in vivo by inhibiting the production of inflammatory mediators and the activation of NF-Kappa B and MAPKs signaling pathways. In a DSS-induced colitis model, aesculetin can alleviate clinical symptoms and reduce the secretion of inflammatory mediators.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Hailin Liu, Xiangnan Hu, Rong Jiang, Jianghui Cai, Qiao Lin, Zhiguo Fan, Pan Zhao, Song Wang, Chunqiao Zou, Weimin Du, Zhi Dong, Yingju Liu
Summary: The study demonstrated that CQMUH-011 has significant anti-inflammatory effects on microglial activation and protects against ischemia/reperfusion injury. CQMUH-011 inhibits the production of inflammatory cytokines in microglia, arrests cell cycle progression, induces apoptosis, and regulates the expression of various cellular proteins and signaling molecules related to neuroinflammation. In vivo, CQMUH-011 administration improves neurological function, reduces infarct volume, and decreases inflammatory response around the injury site.
Review
Chemistry, Medicinal
Emad H. M. Hassanein, Mostafa S. Abd El-Maksoud, Islam M. Ibrahim, Esraa K. Abd-alhameed, Hanan S. Althagafy, Nesma M. Mohamed, Samir A. Ross
Summary: Galangin, a naturally occurring flavonoid, has many biological activities including anti-inflammatory effects. Its mechanism of action involves suppressing p38 MAPK, NF-kB, and NLRP3 signaling pathways, which has been confirmed by molecular docking. Clinical translational research is needed to determine if galangin can be used as a safe natural source of anti-inflammatory medication for humans.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Jianjian Dong, Xun Wang, Chenchen Xu, Manli Gao, Shijing Wang, Jin Zhang, Haiyang Tong, Lulu Wang, Yongzhu Han, Nan Cheng, Yongsheng Han
Summary: The study demonstrates that copper-mediated neuroinflammation is associated with the activation of the NLRP3 inflammasome, contributing to progressive neuropathology in a murine model of WD. Blocking the activation of the NLRP3 inflammasome effectively mitigates cognitive decline, locomotor behavior impairment, and neurodegeneration in the mice.
CELL DEATH & DISEASE
(2021)
Review
Immunology
Frida Lind-Holm Mogensen, Andrea Scafidi, Aurelie Poli, Alessandro Michelucci
Summary: Microglia are immune cells in the brain that play important roles in immune surveillance and neuroprotection. However, they can also contribute to neuroinflammation and neurotoxicity in neurodegenerative diseases like Parkinson's disease. This review focuses on the role of DJ-1, a protein encoded by the PARK7 gene, in microglia genetic programs and immunological traits. It also discusses the potential of targeting dysregulated pathways in microglia under DJ-1 deficiency as therapeutic approaches for PD, and proposes considering DJ-1 as a biomarker and using DJ-1-enhancing compounds to reduce oxidative stress and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Soudeh Ghafouri-Fard, Mahdi Gholipour, Atefe Abak, Mehrdokht Mazdeh, Mohammad Taheri, Arezou Sayad
Summary: The study showed significant differences in the expressions of NF-kappa B-related lncRNAs between PD patients and healthy controls, with certain gene expressions being associated with the pathogenesis of PD and correlated with each other. Among the evaluated genes, CEBPA demonstrated the best performance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Yiwei Fang, Li Yang, Junwei He
Summary: Plantanone C from Hosta plantaginea flowers shows anti-inflammatory effects in RAW 264.7 macrophages by inhibiting NF-kappa B, iNOS, COX-2, MAPKs, and Akt signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Huilei Wang, Xiaomei Li, Bowei Xia, Qingcui Zhang, Junwei He, Li Yang
Summary: This study aimed to reveal the therapeutic effects and potential mechanisms of Hosta plantaginea flower extract on autoimmune chronic prostatitis (ACP) model rats. The results showed that all fractions of the extract exerted significant anti-CP effects by inhibiting NF-Kappa B, MAPKs, JAK-STAT, and PI3K-Akt pathways in ACP model rats. These findings provide scientific evidence for the clinical application of Hosta plantaginea flowers in the treatment of CP.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Yang Zhang, Junjie Fan, Yunxia Xiu, Luyao Zhang, Guangxin Chen, Jinyu Fan, Xiao Lin, Chen Ding, Mingming Feng, Ruliang Wang, Yang Liu
Summary: By using computational fluid dynamics, this study compares the blood flow characteristics between a healthy internal carotid artery and a normal intracranial aneurysm. The results show differences in blood flow, with the aneurysm exhibiting turbulent flow due to vortex formation, making it unstable and susceptible to growth and rupture.
