Article
Microbiology
Ke Liu, Fengxiang Hou, Abdul Wahaab, Lei Kang, Fengyu Xie, Xiaochun Ma, Qiqi Xia, Changguang Xiao, Donghua Shao, Beibei Li, Jianchao Wei, Yafeng Qiu, Huaimin Zhu, Zhiyong Ma
Summary: The study revealed that mosquito defensin enhances Japanese encephalitis virus infection by downregulating the antiviral protein HSC70B. This finding suggests that the defensin and HSC70B axis facilitates viral replication in mosquitoes.
VETERINARY MICROBIOLOGY
(2021)
Article
Virology
Liuxing Qin, Tingting Rao, Xiangmin Li, Huanchun Chen, Ping Qian
Summary: This study identified DnaJA2 as a crucial host factor in JEV infection and suggested it as a potential target for antiviral therapies against JEV.
Review
Virology
Baldeep Khare, Richard J. Kuhn
Summary: In the past three decades, multiple flaviviruses from different antigenic groups have spread geographically, leading to the co-circulation of multiple viruses within regions. The morphological heterogeneity of flaviviruses affects antibody recognition, virus neutralization, and infection control. Cross-reactivity among flaviviruses may result in either cross-protection or disease enhancement, although the molecular determinants and mechanisms driving these outcomes are still unclear.
Article
Toxicology
Min Su, Shuhong Zhou, Jun Li, Nan Lin, Tao Chi, Mengdi Zhang, Xiaoli Lv, Yuxia Hu, Tuya Bai, Fuhou Chang
Summary: This study aimed to clarify the new mechanism of Benzo(a)pyrene (BaP) regulating chaperone-mediated autophagy (CMA) through heat shock protein 90 (HSP90). The results demonstrated that BaP induced CMA and caused DNA damage through HSP90.
TOXICOLOGY LETTERS
(2023)
Article
Fisheries
Warumporn Yingsunthonwattana, Wisarut Junprung, Premruethai Supungul, Anchalee Tassanakajon
Summary: The study investigated the involvement of Litopenaeus vannamei (Lv) HSP90 in white spot syndrome virus (WSSV) infections. Silencing LvHSP90 resulted in reduced shrimp mortality and viral replication, but also induced apoptosis and potentially led to shrimp death.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Li Wang, Xu Zhang, Yan-Tao Liu
Summary: JEV infection is a leading cause of viral encephalitis in Asia, with no specific antiviral therapy currently available. Japanese Encephalitis Vaccine (JE-VC) is an effective prevention measure. This report highlights a case of prolonged granulocytopenia following administration of Inactivated JE-VC.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: Cardiovascular diseases are a major cause of death worldwide, with molecular chaperones like HSP90 playing a crucial role in heart protection and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Xun Fu, Jiang Liu, Xin Yan, Michael E. DiSanto, Xinhua Zhang
Summary: Prostate cancer is the second most common cancer in aging men globally, but its exact pathogenesis is not fully understood. The heat shock protein (HSP) family plays a significant role in promoting tumor growth and protecting cancer cells from death. HSP molecules are closely involved in important biological processes such as cell differentiation, epithelial-mesenchymal transition, and fibrosis. Agents and inhibitors targeting the critical structure of HSP molecules have been developed for their potent antitumor effects. However, only a small number of them have been clinically tested. Further clinical studies are needed to establish the relationship between HSP70 family, HSP90 molecule, and prostate cancer treatment.
Article
Oncology
Enzo M. Scutigliani, Yongxin Liang, Marloes IJff, Hans Rodermond, Xionge Mei, Miriam P. Korver, Vaneesha S. Orie, Ron A. Hoebe, Daisy Picavet, Arlene Oei, Roland Kanaar, Przemek M. Krawczyk
Summary: Summary Hyperthermia can improve the effects of radio- and chemotherapy, but its efficacy is limited by the heat stress response (HSR). In this study, we evaluated the HSP90 inhibitor ganetespib in promoting the effects of radiotherapy or cisplatin combined with hyperthermia. Our results showed that ganetespib could enhance the efficacy of hyperthermia when combined with radiation.
Article
Food Science & Technology
Jina Ahn, Ji Eun Yu, Hanna Kim, Jemin Sung, Gyoonhee Han, Myung Hyun Sohn, Baik-Lin Seong
Summary: We successfully produced homo-pentameric EDIII in E. coli through genetic fusion and RNA-mediated assembly. The pentameric assembly was validated and the chimeric antigen triggered high neutralizing antibodies against JEV Nakayama strain in immunized mice. These results suggest that the bacterially produced recombinant chimeric antigen can serve as a cost-effective alternative to conventional inactivated vaccines against JEV.
Article
Virology
Peng Xu, Wei Tong, Young-Mao Chen
Summary: The study identified FUBP3 as a host protein associated with the 3' UTR of JEV, which plays a crucial role in regulating RNA replication and promoting viral translation and particle production.
Article
Medicine, Research & Experimental
Ho Jin Lee, Hye-Young Min, Young-Sik Yong, Jihyae Ann, Cong Truong Nguyen, Minh Thanh La, Seung Yeob Hyun, Huong Thuy Le, Hyewon Kim, Hyukjin Kwon, Gibeom Nam, Hyun-Ju Park, Jeewoo Lee, Ho-Young Lee
Summary: This study revealed that Hsp90 inhibitors that block the N-terminal ATP-binding pocket activate STAT3, leading to the transcriptional upregulation of Wnt ligands and promoting cell survival in NSCLC. NCT-80 effectively reduced NSCLC cell viability, migration, and CSC-like phenotypes, and inhibited the growth of patient-derived xenograft tumors.
Article
Microbiology
Quan Zeng, Jiaqi Liu, Zhaoyang Li, Yucan Zhang, Shaopo Zu, Xueyan Ding, Honglei Zhang
Summary: This study demonstrates that the nonstructural protein 4B (NS4B) of Japanese encephalitis virus (JEV) suppresses interferon-beta production by targeting TLR3 and TRIF proteins, thereby interfering with the host's antiviral response.
VETERINARY MICROBIOLOGY
(2023)
Article
Immunology
Shuo Zhu, Mengying Tao, Yunchuan Li, Xugang Wang, Zikai Zhao, Yixin Liu, Qi Li, Qiuyan Li, Yanbo Lu, Youhui Si, Shengbo Cao, Jing Ye
Summary: This study found that infection with Japanese encephalitis virus (JEV) leads to an increase in H3K27me3 modification in microglial cells and mouse brain. Inhibiting H3K27me3 modification significantly reduces pro-inflammatory cytokine production during JEV infection, indicating its crucial role in the neuroinflammatory response. The increased H3K27me3 modification of E3 ubiquitin ligases following JEV infection leads to downregulation of Rnf19a expression and negative regulation of the neuroinflammatory response.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Immunology
Weijia Zhang, Qikai Yin, Huanyu Wang, Guodong Liang
Summary: The Japanese encephalitis virus (JEV) has five genotypes, with genotypes 1 and 3 historically being more active. Genotypes 4 and 5 have remained silent in low-latitude tropical regions. However, in recent years, genotype 5 emerged in mosquitoes from Tibet and South Korea, leading to cases of viral encephalitis. Similarly, genotype 4 emerged in Australia, causing a local outbreak. These new genotypes present challenges for the prevention and control of Japanese encephalitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)