Article
Biochemistry & Molecular Biology
Jeong-Min Hong, Ji-Hong Moon, Young Min Oh, Sang-Youel Park
Summary: The activation of calcineurin and autophagy induced by prion peptide leads to neuroinflammation driven by NF-kappa B, suggesting that calcineurin and autophagy may be potential therapeutic targets for neurodegenerative diseases, including prion disease.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Immunology
Stephanie Myers, Kelly McCracken, Daniel J. Buck, J. Thomas Curtis, Randall L. L. Davis
Summary: Neuroinflammation plays a role in various brain disorders, and identifying new anti-inflammatory drugs is of great interest. Previous studies have shown that beta-FNA inhibits inflammatory signaling in human astroglial cells and prevents sickness behavior in a mouse model of LPS-induced neuroinflammation. This study further investigates the temporal importance of beta-FNA treatment in this model and finds that immediate treatment is more effective than treatment 4 hours post-LPS.
INFLAMMOPHARMACOLOGY
(2023)
Article
Plant Sciences
In Gyoung Ju, Eugene Huh, Namkwon Kim, Seungmin Lee, Jin Gyu Choi, Jongki Hong, Myung Sook Oh
Summary: This study showed that Artemisiae Iwayomogii Herba (AIH) attenuates neuroinflammation by regulating the NF-kappa B and MAPK pathways, and it may be used for treating neurological diseases. The inhibitory effects of AIH on microglia-mediated neuroinflammation and NLRP3 inflammasome formation were demonstrated both in vitro and in a mouse model.
Article
Fisheries
Peng Tan, Yi Ding, Xueshan Li, Xiaojing Dong, Kangsen Mai, Qinghui Ai
Summary: This study investigated the effects and regulation of dietary vegetable oil on the Nrf2 and NF-kappa B pathways in large yellow croaker. The results showed that the vegetable oil diet decreased antioxidant capacity and induced inflammatory responses in the fish. Knockdown of the Nrf2 gene affected the anti-inflammatory effect of fatty acids. Overall, the study suggests that dietary vegetable oil can affect antioxidant and inflammatory pathways in fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Geriatrics & Gerontology
Mobina Fathi, Kimia Vakili, Shirin Yaghoobpoor, Mohammad Sadegh Qadirifard, Mohammadreza Kosari, Navid Naghsh, Afsaneh Asgari Taei, Andis Klegeris, Mina Dehghani, Ashkan Bahrami, Hamed Taheri, Ashraf Mohamadkhani, Ramtin Hajibeygi, Mostafa Rezaei Tavirani, Fatemeh Sayehmiri
Summary: Parkinson's disease is characterized by neuroinflammation, and several protein factors and pathways are implicated in the development of PD and other neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Murad-Ali Shah, Ju-Bin Kang, Dong-Ju Park, Myeong-Ok Kim, Phil-Ok Koh
Summary: Chlorogenic acid exhibits neuroprotective effects by reducing oxidative stress and controlling pro-inflammatory proteins in cerebral ischemic damage.
NEUROSCIENCE LETTERS
(2022)
Article
Food Science & Technology
Seungmin Lee, In Gyoung Ju, Yujin Choi, Sangsu Park, Myung Sook Oh
Summary: Neuroinflammation, a typical feature of neurodegenerative diseases, can be alleviated by regulating microglial responses with trichosanthis semen (TS). TS reduces pro-inflammatory mediators and induces anti-inflammatory mediators by inhibiting NF-kappa B signaling and activating HO-1, making it a potential therapeutic candidate for NDDs.
Article
Multidisciplinary Sciences
Young Min Lee, In Sook Kim, Beong Ou Lim
Summary: The study demonstrates that sandalwood oil possesses antioxidant activity and may mitigate inflammation induced by ROS by inhibiting the NF-κB-mediated inflammatory signaling pathway.