BIO-MEDICAL MATERIALS AND ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Ping Li, Yanru Wu, Huizhi Wu, Qiuhong Xiong, Na Zhao, Guangxin Chen, Changxin Wu, Han Xiao
Summary: This study identified a mutation in the FH gene that is associated with uterine leiomyomas and investigated its pathogenicity. The FH mutation exhibited lower enzyme activity and higher fumarate levels, possibly due to impaired homotetramer formation. Additionally, the mutation led to increased cell proliferation and extracellular acidification, as well as inhibited autophagy. These findings provide important insights for accurate genetic counseling and clinical diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Da Wen, Jia Cui, Ping Li, Qiuhong Xiong, Guangxin Chen, Changxin Wu
Summary: In this study, the researchers found that SDC4 plays a role in Mycobacterium tuberculosis infection by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways involved in actin cytoskeleton polymerization. These findings are important for understanding the mechanism of M. tuberculosis infection.
MICROBES AND INFECTION
(2022)
Article
Plant Sciences
Lina Dong, Xiuzhao Fan, Qian Li, Jiankuan Li, Guangxin Chen, Dong Yang, Yafeng Li, Liping Zhao, Haizhen Yin, Xiaoyan Wang, Xiaojing Liu, Zhonghua Zhao, Shumei Lin
Summary: This study investigates the potential therapeutic value and mechanism of Anemone chinensis Bunge (AB) aqueous enema for ulcerative colitis (UC). The network pharmacology analysis demonstrated that AB may affect key targets and proteins related to UC. In a mouse model, AB aqueous enema alleviated colonic damage, restored tight junction proteins, and improved the diversity of gut microbiota.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Engineering, Environmental
Xing Huang, Linbin Wang, Zihang Shen, Jiafei Ren, Guangxin Chen, Qifang Li, Zheng Zhou
Summary: This article introduces a super-stretchable and self-healing hydrogel composite prepared by in situ polymerization in the silver nanowires aerogel. The composite exhibits exceptional EMI shielding performance, high electrical conductivity, and outstanding strain response, making it promising for applications in smart wearable electronics and EMI shielding.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Jiafei Ren, Xing Huang, Jianjun Shi, Wei Wang, Junning Li, Ying Zhang, Haikun Chen, Ruolin Han, Guangxin Chen, Qifang Li, Zheng Zhou
Summary: This study reports a hybrid silica aerogel with excellent comprehensive performance, prepared using methyltriethoxysilane (MTES) and multi-alkoxy polyhedral oligomeric silsesquioxane (POSS) as co-precursors. The hybrid aerogel exhibits high strength, low density, uniform mesopores, high specific surface area, low thermal conductivity, good thermal stability, high transparency, superhydrophobicity, and excellent oil/water separation capability and self-cleaning properties. It also shows superb compressive resilience and exceptional fatigue resistance.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Polymer Science
Ruilu Guo, Lixia Zhou, Jiwei Lin, Guangxin Chen, Zheng Zhou, Qifang Li
Summary: This study successfully prepared a high-strength and self-healing polysiloxane material containing N-acetyl-L-cysteine, which exhibited significant inhibitory effects on Staphylococcus aureus. The modified polysiloxane showed good self-healing properties and excellent biocompatibility, suggesting its potential in the development of polysiloxane antimicrobial coatings.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Zhongyi Wang, Zhaoyang Zhou, Liming Wang, Shuangshuang Yan, Zhihua Cheng, Xiaofeng Liu, Lijie Han, Guangxin Chen, Shaoyun Wang, Weiyuan Song, Jiacai Chen, Liu Liu, Xiaofei Song, Liying Yan, Jianyu Zhao, Xiaolan Zhang
Summary: The variation in fruit neck length has significant impact on the shape and commercial value of cucumber fruit. This study discovered a regulatory module composed of CsHEC1, CsYUC4, and CsOVATE that modulates auxin biosynthesis to control fruit neck length variation in cucumber.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Polymer Science
Fengfeng Zhao, Hui Quan, Shijun Zhang, Yihui Xu, Zheng Zhou, Guangxin Chen, Qifang Li
Summary: Researchers have developed a new polymer that improves the dispersion, stability, and conductivity of graphene in aqueous solution.
