Article
Immunology
Ziang Zhu, Tong Li, Jinya Chen, Jai Kumar, Princy Kumar, Jing Qin, Colleen Hadigan, Irini Sereti, Jason V. Baker, Marta Catalfamo
Summary: This study examines the impact of HIV infection on endothelial inflammation and repair by evaluating cell phenotypes and subsets in the blood of HIV-infected individuals. The researchers found that infection-induced phenotypic changes were associated with inflammatory biomarkers, suggesting that HIV infection may affect endothelial inflammation and repair.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiaoyu Pan, Lin Yang, Shuqi Wang, Yanhui Liu, Lin Yue, Shuchun Chen
Summary: The low-grade inflammatory state in obesity can damage vascular endothelial cells and lead to cardiovascular diseases. Macrophage exosomes improve glucose tolerance and insulin sensitivity in obese mice, but the relationship with endothelial cell injury is unclear. This study examined the effects of lipopolysaccharide (LPS)-induced macrophage exosomes on endothelial progenitor cells (EPCs) and inflammatory factors. It also investigated the role of MicroRNA-155 (miR-155) in macrophage exosomes and EPCs, and the impact of semaglutide on EPC function and inflammation. The results showed that LPS-induced macrophage exosomes impaired EPCs function and increased inflammation, which was exacerbated by high miR-155 expression. In contrast, inhibition of miR-155 improved EPCs function and reduced inflammation. Semaglutide enhanced EPCs viability and reduced inflammatory factors and miR-155 expression in exosomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Zhewei Zhang, Ke Xiao, Sheng Wang, Abdur Rahman Ansari, Xiaoyu Niu, Wenjie Yang, Mengqi Lu, Zhi Yang, Zia ur Rehman, Weihua Zou, Weicheng Bei, Hui Song
Summary: This study investigated the regulatory mechanisms of visfatin in inflammation and apoptosis in RAW264.7 cells and mice immune organs. The results showed that visfatin can modulate inflammation and apoptosis by regulating various signaling pathways and the expression levels of cytokines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Rahul Mallick, Erika Gurzeler, Pyry I. Toivanen, Tiina Nieminen, Seppo Yla-Herttuala
Summary: VEGF-B186R127S induces vascular growth in mouse heart by recruiting EPCs. It is a novel therapeutic agent for cardiac therapeutic angiogenesis to rescue myocardial tissue after an ischemic insult.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nunzia D'Onofrio, Francesco Prattichizzo, Elisa Martino, Camilla Anastasio, Luigi Mele, Rosalba La Grotta, Celestino Sardu, Antonio Ceriello, Raffaele Marfella, Giuseppe Paolisso, Maria Luisa Balestrieri
Summary: miR-27b is highly expressed in endothelial cells and plays a crucial role in regulating inflammatory pathways, cell cycle, apoptosis, and mitochondrial oxidative imbalances. miR-27b mimic can counteract the cytotoxicity and inflammation caused by TNF-alpha, as well as restore mitochondrial function. Mechanistically, miR-27b targets FOXO1 to achieve its functions.
Review
Biochemistry & Molecular Biology
Klara Komici, Angelica Perna, Germano Guerra
Summary: Frailty is a clinical condition characterized by a decline in biological reserves, physiological mechanism failure, and vulnerability to stressors. This review focuses on the role of endothelial progenitor cells (EPCs) in frailty, highlighting their impaired function, number, and survival in the elderly. It also discusses the modification of EPCs in age-related diseases such as atherosclerosis, hypertension, and diabetes mellitus. The review concludes by exploring interventions that may restore EPCs expression and function in frail individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nadia Meyer, Lars Brodowski, Constantin von Kaisenberg, Bianca Schroeder-Heurich, Frauke Von Versen-Hoeynck
Summary: This study investigated the effects of CsA and Tac on endothelial colony-forming cells (ECFCs), finding that these immunosuppressants not only impair vascular repair and angiogenesis, but also trigger an inflammatory cascade and increase cardiovascular risk in transplant patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Chang-Yu Song, Sunny Li-Yun Chang, Chih-Yang Lin, Chun-Hao Tsai, Shang-Yu Yang, Yi-Chin Fong, Yu-Wen Huang, Shih-Wei Wang, Wei-Cheng Chen, Chih-Hsin Tang
Summary: New treatments for chondrosarcoma are crucial due to its poor prognosis, and factors like PDGF and visfatin play significant roles in tumor development and angiogenesis. Research has shown that visfatin promotes chondrosarcoma angiogenesis by modulating miR-1264 expression, potentially offering a new therapeutic approach for the treatment of chondrosarcoma.