Article
Pharmacology & Pharmacy
Qian Lu, Chao Jiang, Jialong Hou, Hao Qian, Feifan Chu, Weiqi Zhang, Mengke Ye, Ziyi Chen, Jian Liu, Hanbing Yao, Jianfeng Zhang, Jiake Xu, Te Wang, Shunwu Fan, Qingqing Wang
Summary: The incidence of osteoporosis is increasing, especially in postmenopausal women. Patchouli alcohol (PA), a natural compound with anti-inflammatory effects, has shown inhibitory effects on osteoclasts and may be a potential treatment for osteoporosis in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Ya Gao, Boting Xi, Jiani Li, Zimeng Li, Jie Xu, Mingli Zhong, Qiongmei Xu, Yuanyu Lian, Riming Wei, Liping Wang, Houkang Cao, Ling Jin, Kefeng Zhang, Jianghui Dong
Summary: This study demonstrated that scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB signaling pathway, with the most significant effect observed at high doses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Maha H. Sharawy, Dalia H. El-Kashef, Ahmed A. Shaaban, Dina S. El-Agamy
Summary: This study demonstrated the hepatoprotective activity of sitagliptin against Con A-induced hepatic fibrosis, potentially through enhancement of the Nrf2 signaling pathway and inhibition of NF-Kappa B. Sitagliptin may be a new candidate for suppressing hepatitis-associated fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Balazs Sonkodi
Summary: Piezo2 channels play a critical role in proprioception. They can be transiently damaged during strenuous contractions, leading to impaired proprioception and reduced range of motion. This damage can also cause neuroinflammation and neuronal activation in the spinal cord, contributing to delayed onset muscle soreness.
Article
Environmental Sciences
Ahmed G. Abd Elhameed
Summary: The study revealed that the combination of oral aspirin and krill oil could significantly alleviate silica-induced pulmonary injury by reducing inflammatory cell accumulation, decreasing oxidative stress levels, and inhibiting the expression of inflammatory and fibrotic mediators. Additionally, this combination also showed a decrease in hydroxyproline content induced by silica and a clear restoration of lung architecture.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
So-Yeon Kim, Sang-Deok Han, Minju Kim, Tamanna Jahan Mony, Eun-Seok Lee, Kyeong-Min Kim, Seung-Hyuk Choi, Sun Hee Hong, Ji Woong Choi, Se Jin Park
Summary: The study demonstrated that Mentha arvensis essential oil (MAEO) exerts anti-inflammatory effects in an atopic dermatitis (AD) model by inhibiting the ERK/NF-kappa B signaling pathway.
Article
Nutrition & Dietetics
Min Hee Park, Jae Chul Jung, Stephen Hill, Elizabeth Cartwright, Margaret H. Dohnalek, Min Yu, Hee Joon Jun, Sang Bae Han, Jin Tae Hong, Dong Ju Son
Article
Biochemistry & Molecular Biology
Kyung-Ran Park, Joon Yeop Lee, Myounglae Cho, Jin Tae Hong, Hyung-Mun Yun
Summary: PALI from Paeonia suffruticosa promotes early and late osteoblast differentiation without cytotoxicity, mainly through the ERK1/2-RUNX2 signaling pathway, which suggests its potential therapeutic action in bone diseases like osteoporosis and periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Young-Jung Lee, In Jun Yeo, Dong Young Choi, Jaesuk Yun, Dong Ju Son, Sang-Bae Han, Jin Tae Hong
Summary: HIV-1 infection can lead to various HIV-associated neurocognitive disorders, with the gp120 protein playing a role in memory impairment through inducing Aβ accumulation and neuroinflammation.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kyung-Ran Park, Joon Yeop Lee, Myounglae Cho, Jin Tae Hong, Hyung-Mun Yun
Summary: Paeonoside (PASI) isolated from Paeonia suffruticosa roots enhances osteoblast migration, early differentiation, and mineralized nodule formation by regulating RUNX2 expression through the BMP2 and Wnt3a pathways, suggesting a potential therapeutic role in treating bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sun Mi Gu, Sowoon Seo, Daejin Park, Sanghyeon Kim, Santosh Lamichhane, Kyoung-Moon Han, Young-Hoon Kim, Sangmin Lee, Jin Tae Hong, Hye Jin Cha, Jaesuk Yun
Summary: The study suggests that CB1 agonist JWH-210 enhances METH-induced CPP by modulating GABAergic neuronal activity. In mice, CB1 regulates GAD67 expression which in turn affects METH-induced CPP. Human research shows decreased GAD67 mRNA levels in drug users' brains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ji Eun Yu, In Jun Yeo, Dong Ju Son, Jaesuk Yun, Sang-Bae Han, Jin Tae Hong
Summary: Chi3L1 is involved in various biological processes, especially in cancer development and metastasis. The anti-Chi3L1 antibody shows potential in inhibiting tumor growth and metastasis in lung cancer models, making it a promising new cancer therapy.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ji-Eun Kim, Yun-Ju Choi, Su-Jin Lee, Jeong-Eun Gong, You-Jung Jin, So-Hae Park, Hee-Seob Lee, Young-Whan Choi, Jin-Tae Hong, Dae-Youn Hwang
Summary: This study demonstrated that exposure to Pt improves the constipation phenotype in SD rats with Lop-induced constipation by regulating membrane water channel expression, GI hormones, the mAChR signaling pathway, and fecal microbiota.