Article
Biochemistry & Molecular Biology
Qiuhong Xiong, Huimin Sun, Wenxiu Xing, Xin Li, Guangxin Chen, Zhonghua Zhao, Changxin Wu, Ping Li
Summary: This study found that WDR45 mutation activates CMA through the ER stress/p38 signaling pathway, promoting the degradation of FTH and resulting in iron overload. Inhibition of the ER stress/p38 signaling pathway reduces CMA activity, leading to increased protein levels of FTH but reduced Fe2+ levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Yang Liu, Yu-Xin Lei, Jian-Wei Li, Yu-Ze Ma, Xue-Yin Wang, Fan-Hua Meng, Yu-Jing Wu, Na Wang, Jing Liang, Cai-Quan Zhao, Yang Yang, Guang-Xin Chen, Shui-Xing Yu
Summary: Clostridium perfringens is a major cause of foodborne disease and the molecular mechanisms of host-pathogen interactions are poorly understood. This study found that GPR120-deficient mice are more susceptible to C. perfringens infection, showing lower survival rates, higher bacterial loads in organs, decreased IL-18 production, and severe organ injury. The study reveals a novel role of GPR120 in host protection and suggests it as a potential therapeutic target for limiting pathogen infection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Polymer Science
Ruilu Guo, Dongxu Li, Wenning Qi, Guangxin Chen, Qifang Li, Zheng Zhou
Summary: Studies are exploring the development of recyclable materials without using petrochemical resources to reduce environmental pollution. A novel supramolecular polysiloxane (SPSO) with excellent mechanical properties, reprocessing molding, and multiple recyclability was created by incorporating UPy into the main chains. The material showed superior tensile strength, retained its properties after recycling, and exhibited excellent adhesive properties and water separation efficiency. The study provides a basis for creating polysiloxane materials with recyclability and strong mechanical properties.
Article
Chemistry, Physical
Jiafei Ren, Xing Huang, Ruolin Han, Guangxin Chen, Zheng Zhou, Qifang Li
Summary: With the advancement of science and technology, the development of sensors with extreme condition-resistance and multifunctionality has become urgent. In this study, an extreme condition-resistant superelastic silica nanofiber (SNF)/MXene composite aerogel was fabricated, showing excellent mechanical and piezoresistive properties at a low density. The assembled aerogel sensor exhibited high sensitivity, low detection limit, rapid response/recovery time, large workable strain range, and good stability. It also maintained its stability in extreme temperature conditions and demonstrated outstanding thermal insulation and low-voltage driven Joule heating performance. This work provides insights into the development of multifunctional aerogel sensors and expands the application scenarios of wearable devices.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Mathematical & Computational Biology
Yuqian Mei, Debao Guan, Xinyu Tong, Qian Liu, Mingcheng Hu, Guangxin Chen, Caijuan Li
Summary: This study aims to identify risk factors contributing to cerebral infarction by computational hemodynamics analysis of cerebral artery fenestration. The study found that the flow division condition throughout the fenestration structure has a key impact on further flow redistribution and flow pattern. Blood viscosity has the potential to be a useful tool in identifying the risk factors for cerebral infarction, with emphasis on the hemodynamic environment at superior cerebellar arteries.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Article
Polymer Science
Xing Huang, Guomin Song, Jianjun Shi, Jiafei Ren, Ruilu Guo, Chunyuan Li, Guangxin Chen, Qifang Li, Zheng Zhou
Summary: Octa(dimethylethoxysiloxy) POSS (ODES) was successfully synthesized and used as a novel curing agent for preparing RTV silicone rubber (SROD) with improved mechanical, thermal, and optical properties compared to traditional silicone rubber cross-linked by tetraethoxysilane (SRTE).