Article
Endocrinology & Metabolism
Jason Phowira, Sherin Bakhashab, Anuradha Doddaballapur, Jolanta U. Weaver
Summary: This study aimed to investigate the changes in endothelial function and circulating endothelial progenitor cells (cEPCs) and circulating angiogenic cells (CACs) counts in SCT patients, as well as the effect of T3 on proangiogenic cell (PAC) function in healthy individuals. The results showed that SCT patients had lower cEPC count and flow-mediated dilation (FMD), indicating increased cardiovascular risk. Furthermore, in vitro studies revealed that T3 increased early apoptosis and reduced endothelial nitric oxide synthase (eNOS) expression in PACs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Yuan Xiang, Zhengshi Zhou, Lingping Zhu, Chuanchang Li, Ying Luo, Jipeng Zhou
Summary: The study found that omentin-1 significantly improved EPC functions and reduced neointimal hyperplasia by inhibiting the p38 MAPK/CREB pathway. Genetically modifying EPC with omentin-1 could be a potential alternative strategy for the treatment of restenosis.
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Immunology
Elisa Weiss, Amanda Vlahos, Bowon Kim, Sachintha Wijegunasekara, Dhanya Shanmuganathan, Thomas Aitken, Ji-Hoon E. Joo, Samira Imran, Rebecca Shepherd, Jeffrey M. Craig, Mark Green, Ursula Hiden, Boris Novakovic, Richard Saffery
Summary: Inflammatory memory involves the reprogramming of innate immune cells to provide non-specific protection. This study found specific transcriptional responses in fetal endothelial cells to initial viral exposure, with both cell types capable of establishing memory. While both cell types showed similar abilities, progenitor ECFCs demonstrated a higher capacity for memory establishment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
June Seok Heo, Sinyoung Kim
Summary: This study found that human adipose mesenchymal stem cell-derived exosomes have anti-inflammatory and pro-angiogenic effects. Exosomes inhibit inflammation by activating ROCK1 and PTEN expression, and promote angiogenesis by releasing miR-132 and miR-146a.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Davide Medica, Rossana Franzin, Alessandra Stasi, Giuseppe Castellano, Massimiliano Migliori, Vincenzo Panichi, Federico Figliolini, Loreto Gesualdo, Giovanni Camussi, Vincenzo Cantaluppi
Summary: The study demonstrates the protective effect of EPC-derived EVs on glomerular endothelial cells and podocytes, showing reductions in apoptosis, antioxidative actions, prevention of leukocyte adhesion, and maintenance of cell function. Additionally, EVs can protect damaged glomerular cells by transferring RNA, suggesting their potential therapeutic role in drug-resistant glomerulonephritis.
Article
Biochemistry & Molecular Biology
Stephanie Simoncini, Simon Toupance, Carlos Labat, Sylvie Gautier, Chloe Dumoulin, Laurent Arnaud, Maria G. Stathopoulou, Sophie Visvikis-Siest, Pascal M. Rossi, Athanase Benetos, Francoise Dignat-George, Florence Sabatier
Summary: This study investigates the relationship between atherosclerotic cardiovascular disease (ASCVD), inflammation markers, and circulating endothelial progenitor cells. The findings suggest that ASCVD impairs the colony forming capacity and angiogenic properties of endothelial colony forming cells (ECFC) in a severity-dependent manner. Additionally, alteration of ECFC is associated with increased senescent phenotype and IL-6 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)