Article
Biochemistry & Molecular Biology
Jin Woo Lee, Jun Gu Kim, Jae Sang Han, Yong Beom Cho, Yu Jin Lee, Dongho Lee, Dae Hwan Shin, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang
Summary: Five undescribed proline-containing orbitides were isolated from Dianthus chinensis in this study, with their structures elucidated through extensive analysis. These orbitides showed biological activities, with dianthiamide A exhibiting cytotoxic activity against A549 cell line.
Review
Public, Environmental & Occupational Health
Jung Hun Ju, Naery Lee, Sun-Hee Kim, Seokkee Chang, Misook Yang, Jihyun Shin, Eunjo Lee, Sunhwa Sung, Jung-Hwan Kim, Jin Tae Hong, Ho Jung Oh
Summary: This paper discusses the considerations for quality control in the manufacturing process of viral vector vaccines, including test items and summary protocol content. With the ongoing COVID-19 pandemic and controversies surrounding the effectiveness of vaccines against new variants, the establishment of standard guidance for accelerated vaccine development is of great importance to the public.
OSONG PUBLIC HEALTH AND RESEARCH PERSPECTIVES
(2022)
Article
Biochemistry & Molecular Biology
Ji-Eun Kim, Yu-Jeong Roh, Yun-Ju Choi, Su-Jin Lee, You-Jeong Jin, Hee-Jin Song, A-Yun Seol, Hong-Joo Son, Jin-Tae Hong, Dae-Youn Hwang
Summary: The neuropathological constipation phenotypes in Tg2576 transgenic mice may be closely linked to dysbiosis of the fecal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Da Eun Hong, Ji Eun Yu, Jin Woo Lee, Dong Ju Son, Hee Pom Lee, Yuri Kim, Ju Young Chang, Dong Won Lee, Won Kyu Lee, Jaesuk Yun, Sang Bae Han, Bang Yeon Hwang, Jin Tae Hong
Summary: In this study, it was found that the natural compound ebractenoid F could inhibit the expression of CHI3L1 and effectively suppress the growth and migration of lung cancer cells while inducing apoptosis. Further investigations revealed that ebractenoid F bound to CHI3L1 and suppressed its associated AKT signaling. Combined treatment with an AKT inhibitor, LY294002, synergistically decreased the expression of CHI3L1 and inhibited the growth and migration of lung cancer cells, as well as inducing apoptosis.
Article
Chemistry, Medicinal
Seonhwa Kim, Na-Yeon Kim, Jae-Young Park, Hyo-Min Park, Chae-Min Lim, Jinju Kim, Hee Pom Lee, Jin Tae Hong, Do-Young Yoon
Summary: MMPP is a novel synthetic analog that exerts anti-inflammatory and anticancer effects by downregulating the STAT3 pathway and enhancing glucose uptake and insulin sensitivity. It can inhibit the expression of inflammatory cytokines and COX-2 in LPS-stimulated monocytes. MMPP directly binds to CD14 and MD2, inhibits the activation of NF-kappa B and JNK/AP-1 pathways, and shows anti-inflammatory activity.
Article
Neurosciences
Seung Sik Yoo, Dong Won Lee, Hyeon Joo Ham, In Jun Yeo, Ju Young Chang, Jaesuk Yun, Dong Ju Son, Sang-Bae Han, Jin Tae Hong
Summary: Alzheimer's disease (AD) is a common form of dementia, and depression is a critical psychiatric complication of AD. GSK3 beta is associated with AD and depression, and DVL regulates GSK3 beta. PS2 and DVL have cross-talk. Stress leads to cortisol hypersecretion and is associated with depression. DKK-1 regulates depression, and A beta and tau phosphorylation are biomarkers of AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Yonghae Son, In-Jun Yeo, Jin-Tae Hong, Seong-Kug Eo, Dongjun Lee, Koanhoi Kim
Summary: The study reveals that elevated levels of IL-1 beta and oxysterols are found in individuals with Alzheimer's disease. Experiments conducted on microglial cells and mice show that side-chain oxysterols can increase the expression of IL-1 beta and activate microglia. These findings suggest that pharmacologic intervention targeting oxysterols could potentially treat neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Seong Hee Jeon, Yong Sun Lee, In Jun Yeo, Hee Pom Lee, Jaesuk Yoon, Dong Ju Son, Sang-Bae Han, Jin Tae Hong
Summary: The study showed that targeting CHI3L1 with K284 can reduce AD-like skin inflammation, suggesting that K284 could be a promising therapeutic agent for AD by inhibiting LTF expression.