期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms18122708
关键词
zinc transporter; SLC39A/ZIP; zinc signaling; physiology; diseases
资金
- KAKENHI of the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) [17H04011]
- Sumitomo Foundation
- Naito Foundation
- Nestle Nutrition Council Japan
- Mitsubishi Foundation
- Vehicle Racing Commemorative Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [17H04011] Funding Source: KAKEN
Zinc (Zn), which is an essential trace element, is involved in numerous mammalian physiological events; therefore, either a deficiency or excess of Zn impairs cellular machineries and influences physiological events, such as systemic growth, bone homeostasis, skin formation, immune responses, endocrine function, and neuronal function. Zn transporters are thought to mainly contribute to Zn homeostasis within cells and in the whole body. Recent genetic, cellular, and molecular studies of Zn transporters highlight the dynamic role of Zn as a signaling mediator linking several cellular events and signaling pathways. Dysfunction in Zn transporters causes various diseases. This review aims to provide an update of Zn transporters and Zn signaling studies and discusses the remaining questions and future directions by focusing on recent progress in determining the roles of SLC39A/ZIP family members in vivo.
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